{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:10:04Z","timestamp":1751353804297,"version":"3.41.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-25-00325","23-25-00325","23-25-00325","23-25-00325"],"award-info":[{"award-number":["23-25-00325","23-25-00325","23-25-00325","23-25-00325"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Telomeres are increasingly recognized for their potential role in the etiology of autism spectrum disorder (ASD) due to their involvement in cellular aging and telomerase-shelterin function. Although shorter telomeres have been observed in individuals with ASD, studies linking telomere dynamics in blood cells and brain regions remain limited. Using the valproic acid (VPA, 500\u00a0mg\/kg) rodent model, this study aimed to assess the impact of three drugs commonly used in ASD treatment (amitriptyline, risperidone, and nooclerin) on telomere length and the expression of telomerase\/shelterin-related genes (<jats:italic>Dkc1<\/jats:italic>, <jats:italic>Gar1<\/jats:italic>, <jats:italic>Pot1a<\/jats:italic>, <jats:italic>Pot1b<\/jats:italic>, <jats:italic>Tep1<\/jats:italic>, <jats:italic>Terc<\/jats:italic>, <jats:italic>Terf2ip<\/jats:italic>, <jats:italic>Tert<\/jats:italic>, <jats:italic>Tinf2<\/jats:italic>, <jats:italic>Tnks<\/jats:italic>, <jats:italic>Tpp1<\/jats:italic>, <jats:italic>Trf1<\/jats:italic>, and <jats:italic>Trf2<\/jats:italic>) in blood cells, the prefrontal cortex, and hippocampus of VPA-exposed Wistar rats. Telomere length and gene expression were measured using quantitative PCR. Risperidone treatment in VPA males resulted in telomere elongation and increased expression of <jats:italic>Tnks<\/jats:italic> in blood cell and <jats:italic>Trf1<\/jats:italic>, <jats:italic>Trf2<\/jats:italic> genes in prefrontal cortex. Nooclerin treatment also showed beneficial effects on telomere length of blood cell in males, alongside increased <jats:italic>Trf1<\/jats:italic> expression. Long telomeres in male blood cells were associated with reduced anxiety, while a positive correlation was found between <jats:italic>Tpp1<\/jats:italic> expression and stereotypical behavior in both male and female VPA rats. These findings suggest that nooclerin and risperidone influence telomere length and gene expression related to the telomere-telomerase complex in a sex-dependent manner, offering insights into the neurobiological mechanisms underlying ASD.<\/jats:p>","DOI":"10.1007\/s12031-025-02353-4","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:56:35Z","timestamp":1745495795000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Pharmacological Treatment on Telomere Length and the Expression of Telomerase\/Shelterin-Related Genes in Rat Models of Autism"],"prefix":"10.1007","volume":"75","author":[{"given":"Elena V.","family":"Valeeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry O.","family":"Nikitin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubov S.","family":"Nikiforova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina I.","family":"Semina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-4020","authenticated-orcid":false,"given":"Ildus I.","family":"Ahmetov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"issue":"82","key":"2353_CR1","doi-asserted-by":"publisher","first-page":"50978","DOI":"10.3791\/50978","volume":"24","author":"M Angoa-P\u00e9rez","year":"2013","unstructured":"Angoa-P\u00e9rez M, Kane MJ, Briggs DI, Francescutti DM, Kuhn DM (2013) Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice. J vis Exp 24(82):50978. https:\/\/doi.org\/10.3791\/50978","journal-title":"J vis Exp"},{"issue":"2","key":"2353_CR2","doi-asserted-by":"publisher","first-page":"dju408","DOI":"10.1093\/jnci\/dju408","volume":"107","author":"LG Aoude","year":"2015","unstructured":"Aoude LG, Pritchard AL, Robles-Espinoza CD, Wadt K, Harland M, Choi J, Gartside M, Quesada V, Johansson P, Palmer JM, Ramsay AJ, Zhang X, Jones K, Symmons J, Holland EA, Schmid H, Bonazzi V, Woods S, Dutton-Regester K, Stark MS, Snowden H, van Doorn R, Montgomery GW, Martin NG, Keane TM, L\u00f3pez-Ot\u00edn C, Gerdes AM, Olsson H, Ingvar C, Borg A, Gruis NA, Trent JM, J\u00f6nsson G, Bishop DT, Mann GJ, Newton-Bishop JA, Brown KM, Adams DJ, Hayward NK (2015) Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. Journal of the National Cancer Institute 107(2):dju408. https:\/\/doi.org\/10.1093\/jnci\/dju408","journal-title":"Journal of the National Cancer Institute"},{"key":"2353_CR3","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1016\/j.csbj.2020.06.040","volume":"18","author":"T Aramburu","year":"2020","unstructured":"Aramburu T, Plucinsky S, Skordalakes E (2020) POT1-TPP1 telomere length regulation and disease. Comput Struct Biotechnol J 18:1939\u20131946. https:\/\/doi.org\/10.1016\/j.csbj.2020.06.040","journal-title":"Comput Struct Biotechnol J"},{"key":"2353_CR4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00109-002-0374-5","volume":"80","author":"A Aviv","year":"2002","unstructured":"Aviv A (2002) Telomeres, sex, reactive oxygen species, and human cardiovascular aging. J Mol Med 80:689\u2013695. https:\/\/doi.org\/10.1007\/s00109-002-0374-5","journal-title":"J Mol Med"},{"issue":"1","key":"2353_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/hipo.23264","volume":"31","author":"SM Banker","year":"2021","unstructured":"Banker SM, Pagliaccio D, Ramphal B, Thomas L, Dranovsky A, Margolis AE (2021) Altered structure and functional connectivity of the hippocampus are associated with social and mathematical difficulties in nonverbal learning disability. Hippocampus 31(1):79\u201388. https:\/\/doi.org\/10.1002\/hipo.23264","journal-title":"Hippocampus"},{"issue":"6","key":"2353_CR6","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1111\/j.1474-9726.2011.00741.x","volume":"10","author":"ELB Barrett","year":"2011","unstructured":"Barrett ELB, Richardson DS (2011) Sex differences in telomeres and lifespan. Aging Cell 10(6):913\u2013921. https:\/\/doi.org\/10.1111\/j.1474-9726.2011.00741.x","journal-title":"Aging Cell"},{"issue":"46","key":"2353_CR7","doi-asserted-by":"publisher","first-page":"13021","DOI":"10.1073\/pnas.1607426113","volume":"113","author":"K Bisht","year":"2016","unstructured":"Bisht K, Smith EM, Tesmer VM, Nandakumar J (2016) Structural and functional consequences of a disease mutation in the telomere protein TPP1. Proc Natl Acad Sci 113(46):13021\u201313026. https:\/\/doi.org\/10.1073\/pnas.1607426113","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"2353_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1158\/1541-7786.mcr-05-0147","volume":"3","author":"EH Blackburn","year":"2005","unstructured":"Blackburn EH (2005) Telomerase and cancer. Mol Cancer Res 3(4):477\u2013482. https:\/\/doi.org\/10.1158\/1541-7786.mcr-05-0147","journal-title":"Mol Cancer Res"},{"issue":"4","key":"2353_CR9","first-page":"45","volume":"4","author":"NA Bondarenko","year":"2017","unstructured":"Bondarenko NA (2017) Anxiety and the problem of \u201cinattentive\u201d animals in water maze tests. Cognitive Science in Moscow 4(4):45\u201351","journal-title":"Cognitive Science in Moscow"},{"key":"2353_CR10","doi-asserted-by":"publisher","unstructured":"Buttet, M., Yu, K., Smith, J., & Johnson, R. (2022). Effect of a lifestyle intervention on telomere length: a systematic review and meta-analysis. Mechanisms of Ageing and Development, 111694. https:\/\/doi.org\/10.1016\/j.mad.2022.111694","DOI":"10.1016\/j.mad.2022.111694"},{"issue":"10","key":"2353_CR11","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","volume":"30","author":"RM Cawthon","year":"2002","unstructured":"Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30(10):e47\u2013e47. https:\/\/doi.org\/10.1093\/nar\/30.10.e47","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"2353_CR12","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1093\/nar\/gkg224","volume":"31","author":"H Cherif","year":"2003","unstructured":"Cherif H, Tarry JL, Ozanne SE, Hales CN (2003) Ageing and telomeres: a study into organ-and gender-specific telomere shortening. Nucleic Acids Res 31(5):1576\u20131583. https:\/\/doi.org\/10.1093\/nar\/gkg224","journal-title":"Nucleic Acids Res"},{"issue":"31","key":"2353_CR13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2215632120","volume":"120","author":"M Cirnigliaro","year":"2023","unstructured":"Cirnigliaro M, Chang TS, Arteaga SA, P\u00e9rez-Cano L, Ruzzo EK, Gordon A, Bicks LK, Jung JY, Lowe JK, Wall DP, Geschwind DH (2023) The contributions of rare inherited and polygenic risk to ASD in multiplex families. Proc Natl Acad Sci USA 120(31):e2215632120. https:\/\/doi.org\/10.1073\/pnas.2215632120","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"2353_CR14","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.neubiorev.2012.07.005","volume":"36","author":"S Coghlan","year":"2012","unstructured":"Coghlan S, Horder J, Inkster B, Mendez MA, Murphy DG, Nutt DJ (2012) GABA system dysfunction in autism and related disorders: from synapse to symptoms. Neurosci Biobehav Rev 36(9):2044\u20132055. https:\/\/doi.org\/10.1016\/j.neubiorev.2012.07.005","journal-title":"Neurosci Biobehav Rev"},{"key":"2353_CR15","doi-asserted-by":"publisher","unstructured":"Corr\u00eaa, M. M., Corr\u00eaa, T., Santos-Rebou\u00e7as, C. B., Rodrigues, M. M., de Luca, G. R., & de Camargo Pinto, L. L. (2022). New insights into candidate genes for autism spectrum disorder in 8p23.1 duplication syndrome. Brazilian Journal of Case Reports, 3(1), 16\u201323. https:\/\/doi.org\/10.52600\/2763-583X.bjcr.2023.3.1.16-23","DOI":"10.52600\/2763-583X.bjcr.2023.3.1.16-23"},{"issue":"3","key":"2353_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/path.2500","volume":"217","author":"G De Boeck","year":"2009","unstructured":"De Boeck G, Forsyth RG, Praet M, Hogendoorn PC (2009) Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanisms. J Pathol 217(3):327\u2013344. https:\/\/doi.org\/10.1002\/path.2500","journal-title":"J Pathol"},{"key":"2353_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2020.106676","volume":"102","author":"PV