{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:54:51Z","timestamp":1785423291700,"version":"3.56.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Construction Project of Dominant Characteristic Disciplines of Qiqihar Medical University","award":["QYZDXK-001"],"award-info":[{"award-number":["QYZDXK-001"]}]},{"name":"Qiqihar City Science and Technology Plan Joint Guidance Project","award":["LSFGG-2022049"],"award-info":[{"award-number":["LSFGG-2022049"]}]},{"name":"Heilongjiang Provincial Administration of Traditional Chinese Medicine Project","award":["ZHY2023-115"],"award-info":[{"award-number":["ZHY2023-115"]}]},{"name":"Clinical Research Fund Project of Qiqihar Academy of Medical Sciences","award":["QMSI2019L-24"],"award-info":[{"award-number":["QMSI2019L-24"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-026-02482-4","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T02:34:50Z","timestamp":1770172490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PRDX6 as a Ferroptosis-Related Hub Gene in the Entorhinal Cortex of Alzheimer\u2019s Disease: A Multidimensional Bioinformatics and Experimental Validation Study"],"prefix":"10.1007","volume":"76","author":[{"given":"Xiaolin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziteng","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"46","key":"2482_CR1","doi-asserted-by":"publisher","first-page":"8742","DOI":"10.1523\/JNEUROSCI.1165-22.2022","volume":"42","author":"JN Adams","year":"2022","unstructured":"Adams JN, Kim S, Rizvi B et al (2022) Entorhinal-Hippocampal circuit integrity is related to mnemonic discrimination and Amyloid-\u03b2 pathology in older adults. J Neurosci 42(46):8742\u20138753","journal-title":"J Neurosci"},{"issue":"12","key":"2482_CR2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3390\/antiox7120172","volume":"7","author":"JA Arevalo","year":"2018","unstructured":"Arevalo JA, V\u00e1zquez-Medina JP (2018) The role of Peroxiredoxin 6 in cell signaling. Antioxid (Basel) 7(12):172","journal-title":"Antioxid (Basel)"},{"issue":"1","key":"2482_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13024-021-00493-w","volume":"16","author":"B Bai","year":"2021","unstructured":"Bai B, Vanderwall D, Li Y et al (2021) Proteomic landscape of alzheimer\u2019s disease: novel insights into pathogenesis and biomarker discovery. Mol Neurodegeneration 16(1):72","journal-title":"Mol Neurodegeneration"},{"issue":"24","key":"2482_CR4","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.3390\/molecules25245789","volume":"25","author":"Z Breijyeh","year":"2020","unstructured":"Breijyeh Z, Karaman R (2020) Comprehensive review on alzheimer\u2019s disease: causes and treatment. Molecules 25(24):5789","journal-title":"Molecules"},{"key":"2482_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.01.002","volume":"180","author":"L Chen","year":"2022","unstructured":"Chen L, Dar NJ, Na R et al (2022) Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice. Free Radic Biol Med 180:1\u201312","journal-title":"Free Radic Biol Med"},{"key":"2482_CR5","doi-asserted-by":"crossref","unstructured":"Chhunchha B, Kubo E, Singh DP (2020) Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6. Cells 9(8):1861","DOI":"10.3390\/cells9081861"},{"issue":"8","key":"2482_CR7","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.4103\/1673-5374.389362","volume":"19","author":"L Feng","year":"2024","unstructured":"Feng L, Sun J, Xia L et al (2024) Ferroptosis mechanism and alzheimer\u2019s disease. Neural Regen Res 19(8):1741\u20131750","journal-title":"Neural Regen Res"},{"key":"2482_CR8","doi-asserted-by":"publisher","first-page":"955178","DOI":"10.3389\/fnsys.2022.955178","volume":"26","author":"T Funane","year":"2022","unstructured":"Funane T, Jun H, Sutoko S et al (2022) Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of alzheimer\u2019s disease. Front Syst Neurosci 26:955178","journal-title":"Front Syst Neurosci"},{"key":"2482_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","volume":"12","author":"WS