{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:44Z","timestamp":1786982204579,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012689"],"award-info":[{"award-number":["2025A1515012689"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-025-02348-1","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:26:39Z","timestamp":1745479599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["UCHL1-Mediated Spastin Degradation Regulates Microtubule Severing and Hippocampal Neurite Outgrowth"],"prefix":"10.1007","volume":"75","author":[{"given":"Ao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongde","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"2348_CR1","doi-asserted-by":"publisher","first-page":"8393","DOI":"10.1523\/JNEUROSCI.1131-22.2022","volume":"42","author":"F Bradke","year":"2022","unstructured":"Bradke F (2022) Mechanisms of axon growth and regeneration: moving between development and disease. J Neurosci 42:8393\u20138405","journal-title":"J Neurosci"},{"key":"2348_CR2","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.celrep.2013.02.014","volume":"3","author":"K Brinkmann","year":"2013","unstructured":"Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, Sch\u00fcll S, Andree M et al (2013) Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep 3:881\u2013891","journal-title":"Cell Rep"},{"key":"2348_CR3","doi-asserted-by":"publisher","first-page":"7857","DOI":"10.1523\/JNEUROSCI.1817-09.2009","volume":"29","author":"AE Cartier","year":"2009","unstructured":"Cartier AE, Djakovic SN, Salehi A, Wilson SM, Masliah E, Patrick GN (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci 29:7857\u20137868","journal-title":"J Neurosci"},{"key":"2348_CR4","first-page":"2463","volume":"7","author":"K Chen","year":"2014","unstructured":"Chen K, Ye Y, Ji Z, Tan M, Li S, Zhang J, Guo G, Lin H (2014) Katanin p60 promotes neurite growth and collateral formation in the hippocampus. Int J Clin Exp Med 7:2463\u20132470","journal-title":"Int J Clin Exp Med"},{"key":"2348_CR5","doi-asserted-by":"publisher","first-page":"13256","DOI":"10.1074\/jbc.M314124200","volume":"279","author":"J Choi","year":"2004","unstructured":"Choi J, Levey AI, Weintraub ST, Rees HD, Gearing M, Chin LS, Li L (2004) Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson\u2019s and Alzheimer\u2019s diseases. J Biol Chem 279:13256\u201313264","journal-title":"J Biol Chem"},{"key":"2348_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.yexcr.2005.06.009","volume":"309","author":"P Claudiani","year":"2005","unstructured":"Claudiani P, Riano E, Errico A, Andolfi G, Rugarli EI (2005) Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus. Exp Cell Res 309:358\u2013369","journal-title":"Exp Cell Res"},{"key":"2348_CR7","doi-asserted-by":"publisher","first-page":"934522","DOI":"10.3389\/fcell.2022.934522","volume":"10","author":"AC Costa","year":"2022","unstructured":"Costa AC, Sousa MM (2022) The role of spastin in axon biology. Front Cell Dev Biol 10:934522","journal-title":"Front Cell Dev Biol"},{"key":"2348_CR8","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41419-023-06003-8","volume":"14","author":"L Ding","year":"2023","unstructured":"Ding L, Chu W, Xia Y, Shi M, Li T, Zhou FQ, Deng DYB (2023) UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury. Cell Death Dis 14:479","journal-title":"Cell Death Dis"},{"key":"2348_CR9","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.3390\/ijms25095008","volume":"25","author":"E Elert-Dobkowska","year":"2024","unstructured":"Elert-Dobkowska E, Stepniak I, Radziwonik-Fraczyk W, Jahic A, Beetz C, Sulek A (2024) SPAST intragenic CNVs lead to hereditary spastic paraplegia via a haploinsufficiency mechanism. Int J Mol Sci 25:5008","journal-title":"Int J Mol Sci"},{"key":"2348_CR10","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s10555-017-9702-0","volume":"36","author":"Y Fang","year":"2017","unstructured":"Fang Y, Shen X (2017) Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications. Cancer Metastasis Rev 36:669\u2013682","journal-title":"Cancer Metastasis Rev"},{"key":"2348_CR11","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1038\/ncomms7153","volume":"6","author":"Y