{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:18:42Z","timestamp":1783333122732,"version":"3.54.6"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-026-02549-2","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:38:29Z","timestamp":1779964709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Mobility Group Box 1 contributes to Neuroinflammation and Central Sensitization After Nitroglycerin Stimulation in Mice"],"prefix":"10.1007","volume":"76","author":[{"given":"Ting","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"issue":"2","key":"2549_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1468-2982.2009.01864.x","volume":"30","author":"EA Bates","year":"2010","unstructured":"Bates EA, Nikai T, Brennan KC, Fu Y, Charles AC, Basbaum AI et al (2010) Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia: Int J headache 30(2):170\u2013178","journal-title":"Cephalalgia: Int J headache"},{"issue":"4","key":"2549_CR2","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/head.14932","volume":"65","author":"AC Charles","year":"2025","unstructured":"Charles AC, Goadsby PJ (2025) The cortical spreading depression\/migraine aura hypothesis - Finally some definitive evidence. Headache 65(4):537\u2013538","journal-title":"Headache"},{"issue":"1","key":"2549_CR3","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1038\/s41598-021-84477-2","volume":"11","author":"M Chen","year":"2021","unstructured":"Chen M, Zhu L, Xue M, Zhu R, Jing L, Wang H et al (2021) HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1\/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin. Sci Rep 11(1):5059","journal-title":"Sci Rep"},{"issue":"3","key":"2549_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s40259-022-00530-0","volume":"36","author":"F Cohen","year":"2022","unstructured":"Cohen F, Yuan H, Silberstein SD (2022) Calcitonin Gene-Related Peptide (CGRP)-Targeted Monoclonal Antibodies and Antagonists in Migraine: Current Evidence and Rationale. BioDrugs 36(3):341\u2013358","journal-title":"BioDrugs"},{"key":"2549_CR5","doi-asserted-by":"publisher","first-page":"105424","DOI":"10.1016\/j.nbd.2021.105424","volume":"156","author":"A Dehghani","year":"2021","unstructured":"Dehghani A, Phisonkunkasem T, Yilmaz OS, Dalkara T, van den Maagdenberg A, Tolner EA et al (2021) Widespread brain parenchymal HMGB1 and NF-kappaB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice. Neurobiol Dis 156:105424","journal-title":"Neurobiol Dis"},{"issue":"1","key":"2549_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s10194-023-01628-8","volume":"24","author":"A Dehghani","year":"2023","unstructured":"Dehghani A, Schenke M, van Heiningen SH, Karatas H, Tolner EA, van den Maagdenberg A (2023) Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice. J Headache Pain 24(1):96","journal-title":"J Headache Pain"},{"issue":"12","key":"2549_CR7","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1007\/s00115-012-3625-3","volume":"84","author":"HC Diener","year":"2013","unstructured":"Diener HC, Holle D, Muller D, Nagel S, Rabe K (2013) [Chronic migraine]. Nervenarzt 84(12):1460\u20131466","journal-title":"Nervenarzt"},{"issue":"14","key":"2549_CR8","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1002\/jnr.22480","volume":"88","author":"O Fukushima","year":"2010","unstructured":"Fukushima O, Nishimura S, Matsunami M, Aoki Y, Nishikawa H, Ishikura H et al (2010) Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms. J Neurosci Res 88(14):3198\u20133205","journal-title":"J Neurosci Res"},{"issue":"1","key":"2549_CR9","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12974-019-1603-4","volume":"16","author":"F Jing","year":"2019","unstructured":"Jing F, Zhang Y, Long T, He W, Qin G, Zhang D et al (2019) P2Y12 receptor mediates microglial activation via RhoA\/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine. J Neuroinflammation 16(1):217","journal-title":"J Neuroinflammation"},{"issue":"1","key":"2549_CR10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12974-023-02977-6","volume":"20","author":"Z Kaya","year":"2023","unstructured":"Kaya Z, Belder N, Sever-Bahcekapili M, Donmez-Demir B, Erdener SE, Bozbeyoglu N et al (2023a) Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes. J Neuroinflammation 20(1):295","journal-title":"J Neuroinflammation"},{"issue":"6","key":"2549_CR12","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.intimp.2011.01.005","volume":"11","author":"Q Lin","year":"2011","unstructured":"Lin Q, Fang J, Fang D, Li B, Zhou H, Su SB (2011) Production of recombinant human HMGB1 and anti-HMGB1 rabbit serum. Int Immunopharmacol 11(6):646\u2013651","journal-title":"Int Immunopharmacol"},{"key":"2549_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.molimm.2018.02.014","volume":"97","author":"R Li","year":"2018","unstructured":"Li R, Wang J, Zhu F, Li R, Liu B, Xu W et al (2018) HMGB1 regulates T helper 2 and T helper17 cell differentiation both directly and indirectly in asthmatic mice. Mol Immunol 97:45\u201355","journal-title":"Mol Immunol"},{"issue":"1","key":"2549_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s10194-019-1070-4","volume":"21","author":"T Long","year":"2020","unstructured":"Long T, He W, Pan Q, Zhang S, Zhang D, Qin G et al (2020) Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. J Headache Pain 21(1):4","journal-title":"J Headache Pain"},{"issue":"4","key":"2549_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1254\/jphs.13R08CP","volume":"123","author":"T Maeda","year":"2013","unstructured":"Maeda T, Ozaki M, Kobayashi Y, Kiguchi N, Kishioka S (2013) HMGB1 as a potential therapeutic target for neuropathic pain. J Pharmacol Sci 123(4):301\u2013305","journal-title":"J Pharmacol