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The clinical data were derived from an observational N-of-1 case in which treatment decisions were made independently by the family and treating clinicians. The research component consisted of retrospective analysis of de-identified data and caregiver-reported assessments. Formal ethics committee approval was not required. Written informed consent was obtained from the participant\u2019s legal guardians. All\n                      C. elegans\n                      experiments were conducted by InVivo Biosystems in accordance with institutional and industry standards for invertebrate model systems. 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