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Ischemic-modified albumin (IMA) is a product of protein oxidation, and recent evidence suggests that IMA can be used as an indicator of oxidative damage. This study aimed to investigate serum EPO and IMA levels in obsessive\u2013compulsive disorder (OCD) patients and to investigate the relationship between EPO and IMA levels and clinical variables such as disease duration and disease severity. A total of 68 adolescents (11\u201318\u00a0years old), including 35 OCD patients (18 males\/17 females) and 33 healthy controls (14 males\/19 females) without comorbid disorders matched for age, gender, and BMI, were included in the study. The enzyme-amplified chemiluminescence technique determined serum EPO levels, and serum IMA levels were determined by the spectrophotometric method. Serum EPO levels were lower in OCD patients compared to healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.002; <jats:italic>Z<\/jats:italic>\u2009=\u2009\u2009\u2212\u20093.123), and serum IMA levels (ABSU) were significantly higher in the OCD group (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). A significant positive correlation was found between IMA levels and the duration of OCD symptoms (<jats:italic>p<\/jats:italic>\u2009=\u20090.015, <jats:italic>r<\/jats:italic>\u2009=\u20090.409). The study\u2019s findings contribute to the growing body of evidence implicating inflammatory and oxidative processes in the pathogenesis of OCD. The potential of EPO and IMA levels as diagnostic biomarkers for OCD aligns with the ongoing efforts to identify reliable biological markers for the disorder. The positive correlation of IMA levels with the duration of OCD shows the importance of early detection of oxidative damage.<\/jats:p>","DOI":"10.1007\/s12031-024-02247-x","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T05:02:04Z","timestamp":1720760524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Erythropoietin and Ischemic-Modified Albumin Levels in Adolescents with Obsessive\u2013Compulsive Disorder"],"prefix":"10.1007","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-7051","authenticated-orcid":false,"given":"Masum","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-8375","authenticated-orcid":false,"given":"Fatma Suba\u015f\u0131","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6959-7552","authenticated-orcid":false,"given":"Davut","family":"Akbal\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0536-2487","authenticated-orcid":false,"given":"Mustafa Erhan","family":"Demirk\u0131ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-1064","authenticated-orcid":false,"given":"\u0130brahim","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"issue":"1","key":"2247_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10072-010-0457-4","volume":"32","author":"JH Ahn","year":"2011","unstructured":"Ahn JH, Choi SC, Lee WG, Jung YS (2011) The usefulness of albumin-adjusted ischemia-modified albumin index as early detecting marker for ischemic stroke. 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