Goto","year":"2015","unstructured":"Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K et al (2015) UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1\u03b1. Nat Commun 6:6153","journal-title":"Nat Commun"},{"key":"2348_CR12","doi-asserted-by":"publisher","first-page":"eabg4574","DOI":"10.1126\/sciadv.abg4574","volume":"7","author":"SJ Ham","year":"2021","unstructured":"Ham SJ, Lee D, Xu WJ, Cho E, Choi S, Min S, Park S, Chung J (2021) Loss of UCHL1 rescues the defects related to Parkinson\u2019s disease by suppressing glycolysis. Sci Adv 7:eabg4574","journal-title":"Sci Adv"},{"key":"2348_CR13","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1093\/hmg\/ddt644","volume":"23","author":"S Havlicek","year":"2014","unstructured":"Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Pl\u00f6tz S et al (2014) Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients\u2019 neurons. Hum Mol Genet 23:2527\u20132541","journal-title":"Hum Mol Genet"},{"key":"2348_CR14","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/dneu.22640","volume":"78","author":"Z Ji","year":"2018","unstructured":"Ji Z, Zhang G, Chen L, Li J, Yang Y, Cha C, Zhang J, Lin H, Guo G (2018) Spastin interacts with CRMP5 to promote neurite outgrowth by controlling the microtubule dynamics. Dev Neurobiol 78:1191\u20131205","journal-title":"Dev Neurobiol"},{"key":"2348_CR15","doi-asserted-by":"publisher","first-page":"105133","DOI":"10.1016\/j.nbd.2020.105133","volume":"146","author":"ZS Ji","year":"2020","unstructured":"Ji ZS, Liu QL, Zhang JF, Yang YH, Li J, Zhang GW, Tan MH, Lin HS, Guo GQ (2020) SUMOylation of spastin promotes the internalization of GluA1 and regulates dendritic spine morphology by targeting microtubule dynamics. Neurobiol Dis 146:105133","journal-title":"Neurobiol Dis"},{"key":"2348_CR16","doi-asserted-by":"publisher","first-page":"555747","DOI":"10.3389\/fncel.2020.555747","volume":"14","author":"T Jiang","year":"2020","unstructured":"Jiang T, Cai Z, Ji Z, Zou J, Liang Z, Zhang G, Liang Y, Lin H, Tan M (2020) The lncRNA MALAT1\/miR-30\/spastin axis regulates hippocampal neurite outgrowth. Front Cell Neurosci 14:555747","journal-title":"Front Cell Neurosci"},{"key":"2348_CR17","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.neuron.2007.10.031","volume":"56","author":"S Jinushi-Nakao","year":"2007","unstructured":"Jinushi-Nakao S, Arvind R, Amikura R, Kinameri E, Liu AW, Moore AW (2007) Knot\/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape. Neuron 56:963\u2013978","journal-title":"Neuron"},{"key":"2348_CR18","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13578-022-00851-1","volume":"12","author":"HM Kang","year":"2022","unstructured":"Kang HM, Kim DH, Kim M, Min Y, Jeong B, Noh KH, Lee DY, Cho H-S et al (2022) FBXL17\/spastin axis as a novel therapeutic target of hereditary spastic paraplegia. Cell Biosci 12:110","journal-title":"Cell Biosci"},{"key":"2348_CR19","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1093\/hmg\/ddx125","volume":"26","author":"L Leo","year":"2017","unstructured":"Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G (2017) Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation. Hum Mol Genet 26:2321\u20132334","journal-title":"Hum Mol Genet"},{"key":"2348_CR20","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0092-8674(02)01012-7","volume":"111","author":"Y Liu","year":"2002","unstructured":"Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson\u2019s disease susceptibility. Cell 111:209\u2013218","journal-title":"Cell"},{"key":"2348_CR21","doi-asserted-by":"crossref","unstructured":"Liu Q, Zhang G, Ji Z, Lin H (2021) Molecular and cellular mechanisms of spastin in neural development and disease (Review). Int J Mol Med 48:218","DOI":"10.3892\/ijmm.2021.5051"},{"key":"2348_CR22","doi-asserted-by":"publisher","first-page":"158942","DOI":"10.1016\/j.scitotenv.2022.158942","volume":"855","author":"S Liu","year":"2022","unstructured":"Liu S, Lei P, Li X, Li Y (2022) Corrigendum to \u201cA nonseparable undesirable output modified three-stage data envelopment analysis application for evaluation of agricultural green total factor: the productivity in China\u201d [Sci. Total Environ. 