{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:41Z","timestamp":1786982201042,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"crossref","award":["52962"],"award-info":[{"award-number":["52962"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"crossref","award":["52962"],"award-info":[{"award-number":["52962"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"crossref","award":["52962"],"award-info":[{"award-number":["52962"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"crossref","award":["52962"],"award-info":[{"award-number":["52962"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-024-02253-z","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:01:58Z","timestamp":1723050118000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug Response of Iranian Alzheimer\u2019s Patients to Rivastigmine Concerning Their Genotype for VDR rs11568820 and MTHFR C677T Variants: A Pharmacogenetic and Association Study"],"prefix":"10.1007","volume":"74","author":[{"given":"Zahra Salimian","family":"Rizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Shams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Rezaei","family":"Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"2253_CR1","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1021\/acschemneuro.1c00295","volume":"12","author":"E Angelopoulou","year":"2021","unstructured":"Angelopoulou E, Paudel YN, Papageorgiou SG, Piperi C (2021) APOE genotype and Alzheimer\u2019s disease: the influence of lifestyle and environmental factors. ACS Chem Neurosci 12:2749\u20132764. https:\/\/doi.org\/10.1021\/acschemneuro.1c00295","journal-title":"ACS Chem Neurosci"},{"key":"2253_CR2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.bbrc.2020.02.027","volume":"525","author":"M Arakawa","year":"2020","unstructured":"Arakawa M, Wagatsuma A (2020) 1\u03b1, 25 (OH) 2D3 regulates agrin-induced acetylcholine receptor clustering through upregulation of rapsyn expression in C2C12 myotubes. Biochem Biophys Res Commun 525:80\u201386. https:\/\/doi.org\/10.1016\/j.bbrc.2020.02.027","journal-title":"Biochem Biophys Res Commun"},{"key":"2253_CR3","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1007\/s12035-018-1375-3","volume":"56","author":"RH Bahous","year":"2019","unstructured":"Bahous RH, Cos\u00edn-Tom\u00e1s M, Deng L, Leclerc D, Malysheva O, Ho M-K, Pall\u00e0s M, Kaliman P, Bedell BJ, Caudill MA (2019) Early manifestations of brain aging in mice due to low dietary folate and mild MTHFR deficiency. Mol Neurobiol 56:4175\u20134191. https:\/\/doi.org\/10.1007\/s12035-018-1375-3","journal-title":"Mol Neurobiol"},{"key":"2253_CR4","doi-asserted-by":"publisher","unstructured":"Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S (2015) Vitamin D and Alzheimer\u2019s disease: neurocognition to therapeutics. Int J Alzheimer\u2019s Disease. https:\/\/doi.org\/10.1155\/2015\/192747","DOI":"10.1155\/2015\/192747"},{"key":"2253_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ajhg.2008.12.008","volume":"84","author":"GW Beecham","year":"2009","unstructured":"Beecham GW, Martin ER, Li Y-J, Slifer MA, Gilbert JR, Haines JL, Pericak-Vance MA (2009) Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet 84:35\u201343. https:\/\/doi.org\/10.1016\/j.ajhg.2008.12.008","journal-title":"Am J Hum Genet"},{"key":"2253_CR6","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s11033-014-3806-1","volume":"42","author":"L Belcavello","year":"2015","unstructured":"Belcavello L, Camporez D, Almeida LD, Morelato RL, Batitucci MC, de Paula F (2015) Association of MTHFR and PICALM polymorphisms with Alzheimer\u2019s disease. Mol Biol Rep 