{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:48:18Z","timestamp":1768319298164,"version":"3.49.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trigeminal neuralgia (TN) is a severe facial pain disease of uncertain pathophysiology and unclear genetic background. Although recent research has reported a more important role of genetic factors in TN pathogenesis, few candidate genes have been proposed to date. The present study aimed to identify independent genetic variants in the protein-coding genes associated with TN. We focused on genes previously linked to TN based on the results of four proteomic studies conducted by our research team. The goal was to validate these findings on the genetic level to enhance our understanding of the role of genetics in TN. The study is based on the participants from UK Biobank cohort. Following quality control, 175 independent single nucleotide polymorphisms (SNPs) in 17 genes were selected. The study sample comprised of diagnosed TN cases (N\u2009=\u2009555) and randomly matched controls (N\u2009=\u20096245) based on specific criteria. Two SNPs corresponding to <jats:italic>C8B<\/jats:italic> rs706484 [odds ratio (OR) (95% confidence interval (CI)): 1.357 (1.158\u20131.590); p: 0.00016] and <jats:italic>MFG-E8<\/jats:italic> rs2015495 [OR (95% CI): 1.313 (1.134\u20131.521); p: 0.00028] showed significant positive association with TN, indicating a positive effect of the SNP alleles on gene expression and disease risk. Interestingly, both SNPs are Expression Quantitative Trait Loci (eQTLs), and are associated with changes in the expression activity of their corresponding gene. Our findings suggest novel genetic associations between C8B, a key component of the complement system, and MFG-E8, which plays a role in regulating neuroinflammation, in relation to TN. The identified genetic variations may help explain why some individuals develop TN while others do not, indicating a potential genetic predisposition to the condition.<\/jats:p>","DOI":"10.1007\/s12031-024-02263-x","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T07:02:05Z","timestamp":1727938925000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia"],"prefix":"10.1007","volume":"74","author":[{"given":"Muataz S.","family":"Lafta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gull","family":"Rukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami Abu","family":"Hamdeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmina","family":"Molero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr V.","family":"Sokolov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helgi B.","family":"Schi\u00f6th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"issue":"9\u201310","key":"2263_CR1","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.jpain.2020.03.002","volume":"21","author":"S Abu Hamdeh","year":"2020","unstructured":"Abu Hamdeh S, Khoonsari PE, Shevchenko G, Gordh T, Ericson H, Kultima K (2020) Increased CSF Levels of Apolipoproteins and Complement Factors in Trigeminal Neuralgia Patients-In Depth Proteomic Analysis Using Mass Spectrometry. J Pain 21(9\u201310):1075\u20131084. https:\/\/doi.org\/10.1016\/j.jpain.2020.03.002","journal-title":"J Pain"},{"issue":"12","key":"2263_CR2","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41582-020-00415-2","volume":"16","author":"M Alsaloum","year":"2020","unstructured":"Alsaloum M, Higerd GP, Effraim PR, Waxman SG (2020) Status of peripheral sodium channel blockers for non-addictive pain treatment. Nat Rev Neurol 16(12):689\u2013705. https:\/\/doi.org\/10.1038\/s41582-020-00415-2","journal-title":"Nat Rev Neurol"},{"issue":"2\u20133","key":"2263_CR3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/s0304-4165(96)00091-8","volume":"1334","author":"N Aoki","year":"1997","unstructured":"Aoki N, Ishii T, Ohira S et al (1997) Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. Biochim Biophys Acta 1334(2\u20133):182\u2013190. https:\/\/doi.org\/10.1016\/s0304-4165(96)00091-8","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2263_CR4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1086\/341719","volume":"71","author":"KG Ardlie","year":"2002","unstructured":"Ardlie KG, Lunetta KL, Seielstad M (2002) Testing for Population Subdivision and Association in Four Case-Control Studies. Am J Hum Genet 71(2):304\u2013311","journal-title":"Am J Hum Genet"},{"issue":"11","key":"2263_CR5","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s10495-011-0630-0","volume":"16","author":"M Aziz","year":"2011","unstructured":"Aziz M, Jacob A, Matsuda A, Wang P (2011) Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation. Apoptosis 16(11):1077\u20131086. https:\/\/doi.org\/10.1007\/s10495-011-0630-0","journal-title":"Apoptosis"},{"issue":"4","key":"2263_CR6","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/jnc.13584","volume":"141","author":"T Benedet","year":"2017","unstructured":"Benedet T, Gonzalez P, Oliveros JC et al (2017) Transcriptional repressor DREAM regulates trigeminal noxious perception. J Neurochem 141(4):544\u2013552. https:\/\/doi.org\/10.1111\/jnc.13584","journal-title":"J Neurochem"},{"issue":"3","key":"2263_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/medicines6030091","volume":"6","author":"P Bista","year":"2019","unstructured":"Bista P, Imlach WL (2019) Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain. Medicines 6(3):91. https:\/\/doi.org\/10.3390\/medicines6030091","journal-title":"Medicines"},{"key":"2263_CR8","doi-asserted-by":"publisher","unstructured":"Cervera-Martinez C, Martinez-Manrique JJ, Revuelta-Gutierrez R. Surgical Management of Familial Trigeminal Neuralgia With Different Inheritance Patterns: A Case Report. Frontiers in Neurology. 2018;9. Accessed January 6, 2024. https:\/\/doi.org\/10.3389\/fneur.2018.00316","DOI":"10.3389\/fneur.2018.00316"},{"issue":"1","key":"2263_CR9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1129-2377-15-42","volume":"15","author":"W Cui","year":"2014","unstructured":"Cui W, Yu X, Zhang H (2014) The serotonin transporter gene polymorphism is associated with the susceptibility and the pain severity in idiopathic trigeminal neuralgia patients. J Headache Pain 15(1):42. https:\/\/doi.org\/10.1186\/1129-2377-15-42","journal-title":"J Headache Pain"},{"issue":"10","key":"2263_CR10","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/acn3.629","volume":"5","author":"M Del Campo","year":"2018","unstructured":"Del Campo M, Galimberti D, Elias N et al (2018) Novel CSF biomarkers to discriminate FTLD and its pathological subtypes. Ann Clin Transl Neurol 5(10):1163\u20131175. https:\/\/doi.org\/10.1002\/acn3.629","journal-title":"Ann Clin Transl Neurol"},{"issue":"2","key":"2263_CR11","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s13566-017-0300-0","volume":"6","author":"RA Denu","year":"2017","unstructured":"Denu RA, Rosenberg SA, Howard SP (2017) Familial trigeminal neuralgia treated with stereotactic radiosurgery: a case report and literature review. J Radiat Oncol 6(2):149\u2013152. https:\/\/doi.org\/10.1007\/s13566-017-0300-0","journal-title":"J Radiat Oncol"},{"issue":"3","key":"2263_CR12","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3171\/jns.2002.96.3.0532","volume":"96","author":"M Devor","year":"2002","unstructured":"Devor M, Govrin-Lippmann R, Rappaport ZH (2002) Mechanism of trigeminal neuralgia: an ultrastructural analysis of trigeminal root specimens obtained during microvascular decompression surgery. J Neurosurg 96(3):532\u2013543. https:\/\/doi.org\/10.3171\/jns.2002.96.3.0532","journal-title":"J Neurosurg"},{"issue":"8","key":"2263_CR13","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1177\/0333102419897623","volume":"40","author":"G Di Stefano","year":"2020","unstructured":"Di Stefano G, Yuan JH, Cruccu G, Waxman SG, Dib-Hajj SD, Truini A (2020) Familial trigeminal neuralgia \u2013 a systematic clinical study with a genomic screen of the neuronal electrogenisome. Cephalalgia 40(8):767\u2013777. https:\/\/doi.org\/10.1177\/0333102419897623","journal-title":"Cephalalgia"},{"issue":"10","key":"2263_CR14","doi-asserted-by":"publisher","first-page":"101552","DOI":"10.1016\/j.isci.2020.101552","volume":"23","author":"W Dong","year":"2020","unstructured":"Dong W, Jin SC, Allocco A et al (2020) Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia. iScience 23(10):101552. https:\/\/doi.org\/10.1016\/j.isci.2020.101552","journal-title":"iScience"},{"issue":"1","key":"2263_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/24740527.2019.1709163","volume":"4","author":"TL