{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:42:36Z","timestamp":1788223356258,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-026-02500-5","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:34:30Z","timestamp":1778153670000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preclinical Evidence of Extracellular Vesicle-derived MicroRNAs in Relieving Diabetic Peripheral Neuropathy: A Systematic Review"],"prefix":"10.1007","volume":"76","author":[{"given":"Amir Reza","family":"Ghafourian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh Soltan","family":"Mohseni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhaneh","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Davoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Choobineh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Nabatchian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-118X","authenticated-orcid":false,"given":"Reza","family":"Afrisham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"2500_CR21","doi-asserted-by":"crossref","unstructured":"Afrisham R, Ahmadvand M, Sadegh-nejadi S, Kashanikhatib Z, Kaviani S, Farrokhi V et al (2026) Circulating small extracellular vesicles of aged individuals promote higher senescence marker expression and lower antioxidant levels in hematopoietic stem cells. Regenerative Eng Translational Med 1\u201312","DOI":"10.1007\/s40883-025-00547-1"},{"issue":"1","key":"2500_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13098-020-00540-4","volume":"12","author":"R Afrisham","year":"2020","unstructured":"Afrisham R, Sadegh-Nejadi S, Meshkani R, Emamgholipour S, Paknejad M (2020) Effect of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A in HepG2 cells. Diabetol Metab Syndr 12(1):32","journal-title":"Diabetol Metab Syndr"},{"key":"2500_CR43","first-page":"55","volume-title":"Modeling diabetic sensory neuropathy in rats","author":"NA Calcutt","year":"2004","unstructured":"Calcutt NA (2004) Modeling diabetic sensory neuropathy in rats. Pain Research, Methods and Protocols: Springer;, pp 55\u201365"},{"key":"2500_CR47","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neulet.2015.01.048","volume":"596","author":"CR Cashman","year":"2015","unstructured":"Cashman CR, H\u00f6ke A (2015) Mechanisms of distal axonal degeneration in peripheral neuropathies. Neurosci Lett 596:33\u201350","journal-title":"Neurosci Lett"},{"issue":"7","key":"2500_CR27","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1007\/s12035-023-03297-9","volume":"60","author":"J Chen","year":"2023","unstructured":"Chen J, Li G, Liu X, Chen K, Wang Y, Qin J et al (2023) Delivery of miR-130a-3p Through Adipose-Derived Stem Cell-Secreted EVs Protects Against Diabetic Peripheral Neuropathy via DNMT1\/NRF2\/HIF1\u03b1\/ACTA1 Axis. Mol Neurobiol 60(7):3678\u20133694","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2500_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40001-025-03288-7","volume":"30","author":"L Chen","year":"2025","unstructured":"Chen L, Amraee F, Sadegh-Nejadi S, Saberian M, Ghahari SA, Miao X et al (2025) Molecular mechanisms linking adipose tissue-derived small extracellular vesicles\/exosomes to the development or amelioration of obesity, insulin resistance, and diabetes-related complications. Eur J Med Res 30(1):1\u201319","journal-title":"Eur J Med Res"},{"key":"2500_CR6","doi-asserted-by":"crossref","unstructured":"Chong ZZ, Souayah N (2025) Neuroinflammation in diabetic peripheral neuropathy and therapeutic implications. Rev Neurosci","DOI":"10.1515\/revneuro-2025-0031"},{"key":"2500_CR29","doi-asserted-by":"crossref","unstructured":"Coy-Dibley J, Jayaraj ND, Ren DJ, Pacifico P, Belmadani A, Wang YZ et al (2025) Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy. Neurobiol Pain 17","DOI":"10.1016\/j.ynpai.2024.100176"},{"issue":"10","key":"2500_CR66","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S1474-4422(22)00188-0","volume":"21","author":"MA Elafros","year":"2022","unstructured":"Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC et al (2022) Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol 21(10):922\u2013936","journal-title":"Lancet Neurol"},{"key":"2500_CR10","unstructured":"Ensmenger PJ (2025) Alpha lipoic acid: a review and comparison to current treatment guidelines of diabetic peripheral neuropathy"},{"issue":"7","key":"2500_CR8","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.3390\/ijms26073195","volume":"26","author":"N Espinoza","year":"2025","unstructured":"Espinoza N, Papadopoulos V (2025) Role of mitochondrial dysfunction in neuropathy. Int J Mol Sci 26(7):3195","journal-title":"Int J Mol Sci"},{"key":"2500_CR39","doi-asserted-by":"publisher","first-page":"558758","DOI":"10.3389\/fneur.2020.558758","volume":"11","author":"B Fan","year":"2020","unstructured":"Fan B, Chopp M, Zhang ZG, Liu XS (2020) Emerging roles of microRNAs as biomarkers and therapeutic targets for diabetic neuropathy. Front Neurol 11:558758","journal-title":"Front Neurol"},{"key":"2500_CR28","doi-asserted-by":"crossref","unstructured":"Fan BY, Chopp M, Zhang ZG, Liu XS (2021) Treatment of diabetic peripheral neuropathy with engineered mesenchymal stromal cell-derived exosomes enriched with microRNA-146a provide amplified therapeutic efficacy. Exp Neurol 341","DOI":"10.1016\/j.expneurol.2021.113694"},{"issue":"2","key":"2500_CR33","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00125-019-05043-0","volume":"63","author":"BY Fan","year":"2020","unstructured":"Fan BY, Li C, Szalad A, Wang L, Pan WL, Zhang RL et al (2020) Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes. Diabetologia 63(2):431\u2013443","journal-title":"Diabetologia"},{"issue":"1","key":"2500_CR42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, De Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14(1):43","journal-title":"BMC Med Res Methodol"},{"issue":"6","key":"2500_CR71","first-page":"545","volume":"37","author":"H Huang","year":"2019","unstructured":"Huang H, Kaur S, Hu Y (2019) Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration. Restor Neurol Neurosci 37(6):545\u2013552","journal-title":"Restor Neurol Neurosci"},{"issue":"12","key":"2500_CR30","doi-asserted-by":"publisher","first-page":"6911","DOI":"10.1096\/fj.201800597R","volume":"32","author":"LF Jia","year":"2018","unstructured":"Jia LF, Chopp M, Wang L, Lu XR, Szalad A, Zhang ZG (2018) Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy. Faseb J 32(12):6911\u20136922","journal-title":"Faseb J"},{"issue":"3","key":"2500_CR4","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1007\/s12035-021-02662-w","volume":"59","author":"P Kaur","year":"2022","unstructured":"Kaur P, Kotru S, Singh S, Munshi A (2022) Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions. Mol Neurobiol 59(3):1836\u20131849","journal-title":"Mol Neurobiol"},{"issue":"3","key":"2500_CR37","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1007\/s12035-021-02662-w","volume":"59","author":"P Kaur","year":"2022","unstructured":"Kaur P, Kotru S, Singh S, Munshi A (2022) Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions. Mol Neurobiol 59(3):1836\u20131849","journal-title":"Mol Neurobiol"},{"issue":"2","key":"2500_CR49","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1085-9489.2005.0010210.x","volume":"10","author":"G Lauria","year":"2005","unstructured":"Lauria G, Lombardi R, Borgna M, Penza P, Bianchi R, Savino C et al (2005) Intraepidermal nerve fiber density in rat foot pad: neuropathologic\u2013neurophysiologic correlation. J Peripheral Nerv Syst 10(2):202\u2013208","journal-title":"J Peripheral Nerv Syst"},{"issue":"4","key":"2500_CR15","doi-asserted-by":"publisher","first-page":"542","DOI":"10.4093\/dmj.2025.0299","volume":"49","author":"J-E Lee","year":"2025","unstructured":"Lee J-E, Won JC (2025) Clinical Phenotypes of Diabetic Peripheral Neuropathy: Implications for Phenotypic-Based Therapeutics Strategies. Diabetes Metabolism J 49(4):542","journal-title":"Diabetes Metabolism J"},{"key":"2500_CR35","doi-asserted-by":"crossref","unstructured":"Li JY, Wu GZ, Li WY, Zhou XY, Li WZ, Xu X et al (2023) Plasma exosomes improve peripheral neuropathy via miR-20b-3p\/Stat3 in type I diabetic rats. J Nanobiotechnol 21(1)","DOI":"10.1186\/s12951-023-02222-5"},{"issue":"2","key":"2500_CR20","doi-asserted-by":"publisher","first-page":"102206","DOI":"10.1016\/j.labinv.2024.102206","volume":"105","author":"X-M Liu","year":"2025","unstructured":"Liu