{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:55:59Z","timestamp":1783558559696,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-025-02420-w","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:31:32Z","timestamp":1759923092000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The ADNP-Mediated Transcriptome Response to Ketamine Impairs the Cytoskeletal Protein Axis"],"prefix":"10.1007","volume":"75","author":[{"given":"Claudio Peter","family":"D\u2019Incal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia","family":"Mateiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"De Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Elinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illana","family":"Gozes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Frank","family":"Kooy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"2420_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3109\/10715762.2015.1011153","volume":"49","author":"A Arya","year":"2015","unstructured":"Arya A et al (2015) NAP (davunetide) protects primary hippocampus culture by modulating expression profile of antioxidant genes during limiting oxygen conditions. Free Radic Res 49:440\u2013452","journal-title":"Free Radic Res"},{"key":"2420_CR2","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1046\/j.1471-4159.1999.0721283.x","volume":"72","author":"M Bassan","year":"1999","unstructured":"Bassan M et al (1999) Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J Neurochem 72:1283\u20131293","journal-title":"J Neurochem"},{"key":"2420_CR3","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1158\/1078-0432.CCR-16-1604","volume":"23","author":"C Blaj","year":"2017","unstructured":"Blaj C et al (2017) ADNP is a therapeutically inducible repressor of WNT signaling in colorectal cancer. Clin Cancer Res 23:2769\u20132780","journal-title":"Clin Cancer Res"},{"key":"2420_CR4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.2174\/157488612802715663","volume":"7","author":"ZJ Bosnjak","year":"2012","unstructured":"Bosnjak ZJ et al (2012) Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Saf 7:106\u2013119","journal-title":"Curr Drug Saf"},{"key":"2420_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuroscience.2014.12.076","volume":"290","author":"BP Brown","year":"2015","unstructured":"Brown BP et al (2015) In vivo and in vitro ketamine exposure exhibits a dose-dependent induction of activity-dependent neuroprotective protein in rat neurons. Neuroscience 290:31\u201340","journal-title":"Neuroscience"},{"key":"2420_CR6","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1113\/jphysiol.2010.195503","volume":"588","author":"V Burzomato","year":"2010","unstructured":"Burzomato V, Frugier G, P\u00e9rez-Ota\u00f1o I, Kittler JT, Attwell D (2010) The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes. J Physiol (Lond) 588:3403\u20133414","journal-title":"J Physiol (Lond)"},{"key":"2420_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41398-024-03005-8","volume":"14","author":"AS Buxbaum Grice","year":"2024","unstructured":"Buxbaum Grice AS et al (2024) Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome. Transl Psychiatry 14:307","journal-title":"Transl Psychiatry"},{"key":"2420_CR8","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.1038\/s41380-023-02129-5","volume":"28","author":"H Cho","year":"2023","unstructured":"Cho H et al (2023) Adnp-mutant mice with cognitive inflexibility, CaMKII\u03b1 hyperactivity, and synaptic plasticity deficits. Mol Psychiatry 28:3548\u20133562","journal-title":"Mol Psychiatry"},{"key":"2420_CR9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0959-4388(00)00215-4","volume":"11","author":"S Cull-Candy","year":"2001","unstructured":"Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11:327\u2013335","journal-title":"Curr Opin Neurobiol"},{"key":"2420_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13148-023-01450-8","volume":"15","author":"CP D\u2019Incal","year":"2023","unstructured":"D\u2019Incal CP et al (2023) Chromatin remodeler activity-dependent neuroprotective protein (ADNP) contributes to syndromic autism. Clin Epigenetics 15:45","journal-title":"Clin Epigenetics"},{"key":"2420_CR11","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41431-024-01556-4","volume":"32","author":"CP D\u2019Incal","year":"2024","unstructured":"D\u2019Incal CP et al (2024a) Loss-of-function of activity-dependent neuroprotective protein (ADNP) by a splice-acceptor site mutation causes Helsmoortel-Van der Aa syndrome. Eur J Hum Genet 32:630\u2013638. https:\/\/doi.org\/10.1038\/s41431-024-01556-4","journal-title":"Eur J Hum