Doshi","year":"2020","unstructured":"Doshi TL, Nixdorf DR, Campbell CM, Raja SN (2020) Biomarkers in Temporomandibular Disorder and Trigeminal Neuralgia: A Conceptual Framework for Understanding Chronic Pain. Can J Pain 4(1):1\u201318. https:\/\/doi.org\/10.1080\/24740527.2019.1709163","journal-title":"Can J Pain"},{"issue":"11","key":"2263_CR16","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1097\/j.pain.0000000000001649","volume":"160","author":"H Ericson","year":"2019","unstructured":"Ericson H, Abu Hamdeh S, Freyhult E et al (2019) Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression. Pain 160(11):2603\u20132611. https:\/\/doi.org\/10.1097\/j.pain.0000000000001649","journal-title":"Pain"},{"key":"2263_CR17","doi-asserted-by":"publisher","unstructured":"Familial trigeminal neuralgia \u2013 a systematic clinical study with a genomic screen of the neuronal electrogenisome - Giulia Di Stefano, Jun-Hui Yuan, Giorgio Cruccu, Stephen G Waxman, Sulayman D Dib-Hajj, Andrea Truini, 2020. Accessed January 6, 2024. https:\/\/doi.org\/10.1177\/0333102419897623","DOI":"10.1177\/0333102419897623"},{"issue":"4","key":"2263_CR18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.nrleng.2016.12.003","volume":"34","author":"B Fern\u00e1ndez Rodr\u00edguez","year":"2019","unstructured":"Fern\u00e1ndez Rodr\u00edguez B, Simonet C, Cerd\u00e1n DM et al (2019) Familial classic trigeminal neuralgia. Neurolog\u00eda (English Edition) 34(4):229\u2013233. https:\/\/doi.org\/10.1016\/j.nrleng.2016.12.003","journal-title":"Neurolog\u00eda (English Edition)"},{"issue":"8","key":"2263_CR19","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1523\/JNEUROSCI.4837-11.2012","volume":"32","author":"M Fricker","year":"2012","unstructured":"Fricker M, Neher JJ, Zhao JW, Th\u00e9ry C, Tolkovsky AM, Brown GC (2012) MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. J Neurosci 32(8):2657\u20132666. https:\/\/doi.org\/10.1523\/JNEUROSCI.4837-11.2012","journal-title":"J Neurosci"},{"key":"2263_CR20","doi-asserted-by":"publisher","first-page":"174480692090189","DOI":"10.1177\/1744806920901890","volume":"16","author":"E Gambeta","year":"2020","unstructured":"Gambeta E, Chichorro JG, Zamponi GW (2020) Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments. Mol Pain 16:1744806920901890. https:\/\/doi.org\/10.1177\/1744806920901890","journal-title":"Mol Pain"},{"key":"2263_CR21","doi-asserted-by":"publisher","unstructured":"GTEx Consortium (2013) The Genotype-Tissue Expression (GTEx) project. Nat Genet 45(6):580\u2013585. https:\/\/doi.org\/10.1038\/ng.2653","DOI":"10.1038\/ng.2653"},{"issue":"6235","key":"2263_CR22","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"GTEx Consortium","year":"2015","unstructured":"GTEx Consortium (2015) Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348(6235):648\u2013660","journal-title":"Science"},{"issue":"5","key":"2263_CR23","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neurad.2012.08.006","volume":"39","author":"KJ Harsha","year":"2012","unstructured":"Harsha KJ, Kesavadas C, Chinchure S, Thomas B, Jagtap S (2012) Imaging of vascular causes of trigeminal neuralgia. J Neuroradiol 39(5):281\u2013289. https:\/\/doi.org\/10.1016\/j.neurad.2012.08.006","journal-title":"J Neuroradiol"},{"issue":"10","key":"2263_CR24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11916-019-0810-0","volume":"23","author":"MR Jones","year":"2019","unstructured":"Jones MR, Urits I, Ehrhardt KP et al (2019) A Comprehensive Review of Trigeminal Neuralgia. Curr Pain Headache Rep 23(10):74. https:\/\/doi.org\/10.1007\/s11916-019-0810-0","journal-title":"Curr Pain Headache Rep"},{"issue":"2","key":"2263_CR25","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1093\/brain\/awaa425","volume":"144","author":"JH Kim","year":"2021","unstructured":"Kim JH, Afridi R, Han J et al (2021) Gamma subunit of complement component 8 is a neuroinflammation inhibitor. Brain 144(2):528\u2013552. https:\/\/doi.org\/10.1093\/brain\/awaa425","journal-title":"Brain"},{"key":"2263_CR26","doi-asserted-by":"publisher","unstructured":"Kim JH, Han J, Suk K (2021) Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown. Frontiers in Physiology. 