Hambright","year":"2017","unstructured":"Hambright WS, Fonseca RS, Chen L et al (2017) Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. Redox Biol 12:8\u201317","journal-title":"Redox Biol"},{"issue":"1","key":"2482_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.14283\/jpad.2018.43","volume":"6","author":"H Hampel","year":"2019","unstructured":"Hampel H, Mesulam MM, Cuello AC et al (2019) Revisiting the cholinergic hypothesis in alzheimer\u2019s disease: emerging evidence from translational and clinical research. J Prev Alzheimers Dis 6(1):2\u201315","journal-title":"J Prev Alzheimers Dis"},{"key":"2482_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neuroscience.2023.01.003","volume":"512","author":"JY Hou","year":"2023","unstructured":"Hou JY, Zhou XL, Wang XY et al (2023) Peroxiredoxin-6 released by astrocytes contributes to neuroapoptosis during ischemia. Neuroscience 512:59\u201369","journal-title":"Neuroscience"},{"issue":"23","key":"2482_CR12","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1016\/j.molcel.2024.10.028","volume":"84","author":"J Ito","year":"2024","unstructured":"Ito J, Nakamura T, Toyama T et al (2024) PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Mol Cell 84(23):4629\u20134644","journal-title":"Mol Cell"},{"issue":"8","key":"2482_CR13","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"CR Jack Jr","year":"2024","unstructured":"Jack CR Jr, Andrews JS, Beach TG et al (2024) Revised criteria for diagnosis and staging of alzheimer\u2019s disease: alzheimer\u2019s association workgroup. Alzheimers Dement 20(8):5143\u20135169","journal-title":"Alzheimers Dement"},{"key":"2482_CR14","doi-asserted-by":"publisher","first-page":"102481","DOI":"10.1016\/j.arr.2024.102481","volume":"101","author":"PT Kamatham","year":"2024","unstructured":"Kamatham PT, Shukla R, Khatri DK, Vora LK (2024) Pathogenesis, diagnostics, and therapeutics for alzheimer\u2019s disease: breaking the memory barrier. Ageing Res Rev 101:102481","journal-title":"Ageing Res Rev"},{"issue":"43","key":"2482_CR15","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.2174\/0113816128264355231121064704","volume":"29","author":"M Kashif","year":"2023","unstructured":"Kashif M, Sivaprakasam P, Vijendra P et al (2023) A recent update on pathophysiology and therapeutic interventions of alzheimer\u2019s disease. Curr Pharm Des 29(43):3428\u20133441","journal-title":"Curr Pharm Des"},{"key":"2482_CR16","doi-asserted-by":"publisher","first-page":"1046410","DOI":"10.3389\/fimmu.2022.1046410","volume":"13","author":"Y Lai","year":"2022","unstructured":"Lai Y, Lin P, Lin F et al (2022) Identification of immune microenvironment subtypes and signature genes for alzheimer\u2019s disease diagnosis and risk prediction based on explainable machine learning. Front Immunol 13:1046410","journal-title":"Front Immunol"},{"issue":"2","key":"2482_CR19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin H et al (2020) Ferroptosis: past, present and future. Cell Death Dis 11(2):88","journal-title":"Cell Death Dis"},{"issue":"02","key":"2482_CR18","first-page":"114","volume":"55","author":"FJ Li","year":"2021","unstructured":"Li FJ, Guo LJ, Wang S (2021) Upregulation of Prdx6 mitigates sevoflurane-induced HT22 hippocampal neuronal ferroptosis. J Harbin Med Univ 55(02):114\u2013119","journal-title":"J Harbin Med Univ"},{"issue":"3","key":"2482_CR20","doi-asserted-by":"publisher","first-page":"611","DOI":"10.4103\/1673-5374.380870","volume":"19","author":"Y Li","year":"2024","unstructured":"Li Y, Li M, Feng S et al (2024) Ferroptosis and Endoplasmic reticulum stress in ischemic stroke. Neural Regen Res 19(3):611\u2013618","journal-title":"Neural Regen Res"},{"issue":"9","key":"2482_CR17","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1007\/s12035-021-02427-5","volume":"58","author":"J Liao","year":"2021","unstructured":"Liao J, Zhang Y, Chen X, Zhang J (2021) The roles of Peroxiredoxin 6 in brain diseases. Mol Neurobiol 58(9):4348\u20134364","journal-title":"Mol