Genet"},{"key":"2420_CR12","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40478-024-01743-w","volume":"12","author":"C D\u2019Incal","year":"2024","unstructured":"D\u2019Incal C et al (2024b) ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel-Van der Aa syndrome autopsy case. Acta Neuropathol Commun 12:62","journal-title":"Acta Neuropathol Commun"},{"key":"2420_CR13","doi-asserted-by":"publisher","first-page":"14710","DOI":"10.1038\/s41598-024-65608-x","volume":"14","author":"CP D\u2019Incal","year":"2024","unstructured":"D\u2019Incal CP et al (2024c) Tracing the invisible mutant ADNP protein in Helsmoortel-Van der Aa syndrome patients. Sci Rep 14:14710","journal-title":"Sci Rep"},{"key":"2420_CR14","doi-asserted-by":"publisher","unstructured":"D\u2019Incal CP et al. (2025) A novel Adnp frameshift variant disrupts Wnt signaling leading to chromatocytoskeletal defects and autism-related behavior in mice. https:\/\/doi.org\/10.2139\/ssrn.5353802","DOI":"10.2139\/ssrn.5353802"},{"key":"2420_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/add.15154","volume":"116","author":"S Darke","year":"2021","unstructured":"Darke S, Duflou J, Farrell M, Peacock A, Lappin J (2021) Characteristics and circumstances of death related to the self-administration of ketamine. Addiction 116:339\u2013345","journal-title":"Addiction"},{"key":"2420_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182251","author":"M Ganaiem","year":"2023","unstructured":"Ganaiem M et al (2023) NAP (davunetide): the neuroprotective ADNP drug candidate penetrates cell nuclei explaining pleiotropic mechanisms. Cells. https:\/\/doi.org\/10.3390\/cells12182251","journal-title":"Cells"},{"key":"2420_CR17","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/s41431-023-01323-x","volume":"31","author":"M Georget","year":"2023","unstructured":"Georget M et al (2023) Loss of function of ADNP by an intragenic inversion. Eur J Hum Genet 31:967\u2013970. https:\/\/doi.org\/10.1038\/s41431-023-01323-x","journal-title":"Eur J Hum Genet"},{"key":"2420_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312827","author":"M Ghasemi","year":"2021","unstructured":"Ghasemi M, Turnbull T, Sebastian S, Kempson I (2021) The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms222312827","journal-title":"Int J Mol Sci"},{"key":"2420_CR19","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1527-3458.2005.tb00053.x","volume":"11","author":"I Gozes","year":"2005","unstructured":"Gozes I et al (2005) NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Rev 11:353\u2013368","journal-title":"CNS Drug Rev"},{"key":"2420_CR20","doi-asserted-by":"publisher","first-page":"e1043","DOI":"10.1038\/tp.2017.27","volume":"7","author":"I Gozes","year":"2017","unstructured":"Gozes I et al (2017) Premature primary tooth eruption in cognitive\/motor-delayed ADNP-mutated children. Transl Psychiatry 7:e1043","journal-title":"Transl Psychiatry"},{"key":"2420_CR21","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41398-020-00904-4","volume":"10","author":"I Grigg","year":"2020","unstructured":"Grigg I et al (2020) Tauopathy in the young autistic brain: novel biomarker and therapeutic target. Transl Psychiatry 10:228","journal-title":"Transl Psychiatry"},{"key":"2420_CR22","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1172\/JCI98199","volume":"128","author":"G Hacohen-Kleiman","year":"2018","unstructured":"Hacohen-Kleiman G et al (2018) Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. J Clin Invest 128:4956\u20134969","journal-title":"J Clin Invest"},{"key":"2420_CR23","doi-asserted-by":"publisher","first-page":"8465","DOI":"10.1038\/s41598-018-26547-6","volume":"8","author":"A Hadar","year":"2018","unstructured":"Hadar A et al (2018) SIRT1, miR-132 and miR-212 link human longevity to Alzheimer\u2019s disease. Sci Rep 8:8465","journal-title":"Sci Rep"},{"key":"2420_CR24","doi-asserted-by":"publisher","first-page":"e909","DOI":"10.1038\/tp.2016.179","volume":"6","author":"A Hadar","year":"2016","unstructured":"Hadar A et al (2016) RGS2 expression predicts amyloid-\u03b2 sensitivity, MCI and Alzheimer\u2019s disease: genome-wide transcriptomic profiling and bioinformatics data mining. Transl Psychiatry 6:e909","journal-title":"Transl Psychiatry"},{"issue":"Pt 3","key":"2420_CR25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1046\/j.1469-7580.2000.19730477.x","volume":"197","author":"SJ Harris","year":"2000","unstructured":"Harris SJ, Wilce P, Bedi KS (2000) Exposure of rats to a high but not low dose of ethanol during early postnatal life increases the rate of loss of optic nerve axons and decreases the rate of myelination. J Anat 197(Pt 3):477\u2013485","journal-title":"J