X-M, Halushka MK (2025) Beyond the bubble: a debate on microRNA sorting into extracellular vesicles. Lab Invest 105(2):102206","journal-title":"Lab Invest"},{"key":"2500_CR2","doi-asserted-by":"crossref","unstructured":"Liu YP, Tian MY, Yang YD, Li H, Zhao TT, Zhu J et al (2022) Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth. Iscience 25(10)","DOI":"10.1016\/j.isci.2022.105141"},{"key":"2500_CR16","doi-asserted-by":"publisher","first-page":"100080","DOI":"10.1016\/j.vesic.2025.100080","volume":"5","author":"VY Li","year":"2025","unstructured":"Li VY, Rosas N, Fleischer S, Vunjak-Novakovic G, Cheng K (2025) MicroRNAs won the Nobel Prize. Now, can extracellular vesicles help them become drugs? Extracell Vesicle 5:100080","journal-title":"Extracell Vesicle"},{"issue":"1","key":"2500_CR11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s13287-025-04432-0","volume":"16","author":"X Lu","year":"2025","unstructured":"Lu X, Xu R, Dong X, Bai D, Ji W, Chen X et al (2025) Cell-derived exosome therapy for diabetic peripheral neuropathy: a preclinical animal studies systematic review and meta-analysis. Stem Cell Res Ther 16(1):297","journal-title":"Stem Cell Res Ther"},{"key":"2500_CR26","doi-asserted-by":"crossref","unstructured":"Masoomeh Hamdi AR, Mojdeh Ahmadi M, Davoodi S, Sadegh-Nejadi A, Ghafourian (2026) Hamid Choobineh & Reza Afrisham. A systematic review of urinary extracellular vesicle-derived non-coding RNAs in diabetic nephropathy: expression profiles, clinical correlations, and diagnostic performance. Mol Biol Rep 53","DOI":"10.1007\/s11033-026-11523-5"},{"key":"2500_CR13","doi-asserted-by":"crossref","unstructured":"Merghany RM, Saleh RA, Hamed AA, El-Dessouki AM, El-Shiekh RA, Zaki ES et al (2025) Natural therapy proposed for the management of diabetic peripheral neuropathy (DPN). Inflammopharmacology 1\u201338","DOI":"10.1007\/s10787-025-01790-2"},{"key":"2500_CR23","doi-asserted-by":"crossref","unstructured":"Miao X, Ghafourian A, Karimi Khaneghah M, Ayyoubzadeh SM, Afrisham R, Ahmadi M (2025) Extracellular vesicles as therapeutic agents in rheumatoid arthritis: a systematic review of current evidence. Inflammopharmacology 1\u201327","DOI":"10.1007\/s10787-025-01670-9"},{"issue":"8","key":"2500_CR14","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.4103\/NRR.NRR-D-24-00270","volume":"20","author":"R Mittal","year":"2025","unstructured":"Mittal R, McKenna K, Keith G, McKenna E, Lemos JRN, Mittal J et al (2025) Diabetic peripheral neuropathy and neuromodulation techniques: a systematic review of progress and prospects. Neural Regeneration Res 20(8):2218\u20132230","journal-title":"Neural Regeneration Res"},{"issue":"4","key":"2500_CR44","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrn2606","volume":"10","author":"JS Mogil","year":"2009","unstructured":"Mogil JS (2009) Animal models of pain: progress and challenges. Nat Rev Neurosci 10(4):283\u2013294","journal-title":"Nat Rev Neurosci"},{"key":"2500_CR68","doi-asserted-by":"crossref","unstructured":"Nashtahosseini Z, Eslami M, Paraandavaji E, Haraj A, Dowlat BF, Hosseinzadeh E et al (2025) Cytokine signaling in diabetic neuropathy: a key player in peripheral nerve damage. Biomedicines 13(3)","DOI":"10.3390\/biomedicines13030589"},{"issue":"3","key":"2500_CR7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3390\/biomedicines13030589","volume":"13","author":"Z Nashtahosseini","year":"2025","unstructured":"Nashtahosseini Z, Eslami M, Paraandavaji E, Haraj A, Dowlat BF, Hosseinzadeh E et al (2025) Cytokine Signaling in Diabetic Neuropathy: A Key Player in Peripheral Nerve Damage. Biomedicines 13(3):589","journal-title":"Biomedicines"},{"issue":"4","key":"2500_CR46","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.nurt.2009.07.004","volume":"6","author":"IG Obrosova","year":"2009","unstructured":"Obrosova IG (2009) Diabetic painful and insensate neuropathy: pathogenesis and potential treatments. Neurotherapeutics 6(4):638\u2013647","journal-title":"Neurotherapeutics"},{"key":"2500_CR41","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372","DOI":"10.1186\/s13643-021-01626-4"},{"key":"2500_CR25","doi-asserted-by":"publisher","first-page":"664904","DOI":"10.3389\/fonc.2021.664904","volume":"11","author":"Y