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HS neurons are proposed to be particularly sensitive to the deleterious effects of pathological exposure to amyloid-\u03b2 (A\u03b2), as would occur during Alzheimer\u2019s disease (AD). However, it is not known how HS GABA release in the MS\/DBB is altered during the progression of AD. To target HS neurons in a mouse model of AD, we crossed SST-Cre mice to 5XFAD mice and performed stereotaxic injections of Cre-dependent AAV containing mCherry\/channelrhodopsin-2 (ChR2) into the hippocampus of offspring at 4, 6, 9, and 12\u00a0months. We used optogenetics to selectively stimulate HS terminals while performing whole-cell patch-clamp recordings from MS\/DBB neurons in slices. There was a transient reduction in HS-inhibitory postsynaptic current (IPSC) amplitude in female 5XFAD mice at 6\u00a0months, but no difference in males at any age, and no difference in paired-pulse ratio in either sex at any age. When bath applying the GABA<jats:sub>B<\/jats:sub>R agonist, baclofen, we found a larger decrease in HS-IPSC amplitude in 5XFAD females at 9\u00a0months and 5XFAD males at 12\u00a0months. In 12-month-old 5XFAD females, response to baclofen was significantly reduced. These data suggest that there is a transient increase in responsiveness to GABA<jats:sub>B<\/jats:sub>R activation in 5XFAD mice that occurs earlier in females than in males. These sex-specific changes to HS function are likely to impact the relay of information between the hippocampus and MS\/DBB.<\/jats:p>","DOI":"10.1007\/s12031-024-02260-0","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T07:02:42Z","timestamp":1725001362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner"],"prefix":"10.1007","volume":"74","author":[{"given":"Joanne C.","family":"Damborsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrel L.","family":"Yakel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"2260_CR1","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1007\/s11011-018-0292-5","volume":"33","author":"A Almasi","year":"2018","unstructured":"Almasi A, Zarei M, Raoufi S, Sarihi A, Salehi I, Komaki A, Hashemi-Firouzi N, Shahidi S (2018) Influence of hippocampal GABA(B) receptor inhibition on memory in rats with acute beta-amyloid toxicity. 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