Anat"},{"key":"2420_CR26","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/ng.2899","volume":"46","author":"C Helsmoortel","year":"2014","unstructured":"Helsmoortel C et al (2014) A SWI\/SNF-related autism syndrome caused by de novo mutations in ADNP. Nat Genet 46:380\u2013384","journal-title":"Nat Genet"},{"key":"2420_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.biopsych.2021.09.018","volume":"92","author":"G Karmon","year":"2022","unstructured":"Karmon G et al (2022) Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies. Biol Psychiatry 92:81\u201395","journal-title":"Biol Psychiatry"},{"key":"2420_CR28","doi-asserted-by":"publisher","first-page":"100138","DOI":"10.1016\/j.xhgg.2022.100138","volume":"3","author":"A Kolevzon","year":"2022","unstructured":"Kolevzon A et al (2022) An open-label study evaluating the safety, behavioral, and electrophysiological outcomes of low-dose ketamine in children with ADNP syndrome. Hum Genet Genomics Adv 3:100138","journal-title":"Hum Genet Genomics Adv"},{"key":"2420_CR29","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.2174\/0929867321666140217124945","volume":"21","author":"I Magen","year":"2014","unstructured":"Magen I, Gozes I (2014) Davunetide: peptide therapeutic in neurological disorders. Curr Med Chem 21:2591\u20132598","journal-title":"Curr Med Chem"},{"key":"2420_CR30","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.ydbio.2006.11.039","volume":"303","author":"S Mandel","year":"2007","unstructured":"Mandel S, Rechavi G, Gozes I (2007) Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol 303:814\u2013824","journal-title":"Dev Biol"},{"key":"2420_CR31","doi-asserted-by":"publisher","first-page":"34448","DOI":"10.1074\/jbc.M704756200","volume":"282","author":"S Mandel","year":"2007","unstructured":"Mandel S, Gozes I (2007) Activity-dependent neuroprotective protein constitutes a novel element in the SWI\/SNF chromatin remodeling complex. J Biol Chem 282:34448\u201334456","journal-title":"J Biol Chem"},{"key":"2420_CR32","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s10571-010-9519-7","volume":"30","author":"AP Mashkina","year":"2010","unstructured":"Mashkina AP, Cizkova D, Vanicky I, Boldyrev AA (2010) NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo. Cell Mol Neurobiol 30:901\u2013907","journal-title":"Cell Mol Neurobiol"},{"key":"2420_CR33","doi-asserted-by":"publisher","first-page":"R584","DOI":"10.1152\/ajpregu.00452.2009","volume":"298","author":"TA McNearney","year":"2010","unstructured":"McNearney TA et al (2010) A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol 298:R584\u2013R598","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2420_CR34","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/s41586-018-0153-8","volume":"557","author":"V Ostapcuk","year":"2018","unstructured":"Ostapcuk V et al (2018) Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Nature 557:739\u2013743","journal-title":"Nature"},{"key":"2420_CR35","doi-asserted-by":"publisher","first-page":"e51458","DOI":"10.1371\/journal.pone.0051458","volume":"7","author":"S Oz","year":"2012","unstructured":"Oz S, Ivashko-Pachima Y, Gozes I (2012) The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities. PLoS One 7:e51458","journal-title":"PLoS One"},{"key":"2420_CR36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0165-3806(03)00162-7","volume":"144","author":"A Pinhasov","year":"2003","unstructured":"Pinhasov A et al (2003) Activity-dependent neuroprotective protein: a novel gene essential for brain formation. Brain Res Dev Brain Res 144:83\u201390","journal-title":"Brain Res Dev Brain Res"},{"key":"2420_CR37","doi-asserted-by":"publisher","first-page":"104855","DOI":"10.1016\/j.ejmg.2023.104855","volume":"66","author":"J Rosenblum","year":"2023","unstructured":"Rosenblum J, Van der Veeken L, Aertsen M, Meuwissen M, Jansen AC (2023) Abnormal fetal ultrasound leading to the diagnosis of ADNP syndrome. Eur J Med Genet 66:104855","journal-title":"Eur J Med Genet"},{"key":"2420_CR38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1515\/JBCPP.2005.16.4.231","volume":"16","author":"M Rudin","year":"2005","unstructured":"Rudin M et al (2005) Single-dose ketamine administration induces apoptosis in neonatal mouse brain. J Basic Clin Physiol Pharmacol 16:231\u2013243","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"2420_CR39","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1038\/s41380-024-02879-w","volume":"30","author":"G Shapira","year":"2025","unstructured":"Shapira G et al (2025) ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation. Mol Psychiatry 30:2696\u20132706","journal-title":"Mol Psychiatry"},{"key":"2420_CR40","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41398-018-0357-6","volume":"9","author":"S