2021;12. Accessed January 6, 2024. https:\/\/doi.org\/10.3389\/fphys.2021.671250","DOI":"10.3389\/fphys.2021.671250"},{"issue":"1","key":"2263_CR27","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.cell.2012.05.032","volume":"150","author":"NJ Krautler","year":"2012","unstructured":"Krautler NJ, Kana V, Kranich J et al (2012) Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell 150(1):194\u2013206. https:\/\/doi.org\/10.1016\/j.cell.2012.05.032","journal-title":"Cell"},{"issue":"8","key":"2263_CR28","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.pain.2011.04.014","volume":"152","author":"ML LaCroix-Fralish","year":"2011","unstructured":"LaCroix-Fralish ML, Austin JS, Zheng FY, Levitin DJ, Mogil JS (2011) Patterns of pain: meta-analysis of microarray studies of pain. Pain 152(8):1888\u20131898. https:\/\/doi.org\/10.1016\/j.pain.2011.04.014","journal-title":"Pain"},{"issue":"6","key":"2263_CR29","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/ejp.2231","volume":"28","author":"MS Lafta","year":"2023","unstructured":"Lafta MS, Sokolov AV, Landtblom AM, Ericson H, Schi\u00f6th HB, Abu HS (2023) Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression: A comparison with multiple sclerosis patients and non-neurological controls. Eur J Pain 28(6):929\u2013942. https:\/\/doi.org\/10.1002\/ejp.2231","journal-title":"Eur J Pain"},{"issue":"Suppl 1","key":"2263_CR30","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1186\/1753-6561-1-S1-S144","volume":"1","author":"AC Lam","year":"2007","unstructured":"Lam AC, Schouten M, Aulchenko YS, Haley CS, de Koning DJ (2007) Rapid and robust association mapping of expression quantitative trait loci. BMC Proc 1(Suppl 1):S144","journal-title":"BMC Proc"},{"issue":"6","key":"2263_CR31","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.3171\/2014.2.JNS131288","volume":"120","author":"PRL Leal","year":"2014","unstructured":"Leal PRL, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M (2014) Atrophic changes in the trigeminal nerves of patients with trigeminal neuralgia due to neurovascular compression and their association with the severity of compression and clinical outcomes: Clinical article. J Neurosurg 120(6):1484\u20131495. https:\/\/doi.org\/10.3171\/2014.2.JNS131288","journal-title":"J Neurosurg"},{"issue":"12","key":"2263_CR32","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.1111\/j.1460-9568.2007.05971.x","volume":"26","author":"M Li","year":"2007","unstructured":"Li M, Peake PW, Charlesworth JA, Tracey DJ, Moalem-Taylor G (2007) Complement activation contributes to leukocyte recruitment and neuropathic pain following peripheral nerve injury in rats. Eur J Neurosci 26(12):3486\u20133500. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05971.x","journal-title":"Eur J Neurosci"},{"issue":"11","key":"2263_CR33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1517\/14728222.2013.829455","volume":"17","author":"BZ Li","year":"2013","unstructured":"Li BZ, Zhang HY, Pan HF, Ye DQ (2013) Identification of MFG-E8 as a novel therapeutic target for diseases. Expert Opin Ther Targets 17(11):1275\u20131285. https:\/\/doi.org\/10.1517\/14728222.2013.829455","journal-title":"Expert Opin Ther Targets"},{"key":"2263_CR34","doi-asserted-by":"publisher","first-page":"s12990-015-0076","DOI":"10.1186\/s12990-015-0076-4","volume":"11","author":"AP Lulz","year":"2015","unstructured":"Lulz AP, Kopach O, Santana-Varela S, Wood JN (2015) The Role of Nav19 Channel in the Development of Neuropathic Orofacial Pain Associated with Trigeminal Neuralgia. Molecular Pain 11:s12990-015-0076\u20134","journal-title":"Molecular Pain"},{"issue":"2","key":"2263_CR35","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/ALN.0b013e3182604b2b","volume":"117","author":"F Ma","year":"2012","unstructured":"Ma F, Zhang L, Westlund KN (2012) Trigeminal Nerve Injury ErbB3\/ErbB2 Promotes Mechanical Hypersensitivity. Anesthesiology 117(2):381\u2013388. https:\/\/doi.org\/10.1097\/ALN.0b013e3182604b2b","journal-title":"Anesthesiology"},{"key":"2263_CR36","doi-asserted-by":"publisher","first-page":"174480692110161","DOI":"10.1177\/17448069211016139","volume":"17","author":"MA