42:611\u2013616. https:\/\/doi.org\/10.1007\/s11033-014-3806-1","journal-title":"Mol Biol Rep"},{"key":"2253_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1001\/archpsyc.1997.01830150090013","volume":"54","author":"AM Bergem","year":"1997","unstructured":"Bergem AM, Engedal K, Kringlen E (1997) The role of heredity in late-onset Alzheimer disease and vascular dementia: a twin study. Arch Gen Psychiatry 54:264\u2013270. https:\/\/doi.org\/10.1001\/archpsyc.1997.01830150090013","journal-title":"Arch Gen Psychiatry"},{"key":"2253_CR8","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.neurobiolaging.2007.12.010","volume":"30","author":"X-H Bi","year":"2009","unstructured":"Bi X-H, Zhao H-L, Zhang Z-X, Zhang J-W (2009) Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer\u2019s disease. Neurobiol Aging 30:1601\u20131607. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2007.12.010","journal-title":"Neurobiol Aging"},{"key":"2253_CR9","doi-asserted-by":"publisher","first-page":"111264","DOI":"10.1016\/j.exger.2021.111264","volume":"147","author":"I Blasko","year":"2021","unstructured":"Blasko I, Defrancesco M, Oberacher H, Loacker L, Kemmler G, Marksteiner J, Humpel C (2021) Plasma phosphatidylcholines and vitamin B12\/folate levels are possible prognostic biomarkers for progression of Alzheimer\u2019s disease. Exp Gerontol 147:111264. https:\/\/doi.org\/10.1016\/j.exger.2021.111264","journal-title":"Exp Gerontol"},{"key":"2253_CR10","doi-asserted-by":"publisher","unstructured":"Bouguerra K, Tazir M, Melouli H, & Khelil M (2022) The methylenetetrahydrofolate reductase C677T and A1298C genetic polymorphisms and plasma homocysteine in Alzheimer\u2019s disease in an Algerian population. Int J Neurosci, 1\u20136. https:\/\/doi.org\/10.1080\/00207454.2022.2158825","DOI":"10.1080\/00207454.2022.2158825"},{"key":"2253_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-9-21","volume":"9","author":"S-Y Chen","year":"2012","unstructured":"Chen S-Y, Chen T-F, Lai L-C, Chen J-H, Sun Y, Wen L-L, Yip P-K, Chu Y-M, Chen Y-C (2012) Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer\u2019s disease. J Neuroinflammation 9:1\u20139. https:\/\/doi.org\/10.1186\/1742-2094-9-21","journal-title":"J Neuroinflammation"},{"key":"2253_CR12","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s00580-018-2676-7","volume":"27","author":"FD Colagari","year":"2018","unstructured":"Colagari FD, Hossienzadeh Colagar A, Zamani MR (2018) Human MTHFR-C677T gene transition increased risk of Alzheimer disease: a case-control study which performed by optimized PCR-CTPP method. Comp Clinic Pathol 27:879\u2013885. https:\/\/doi.org\/10.1007\/s00580-018-2676-7","journal-title":"Comp Clinic Pathol"},{"key":"2253_CR13","doi-asserted-by":"publisher","first-page":"119386","DOI":"10.1016\/j.lfs.2021.119386","volume":"277","author":"TM dos Santos","year":"2021","unstructured":"dos Santos TM, J\u00fanior OVR, Alves VS, Coutinho-Silva R, Savio LEB, Wyse AT (2021) Hyperhomocysteinemia alters cytokine gene expression, cytochrome c oxidase activity and oxidative stress in striatum and cerebellum of rodents. Life Sci 277:119386. https:\/\/doi.org\/10.1016\/j.lfs.2021.119386","journal-title":"Life Sci"},{"key":"2253_CR14","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.gene.2019.05.030","volume":"707","author":"A Durmaz","year":"2019","unstructured":"Durmaz A, Kumral E, Durmaz B, Onay H, Aslan GI, Ozkinay F, Pehlivan S, Orman M, Cogulu O (2019) Genetic factors associated with the predisposition to late onset Alzheimer\u2019s disease. Gene 707:212\u2013215. https:\/\/doi.org\/10.1016\/j.gene.2019.05.030","journal-title":"Gene"},{"key":"2253_CR15","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3389\/fneur.2020.00454","volume":"11","author":"ME