Neurobiol"},{"issue":"2","key":"2482_CR21","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1007\/s12035-024-04417-9","volume":"62","author":"M Ma","year":"2025","unstructured":"Ma M, Jing G, Tian Y et al (2025) Ferroptosis in cognitive impairment associated with diabetes and alzheimer\u2019s disease: mechanistic insights and new therapeutic opportunities. Mol Neurobiol 62(2):2435\u20132449","journal-title":"Mol Neurobiol"},{"key":"2482_CR22","doi-asserted-by":"publisher","first-page":"115522","DOI":"10.1016\/j.bcp.2023.115522","volume":"211","author":"AR Monteiro","year":"2023","unstructured":"Monteiro AR, Barbosa DJ, Remi\u00e3o F, Silva R (2023) Alzheimer\u2019s disease: insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs. Biochem Pharmacol 211:115522","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"2482_CR23","doi-asserted-by":"publisher","first-page":"bio056796","DOI":"10.1242\/bio.056796","volume":"10","author":"OJ Olajide","year":"2021","unstructured":"Olajide OJ, Suvanto ME, Chapman CA (2021) Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of alzheimer\u2019s disease. Biol Open 10(1):bio056796","journal-title":"Biol Open"},{"issue":"1","key":"2482_CR24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13024-020-00401-8","volume":"15","author":"JE Pankiewicz","year":"2020","unstructured":"Pankiewicz JE, Diaz JR, Mart\u00e1-Ariza M et al (2020) Peroxiredoxin 6 mediates protective function of astrocytes in A\u03b2 proteostasis. Mol Neurodegener 15(1):50","journal-title":"Mol Neurodegener"},{"issue":"1","key":"2482_CR25","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12964-024-01476-2","volume":"22","author":"L Peng","year":"2024","unstructured":"Peng L, Ji Y, Li Y et al (2024) PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia. Cell Commun Signal 22(1):76","journal-title":"Cell Commun Signal"},{"issue":"8","key":"2482_CR26","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1089\/ars.2020.8134","volume":"34","author":"G Plascencia-Villa","year":"2021","unstructured":"Plascencia-Villa G, Perry G (2021) Preventive and therapeutic strategies in alzheimer\u2019s disease: focus on oxidative Stress, redox Metals, and ferroptosis. Antioxid Redox Signal 34(8):591\u2013610","journal-title":"Antioxid Redox Signal"},{"issue":"13\u201315","key":"2482_CR27","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1089\/ars.2023.0287","volume":"40","author":"H Rahaman","year":"2024","unstructured":"Rahaman H, Herojit K, Singh LR et al (2024) Structural and functional diversity of the Peroxiredoxin 6 enzyme family. Antioxid Redox Signal 40(13\u201315):759\u2013775","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2482_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14348\/molcells.2016.2368","volume":"39","author":"SG Rhee","year":"2016","unstructured":"Rhee SG (2016) Overview on Peroxiredoxin. Mol Cells 39(1):1\u20135","journal-title":"Mol Cells"},{"issue":"10284","key":"2482_CR29","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M et al (2021) Alzheimer\u2019s disease. Lancet 397(10284):1577\u20131590","journal-title":"Lancet"},{"issue":"1","key":"2482_CR30","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.00229.2015","volume":"310","author":"SP Singh","year":"2016","unstructured":"Singh SP, Chhunchha B, Fatma N et al (2016) Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells. Am J Physiol Cell Physiol 310(1):C1\u2013C16","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"2482_CR31","doi-asserted-by":"publisher","first-page":"100005","DOI":"10.1124\/pharmrev.123.000823","volume":"77","author":"WJ Streit","year":"2025","unstructured":"Streit WJ, Phan L, Bechmann I (2025) Ferroptosis and pathogenesis of neuritic plaques in alzheimer disease. Pharmacol Rev 77(1):100005","journal-title":"Pharmacol Rev"},{"key":"2482_CR32","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.2147\/IJN.S200490","volume":"14","author":"S Tiwari","year":"2019","unstructured":"Tiwari S, Atluri V, Kaushik A et al (2019) Alzheimer\u2019s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomed 14:5541\u20135554","journal-title":"Int J