Dixit","year":"2020","unstructured":"Dixit PV, Sahu R, Mishra DK (2020) Marble-burying behavior test as a murine model of compulsive-like behavior. J Pharmacol Toxicol Methods 102:106676. https:\/\/doi.org\/10.1016\/j.vascn.2020.106676","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"5","key":"2353_CR18","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.celrep.2014.10.022","volume":"9","author":"WQ Fang","year":"2014","unstructured":"Fang WQ, Chen WW, Jiang L, Liu K, Yung WH, Fu AK, Ip NY (2014) Overproduction of upper-layer neurons in the neocortex leads to autism-like features in mice. Cell Rep 9(5):1635\u20131643. https:\/\/doi.org\/10.1016\/j.celrep.2014.10.022","journal-title":"Cell Rep"},{"key":"2353_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2019.100818","volume":"56","author":"CA Finney","year":"2020","unstructured":"Finney CA, Rooney TP, Quattrochi CL, Wellman CL (2020) The role of hippocampal estradiol in synaptic plasticity and memory: a systematic review. Front Neuroendocrinol 56:100818. https:\/\/doi.org\/10.1016\/j.yfrne.2019.100818","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"2353_CR20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jaac.2013.11.014","volume":"53","author":"TW Frazier","year":"2014","unstructured":"Frazier TW, Georgiades S, Bishop SL, Hardan AY (2014) Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. J Am Acad Child Adolesc Psychiatry 53(3):329\u2013340. https:\/\/doi.org\/10.1016\/j.jaac.2013.11.014","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2353_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103278","volume":"75","author":"S Gao","year":"2024","unstructured":"Gao S, Huang S, Xu Y, Wang B, Cheng P, Lu Y, Gilson E, Ye J (2024) Role of the telomeric factor TRF2 in post-hypoxic brain damages. Redox Biol 75:103278. https:\/\/doi.org\/10.1016\/j.redox.2024.103278","journal-title":"Redox Biol"},{"key":"2353_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.exger.2013.12.004","volume":"51","author":"Gardner, M., Bann, D., Wiley, L., Cooper, R., Hardy, R., Nitsch, D., Martin-Ruiz, C., Shiels, P., Sayer, A.A., Barbieri, M., Bekaert, S., Bischoff, C., Brooks-Wilson, A., Chen, W., Cooper, C., Christensen, K., Meyer, T.D., Deary, I., Der, G., Roux, A. D., Fitzpatrick, A., Hajat, A., Halaschek-Wiener, J., Harris, S., Hunt, C., Jagger, C., Jeon, H.-S., Kaplan, R., Kimura, M., Lansdorp, P., Li, C., Maeda, T., Mangino, M., Nawrot, T.S., Nilsson, P., Nordfjall, K., Paolisso, G., Ren, F., Riabowol, K., Robertson, T., Roos, G., Staessen, J. A., Spector, T., Tang, N., Unryn, B., Harst, P., Woo, J., Xing, C., Yadegarfar, M. E., Park J. Y., Young, N., Kuh, D., von Zglinicki T., Ben-Shlomo Y., Halcyon Study Team","year":"2014","unstructured":"Gardner, M., Bann, D., Wiley, L., Cooper, R., Hardy, R., Nitsch, D., Martin-Ruiz, C., Shiels, P., Sayer, A.A., Barbieri, M., Bekaert, S., Bischoff, C., Brooks-Wilson, A., Chen, W., Cooper, C., Christensen, K., Meyer, T.D., Deary, I., Der, G., Roux, A. D., Fitzpatrick, A., Hajat, A., Halaschek-Wiener, J., Harris, S., Hunt, C., Jagger, C., Jeon, H.-S., Kaplan, R., Kimura, M., Lansdorp, P., Li, C., Maeda, T., Mangino, M., Nawrot, T.S., Nilsson, P., Nordfjall, K., Paolisso, G., Ren, F., Riabowol, K., Robertson, T., Roos, G., Staessen, J. A., Spector, T., Tang, N., Unryn, B., Harst, P., Woo, J., Xing, C., Yadegarfar, M. E., Park J. Y., Young, N., Kuh, D., von Zglinicki T., Ben-Shlomo Y., Halcyon Study Team (2014) Gender and telomere length: systematic review and meta-analysis. Exp Gerontol 51:15\u201327. https:\/\/doi.org\/10.1016\/j.exger.2013.12.004","journal-title":"Exp Gerontol"},{"issue":"6","key":"2353_CR23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.neuropharm.2012.07.028","volume":"63","author":"HS Go","year":"2012","unstructured":"Go HS, Kim KC, Choi CS, Jeon SJ, Kwon KJ, Han SH, Lee J, Cheong JH, Ryu JH, Kim CH, Ko KH, Shin CY (2012) Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3\u03b2\/\u03b2-catenin pathway. Neuropharmacology 63(6):1028\u20131041. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.07.028","journal-title":"Neuropharmacology"},{"issue":"18","key":"2353_CR24","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1182\/blood-2014-04-568508","volume":"124","author":"Y Guo","year":"2014","unstructured":"Guo Y, Kartawinata M, Li J, Pickett HA, Teo J, Kilo T, Barbaro PM, Keating B, Chen Y, Tian L, Al-Odaib A, Reddel RR, Christodoulou J, Xu X, Hakonarson H, Bryan TM (2014) Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood 124(18):2767\u20132774. https:\/\/doi.org\/10.1182\/blood-2014-04-568508","journal-title":"Blood"},{"issue":"11\u201312","key":"2353_CR25","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1080\/10715762.2021.2017913","volume":"55","author":"JM Hansen","year":"2021","unstructured":"Hansen JM, Buckland ME, Crowe A (2021) Valproic acid promotes SOD2 acetylation: a potential mechanism of valproic acid-induced oxidative stress in