Qiu","year":"2021","unstructured":"Qiu Y, Li P, Zhang Z, Wu M (2021) Insights Into Exosomal Non-Coding RNAs Sorting Mechanism and Clinical Application. Front Oncol 11:664904","journal-title":"Front Oncol"},{"issue":"2","key":"2500_CR69","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1046\/j.0022-202x.2001.01409.x","volume":"117","author":"M Raisova","year":"2001","unstructured":"Raisova M, Hossini AM, Eberle J, Riebeling C, Wieder T, Sturm I et al (2001) The Bax\/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95\/Fas-mediated apoptosis. J Invest Dermatol 117(2):333\u2013340","journal-title":"J Invest Dermatol"},{"key":"2500_CR17","doi-asserted-by":"crossref","unstructured":"Rohm TV, Cunha e Rocha K, Olefsky JM (2025) Metabolic messengers: small extracellular vesicles. Nat Metabolism 1\u201310","DOI":"10.1038\/s42255-024-01214-5"},{"key":"2500_CR19","doi-asserted-by":"crossref","unstructured":"Saberian M, Davoudi M, Ghafourian A, Moradi-Sardareh H, Taslim Bakhsh F, Afrisham R (2025) Biogenesis, isolation, and mechanistic applications of platelet-rich plasma and PRP-derived exosomes in diabetic and chronic wound healing: a comprehensive narrative review. Regenerative Eng Translational Med 1\u201316","DOI":"10.1007\/s40883-025-00468-z"},{"issue":"9","key":"2500_CR24","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1002\/iub.2305","volume":"72","author":"S Sadegh-Nejadi","year":"2020","unstructured":"Sadegh-Nejadi S, Afrisham R, Emamgholipour S, Izadi P, Eivazi N, Tahbazlahafi B et al (2020) Influence of plasma circulating exosomes obtained from obese women on tumorigenesis and tamoxifen resistance in MCF\u20107 cells. IUBMB Life 72(9):1930\u20131940","journal-title":"IUBMB Life"},{"issue":"11","key":"2500_CR5","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s00415-008-0999-z","volume":"255","author":"G Said","year":"2008","unstructured":"Said G, Baudoin D, Toyooka K (2008) Sensory loss, pains, motor deficit and axonal regeneration in length-dependent diabetic polyneuropathy. J Neurol 255(11):1693\u20131702","journal-title":"J Neurol"},{"key":"2500_CR12","doi-asserted-by":"crossref","unstructured":"Silva A, Prior R, D\u2019Antonio M, Swinnen JV, Van Den Bosch L (2025) Lipid metabolism alterations in peripheral neuropathies. Neuron","DOI":"10.1016\/j.neuron.2025.04.006"},{"issue":"18","key":"2500_CR40","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.3390\/ijms20184627","volume":"20","author":"R Simeoli","year":"2019","unstructured":"Simeoli R, Fierabracci A (2019) Insights into the Role of MicroRNAs in the Onset and Development of Diabetic Neuropathy. Int J Mol Sci 20(18):4627","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2500_CR48","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/s41574-021-00496-z","volume":"17","author":"G Sloan","year":"2021","unstructured":"Sloan G, Selvarajah D, Tesfaye S (2021) Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nat Reviews Endocrinol 17(7):400\u2013420","journal-title":"Nat Reviews Endocrinol"},{"issue":"2","key":"2500_CR36","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.als.2016.11.007","volume":"10","author":"MH Sohel","year":"2016","unstructured":"Sohel MH (2016) Extracellular\/circulating microRNAs: release mechanisms, functions and challenges. Achievements Life Sci 10(2):175\u2013186","journal-title":"Achievements Life Sci"},{"issue":"1","key":"2500_CR38","first-page":"5593608","volume":"2021","author":"V Spallone","year":"2021","unstructured":"Spallone V, Ciccacci C, Latini A, Borgiani P (2021) What is in the field for genetics and epigenetics of diabetic neuropathy: the role of microRNAs. J Diabetes Res 2021(1):5593608","journal-title":"J Diabetes Res"},{"issue":"5","key":"2500_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.pcd.2019.12.005","volume":"14","author":"J Sun","year":"2020","unstructured":"Sun J, Wang Y, Zhang X, Zhu S, He H (2020) Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis. Prim Care Diabetes 14(5):435\u2013444","journal-title":"Prim Care Diabetes"},{"issue":"11","key":"2500_CR45","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1111\/ejn.12643","volume":"39","author":"A