Nanomed"},{"issue":"16","key":"2482_CR33","doi-asserted-by":"publisher","first-page":"8805","DOI":"10.3390\/ijms22168805","volume":"22","author":"EA Turovsky","year":"2021","unstructured":"Turovsky EA, Varlamova EG, Plotnikov EY (2021) Mechanisms underlying the protective effect of the Peroxiredoxin-6 are mediated via the protection of astrocytes during Ischemia\/Reoxygenation. Int J Mol Sci 22(16):8805","journal-title":"Int J Mol Sci"},{"key":"2482_CR37","doi-asserted-by":"publisher","first-page":"830569","DOI":"10.3389\/fnagi.2022.830569","volume":"14","author":"F Wang","year":"2022","unstructured":"Wang F, Wang J, Shen Y et al (2022) Iron dyshomeostasis and ferroptosis: A new alzheimer\u2019s disease hypothesis? Front Aging Neurosci 14:830569","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"2482_CR34","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jalz.2017.08.012","volume":"14","author":"M Xu","year":"2018","unstructured":"Xu M, Zhang DF, Luo R et al (2018) A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in alzheimer\u2019s disease. Alzheimer\u2019s Dement 14(2):215\u2013229","journal-title":"Alzheimer\u2019s Dement"},{"issue":"4","key":"2482_CR35","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/antiox13040449","volume":"13","author":"M Xue","year":"2024","unstructured":"Xue M, Huang X, Zhu T et al (2024) Unveiling the significance of Peroxiredoxin 6 in central nervous system disorders. Antioxid (Basel) 13(4):449","journal-title":"Antioxid (Basel)"},{"issue":"12","key":"2482_CR36","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1007\/s11064-023-04003-w","volume":"48","author":"A Yamamuro-Tanabe","year":"2023","unstructured":"Yamamuro-Tanabe A, Mukai Y, Kojima W et al (2023) An increase in Peroxiredoxin 6 expression induces neurotoxic A1 astrocytes in the lumbar spinal cord of amyotrophic lateral sclerosis mice model. Neurochem Res 48(12):3571\u20133584","journal-title":"Neurochem Res"},{"issue":"1","key":"2482_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","volume":"7","author":"Y Yu","year":"2021","unstructured":"Yu Y, Yan Y, Niu FL et al (2021) Ferroptosis: a cell death connecting oxidative stress, inflammation, and cardiovascular diseases. Cell Death Discovery 7(1):193","journal-title":"Cell Death Discovery"},{"issue":"3","key":"2482_CR38","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s12035-013-8479-6","volume":"48","author":"HM Yun","year":"2013","unstructured":"Yun HM, Jin P, Han JY et al (2013) Acceleration of the development of alzheimer\u2019s disease in amyloid beta-infused Peroxiredoxin 6 overexpression Transgenic mice. Mol Neurobiol 48(3):941\u2013951","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2482_CR39","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s12035-014-8885-4","volume":"52","author":"HM Yun","year":"2015","unstructured":"Yun HM, Choi DY, Oh KW et al (2015) PRDX6 exacerbates dopaminergic neurodegeneration in a MPTP mouse model of parkinson\u2019s disease. Mol Neurobiol 52(1):422\u2013431","journal-title":"Mol Neurobiol"},{"key":"2482_CR41","doi-asserted-by":"publisher","first-page":"683483","DOI":"10.3389\/fnagi.2021.683483","volume":"13","author":"ZH Zhen","year":"2021","unstructured":"Zhen ZH, Guo MR, Li HM et al (2021) Normal and abnormal Sharp wave ripples in the Hippocampal-Entorhinal cortex system: implications for memory Consolidation, alzheimer\u2019s Disease, and Temporal lobe epilepsy. Front Aging Neurosci 13:683483","journal-title":"Front Aging Neurosci"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02482-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-026-02482-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02482-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:43:16Z","timestamp":1774402996000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-026-02482-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["2482"],"URL":"https:\/\/doi.org\/10.1007\/s12031-026-02482-4","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"8 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}