{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:21:54Z","timestamp":1783336914005,"version":"3.54.6"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing Municipal Administration of Hospital Incubating Program","award":["PX2023070; PX2024072"],"award-info":[{"award-number":["PX2023070; PX2024072"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["SF2024-4-2134"],"award-info":[{"award-number":["SF2024-4-2134"]}]},{"name":"Beijing Hospitals Authority Youth Programme","award":["QML20232003"],"award-info":[{"award-number":["QML20232003"]}]},{"name":"Jiangsu Youth Talent Support Project","award":["JSTJ-2025-755"],"award-info":[{"award-number":["JSTJ-2025-755"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-026-02550-9","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:20:57Z","timestamp":1780132857000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared Immunogenetic Basis Between Spleen Volume and Psychiatric Disorders"],"prefix":"10.1007","volume":"76","author":[{"given":"Fang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"issue":"2","key":"2550_CR1","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J et al (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512\u2013525","journal-title":"Int J Epidemiol"},{"issue":"4","key":"2550_CR2","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J et al (2016) Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304\u2013314","journal-title":"Genet Epidemiol"},{"key":"2550_CR3","doi-asserted-by":"crossref","unstructured":"Breunig S et al (2025) Immune markers mediate genetic relationships between immune diseases and psychiatric disorders. MedRxiv [Preprint]","DOI":"10.1101\/2025.10.17.25338241"},{"key":"2550_CR4","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.neubiorev.2021.05.018","volume":"127","author":"SJ Brown","year":"2021","unstructured":"Brown SJ et al (2021) The kynurenine pathway in major depression: what we know and where to next. Neurosci Biobehav Rev 127:917\u2013927","journal-title":"Neurosci Biobehav Rev"},{"issue":"11","key":"2550_CR5","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"B Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan B et al (2015) An atlas of genetic correlations across human diseases and traits. Nat Genet 47(11):1236\u20131241","journal-title":"Nat Genet"},{"key":"2550_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.3","volume":"4","author":"S Burgess","year":"2023","unstructured":"Burgess S et al (2023) Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Res 4:186","journal-title":"Wellcome Open Res"},{"key":"2550_CR7","doi-asserted-by":"crossref","unstructured":"Castagnoli F et al (2022) Splenic volume as a predictor of treatment response in patients with non-small cell lung cancer receiving immunotherapy. PLoS ONE 17(7):e0270950","DOI":"10.1371\/journal.pone.0270950"},{"issue":"2","key":"2550_CR8","doi-asserted-by":"publisher","first-page":"NS20220054","DOI":"10.1042\/NS20220054","volume":"7","author":"M Corrigan","year":"2023","unstructured":"Corrigan M et al (2023) Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin. Neuronal Signal 7(2):NS20220054","journal-title":"Neuronal Signal"},{"issue":"23","key":"2550_CR9","doi-asserted-by":"publisher","first-page":"7285","DOI":"10.1073\/pnas.1507125112","volume":"112","author":"S Darmanis","year":"2015","unstructured":"Darmanis S et al (2015) A survey of human brain transcriptome diversity at the single cell level. Proc Natl Acad Sci U S A 112(23):7285\u20137290","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2550_CR10","doi-asserted-by":"crossref","unstructured":"de Leeuw CA et al (2015) MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol. 11(4):e1004219","DOI":"10.1371\/journal.pcbi.1004219"},{"issue":"6","key":"2550_CR11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nrg.2016.29","volume":"17","author":"CA de Leeuw","year":"2016","unstructured":"de Leeuw CA et al (2016) The statistical properties of gene-set analysis. Nat Rev Genet 17(6):353\u2013364","journal-title":"Nat Rev Genet"},{"issue":"3","key":"2550_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41573-021-00368-1","volume":"21","author":"WC Drevets","year":"2022","unstructured":"Drevets WC et al (2022) Immune targets for therapeutic development in depression: towards precision medicine. Nat Rev Drug Discov 21(3):224\u2013244","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"2550_CR13","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.3390\/cancers13123020","volume":"13","author":"L