838P1 (2022) 155947]. Sci Total Environ 855:158942","journal-title":"Sci Total Environ"},{"key":"2348_CR23","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbamcr.2011.08.010","volume":"1823","author":"JH Lumb","year":"2012","unstructured":"Lumb JH, Connell JW, Allison R, Reid E (2012) The AAA ATPase spastin links microtubule severing to membrane modelling. Biochim Biophys Acta 1823:192\u2013197","journal-title":"Biochim Biophys Acta"},{"key":"2348_CR24","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1186\/s12967-024-05669-8","volume":"22","author":"M Luo","year":"2024","unstructured":"Luo M, Wang Y, Liang J, Wan X (2024) Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation. J Transl Med 22:872","journal-title":"J Transl Med"},{"key":"2348_CR25","doi-asserted-by":"publisher","first-page":"101856","DOI":"10.1016\/j.arr.2023.101856","volume":"86","author":"Z Mi","year":"2023","unstructured":"Mi Z, Graham SH (2023) Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury. Ageing Res Rev 86:101856","journal-title":"Ageing Res Rev"},{"key":"2348_CR26","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1093\/hmg\/ddg211","volume":"12","author":"H Osaka","year":"2003","unstructured":"Osaka H, Wang YL, Takada K, Takizawa S, Setsuie R, Li H, Sato Y, Nishikawa K et al (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet 12:1945\u20131958","journal-title":"Hum Mol Genet"},{"key":"2348_CR27","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1016\/j.gim.2022.07.006","volume":"24","author":"J Park","year":"2022","unstructured":"Park J, Tucci A, Cipriani V, Demidov G, Rocca C, Senderek J, Butryn M, Velic A et al (2022) Heterozygous UCHL1 loss-of-function variants cause a neurodegenerative disorder with spasticity, ataxia, neuropathy, and optic atrophy. Genet Med 24:2079\u20132090","journal-title":"Genet Med"},{"key":"2348_CR28","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/mds.30072","volume":"40","author":"S Ramakrishnan","year":"2025","unstructured":"Ramakrishnan S, Mohan N, Dong Z, Liu M, Qiang L (2025) Unraveling isoform complexity: The roles of M1- and M87-Spastin in Spastic Paraplegia 4 (SPG4). Mov Disord 40:420\u2013430","journal-title":"Mov Disord"},{"key":"2348_CR29","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1111\/j.1471-4159.2005.03472.x","volume":"95","author":"S Salinas","year":"2005","unstructured":"Salinas S, Carazo-Salas RE, Proukakis C, Cooper JM, Weston AE, Schiavo G, Warner TT (2005) Human spastin has multiple microtubule-related functions. J Neurochem 95:1411\u20131420","journal-title":"J Neurochem"},{"key":"2348_CR30","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1093\/brain\/awae095","volume":"147","author":"F Sardina","year":"2024","unstructured":"Sardina F, Carsetti C, Giorgini L, Fattorini G, Cestra G, Rinaldo C (2024) Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models. Brain. 147:3534","journal-title":"Brain."},{"key":"2348_CR31","doi-asserted-by":"crossref","unstructured":"Sardina F, Pisciottani A, Ferrara M, Valente D, Casella M, Crescenzi M, Peschiaroli A, Casali C et al (2020) Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. Life Sci Alliance 3:e202000799","DOI":"10.26508\/lsa.202000799"},{"key":"2348_CR32","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1093\/brain\/awv178","volume":"138","author":"JM Solowska","year":"2015","unstructured":"Solowska JM, Baas PW (2015) Hereditary spastic paraplegia SPG4: what is known and not known about the disease. Brain 138:2471\u20132484","journal-title":"Brain"},{"key":"2348_CR33","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1523\/JNEUROSCI.3159-07.2008","volume":"28","author":"JM Solowska","year":"2008","unstructured":"Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D, Baas PW (2008) Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. J Neurosci 28:2147\u20132157","journal-title":"J Neurosci"},{"key":"2348_CR34","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1093\/hmg\/ddq177","volume":"19","author":"JM Solowska","year":"2010","unstructured":"Solowska