Tappe-Theodor","year":"2014","unstructured":"Tappe-Theodor A, Kuner R (2014) Studying ongoing and spontaneous pain in rodents\u2013challenges and opportunities. Eur J Neurosci 39(11):1881\u20131890","journal-title":"Eur J Neurosci"},{"issue":"1","key":"2500_CR70","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s11658-024-00551-3","volume":"29","author":"Z Vahidinia","year":"2024","unstructured":"Vahidinia Z, Azami Tameh A, Barati S, Izadpanah M, Seyed Hosseini E (2024) Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies. Cell Mol Biol Lett 29(1):30","journal-title":"Cell Mol Biol Lett"},{"issue":"4","key":"2500_CR31","doi-asserted-by":"publisher","first-page":"749","DOI":"10.2337\/db19-0432","volume":"69","author":"L Wang","year":"2020","unstructured":"Wang L, Chopp M, Szalad A, Lu XR, Zhang Y, Wang XL et al (2020) Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice. Diabetes 69(4):749\u2013759","journal-title":"Diabetes"},{"key":"2500_CR34","doi-asserted-by":"crossref","unstructured":"Wang L, Lu XR, Szalad A, Liu XS, Zhang Y, Wang XL et al (2024) Schwann cell-derived exosomes ameliorate peripheral neuropathy induced by ablation of dicer in Schwann cells. Front Cell Neurosci 18","DOI":"10.3389\/fncel.2024.1462228"},{"issue":"2","key":"2500_CR72","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","volume":"13","author":"JA Welsh","year":"2024","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L, Buzas EI, Blenkiron C, Bussolati B et al (2024) Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell vesicles 13(2):e12404","journal-title":"J Extracell vesicles"},{"key":"2500_CR32","doi-asserted-by":"crossref","unstructured":"Wu X, Wang X, Yin Y, Zhu L, Zhang F, Yang J (2021) Investigation of the role of miR-221 in diabetic peripheral neuropathy and related molecular mechanisms. Adv Clin Experimental Med 30(6)","DOI":"10.17219\/acem\/131217"},{"issue":"1","key":"2500_CR67","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0896-6273(00)80672-8","volume":"22","author":"HH Yu","year":"1999","unstructured":"Yu HH, Kolodkin AL (1999) Semaphorin signaling: a little less per-plexin. Neuron 22(1):11\u201314","journal-title":"Neuron"},{"key":"2500_CR3","doi-asserted-by":"publisher","first-page":"719356","DOI":"10.3389\/fendo.2021.719356","volume":"12","author":"Y Yu","year":"2021","unstructured":"Yu Y (2021) Gold Standard for Diagnosis of DPN. Front Endocrinol (Lausanne) 12:719356","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2500_CR9","doi-asserted-by":"crossref","unstructured":"Zhang X, Yue Y, Zhang L, Mou Z (2025) Mitochondrial DNA stress promotes the ferroptosis of Endothelial cells in diabetic peripheral neuropathy by upregulating ALOX15. Crit Reviews\u2122 Eukaryot Gene Expression 35(6)","DOI":"10.1615\/CritRevEukaryotGeneExpr.2025059114"},{"key":"2500_CR65","doi-asserted-by":"publisher","first-page":"1265372","DOI":"10.3389\/fendo.2023.1265372","volume":"14","author":"J Zhu","year":"2023","unstructured":"Zhu J, Hu Z, Luo Y, Liu Y, Luo W, Du X et al (2023) Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment. Front Endocrinol (Lausanne) 14:1265372","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02500-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-026-02500-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02500-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:56:09Z","timestamp":1783331769000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-026-02500-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":57,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2500"],"URL":"https:\/\/doi.org\/10.1007\/s12031-026-02500-5","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This systematic review was conducted based on previously published studies and was approved by the Ethics Committee of Tehran University of Medical Sciences with the code IR.TUMS.SPH.REC.1405.045.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"During the preparation of this review, the authors used ChatGPT to check the grammar and improve readability. After using the tools, we reviewed and edited the content and took full responsibility for the content presented in the publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"78"}}