Mannerak","year":"2021","unstructured":"Mannerak MA, Lashkarivand A, Eide PK (2021) Trigeminal neuralgia and genetics: A systematic review. Mol Pain 17:17448069211016140. https:\/\/doi.org\/10.1177\/17448069211016139","journal-title":"Mol Pain"},{"issue":"7","key":"2263_CR37","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/head.13576","volume":"59","author":"JL M\u00e9reaux","year":"2019","unstructured":"M\u00e9reaux JL, Lefaucheur R, Hebant B, Gu\u00e9gan-Massardier E, Grangeon L (2019) Trigeminal Neuralgia and Charcot-Marie-Tooth Disease: An Intriguing Association. Lessons From a Large Family Case Report and Review of Literature. Headache: J Head Face Pain 59(7):1074\u20131079","journal-title":"Headache: J Head Face Pain"},{"key":"2263_CR38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2147\/TCRM.S37592","volume":"11","author":"N Montano","year":"2015","unstructured":"Montano N, Conforti G, Bonaventura RD, Meglio M, Fernandez E, Papacci F (2015) Advances in diagnosis and treatment of trigeminal neuralgia. TCRM 11:289\u2013299. https:\/\/doi.org\/10.2147\/TCRM.S37592","journal-title":"TCRM"},{"issue":"15","key":"2263_CR39","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1177\/0333102411424619","volume":"31","author":"D Mueller","year":"2011","unstructured":"Mueller D, Obermann M, Yoon MS et al (2011) Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: a population-based study. Cephalalgia 31(15):1542\u20131548. https:\/\/doi.org\/10.1177\/0333102411424619","journal-title":"Cephalalgia"},{"key":"2263_CR40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fgene.2020.00157","volume":"11","author":"TA Myers","year":"2020","unstructured":"Myers TA, Chanock SJ, Machiela MJ (2020) LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations. Front Genet 11:157. https:\/\/doi.org\/10.3389\/fgene.2020.00157","journal-title":"Front Genet"},{"issue":"9","key":"2263_CR41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/brainsci8090167","volume":"8","author":"Y Nakashima","year":"2018","unstructured":"Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T (2018) The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson\u2019s Disease. Brain Sci 8(9):167. https:\/\/doi.org\/10.3390\/brainsci8090167","journal-title":"Brain Sci"},{"issue":"1","key":"2263_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/jamaneurol.2018.3322","volume":"76","author":"S Panchagnula","year":"2019","unstructured":"Panchagnula S, Sularz AK, Kahle KT (2019) Familial Trigeminal Neuralgia Cases Implicate Genetic Factors in Disease Pathogenesis. JAMA Neurol 76(1):9\u201310. https:\/\/doi.org\/10.1001\/jamaneurol.2018.3322","journal-title":"JAMA Neurol"},{"issue":"7\u20138","key":"2263_CR43","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/s0161-5890(02)00121-9","volume":"39","author":"CL Parker","year":"2002","unstructured":"Parker CL, Sodetz JM (2002) Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essential. Mol Immunol 39(7\u20138):453\u2013458. https:\/\/doi.org\/10.1016\/s0161-5890(02)00121-9","journal-title":"Mol Immunol"},{"key":"2263_CR44","doi-asserted-by":"publisher","unstructured":"Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain | PNAS. Accessed January 6, 2024. https:\/\/doi.org\/10.1073\/pnas.1600418113","DOI":"10.1073\/pnas.1600418113"},{"issue":"1","key":"2263_CR45","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/imr.12500","volume":"274","author":"D Ricklin","year":"2016","unstructured":"Ricklin D, Reis ES, Mastellos DC, Gros P, Lambris JD (2016) Complement component C3 - The \u201cSwiss Army Knife\u201d of innate immunity and host defense. Immunol Rev 274(1):33\u201358. https:\/\/doi.org\/10.1111\/imr.12500","journal-title":"Immunol Rev"},{"issue":"D1","key":"2263_CR46","doi-asserted-by":"publisher","first-page":"D56","DOI":"10.1093\/nar\/gks1172","volume":"41","author":"KR Rosenbloom","year":"2012","unstructured":"Rosenbloom KR, Sloan CA, Malladi VS et al (2012) ENCODE Data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res 41(D1):D56\u2013D63. https:\/\/doi.org\/10.1093\/nar\/gks1172","journal-title":"Nucleic Acids Res"},{"key":"2263_CR47","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neulet.2015.03.045","volume":"594","author":"X