developing systems. Free Radical Res 55(11\u201312):1130\u20131144. https:\/\/doi.org\/10.1080\/10715762.2021.2017913","journal-title":"Free Radical Res"},{"issue":"6","key":"2353_CR26","doi-asserted-by":"publisher","first-page":"262","DOI":"10.5498\/wjp.v13.i6.262","volume":"13","author":"J Hellings","year":"2023","unstructured":"Hellings J (2023) Pharmacotherapy in autism spectrum disorders, including promising older drugs warranting trials. World Journal of Psychiatry 13(6):262\u2013277. https:\/\/doi.org\/10.5498\/wjp.v13.i6.262","journal-title":"World Journal of Psychiatry"},{"issue":"2","key":"2353_CR27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1001\/jama.2022.23661","volume":"329","author":"T Hirota","year":"2023","unstructured":"Hirota T, King BH (2023) Autism spectrum disorder: a review. JAMA 329(2):157\u2013168. https:\/\/doi.org\/10.1001\/jama.2022.23661","journal-title":"JAMA"},{"issue":"1","key":"2353_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2006.04.044","volume":"126","author":"D Hockemeyer","year":"2006","unstructured":"Hockemeyer D, Daniels JP, Takai H, de Lange T (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126(1):63\u201377. https:\/\/doi.org\/10.1016\/j.cell.2006.04.044","journal-title":"Cell"},{"issue":"6","key":"2353_CR29","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.biopsych.2019.04.028","volume":"86","author":"GE Hodes","year":"2019","unstructured":"Hodes GE, Epperson CN (2019) Sex Differences in Vulnerability and Resilience to Stress Across the Life Span. Biological Psychiatry 86(6):421\u2013432. https:\/\/doi.org\/10.1016\/j.biopsych.2019.04.028","journal-title":"Biological Psychiatry"},{"issue":"3","key":"2353_CR30","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0892-0362(00)00028-3","volume":"22","author":"JL Ingram","year":"2000","unstructured":"Ingram JL, Zorumski CF, Paul IA (2000) Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol Teratol 22(3):319\u2013324. https:\/\/doi.org\/10.1016\/S0892-0362(00)00028-3","journal-title":"Neurotoxicol Teratol"},{"issue":"11","key":"2353_CR31","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.tics.2012.09.006","volume":"16","author":"DP Kennedy","year":"2012","unstructured":"Kennedy DP, Adolphs R (2012) The social brain in psychiatric and neurological disorders. Trends Cogn Sci 16(11):559\u2013572. https:\/\/doi.org\/10.1016\/j.tics.2012.09.006","journal-title":"Trends Cogn Sci"},{"issue":"1","key":"2353_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2047-9158-2-17","volume":"2","author":"JK Kern","year":"2013","unstructured":"Kern JK, Geier DA, Sykes LK, Geier MR (2013) Evidence of neurodegeneration in autism spectrum disorder. Translational Neurodegeneration 2(1):1\u20136. https:\/\/doi.org\/10.1186\/2047-9158-2-17","journal-title":"Translational Neurodegeneration"},{"issue":"5","key":"2353_CR33","doi-asserted-by":"publisher","first-page":"252","DOI":"10.5607\/en.2017.26.5.252","volume":"26","author":"KC Kim","year":"2017","unstructured":"Kim KC, Choi CS, Gonzales ELT, Mabunga DFN, Lee SH, Jeon SJ, Hwangbo R, Hong M, Ryu JH, Han SH, Bahn GH, Shin CY (2017) Valproic acid induces telomerase reverse transcriptase expression during cortical development. Experimental Neurobiology 26(5):252\u2013265. https:\/\/doi.org\/10.5607\/en.2017.26.5.252","journal-title":"Experimental Neurobiology"},{"key":"2353_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12035-015-9296-5","volume":"53","author":"KC Kim","year":"2016","unstructured":"Kim KC, Choi CS, Kim JW, Han SH, Cheong JH, Ryu JH, Shin CY (2016) MeCP2 modulates sex differences in the postsynaptic development of the valproate animal model of autism. Mol Neurobiol 53:40\u201356. https:\/\/doi.org\/10.1007\/s12035-015-9296-5","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2353_CR35","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s12035-013-8535-2","volume":"49","author":"KC Kim","year":"2014","unstructured":"Kim KC, Lee DK, Go HS, Kim P, Choi CS, Kim JW, Jeon SJ, Song MR, Shin CY (2014) Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring. Mol Neurobiol 49(1):512\u2013528. https:\/\/doi.org\/10.1007\/s12035-013-8535-2","journal-title":"Mol Neurobiol"},{"issue":"6","key":"2353_CR36","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/jnc.12255","volume":"124","author":"KC Kim","year":"2013","unstructured":"Kim KC, Park KH, Choi MS, Kim YH (2013) Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder. J Neurochem 124(6):832\u2013843. https:\/\/doi.org\/10.1111\/jnc.12255","journal-title":"J Neurochem"},{"key":"2353_CR37","doi-asserted-by":"publisher","unstructured":"Kimura, A., Ohmichi, M., Kawagoe, J., Kyo, S., & Matsuzawa, Y. (2004). Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines. Oncogene, 23(4505\u20134515). https:\/\/doi.org\/10.1038\/sj.onc.1207582","DOI":"10.1038\/sj.onc.1207582"},{"issue":"10","key":"2353_CR38","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1038\/sj.leu.2403086","volume":"17","author":"W Klapper","year":"2003","unstructured":"Klapper W, Qian W, Schulte C, Parwaresch R (2003) DNA damage transiently increases TRF2 mRNA expression and telomerase activity. Leukemia 17(10):2007\u20132015. https:\/\/doi.org\/10.1038\/sj.leu.2403086","journal-title":"Leukemia"},{"issue":"8","key":"2353_CR39","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.arcmed.2022.09.006","volume":"53","author":"PM Lansdorp","year":"2022","unstructured":"Lansdorp PM (2022) Telomeres, telomerase and cancer. Arch Med Res 53(8):741\u2013746. https:\/\/doi.org\/10.1016\/j.arcmed.2022.09.006","journal-title":"Arch Med Res"},{"issue":"7","key":"2353_CR40","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/aur.2307","volume":"13","author":"CR Lewis","year":"2020","unstructured":"Lewis CR, Taguinod F, Jepsen WM, Cohen J, Agrawal K, Huentelman MJ, Smith CJ, Ringenbach SDR, Braden BB (2020) Telomere length and autism spectrum disorder within the family: relationships with cognition and sensory symptoms. Autism Res 13(7):1094\u20131101. https:\/\/doi.org\/10.1002\/aur.2307","journal-title":"Autism Res"},{"key":"2353_CR41","doi-asserted-by":"publisher","first-page":"7073","DOI":"10.1038\/srep07073","volume":"4","author":"Z Li","year":"2014","unstructured":"Li Z, Tang J, Li H, Chen S, He Y, Liao Y, Wei Z, Wan G, Xiang X, Xia K, Chen X (2014) Shorter telomere length in peripheral blood leukocytes is associated with childhood autism. Sci Rep 4:7073. https:\/\/doi.org\/10.1038\/srep07073","journal-title":"Sci Rep"},{"key":"2353_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2022.102067","volume":"99","author":"X Lin","year":"2022","unstructured":"Lin X, He H, Wang F, Zhang H, Wang Y (2022) Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder. Research in Autism Spectrum Disorders 99:102067. https:\/\/doi.org\/10.1016\/j.rasd.2022.102067","journal-title":"Research in Autism Spectrum Disorders"},{"key":"2353_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.641284","volume":"15","author":"H Liu","year":"2021","unstructured":"Liu H, Tan M, Cheng B, Wang S, Xiao L, Zhu J, Li T, Liu Y, Wang J, Zhou Y (2021) Valproic acid induces autism-like synaptic and behavioral deficits by disrupting histone acetylation of prefrontal cortex ALDH1A1 in rats. Front Neurosci 15:641284. https:\/\/doi.org\/10.3389\/fnins.2021.641284","journal-title":"Front Neurosci"},{"issue":"4","key":"2353_CR44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1127","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1127","journal-title":"Methods"},{"key":"2353_CR45","doi-asserted-by":"publisher","unstructured":"Maenner, M. J. (2021). Prevalence and characteristics of autism spectrum disorder among children aged 8 years\u2014autism and developmental disabilities monitoring network, 11 sites, United States, 2018. MMWR. Surveillance Summaries, 70. https:\/\/doi.org\/10.15585\/mmwr.ss7001a1","DOI":"10.15585\/mmwr.ss7001a1"},{"issue":"9","key":"2353_CR46","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1038\/tp.2015.125","volume":"5","author":"F Mamdani","year":"2015","unstructured":"Mamdani F, Rollins B, Morgan L, Myers RM, Barchas JD, Schatzberg AF, Sequeira PA (2015) Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder. Translational psychiatry 5(9):e636\u2013e636. https:\/\/doi.org\/10.1038\/tp.2015.125","journal-title":"Translational psychiatry"},{"key":"2353_CR47","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/35011073","volume":"1","author":"NF Mathon","year":"2001","unstructured":"Mathon NF, Lloyd AC (2001) Cell senescence and cancer. Nat Rev Cancer 1:203\u2013213. https:\/\/doi.org\/10.1038\/35011073","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"2353_CR48","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1002\/humu.21220","volume":"31","author":"L Mirabello","year":"2010","unstructured":"Mirabello L, Yu K, Hunt SC, Chen L, Skol AD (2010) The association of telomere length and genetic variation in telomere biology genes. Hum Mutat 31(9):1050\u20131058. https:\/\/doi.org\/10.1002\/humu.21220","journal-title":"Hum Mutat"},{"key":"2353_CR49","doi-asserted-by":"publisher","unstructured":"Mohapatra, A. N., & Wagner, S. (2023). The role of the prefrontal cortex in social interactions of animal models and the implications for autism spectrum disorder. Frontiers in Psychiatry, 14, 1205199.https:\/\/doi.org\/10.3389\/fpsyt.2023.1205199","DOI":"10.3389\/fpsyt.2023.1205199"},{"key":"2353_CR50","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jpsychires.2017.01.002","volume":"90","author":"N Monroy-Jaramillo","year":"2017","unstructured":"Monroy-Jaramillo N, Rodr\u00edguez-Agudelo Y, Avi\u00f1a-Cervantes LC, Roberts DL, Velligan DI, Walss-Bass C (2017) Leukocyte telomere length in Hispanic schizophrenia patients under treatment with olanzapine. J Psychiatr Res 90:26\u201330. https:\/\/doi.org\/10.1016\/j.jpsychires.2017.01.002","journal-title":"J Psychiatr Res"},{"issue":"11","key":"2353_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007782","volume":"14","author":"AK Mukherjee","year":"2018","unstructured":"Mukherjee