{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:48:35Z","timestamp":1792090115278,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"DOI":"10.1007\/s12031-026-02611-z","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:00:36Z","timestamp":1792087236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Transcriptome-Derived Candidate Genes Associated with Post-Translational Modification Gene Sets in Neonatal Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1007","volume":"76","author":[{"given":"Baoying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoqiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"2611_CR17","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T et al (2013) NCBI GEO: archive for functional genomics data sets\u2014update. Nucleic Acids Res 41:D991\u2013D995","journal-title":"Nucleic Acids Res"},{"key":"2611_CR9","doi-asserted-by":"crossref","first-page":"101263","DOI":"10.1016\/j.siny.2021.101263","volume":"26","author":"MJNL Benders","year":"2021","unstructured":"Benders MJNL et al (2021) Early biomarkers for neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy. Semin Fetal Neonatal Med 26:101263","journal-title":"Semin Fetal Neonatal Med"},{"key":"2611_CR10","first-page":"644","volume":"44","author":"L Bennet","year":"2022","unstructured":"Bennet L et al (2022) Potential for cell therapy in hypoxic-ischemic encephalopathy. Dev Neurosci 44:644\u2013661","journal-title":"Dev Neurosci"},{"key":"2611_CR7","first-page":"e2128870","volume":"4","author":"LF Chalak","year":"2021","unstructured":"Chalak LF et al (2021) Neurodevelopmental outcomes after neonatal seizures: a multicenter cohort study. JAMA Netw Open 4:e2128870","journal-title":"JAMA Netw Open"},{"key":"2611_CR39","doi-asserted-by":"publisher","unstructured":"CharlesHahn (2024) CharlesHahn\/DuIvyTools: Confusion, that\u2019s my epitaph (v0.6.0). https:\/\/doi.org\/10.5281\/zenodo.7261543. Zenodo","DOI":"10.5281\/zenodo.7261543"},{"issue":"2","key":"2611_CR20","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.18632\/aging.205407","volume":"16","author":"H Chen","year":"2024","unstructured":"Chen H, Wang Y, Shao C et al (2024) Molecular subgroup establishment and signature creation of lncRNAs associated with acetylation in lung adenocarcinoma. Aging 16(2):1276\u20131297","journal-title":"Aging"},{"issue":"5","key":"2611_CR22","doi-asserted-by":"publisher","first-page":"644","DOI":"10.3390\/ph16050644","volume":"16","author":"Z Cheng","year":"2023","unstructured":"Cheng Z, Huang H, Li M, Liang X, Tan Y, Chen Y (2023) Lactylation-Related Gene Signature Effectively Predicts Prognosis and Treatment Responsiveness in Hepatocellular Carcinoma. Pharmaceuticals (Basel) 16(5):644","journal-title":"Pharmaceuticals (Basel)"},{"key":"2611_CR45","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1038\/s41380-022-01711-7","volume":"27","author":"M Du","year":"2022","unstructured":"Du M et al (2022) A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury. Mol Psychiatry 27:4575\u20134589. https:\/\/doi.org\/10.1038\/s41380-022-01711-7","journal-title":"Mol Psychiatry"},{"issue":"5","key":"2611_CR34","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","volume":"44","author":"H Dweep","year":"2011","unstructured":"Dweep H, Sticht C, Pandey P et al (2011) miRWalk\u2013database: prediction of possible miRNA binding sites by walking the genes of three genomes [J]. J Biomed Inform 44(5):839\u2013847","journal-title":"J Biomed Inform"},{"issue":"8","key":"2611_CR36","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt J, Santos-Martins D, Tillack AF, Forli S (2021) AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings. J Chem Inf Model 61(8):3891\u20133898","journal-title":"J Chem Inf Model"},{"issue":"1","key":"2611_CR23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12931-024-03093-6","volume":"26","author":"T Fan","year":"2025","unstructured":"Fan T, Xiao C, Deng Z et al (2025) Signatures of H3K4me3 modification predict cancer immunotherapy response and identify a new immune checkpoint-SLAMF9. Respir Res 26(1):17 Published 2025 Jan 15","journal-title":"Respir Res"},{"key":"2611_CR8","first-page":"345","volume":"97","author":"GJ Gerner","year":"2025","unstructured":"Gerner GJ et al (2025) Challenges and opportunities in prognostic model development for neonatal HIE: a 2025 perspective. Pediatr Res 97:345\u2013352","journal-title":"Pediatr Res"},{"key":"2611_CR37","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.11148655","author":"GROMACS Development Team","year":"2024","unstructured":"GROMACS Development Team (2024) GROMACS 2024.2 [Software]. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.11148655","journal-title":"Zenodo"},{"key":"2611_CR27","unstructured":"Gu Z, ComplexHeatmap (2024) Make Complex Heatmaps [EB\/OL]. Bioconductor"},{"key":"2611_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1474-4422(13)70261-8","volume":"13","author":"H Hagberg","year":"2014","unstructured":"Hagberg H, Mallard C, Rousset CI, Thornton C (2014) Mitochondria: hub of injury responses in the developing brain. Lancet Neurol 13:217\u2013232. https:\/\/doi.org\/10.1016\/S1474-4422(13)70261-8","journal-title":"Lancet Neurol"},{"key":"2611_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","volume":"50","author":"TR Hammond","year":"2019","unstructured":"Hammond TR et al (2019) Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes. Immunity 50:253\u2013271","journal-title":"Immunity"},{"key":"2611_CR16","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.3390\/biomedicines12102371","volume":"12","author":"L He","year":"2024","unstructured":"He L et al (2024) Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway. Biomedicines 12:2371. https:\/\/doi.org\/10.3390\/biomedicines12102371","journal-title":"Biomedicines"},{"key":"2611_CR1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.clp.2024.04.008","volume":"51","author":"SL Huntingford","year":"2024","unstructured":"Huntingford SL et al (2024) Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy. Clin Perinatol 51:683\u2013709. https:\/\/doi.org\/10.1016\/j.clp.2024.04.008","journal-title":"Clin Perinatol"},{"key":"2611_CR42","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/epi.18235","volume":"66","author":"X Jia","year":"2025","unstructured":"Jia X et al (2025) Elevated astrocytic NFAT5 of the hippocampus increases epilepsy susceptibility in hypoxic-ischemic mice. Epilepsia 66:817\u2013832","journal-title":"Epilepsia"},{"issue":"8","key":"2611_CR33","doi-asserted-by":"publisher","first-page":"e70000","DOI":"10.1002\/iid3.70000","volume":"12","author":"N Jin","year":"2024","unstructured":"Jin N, Sha S, Ruan Y, Ouyang Y (2024) Identification and analysis of oxidative stress-related genes in hypoxic-ischemic brain damage using bioinformatics and experimental verification. Immun Inflamm Dis 12(8):e70000","journal-title":"Immun Inflamm Dis"},{"issue":"1","key":"2611_CR35","first-page":"122","volume":"24","author":"HA Kestler","year":"2008","unstructured":"Kestler HA, M\u00fcller A, Kraus JM, Buchholz M, Gress TM, Liu H, Kane DW, Zeeberg BR, Weinstein JN (2008) Association profiling of genes and proteins by literature mining. Bioinformatics 24(1):122\u2013129","journal-title":"Bioinformatics"},{"key":"2611_CR29","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559","journal-title":"BMC Bioinformatics"},{"key":"2611_CR12","first-page":"980099","volume":"13","author":"B Li","year":"2022","unstructured":"Li B et al (2022) Comprehensive analysis of the pyroptosis-related gene signature in the diagnosis and prognosis of neonatal hypoxic-ischemic encephalopathy. Front Immunol 13:980099","journal-title":"Front Immunol"},{"key":"2611_CR18","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.3390\/cells11233778","volume":"11","author":"S Li","year":"2022","unstructured":"Li S et al (2022) New Insights into Mechanisms of Ferroptosis Associated with Immune Infiltration in Neonatal Hypoxic-Ischemic Brain Damage. Cells 11:3778. https:\/\/doi.org\/10.3390\/cells11233778","journal-title":"Cells"},{"key":"2611_CR24","doi-asserted-by":"publisher","first-page":"1280428","DOI":"10.3389\/fphar.2023.1280428","volume":"14","author":"J Liu","year":"2023","unstructured":"Liu J, He Y, Zhou W, Tang Z, Xiao Z (2023) A glycosylation risk score comprehensively assists the treatment of bladder neoplasm in the real-world cohort, including the tumor microenvironment, molecular and clinical prognosis. Front Pharmacol 14:1280428","journal-title":"Front Pharmacol"},{"key":"2611_CR38","unstructured":"Lu T (2024) Sobtop, version 1.0. http:\/\/sobereva.com\/soft\/Sobtop"},{"key":"2611_CR4","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ana.22419","volume":"69","author":"FJ Northington","year":"2011","unstructured":"Northington FJ, Chavez-Valdez R, Martin LJ (2011) Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol 69:743\u2013758. https:\/\/doi.org\/10.1002\/ana.22419","journal-title":"Ann Neurol"},{"key":"2611_CR40","doi-asserted-by":"publisher","first-page":"1616312","DOI":"10.3389\/fimmu.2025.1616312","volume":"16","author":"C Qin","year":"2025","unstructured":"Qin C et al (2025) Identifying pyroptosis-hub genes and immune infiltration in neonatal hypoxic-ischemic brain injury. Front Immunol 16:1616312","journal-title":"Front Immunol"},{"key":"2611_CR19","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/bioengineering9100498","volume":"9","author":"GK Rasineni","year":"2022","unstructured":"Rasineni GK et al (2022) Diagnostic and Therapeutic Roles of the Omics in Hypoxic\u2013Ischemic Encephalopathy in Neonates. Bioengineering 9:498. https:\/\/doi.org\/10.3390\/bioengineering9100498","journal-title":"Bioengineering"},{"key":"2611_CR25","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47","journal-title":"Nucleic Acids Res"},{"key":"2611_CR3","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","volume":"366","author":"S Shankaran","year":"2012","unstructured":"Shankaran S et al (2012) Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 366:2085\u20132092. https:\/\/doi.org\/10.1056\/NEJMoa1112066","journal-title":"N Engl J Med"},{"issue":"11","key":"2611_CR32","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Ideker T (2003) Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"key":"2611_CR41","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.21037\/tp-24-148","volume":"13","author":"H Shen","year":"2024","unstructured":"Shen H et al (2024) Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis. Transl Pediatr 13:1378\u20131394","journal-title":"Transl Pediatr"},{"issue":"D1","key":"2611_CR31","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M et al (2023) The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest [J]. Nucleic Acids Res 51(D1):D638\u2013D646","journal-title":"Nucleic Acids Res"},{"key":"2611_CR2","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","volume":"166","author":"MA Tagin","year":"2012","unstructured":"Tagin MA et al (2012) Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med 166:558\u2013566. https:\/\/doi.org\/10.1001\/archpediatrics.2011.1772","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2611_CR6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jpeds.2021.12.049","volume":"243","author":"M Thoresen","year":"2022","unstructured":"Thoresen M et al (2022) Prognostic tools in neonatal hypoxic-ischemic encephalopathy: a systematic review. J Pediatr 243:8\u201316","journal-title":"J Pediatr"},{"key":"2611_CR14","doi-asserted-by":"publisher","first-page":"3886","DOI":"10.21037\/jtd-22-1000","volume":"14","author":"W Wang","year":"2022","unstructured":"Wang W et al (2022) Histone acetylation modification regulator-mediated tumor microenvironment infiltration characteristics and prognostic model of lung adenocarcinoma patients. J Thorac Dis 14:3886\u20133902","journal-title":"J Thorac Dis"},{"key":"2611_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-025-04538-4","author":"X Wang","year":"2025","unstructured":"Wang X et al (2025) Mechanisms of lactylation-related biomarker in neonatal hypoxic-ischemic brain damage analyzed through multi-omics data. Pediatr Res. https:\/\/doi.org\/10.1038\/s41390-025-04538-4","journal-title":"Pediatr Res"},{"key":"2611_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"H Wickham","year":"2016","unstructured":"Wickham H (2016) ggplot2: Elegant Graphics for Data Analysis. Springer-, New York"},{"issue":"3","key":"2611_CR30","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, Fu X, Liu S, Bo X, Yu G (2021) clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov 2(3):100141","journal-title":"Innov"},{"key":"2611_CR15","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1021\/acs.jproteome.5c00139","volume":"24","author":"T Xu","year":"2025","unstructured":"Xu T et al (2025) The Proteoform Landscape of Tau from the Human Brain. J Proteome Res 24:2916\u20132925. https:\/\/doi.org\/10.1021\/acs.jproteome.5c00139","journal-title":"J Proteome Res"},{"issue":"20","key":"2611_CR21","doi-asserted-by":"publisher","first-page":"e70083","DOI":"10.1111\/jcmm.70083","volume":"28","author":"B Yang","year":"2024","unstructured":"Yang B, Wen F, Cui Y (2024) Integrative transcriptome analysis identifies a crotonylation gene signature for predicting prognosis and drug sensitivity in hepatocellular carcinoma. J Cell Mol Med 28(20):e70083","journal-title":"J Cell Mol Med"},{"issue":"1","key":"2611_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12967-019-1981-5","volume":"17","author":"L Zhang","year":"2019","unstructured":"Zhang L, Chen S, Zeng X et al (2019) Revealing the pathogenic changes of PAH based on multiomics characteristics. J Transl Med 17(1):231","journal-title":"J Transl Med"},{"key":"2611_CR44","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41419-021-03541-x","volume":"12","author":"Z-B Zhang","year":"2021","unstructured":"Zhang Z-B et al (2021) MiR-127-3p targeting CISD1 regulates autophagy in hypoxic\u2013ischemic cortex. Cell Death Dis 12:279. https:\/\/doi.org\/10.1038\/s41419-021-03541-x","journal-title":"Cell Death Dis"},{"key":"2611_CR13","doi-asserted-by":"publisher","first-page":"e010787","DOI":"10.1136\/jitc-2024-010787","volume":"13","author":"P Zhang","year":"2025","unstructured":"Zhang P et al (2025) Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma. J Immunother Cancer 13:e010787","journal-title":"J Immunother Cancer"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02611-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-026-02611-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-026-02611-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:00:38Z","timestamp":1792087238000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-026-02611-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2611"],"URL":"https:\/\/doi.org\/10.1007\/s12031-026-02611-z","relation":{},"ISSN":["1559-1166"],"issn-type":[{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"19 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study analysed publicly available mouse datasets from the NCBI Gene Expression Omnibus. No human participants were recruited and no individual-level patient data were collected for the present analysis.","order":3,"name":"Ethics","label":"Patient Consent Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":5,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"154"}}