Fullard","year":"2020","unstructured":"Fullard ME, Duda JE (2020) A review of the relationship between vitamin D and Parkinson disease symptoms. Front Neurol 11:454. https:\/\/doi.org\/10.3389\/fneur.2020.00454","journal-title":"Front Neurol"},{"key":"2253_CR16","doi-asserted-by":"publisher","first-page":"M117","DOI":"10.1093\/gerona\/52A.2.M117","volume":"52","author":"M Gatz","year":"1997","unstructured":"Gatz M, Pedersen NL, Berg S, Johansson B, Johansson K, Mortimer JA, Posner SF, Viitanen M, Winblad B, Ahlbom A (1997) Heritability for Alzheimer\u2019s disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci 52:M117\u2013M125. https:\/\/doi.org\/10.1093\/gerona\/52A.2.M117","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2253_CR17","doi-asserted-by":"publisher","unstructured":"Gholamzadeh S, Heshmati B, Mani A, Petramfar P Baghery Z (2017) The prevalence of Alzheimer\u2019s disease; its risk and protective factors among the elderly population in Iran. Shiraz E-Medical J, 18. https:\/\/doi.org\/10.5812\/semj.57576","DOI":"10.5812\/semj.57576"},{"key":"2253_CR18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.9758\/cpn.2021.19.3.459","volume":"19","author":"S-W Hsieh","year":"2021","unstructured":"Hsieh S-W, Chen J-C, Chen N-C, Jhang K-M, Wang W, Yang Y-H (2021) Real-world evaluation of tolerability, safety and efficacy of Rivastigmine oral solution in patients with mild to moderate Alzheimer\u2019s disease dementia. Clinic Psychopharmacol Neurosci 19:459. https:\/\/doi.org\/10.9758\/cpn.2021.19.3.459","journal-title":"Clinic Psychopharmacol Neurosci"},{"key":"2253_CR19","doi-asserted-by":"publisher","unstructured":"Huang Z, Ang W, Huang H, Wang Y (2024) VD\/VDR-mediated ATG16L1 activation reduces Alzheimer\u2019s disease-like pathology and cognitive decline. Mol Cell Toxicol, 1\u201312. https:\/\/doi.org\/10.1007\/s13273-024-00429-7","DOI":"10.1007\/s13273-024-00429-7"},{"key":"2253_CR20","doi-asserted-by":"publisher","unstructured":"Ibrahim AN, Attallah MI, Elnaggar RA (2018) Combination of cholecalciferol and rivastigmine improves cognitive dysfunction and reduces inflammation in stz induced alzheimer\u2019s model experimentally in rats. Egypt J Basic Clinic Pharmacol, 8. https:\/\/doi.org\/10.11131\/2018\/101369","DOI":"10.11131\/2018\/101369"},{"key":"2253_CR21","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s11064-006-9119-6","volume":"31","author":"MR Keikhaee","year":"2006","unstructured":"Keikhaee MR, Hashemi SB, Najmabadi H, Noroozian M (2006) C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer\u2019s disease in Iranian population. Neurochem Res 31:1079\u20131083. https:\/\/doi.org\/10.1007\/s11064-006-9119-6","journal-title":"Neurochem Res"},{"key":"2253_CR22","first-page":"1253","volume":"42","author":"HRK Khorshid","year":"2013","unstructured":"Khorshid HRK, Gozalpour E, Saliminejad K, Karimloo M, Ohadi M, Kamali K (2013) Vitamin D Receptor (VDR) polymorphisms and late-onset Alzheimer\u2019s disease: an association study. Iran J Public Health 42:1253","journal-title":"Iran J Public Health"},{"key":"2253_CR23","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/cells12040660","volume":"12","author":"W Laso\u0144","year":"2023","unstructured":"Laso\u0144 W, Jantas D, Le\u015bkiewicz M, Regulska M, Basta-Kaim A (2023) The vitamin D receptor as a potential target for the treatment of age-related neurodegenerative diseases such as Alzheimer\u2019s and Parkinson\u2019s diseases: a narrative review. Cells 