AK, Sharma S, Sengupta S, Saha D, Kumar P, Hussain T, Srivastava A, Gupta S, Roy M, Roy AG, Chowdhury S (2018) Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends. PLoS Genet 14(11):e1007782. https:\/\/doi.org\/10.1371\/journal.pgen.1007782","journal-title":"PLoS Genet"},{"issue":"3","key":"2353_CR52","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nrm2845","volume":"11","author":"RJ O\u2019Sullivan","year":"2010","unstructured":"O\u2019Sullivan RJ, Karlseder J (2010) Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 11(3):171\u2013181. https:\/\/doi.org\/10.1038\/nrm2845","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2353_CR53","doi-asserted-by":"publisher","unstructured":"Ohashi, M., Korsakova, E., Allen, D., Lee, P., Fu, K., Vargas, B. S., Cinkornpumin, J., Salas, C., Park, J. C., Germanguz, I., Langerman, J., Chronis, C., Kuoy, E., Tran, S., Xiao, X., Pellegrini, M., Plath, K., & Lowry, W. E. (2017). Loss of MECP2 leads to telomere dysfunction and neuronal stress.\u00a0bioRxiv, 130401. https:\/\/doi.org\/10.1016\/j.stemcr.2018.04.001","DOI":"10.1016\/j.stemcr.2018.04.001"},{"key":"2353_CR54","unstructured":"Okovity, S. V., Shustov, E. B., Bolotova, V. T., & Titovich, I. A. (2016). Neuroprotective agent based bis {2-[(2E)-4-hydroxy-4-oxobut-2-enoyloxy]-N, N-diethylethanamine} butanedioate. Grew up.\u00a0Federation: Patent, (2015118789\/152588365). https:\/\/yandex.ru\/patents\/doc\/RU2588365C1_20160627"},{"issue":"5","key":"2353_CR55","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1007\/s10803-022-05486-2","volume":"53","author":"Y Panahi","year":"2023","unstructured":"Panahi Y, Salasar Moghaddam F, Babaei K, Eftekhar M, Shervin Badv R, Eskandari MR, Vafaee-Shahi M, Pezeshk H, Pedram M (2023) Sexual dimorphism in telomere length in childhood autism. J Autism Dev Disord 53(5):2050\u20132061. https:\/\/doi.org\/10.1007\/s10803-022-05486-2","journal-title":"J Autism Dev Disord"},{"issue":"5","key":"2353_CR56","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.4103\/1673-5374.324852","volume":"17","author":"GB Polho","year":"2022","unstructured":"Polho GB, Cardillo GM, Kerr DS, Chile T, Gattaz WF, Forlenza OV, Brentani HP, De-Paula VJ (2022) Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury. Neural Regen Res 17(5):1156\u20131160. https:\/\/doi.org\/10.4103\/1673-5374.324852","journal-title":"Neural Regen Res"},{"issue":"2\u20133","key":"2353_CR57","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.schres.2015.04.025","volume":"165","author":"GB Polho","year":"2015","unstructured":"Polho GB, De-Paula VJ, Cardillo G, dos Santos B, Kerr DS (2015) Leukocyte telomere length in patients with schizophrenia: a meta-analysis. Schizophr Res 165(2\u20133):195\u2013200. https:\/\/doi.org\/10.1016\/j.schres.2015.04.025","journal-title":"Schizophr Res"},{"issue":"2\u20133","key":"2353_CR58","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.schres.2008.04.003","volume":"106","author":"B Porton","year":"2008","unstructured":"Porton B, Delisi LE, Bertisch HC, Ji F, Gordon D, Li P, Benedict MM, Greenberg WM, Kao HT (2008) Telomerase levels in schizophrenia: a preliminary study. Schizophr Res 106(2\u20133):242\u2013247. https:\/\/doi.org\/10.1016\/j.schres.2008.04.003","journal-title":"Schizophr Res"},{"issue":"12","key":"2353_CR59","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1534\/g3.112.004689","volume":"2","author":"A Prasad","year":"2012","unstructured":"Prasad A, Merico D, Thiruvahindrapuram B, Wei J, Lionel AC, Sato D, Rickaby J, Lu C, Szatmari P, Roberts W, Fernandez BA, Marshall CR, Hatchwell E, Eis PS, Scherer SW (2012) A discovery resource of rare copy number variations in individuals with autism spectrum disorder. G3: Genes, Genomes, Genetics 2(12):1665\u20131685. https:\/\/doi.org\/10.1534\/g3.112.004689","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"2353_CR60","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jad.2015.11.052","volume":"191","author":"KK Ridout","year":"2016","unstructured":"Ridout KK, Ridout SJ, Price LH, Sen S, Tyrka AR (2016) Depression and telomere length: a meta-analysis. J Affect Disord 191:237\u2013247. https:\/\/doi.org\/10.1016\/j.jad.2015.11.052","journal-title":"J Affect Disord"},{"key":"2353_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13229-016-0073-0","volume":"7","author":"A Rynkiewicz","year":"2016","unstructured":"Rynkiewicz A, Schuller B, Marchi E, Piana S, Camurri A, Lassalle A, Baron-Cohen S (2016) An investigation of the \u201cfemale camouflage effect\u201d in autism using a computerized ADOS-2 and a test of sex\/gender differences. Molecular Autism 7:1\u20138. https:\/\/doi.org\/10.1186\/s13229-016-0073-0","journal-title":"Molecular Autism"},{"issue":"1","key":"2353_CR62","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/sj.npp.1300604","volume":"30","author":"T Schneider","year":"2005","unstructured":"Schneider T, Przew\u0142ocki R (2005) Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology 30(1):80\u201389. https:\/\/doi.org\/10.1038\/sj.npp.1300604","journal-title":"Neuropsychopharmacology"},{"issue":"6585","key":"2353_CR63","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1126\/science.abn6840","volume":"375","author":"Z Sekne","year":"2022","unstructured":"Sekne Z, Ghanim GE, van Roon AM, Nguyen THD (2022) Structural basis of human telomerase recruitment by TPP1-POT1. Science 375(6585):1173\u20131176. https:\/\/doi.org\/10.1126\/science.abn6840","journal-title":"Science"},{"issue":"6","key":"2353_CR64","doi-asserted-by":"publisher","first-page":"918","DOI":"10.17750\/KMJ2019-100-6-918","volume":"100","author":"II Semina","year":"2019","unstructured":"Semina II, Mukharyamova LM, Sabirov IS, Valeeva EV, Safiullina LR, Nikitin DO (2019) The current state of the problem of autism spectrum disorders\u2014some biomedical and socio-humanitarian aspects. Kazan medical journal 100(6):918\u2013929. https:\/\/doi.org\/10.17750\/KMJ2019-100-6-918","journal-title":"Kazan medical journal"},{"issue":"4","key":"2353_CR65","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s11055-023-01458-w","volume":"53","author":"II Semina","year":"2023","unstructured":"Semina II, Valeeva EV, Nikitin DO, Baichurina AZ, Nikitina AV, Shilovskaya EV, Kravtsova OA (2023) Sex differences in rats with the valproate model of autism: Disturbances in social behavior and changes in Drd1 gene expression in various brain structures. Neurosci Behav Physiol 53(4):597\u2013608. https:\/\/doi.org\/10.1007\/s11055-023-01458-w","journal-title":"Neurosci Behav Physiol"},{"key":"2353_CR66","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.pharmthera.2018.05.003","volume":"190","author":"SR Sharma","year":"2018","unstructured":"Sharma SR, Gonda X, Tarazi FI (2018) Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther 190:91\u2013104. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.05.003","journal-title":"Pharmacol Ther"},{"key":"2353_CR67","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.semcancer.2011.07.001","volume":"21","author":"JW Shay","year":"2011","unstructured":"Shay JW, Wright WE (2011) Role of telomeres and telomerase in cancer. Semin Cancer Biol 21:349\u2013353. https:\/\/doi.org\/10.1016\/j.semcancer.2011.07.001","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"2353_CR68","doi-asserted-by":"publisher","first-page":"41","DOI":"10.17116\/jnevro201911911141","volume":"119","author":"EM Shipilova","year":"2019","unstructured":"Shipilova EM, Nesterovsky YE (2019) The influence of nooclerin on the structure of sleep disturbances in children with tension headaches. Zhurnal Nevrologii i Psikhiatrii Imeni S.S Korsakova 119(11):41\u201346. https:\/\/doi.org\/10.17116\/jnevro201911911141","journal-title":"Zhurnal Nevrologii i Psikhiatrii Imeni S.S Korsakova"},{"issue":"5","key":"2353_CR69","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1128\/MCB.20.5.1659-1668.2000","volume":"20","author":"A Smogorzewska","year":"2000","unstructured":"Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20(5):1659\u20131668. https:\/\/doi.org\/10.1128\/MCB.20.5.1659-1668.2000","journal-title":"Mol Cell Biol"},{"issue":"21","key":"2353_CR70","doi-asserted-by":"publisher","first-page":"11855","DOI":"10.3390\/ijms222111855","volume":"22","author":"P So\u0142ek","year":"2021","unstructured":"So\u0142ek P, Mytych J, Tab\u0119cka-\u0141onczy\u0144ska A, Koziorowski M (2021) Molecular consequences of depression treatment: a potential in vitro mechanism for antidepressants-induced reprotoxic side effects. Int J Mol Sci 22(21):11855. https:\/\/doi.org\/10.3390\/ijms222111855","journal-title":"Int J Mol Sci"},{"key":"2353_CR71","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s10803-011-1215-z","volume":"42","author":"M Solomon","year":"2012","unstructured":"Solomon M, Miller M, Taylor SL, Hinshaw SP, Carter CS (2012) Autism symptoms and internalizing psychopathology in girls and boys with autism spectrum disorders. J Autism Dev Disord 42:48\u201359. https:\/\/doi.org\/10.1007\/s10803-011-1215-z","journal-title":"J Autism Dev Disord"},{"key":"2353_CR72","unstructured":"Stahl, S. M. (2008). Classical antidepressants, serotonin selective reuptake inhibitors and noradrenergic reuptake inhibitors. In Stahl\u2019s essential psychopharmacology: neuroscientific basis and practical application. Cambridge: Cambridge University Press."