JM, Garbern JY, Baas PW (2010) Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia. Hum Mol Genet 19:2767\u20132779","journal-title":"Hum Mol Genet"},{"key":"2348_CR35","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1091\/mbc.e17-01-0047","volume":"28","author":"JM Solowska","year":"2017","unstructured":"Solowska JM, Rao AN, Baas PW (2017) Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin. Mol Biol Cell 28:1728\u20131737","journal-title":"Mol Biol Cell"},{"key":"2348_CR36","doi-asserted-by":"publisher","first-page":"E1715","DOI":"10.1073\/pnas.1205918109","volume":"109","author":"JI Su\u0142kowska","year":"2012","unstructured":"Su\u0142kowska JI, Rawdon EJ, Millett KC, Onuchic JN, Stasiak A (2012) Conservation of complex knotting and slipknotting patterns in proteins. Proc Natl Acad Sci USA 109:E1715-1723","journal-title":"Proc Natl Acad Sci USA"},{"key":"2348_CR37","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00018-024-05186-3","volume":"81","author":"J Wang","year":"2024","unstructured":"Wang J, Ji C, Ye W, Rong Y, Ge X, Wang Z, Tang P, Zhou Z et al (2024) Deubiquitinase UCHL1 promotes angiogenesis and blood-spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17. Cell Mol Life Sci 81:137","journal-title":"Cell Mol Life Sci"},{"key":"2348_CR38","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1093\/hmg\/ddl212","volume":"15","author":"JD Wood","year":"2006","unstructured":"Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ, Cunliffe VT (2006) The microtubule-severing protein spastin is essential for axon outgrowth in the zebrafish embryo. Hum Mol Genet 15:2763\u20132771","journal-title":"Hum Mol Genet"},{"key":"2348_CR39","doi-asserted-by":"publisher","first-page":"151426","DOI":"10.1016\/j.bbrc.2025.151426","volume":"752","author":"Z Xie","year":"2025","unstructured":"Xie Z, Song W, Meng Z, Ma A, Zhu J, Liang Y, Lin H, Lei C, Tan M (2025) The interaction between KATNA1 and CRMP3 modulates microtubule dynamics and neurite outgrowth. Biochem Biophys Res Commun 752:151426","journal-title":"Biochem Biophys Res Commun"},{"key":"2348_CR40","doi-asserted-by":"publisher","first-page":"110806","DOI":"10.1016\/j.brainresbull.2023.110806","volume":"205","author":"J Yang","year":"2023","unstructured":"Yang J, Zhang Y, Cai Z, Zou J, Li S, Miao G, Lin H, Zhao X, Tan M (2023a) Inhibition of spastin impairs motor function recovery after spinal cord injury. Brain Res Bull 205:110806","journal-title":"Brain Res Bull"},{"key":"2348_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bbrc.2022.12.066","volume":"643","author":"Y Yang","year":"2023","unstructured":"Yang Y, Yang J, Liang Y, Zhang G, Cai Z, Zhang Y, Lin H, Tan M (2023b) Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons. Biochem Biophys Res Commun 643:77\u201387","journal-title":"Biochem Biophys Res Commun"},{"key":"2348_CR42","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.4081\/ejh.2023.3594","volume":"67","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, He X, Zou J, Yang J, Ma A, Tan M (2023) Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability. Eur J Histochem 67:3594","journal-title":"Eur J Histochem"},{"key":"2348_CR43","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.4081\/ejh.2021.3352","volume":"65","author":"J Zou","year":"2021","unstructured":"Zou J, Cai Z, Liang Z, Liang Y, Zhang G, Yang J, Zhang Y, Lin H, Tan M (2021) Different fusion tags affect the activity of ubiquitin overexpression on spastin protein stability. Eur J Histochem 65:3352","journal-title":"Eur J Histochem"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-025-02348-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-025-02348-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-025-02348-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:03:27Z","timestamp":1751342607000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-025-02348-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2348"],"URL":"https:\/\/doi.org\/10.1007\/s12031-025-02348-1","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"10 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"54"}}