12:660. https:\/\/doi.org\/10.3390\/cells12040660","journal-title":"Cells"},{"key":"2253_CR24","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/biof.2013","volume":"50","author":"M Mohanad","year":"2024","unstructured":"Mohanad M, Mohamed SK, Aboulhoda BE, Ahmed MA (2024) Neuroprotective effects of vitamin D in an Alzheimer\u2019s disease rat model: improvement of mitochondrial dysfunction via calcium\/calmodulin-dependent protein kinase kinase 2 activation of Sirtuin1 phosphorylation. BioFactors 50:371\u2013391. https:\/\/doi.org\/10.1002\/biof.2013","journal-title":"BioFactors"},{"key":"2253_CR25","first-page":"19268","volume":"9","author":"M-J Mun","year":"2016","unstructured":"Mun M-J, Kim M-S, Kim J-H, Jang W-C (2016) A TaqI polymorphism of vitamin D receptor is associated with Alzheimer\u2019s disease in Korean population: a case-control study. Int J Clin Exp Med 9:19268\u201319279","journal-title":"Int J Clin Exp Med"},{"key":"2253_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-019-0351-3","volume":"14","author":"RS Pandey","year":"2019","unstructured":"Pandey RS, Graham L, Uyar A, Preuss C, Howell GR, Carter GW (2019) Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer\u2019s disease. Mol Neurodegener 14:1\u201315. https:\/\/doi.org\/10.1186\/s13024-019-0351-3","journal-title":"Mol Neurodegener"},{"key":"2253_CR27","doi-asserted-by":"publisher","unstructured":"Santamar\u00eda TZ, G\u00f3mez PY, Galindo MG Gonz\u00e1lez IF, V\u00e1zquez AO, L\u00f3pez ML (2022) Pharmacogenetic Studies in Alzheimer Disease Neurolog\u00eda (english Edition) 37 287 303 https:\/\/doi.org\/10.1016\/j.nrleng.2018.03.022","DOI":"10.1016\/j.nrleng.2018.03.022"},{"key":"2253_CR28","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1590\/S0004-282X2006000600010","volume":"64","author":"VCD Silva","year":"2006","unstructured":"Silva VCD, Ramos FJDC, Freitas EM, Brito-Marques PRD, Cavalcanti MNDH, D\u2019Almeida V, Cabral-Filho JE, Muniz MTC (2006) Alzheimer\u2019s disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms. Arq Neuropsiquiatr 64:941\u2013945. https:\/\/doi.org\/10.1590\/S0004-282X2006000600010","journal-title":"Arq Neuropsiquiatr"},{"key":"2253_CR29","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41593-020-0599-5","volume":"23","author":"R Sims","year":"2020","unstructured":"Sims R, Hill M, Williams J (2020) The multiplex model of the genetics of Alzheimer\u2019s disease. Nat Neurosci 23:311\u2013322. https:\/\/doi.org\/10.1038\/s41593-020-0599-5","journal-title":"Nat Neurosci"},{"key":"2253_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11011-005-4147-5","volume":"20","author":"FM Stefanello","year":"2005","unstructured":"Stefanello FM, Franzon R, Tagliari B, Wannmacher CM, Wajner M, Wyse AT (2005) Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia. Metab Brain Dis 20:97\u2013103. https:\/\/doi.org\/10.1007\/s11011-005-4147-5","journal-title":"Metab Brain Dis"},{"key":"2253_CR31","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3233\/JAD-161081","volume":"56","author":"A Stoccoro","year":"2017","unstructured":"Stoccoro A, Tannorella P, Salluzzo MG, Ferri R, Romano C, Nacmias B, Siciliano G, Migliore L, Coppede F (2017) The methylenetetrahydrofolate reductase C677T polymorphism and risk for late-onset Alzheimer\u2019s disease: further evidence in an Italian multicenter study. J Alzheimer\u2019s Dis 56:1451\u20131457. https:\/\/doi.org\/10.3233\/JAD-161081","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2253_CR32","unstructured":"R Tabrizi M Moosazadeh M Akbari MH Dabbaghmanesh M Mohamadkhani Z Asemi ST Heydari M Akbari KB Lankarani 2018 Iran J Med Sci 43 125"},{"key":"2253_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1385\/JMN:27:1:023","volume":"27","author":"B