Sci"},{"key":"2549_CR14","doi-asserted-by":"publisher","first-page":"118013","DOI":"10.1016\/j.jep.2024.118013","volume":"328","author":"S Ma","year":"2024","unstructured":"Ma S, Chong Y, Zhang R, Quan W, Gui J, Li L et al (2024) Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1\/2-dependent pathways. J Ethnopharmacol 328:118013","journal-title":"J Ethnopharmacol"},{"key":"2549_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/cpns.33","volume":"80","author":"LS Moye","year":"2017","unstructured":"Moye LS, Pradhan A (2017) Animal Model of Chronic Migraine-Associated Pain. Curr Protoc Neurosci 80:9\u201360","journal-title":"Curr Protoc Neurosci"},{"key":"2549_CR17","doi-asserted-by":"crossref","unstructured":"Nakaya Y, Tsuboi Y, Okada-Ogawa A, Shinoda M, Kubo A, Chen JY et al (2016) ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue. Mol Pain, 12","DOI":"10.1177\/1744806916641680"},{"key":"2549_CR18","doi-asserted-by":"publisher","first-page":"686340","DOI":"10.3389\/fncel.2021.686340","volume":"15","author":"S Prasad","year":"2021","unstructured":"Prasad S, Sheng WS, Hu S, Chauhan P, Lokensgard JR (2021) Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation. Front Cell Neurosci 15:686340","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"2549_CR19","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s11916-014-0467-7","volume":"19","author":"RJ Storer","year":"2015","unstructured":"Storer RJ, Supronsinchai W, Srikiatkhachorn A (2015) Animal models of chronic migraine. Curr Pain Headache Rep 19(1):467","journal-title":"Curr Pain Headache Rep"},{"key":"2549_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jneuroim.2015.02.005","volume":"280","author":"Y Sun","year":"2015","unstructured":"Sun Y, Chen H, Dai J, Zou H, Gao M, Wu H et al (2015) HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis. J Neuroimmunol 280:29\u201335","journal-title":"J Neuroimmunol"},{"issue":"1","key":"2549_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s10194-024-01730-5","volume":"25","author":"D Vuralli","year":"2024","unstructured":"Vuralli D, Ceren AM, Gok DH, Gulbahar O, Yalinay M, Bolay H (2024a) Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1alpha levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation. J Headache Pain 25(1):23","journal-title":"J Headache Pain"},{"issue":"1","key":"2549_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.55730\/1300-0144.5763","volume":"54","author":"D Vuralli","year":"2024","unstructured":"Vuralli D, Dagidir HG, Topa EA, Belen HB (2024b) Leaky gut and inflammatory biomarkers in a medication overuse headache model in male rats. Turk J Med Sci 54(1):33\u201341","journal-title":"Turk J Med Sci"},{"key":"2549_CR24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bbi.2020.06.019","volume":"88","author":"B Wang","year":"2020","unstructured":"Wang B, Huang X, Pan X, Zhang T, Hou C, Su WJ et al (2020) Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons. Brain Behav Immun 88:132\u2013143","journal-title":"Brain Behav Immun"},{"key":"2549_CR23","doi-asserted-by":"crossref","unstructured":"Wan W, Cao L, Khanabdali R, Kalionis B, Tai X, Xia S (2016) The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation. J Immunol Res, 2016, 6430423","DOI":"10.1155\/2016\/6430423"},{"issue":"2","key":"2549_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/14728222.2020.1724285","volume":"24","author":"AS Wattiez","year":"2020","unstructured":"Wattiez AS, Sowers LP, Russo AF (2020) Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting. Expert Opin Ther Targets 24(2):91\u2013100","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"2549_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12974-021-02342-5","volume":"18","author":"Q Wen","year":"2021","unstructured":"Wen Q, Wang Y, Pan Q, Tian R, Zhang D, Qin G et al (2021) MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model. J Neuroinflammation 18(1):287","journal-title":"J Neuroinflammation"},{"issue":"1","key":"2549_CR27","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s10194-023-01646-6","volume":"24","author":"W Xie","year":"2023","unstructured":"Xie W, Li R, Tang W, Ma Z, Miao S, Li C et al (2023) Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine. J Headache Pain 24(1):122","journal-title":"J Headache Pain"},{"issue":"12","key":"2549_CR28","doi-asserted-by":"publisher","first-page":"997","DOI":"10.5692\/clinicalneurol.54.997","volume":"54","author":"K Yamane","year":"2014","unstructured":"Yamane K (2014) [Progression from episodic migraine to chronic migraine]. Rinsho Shinkeigaku 54(12):997\u2013999","journal-title":"Rinsho Shinkeigaku"},{"key":"2549_CR29","doi-asserted-by":"crossref","unstructured":"Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H (2020) Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells, 9(7)","DOI":"10.3390\/cells9071714"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02549-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-026-02549-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02549-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:57:40Z","timestamp":1783331860000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-026-02549-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2549"],"URL":"https:\/\/doi.org\/10.1007\/s12031-026-02549-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8598066\/v1","asserted-by":"object"}]},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"14 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee for Animal Experimentation of Southwest Medical University (No. 20240223-012). All animal experiments were conducted in accordance with the institutional guidelines for the care and use of laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}