Galland","year":"2021","unstructured":"Galland L et al (2021) Splenic volume as a surrogate marker of immune checkpoint inhibitor efficacy in metastatic non small cell lung cancer. Cancers (Basel) 13(12):3020","journal-title":"Cancers (Basel)"},{"issue":"2","key":"2550_CR14","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s43657-023-00147-5","volume":"5","author":"Y Gao","year":"2024","unstructured":"Gao Y et al (2024) Organ crosstalk: the role of spleen. Phenomics 5(2):192\u2013207","journal-title":"Phenomics"},{"issue":"1","key":"2550_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo Q et al (2024) NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 9(1):53","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"2550_CR16","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nmeth.4407","volume":"14","author":"N Habib","year":"2017","unstructured":"Habib N et al (2017) Massively parallel single-nucleus RNA-seq with DroNc-seq. Nat Methods 14(10):955\u2013958","journal-title":"Nat Methods"},{"issue":"9","key":"2550_CR17","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/s41380-025-03044-7","volume":"30","author":"H Han","year":"2025","unstructured":"Han H et al (2025) Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy. Mol Psychiatry 30(9):4409\u20134421","journal-title":"Mol Psychiatry"},{"issue":"6","key":"2550_CR18","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"FP Hartwig","year":"2017","unstructured":"Hartwig FP et al (2017) Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46(6):1985\u20131998","journal-title":"Int J Epidemiol"},{"key":"2550_CR19","doi-asserted-by":"publisher","first-page":"113935","DOI":"10.1016\/j.bcp.2020.113935","volume":"177","author":"K Hashimoto","year":"2020","unstructured":"Hashimoto K (2020) Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine. Biochem Pharmacol 177:113935","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"2550_CR20","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G et al (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13(11):e1007081","journal-title":"PLoS Genet"},{"issue":"1","key":"2550_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12974-024-03312-3","volume":"22","author":"W Jiao","year":"2025","unstructured":"Jiao W et al (2025) The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms. J Neuroinflammation 22(1):10","journal-title":"J Neuroinflammation"},{"issue":"5","key":"2550_CR22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3390\/cells13050423","volume":"13","author":"BR Kouba","year":"2024","unstructured":"Kouba BR et al (2024) Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets. Cells 13(5):423","journal-title":"Cells"},{"issue":"2","key":"2550_CR23","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.cell.2016.09.027","volume":"167","author":"G La Manno","year":"2016","unstructured":"La Manno G et al (2016) Molecular diversity of midbrain development in mouse, human, and stem cells. Cell 167(2):566\u2013580e19","journal-title":"Cell"},{"issue":"1","key":"2550_CR24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.biopsych.2017.01.021","volume":"83","author":"GGR Leday","year":"2017","unstructured":"Leday GGR et al (2017) Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biol Psychiatry 83(1):70\u201380","journal-title":"Biol Psychiatry"},{"issue":"33","key":"2550_CR25","doi-asserted-by":"publisher","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","volume":"4","author":"SM Lewis","year":"2019","unstructured":"Lewis SM et al (2019) Structure and function of the immune system in the spleen. Sci Immunol 4(33):eaau6085","journal-title":"Sci Immunol"},{"issue":"1","key":"2550_CR27","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1186\/s12888-025-06853-w","volume":"25","author":"Z Lin","year":"2025","unstructured":"Lin Z et al (2025) Correlations between major depressive disorder, splenic morphology, and immune function. BMC Psychiatry 25(1):477","journal-title":"BMC Psychiatry"},{"key":"2550_CR26","doi-asserted-by":"publisher","first-page":"741705","DOI":"10.3389\/fimmu.2021.741705","volume":"12","author":"X Li","year":"2021","unstructured":"Li X et al (2021) Heritability enrichment of immunoglobulin G N-glycosylation in specific tissues. Front Immunol 12:741705","journal-title":"Front Immunol"},{"key":"2550_CR28","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3389\/fnins.2018.00547","volume":"12","author":"EM Medina-Rodriguez","year":"2018","unstructured":"Medina-Rodriguez EM et al (2018) Involvement of innate and adaptive