Wang","year":"2005","unstructured":"Wang B, Jin F, Kan R, Ji S, Zhang C, Lu Z, Zheng C, Yang Z, Wang L (2005) Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer\u2019s disease. J Mol Neurosci 27:23\u201327. https:\/\/doi.org\/10.1385\/JMN:27:1:023","journal-title":"J Mol Neurosci"},{"key":"2253_CR34","doi-asserted-by":"publisher","first-page":"135598","DOI":"10.1016\/j.neulet.2020.135598","volume":"744","author":"J Wang","year":"2021","unstructured":"Wang J, Guo M-N, Liu Z-Z, Ma S-F, Liu W-J, Qian J-J, Zhang W-N (2021) PGC-1\u03b1 reduces Amyloid-\u03b2 deposition in Alzheimer\u2019s disease: effect of increased VDR expression. Neurosci Lett 744:135598. https:\/\/doi.org\/10.1016\/j.neulet.2020.135598","journal-title":"Neurosci Lett"},{"key":"2253_CR35","doi-asserted-by":"publisher","unstructured":"Wang L, Hara K, Van Baaren JM, Price JC, Beecham GW, Gallins PJ, Whitehead PL. Wang G, Lu C, Slifer MA (2012) Vitamin D receptor and Alzheimer\u2019s disease: a genetic and functional study. Neurobiology of aging, 33, 1844. e1\u20131844. e9. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.12.038","DOI":"10.1016\/j.neurobiolaging.2011.12.038"},{"key":"2253_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1001\/archneur.65.3.329","volume":"65","author":"SC Waring","year":"2008","unstructured":"Waring SC, Rosenberg RN (2008) Genome-wide association studies in Alzheimer disease. Arch Neurol 65:329\u2013334. https:\/\/doi.org\/10.1001\/archneur.65.3.329","journal-title":"Arch Neurol"},{"key":"2253_CR37","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1515\/med-2019-0006","volume":"14","author":"J Yi","year":"2019","unstructured":"Yi J, Xiao L, Zhou S-Q, Zhang W-J, Liu B-Y (2019) The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer\u2019s disease. Open Medicine 14:32\u201340. https:\/\/doi.org\/10.1515\/med-2019-0006","journal-title":"Open Medicine"},{"key":"2253_CR38","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000329514","volume":"1","author":"M Zamani","year":"2011","unstructured":"Zamani M, Mehri M, Kollaee A, Yenki P, Ghaffarpor M, Harirchian M, Shahbazi M (2011) Pharmacogenetic study on the effect of rivastigmine on PS2 and APOE genes in Iranian Alzheimer patients. Dement Geriatr Cogn Disord Extra 1:180\u2013189. https:\/\/doi.org\/10.1159\/000329514","journal-title":"Dement Geriatr Cogn Disord Extra"},{"key":"2253_CR39","doi-asserted-by":"publisher","unstructured":"Zou J, Chen Z, Liang C, Fu Y, Wei X, Lu J, Pan M, Guo Y, Liao X, Xie H (2018) Trefoil factor 3, cholinesterase and homocysteine: potential predictors for Parkinson\u2019s disease dementia and vascular parkinsonism dementia in advanced stage. Aging and disease, 9, 51. https:\/\/doi.org\/10.14336\/AD.2017.0416","DOI":"10.14336\/AD.2017.0416"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-024-02253-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-024-02253-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-024-02253-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T06:14:53Z","timestamp":1728022493000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-024-02253-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["2253"],"URL":"https:\/\/doi.org\/10.1007\/s12031-024-02253-z","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"assertion":[{"value":"29 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval was obtained from the ethics committee and the review board of the Tehran University of Medical Sciences. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Patients signed informed consent regarding publishing their data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"75"}}