},{"key":"2353_CR73","unstructured":"U.S. Food and Drug Administration. (2020). Risperdal (risperidone) for oral use. Retrieved from https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/020272s085,020588s072,021444s058lbl.pdf"},{"issue":"2","key":"2353_CR74","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nprot.2007.44","volume":"2","author":"AA Walf","year":"2007","unstructured":"Walf AA, Frye CA (2007) The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2(2):322\u2013328. https:\/\/doi.org\/10.1038\/nprot.2007.44","journal-title":"Nat Protoc"},{"issue":"1","key":"2353_CR75","first-page":"578","volume":"8","author":"L Wang","year":"2015","unstructured":"Wang L, Liu Y, Li S, Long ZY, Wu YM (2015) Wnt signaling pathway participates in valproic acid-induced neuronal differentiation of neural stem cells. Int J Clin Exp Pathol 8(1):578\u2013585","journal-title":"Int J Clin Exp Pathol"},{"key":"2353_CR76","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.arr.2018.09.002","volume":"48","author":"Q Wang","year":"2018","unstructured":"Wang Q, Zhan Y, Pedersen NL, Fang F, H\u00e4gg S (2018) Telomere length and all-cause mortality: a meta-analysis. Ageing Res Rev 48:11\u201320. https:\/\/doi.org\/10.1016\/j.arr.2018.09.002","journal-title":"Ageing Res Rev"},{"issue":"8\u20139","key":"2353_CR77","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1080\/10408440590964217","volume":"35","author":"J Wiltse","year":"2005","unstructured":"Wiltse J (2005) Mode of action: inhibition of histone deacetylase, altering WNT-dependent gene expression, and regulation of beta-catenin\u2014developmental effects of valproic acid. Crit Rev Toxicol 35(8\u20139):727\u2013738. https:\/\/doi.org\/10.1080\/10408440590964217","journal-title":"Crit Rev Toxicol"},{"key":"2353_CR78","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1007\/s11033-010-0439-x","volume":"38","author":"A Wojtyla","year":"2011","unstructured":"Wojtyla A, Gladych M, Rubis B (2011) Human telomerase activity regulation. Mol Biol Rep 38:3339\u20133349. https:\/\/doi.org\/10.1007\/s11033-010-0439-x","journal-title":"Mol Biol Rep"},{"key":"2353_CR79","doi-asserted-by":"publisher","first-page":"5046867","DOI":"10.1155\/2019\/5046867","volume":"2019","author":"X Xu","year":"2019","unstructured":"Xu X, Hu H, Lin Y, Huang F, Ji H, Li Y, Lin S, Chen X, Duan S (2019) Differences in leukocyte telomere length between coronary heart disease and normal population: a multipopulation meta-analysis. Biomed Res Int 2019:5046867. https:\/\/doi.org\/10.1155\/2019\/5046867","journal-title":"Biomed Res Int"},{"key":"2353_CR80","first-page":"244","volume":"33","author":"WY Yu","year":"2008","unstructured":"Yu WY, Chang HW, Lin CH, Cho CL (2008) Short telomeres in patients with chronic schizophrenia who show a poor response to treatment. J Psychiatry Neurosci 33:244\u2013247","journal-title":"J Psychiatry Neurosci"},{"issue":"5","key":"2353_CR81","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1093\/rheumatology\/kez524","volume":"59","author":"Z Zeng","year":"2020","unstructured":"Zeng Z, Zhang W, Qian Y, Huang H, Wu DJH, He Z, Ye D, Mao Y, Wen C (2020) Association of telomere length with risk of rheumatoid arthritis: A meta-analysis and Mendelian randomization. Rheumatology (Oxford) 59(5):940\u2013947. https:\/\/doi.org\/10.1093\/rheumatology\/kez524","journal-title":"Rheumatology (Oxford)"},{"key":"2353_CR82","doi-asserted-by":"publisher","first-page":"1209638","DOI":"10.3389\/fpsyt.2023.1209638","volume":"14","author":"T Zhang","year":"2023","unstructured":"Zhang T, Sun Y, Wei J, Zhao G, Hao W, Lv Z, Chen X, Liu Y, Wei F (2023) Shorter telomere length in children with autism spectrum disorder is associated with oxidative stress. Front Psych 14:1209638. https:\/\/doi.org\/10.3389\/fpsyt.2023.1209638","journal-title":"Front Psych"},{"issue":"9","key":"2353_CR83","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s41588-022-01148-2","volume":"54","author":"Zhou, X., Feliciano, P., Shu, C., Wang, T., Astrovskaya, I., Hall, J. B., Obiajulu, J. U., Wright, J. R., Murali, S. C., Xu, S. X., Brueggeman, L., Thomas, T. R., Marchenko, O., Fleisch, C., Barns, S. D., Snyder, L. G., Han, B., Chang, T. S., Turner, T. N., Harvey, W. T., Nishida, A., O'Roak, B. J., Geschwind, D. H., SPARK Consortium, Michaelson, J. J., Volfovsky, N., Eichler, E. E., Shen, Y., & Chung, W. K","year":"2022","unstructured":"Zhou, X., Feliciano, P., Shu, C., Wang, T., Astrovskaya, I., Hall, J. B., Obiajulu, J. U., Wright, J. R., Murali, S. C., Xu, S. X., Brueggeman, L., Thomas, T. R., Marchenko, O., Fleisch, C., Barns, S. D., Snyder, L. G., Han, B., Chang, T. S., Turner, T. N., Harvey, W. T., Nishida, A., O\u2019Roak, B. J., Geschwind, D. H., SPARK Consortium, Michaelson, J. J., Volfovsky, N., Eichler, E. E., Shen, Y., & Chung, W. K (2022) Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes. Nat Genet 54(9):1305\u20131319. https:\/\/doi.org\/10.1038\/s41588-022-01148-2","journal-title":"Nat Genet"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-025-02353-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-025-02353-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-025-02353-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:28:47Z","timestamp":1751351327000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-025-02353-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":83,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2353"],"URL":"https:\/\/doi.org\/10.1007\/s12031-025-02353-4","relation":{},"ISSN":["1559-1166"],"issn-type":[{"type":"electronic","value":"1559-1166"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"19 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"55"}}