immune systems alterations in the pathophysiology and treatment of depression. Front Neurosci 12:547","journal-title":"Front Neurosci"},{"issue":"1","key":"2550_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2009.09.009","volume":"24","author":"AH Miller","year":"2009","unstructured":"Miller AH (2009) Depression and immunity: a role for T cells? Brain Behav Immun 24(1):1\u20138","journal-title":"Brain Behav Immun"},{"issue":"4","key":"2550_CR30","doi-asserted-by":"publisher","first-page":"R375","DOI":"10.1152\/ajpregu.00151.2022","volume":"323","author":"CMD Mota","year":"2022","unstructured":"Mota CMD, Madden CJ (2022) Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments. Am J Physiol Regul Integr Comp Physiol 323(4):R375\u2013R384","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"2550_CR31","doi-asserted-by":"publisher","first-page":"e989","DOI":"10.1038\/tp.2016.249","volume":"7","author":"TM Murphy","year":"2017","unstructured":"Murphy TM et al (2017) Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry 7(1):e989","journal-title":"Transl Psychiatry"},{"issue":"Pt 2","key":"2550_CR32","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/brain\/awn109","volume":"132","author":"H Neumann","year":"2008","unstructured":"Neumann H et al (2008) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132(Pt 2):288\u2013295","journal-title":"Brain"},{"issue":"4","key":"2550_CR33","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/jcpp.13961","volume":"65","author":"R Nusslock","year":"2024","unstructured":"Nusslock R et al (2024) Annual Research Review: Neuroimmune network model of depression: a developmental perspective. J Child Psychol Psychiatry 65(4):538\u2013567","journal-title":"J Child Psychol Psychiatry"},{"key":"2550_CR34","doi-asserted-by":"publisher","first-page":"1282242","DOI":"10.3389\/fnbeh.2023.1282242","volume":"17","author":"I Pastis","year":"2024","unstructured":"Pastis I et al (2024) Exploring the role of inflammation in major depressive disorder: beyond the monoamine hypothesis. Front Behav Neurosci 17:1282242","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"2550_CR35","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41398-024-02921-z","volume":"14","author":"S Poletti","year":"2024","unstructured":"Poletti S et al (2024) Inflammatory mediators in major depression and bipolar disorder. Transl Psychiatry 14(1):247","journal-title":"Transl Psychiatry"},{"key":"2550_CR36","doi-asserted-by":"publisher","first-page":"1574458","DOI":"10.3389\/fpsyt.2025.1574458","volume":"16","author":"Priyanka","year":"2025","unstructured":"Priyanka et al (2025) Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder. Front Psychiatry 16:1574458","journal-title":"Front Psychiatry"},{"issue":"1","key":"2550_CR37","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12974-023-02866-y","volume":"20","author":"JD Quick","year":"2023","unstructured":"Quick JD et al (2023) Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration. J Neuroinflammation 20(1):185","journal-title":"J Neuroinflammation"},{"issue":"10","key":"2550_CR38","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/pcn.13872","volume":"79","author":"H Shiwaku","year":"2025","unstructured":"Shiwaku H (2025) Autoantibodies and inflammation in schizophrenia. Psychiatry Clin Neurosci 79(10):611\u2013618","journal-title":"Psychiatry Clin Neurosci"},{"issue":"1","key":"2550_CR39","doi-asserted-by":"publisher","first-page":"C205","DOI":"10.1152\/ajpcell.00246.2024","volume":"327","author":"J Steffen","year":"2024","unstructured":"Steffen J et al (2024) Recognizing depression as an inflammatory disease: the search for endotypes. Am J Physiol Cell Physiol 327(1):C205\u2013C212","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"2550_CR40","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/ejn.14720","volume":"53","author":"R Troubat","year":"2020","unstructured":"Troubat R et al (2020) Neuroinflammation and depression: a review. Eur J Neurosci 53(1):151\u2013171","journal-title":"Eur J Neurosci"},{"issue":"5","key":"2550_CR41","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M et al (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50(5):693\u2013698","journal-title":"Nat Genet"},{"issue":"1","key":"2550_CR42","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.1038\/s41467-019-11181-1","volume":"10","author":"K Watanabe","year":"2019","unstructured":"Watanabe K et al (2019) Genetic mapping of cell type specificity for complex traits. Nat Commun 10(1):3222","journal-title":"Nat