Shi","year":"2015","unstructured":"Shi X, Zheng Z, Li J et al (2015) Curcumin inhibits A\u03b2-induced microglial inflammatory responses in vitro: Involvement of ERK1\/2 and p38 signaling pathways. Neurosci Lett 594:105\u2013110. https:\/\/doi.org\/10.1016\/j.neulet.2015.03.045","journal-title":"Neurosci Lett"},{"issue":"6","key":"2263_CR48","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrg2361","volume":"9","author":"M Slatkin","year":"2008","unstructured":"Slatkin M (2008) Linkage disequilibrium \u2014 understanding the evolutionary past and mapping the medical future. Nat Rev Genet 9(6):477\u2013485. https:\/\/doi.org\/10.1038\/nrg2361","journal-title":"Nat Rev Genet"},{"key":"2263_CR49","doi-asserted-by":"publisher","first-page":"106397","DOI":"10.1016\/j.clineuro.2020.106397","volume":"200","author":"CA Smith","year":"2021","unstructured":"Smith CA, Paskhover B, Mammis A (2021) Molecular mechanisms of trigeminal neuralgia: A systematic review. Clin Neurol Neurosurg 200:106397. https:\/\/doi.org\/10.1016\/j.clineuro.2020.106397","journal-title":"Clin Neurol Neurosurg"},{"issue":"8","key":"2263_CR50","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1046\/j.1526-4610.2003.03172.x","volume":"43","author":"P Smyth","year":"2003","unstructured":"Smyth P, Greenough G, Stommel E (2003) Familial Trigeminal Neuralgia: Case Reports and Review of the Literature. J Head Face Pain 43(8):910\u2013915. https:\/\/doi.org\/10.1046\/j.1526-4610.2003.03172.x","journal-title":"J Head Face Pain"},{"issue":"3","key":"2263_CR51","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N et al (2015) UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 12(3):e1001779. https:\/\/doi.org\/10.1371\/journal.pmed.1001779","journal-title":"PLoS Med"},{"issue":"5","key":"2263_CR52","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/biomedicines10050998","volume":"10","author":"T SvedungWettervik","year":"2022","unstructured":"SvedungWettervik T, Folkvaljon D, Gordh T et al (2022) Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers. Biomedicines 10(5):998. https:\/\/doi.org\/10.3390\/biomedicines10050998","journal-title":"Biomedicines"},{"key":"2263_CR53","doi-asserted-by":"publisher","first-page":"338","DOI":"10.2119\/molmed.2016.00131","volume":"22","author":"BS Tanaka","year":"2016","unstructured":"Tanaka BS, Zhao P, Dib-Hajj FB et al (2016) A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia. Mol Med 22:338\u2013348. https:\/\/doi.org\/10.2119\/molmed.2016.00131","journal-title":"Mol Med"},{"key":"2263_CR54","doi-asserted-by":"publisher","unstructured":"Trigeminal Injury Causes kappa Opioid-Dependent Allodynic, Glial and Immune Cell Responses in Mice - Megumi Aita, Margaret R Byers, Charles Chavkin, Mei Xu, 2010. Accessed January 6, 2024. https:\/\/doi.org\/10.1186\/1744-8069-6-8","DOI":"10.1186\/1744-8069-6-8"},{"issue":"10","key":"2263_CR55","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.bbadis.2014.04.024","volume":"1842","author":"HJ Westra","year":"2014","unstructured":"Westra HJ, Franke L (2014) From genome to function by studying eQTLs. Biochim Biophys Acta 1842(10):1896\u20131902. https:\/\/doi.org\/10.1016\/j.bbadis.2014.04.024","journal-title":"Biochim Biophys Acta"},{"key":"2263_CR56","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cellimm.2018.05.008","volume":"331","author":"X Xu","year":"2018","unstructured":"Xu X, Cai X, Zhu Y et al (2018) MFG-E8 inhibits A\u03b2-induced microglial production of cathelicidin-related antimicrobial peptide: A suitable target against Alzheimer\u2019s disease. Cell Immunol 331:59\u201366. https:\/\/doi.org\/10.1016\/j.cellimm.2018.05.008","journal-title":"Cell Immunol"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-024-02263-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-024-02263-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-024-02263-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T04:38:47Z","timestamp":1735965527000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-024-02263-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2263"],"URL":"https:\/\/doi.org\/10.1007\/s12031-024-02263-x","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"12 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"91"}}