Sragovich","year":"2019","unstructured":"Sragovich S et al (2019) The autism\/neuroprotection-linked ADNP\/NAP regulate the excitatory glutamatergic synapse. Transl Psychiatry 9:2","journal-title":"Transl Psychiatry"},{"key":"2420_CR41","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1038\/s41467-020-16799-0","volume":"11","author":"X Sun","year":"2020","unstructured":"Sun X, Peng X, Cao Y, Zhou Y, Sun Y (2020) ADNP promotes neural differentiation by modulating Wnt\/\u03b2-catenin signaling. Nat Commun 11:2984","journal-title":"Nat Commun"},{"key":"2420_CR42","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/j.1755-3768.2009.01828.x","volume":"89","author":"B Teuchner","year":"2011","unstructured":"Teuchner B et al (2011) VIP, PACAP-38, BDNF and ADNP in NMDA-induced excitotoxicity in the rat retina. Acta Ophthalmol 89:670\u2013675","journal-title":"Acta Ophthalmol"},{"key":"2420_CR43","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.neuroscience.2012.02.015","volume":"210","author":"CP Turner","year":"2012","unstructured":"Turner CP et al (2012) Strategies to defeat ketamine-induced neonatal brain injury. Neuroscience 210:384\u2013392","journal-title":"Neuroscience"},{"key":"2420_CR44","doi-asserted-by":"publisher","first-page":"14163","DOI":"10.1073\/pnas.0802075105","volume":"105","author":"MH Ulbrich","year":"2008","unstructured":"Ulbrich MH, Isacoff EY (2008) Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci USA 105:14163\u201314168","journal-title":"Proc Natl Acad Sci USA"},{"key":"2420_CR45","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.biopsych.2018.02.1173","volume":"85","author":"A Van Dijck","year":"2019","unstructured":"Van Dijck A et al (2019) Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Biol Psychiatry 85:287\u2013297. https:\/\/doi.org\/10.1016\/j.biopsych.2018.02.1173","journal-title":"Biol Psychiatry"},{"key":"2420_CR46","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1124\/jpet.107.129551","volume":"323","author":"I Vulih-Shultzman","year":"2007","unstructured":"Vulih-Shultzman I et al (2007) Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. J Pharmacol Exp Ther 323:438\u2013449","journal-title":"J Pharmacol Exp Ther"},{"key":"2420_CR47","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2147\/DDDT.S188636","volume":"13","author":"R Wang","year":"2019","unstructured":"Wang R, Zhang Z, Kumar M, Xu G, Zhang M (2019) Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K\/AKT\/GSK-3\u03b2 pathway. Drug des Devel Ther 13:501\u2013512","journal-title":"Drug des Devel Ther"},{"key":"2420_CR48","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/ANA.0000000000000027","volume":"26","author":"J Yan","year":"2014","unstructured":"Yan J, Jiang H (2014) Dual effects of ketamine: neurotoxicity versus neuroprotection in anesthesia for the developing brain. J Neurosurg Anesthesiol 26:155\u2013160","journal-title":"J Neurosurg Anesthesiol"},{"key":"2420_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neuropharm.2013.03.030","volume":"74","author":"Q Zhou","year":"2013","unstructured":"Zhou Q, Sheng M (2013) NMDA receptors in nervous system diseases. Neuropharmacology 74:69\u201375","journal-title":"Neuropharmacology"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-025-02420-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-025-02420-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-025-02420-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T20:01:55Z","timestamp":1768161715000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-025-02420-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2420"],"URL":"https:\/\/doi.org\/10.1007\/s12031-025-02420-w","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"20 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Lymphoblastoid cell lines were generated from peripheral blood lymphocytes donated by consenting patients and guardians\/physicians in the laboratory of prof. dr. Frank Kooy. All procedures were approved by the Ethics Committee of the Antwerp University Hospital (UZA), Antwerp, Belgium.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"A written informed consent was obtained for the individuals enclosed in this study that allows the medical doctors and researchers of the Department of Medical Genetics, University Hospital Antwerp, to use photographs, biopsies and\/or X-rays for medical reasons (discussions between colleagues, teaching, or publication in scientific papers).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors reviewed the manuscript and agreed to the published version of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"136"}}