Commun"},{"issue":"8","key":"2550_CR43","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.biopsych.2018.10.009","volume":"85","author":"MD Weber","year":"2018","unstructured":"Weber MD et al (2018) The influence of microglial elimination and repopulation on stress sensitization induced by repeated social defeat. Biol Psychiatry 85(8):667\u2013678","journal-title":"Biol Psychiatry"},{"key":"2550_CR44","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.brainresbull.2022.02.008","volume":"182","author":"Y Wei","year":"2022","unstructured":"Wei Y et al (2022) Brain-spleen axis in health and diseases: a review and future perspective. Brain Res Bull 182:130\u2013140","journal-title":"Brain Res Bull"},{"key":"2550_CR45","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.bbi.2024.09.014","volume":"123","author":"X Xie","year":"2024","unstructured":"Xie X et al (2024) Metformin reprograms tryptophan metabolism via gut microbiome-derived bile acid metabolites to ameliorate depression-Like behaviors in mice. Brain Behav Immun 123:442\u2013455","journal-title":"Brain Behav Immun"},{"issue":"22","key":"2550_CR46","doi-asserted-by":"publisher","first-page":"5224","DOI":"10.1111\/bph.15261","volume":"177","author":"X Xu","year":"2020","unstructured":"Xu X et al (2020) Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1\/TLR4\/NF-\u03baB and TNF-\u03b1\/TNFR1\/NF-\u03baB pathways. Br J Pharmacol 177(22):5224\u20135245","journal-title":"Br J Pharmacol"},{"key":"2550_CR47","doi-asserted-by":"crossref","unstructured":"Yang B et al (2017) Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain-liver axis. Transl Psychiatry 7(5):e1128","DOI":"10.1038\/tp.2017.95"},{"issue":"3","key":"2550_CR48","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00406-021-01325-0","volume":"272","author":"Y Yang","year":"2021","unstructured":"Yang Y et al (2021) Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX5622. Eur Arch Psychiatry Clin Neurosci 272(3):483\u2013495","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2550_CR49","doi-asserted-by":"publisher","first-page":"107322","DOI":"10.1016\/j.phrs.2024.107322","volume":"207","author":"Y Yin","year":"2024","unstructured":"Yin Y et al (2024) Inflamed depression: a review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression. Pharmacol Res 207:107322","journal-title":"Pharmacol Res"},{"key":"2550_CR50","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jad.2020.03.128","volume":"272","author":"J Zhang","year":"2020","unstructured":"Zhang J et al (2020a) Abnormal expression of colony stimulating factor 1 receptor (CSF1R) and transcription factor PU.1 (SPI1) in the spleen from patients with major psychiatric disorders: A role of brain-spleen axis. J Affect Disord 272:110\u2013115","journal-title":"J Affect Disord"},{"issue":"3","key":"2550_CR51","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00406-019-01092-z","volume":"271","author":"K Zhang","year":"2019","unstructured":"Zhang K et al (2019) Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine. Eur Arch Psychiatry Clin Neurosci 271(3):447\u2013456","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"7807","key":"2550_CR52","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41586-020-2235-7","volume":"581","author":"X Zhang","year":"2020","unstructured":"Zhang X et al (2020b) Brain control of humoral immune responses amenable to behavioural modulation. Nature 581(7807):204\u2013208","journal-title":"Nature"},{"key":"2550_CR53","doi-asserted-by":"publisher","first-page":"1775841","DOI":"10.3389\/fimmu.2026.1775841","volume":"17","author":"X Zou","year":"2026","unstructured":"Zou X et al (2026) Focusing on microglial mitochondria-lysosome crosstalk and neuroinflammation underlying depression: from molecular pathways to potential therapeutic interventions. Front Immunol 17:1775841","journal-title":"Front Immunol"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02550-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-026-02550-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02550-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:02:25Z","timestamp":1783335745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-026-02550-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2550"],"URL":"https:\/\/doi.org\/10.1007\/s12031-026-02550-9","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]},"assertion":[{"value":"17 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Informed Consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"98"}}