{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:45:53Z","timestamp":1774579553529,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s12032-009-9267-z","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T19:35:06Z","timestamp":1249328106000},"page":"673-679","source":"Crossref","is-referenced-by-count":15,"title":["The role of heterogeneous nuclear ribonucleoprotein K in the progression of chronic myeloid leukemia"],"prefix":"10.1007","volume":"27","author":[{"given":"Qingfeng","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,8,4]]},"reference":[{"key":"9267_CR1","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1182\/blood-2003-12-4111","volume":"103","author":"B Calabretta","year":"2004","unstructured":"Calabretta B, Perrotti D. The biology of CML blast crisis. Blood. 2004;103:4010\u201322.","journal-title":"Blood"},{"key":"9267_CR2","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"BJ Druker","year":"2006","unstructured":"Druker BJ, Guilhot F, O\u2019Brien SG. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355:2408\u201317.","journal-title":"N Engl J Med"},{"key":"9267_CR3","doi-asserted-by":"crossref","first-page":"8912","DOI":"10.1158\/0008-5472.CAN-05-0076","volume":"65","author":"DJ Barnes","year":"2005","unstructured":"Barnes DJ, Palaiologou D, Panousopoulou E. Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia. Cancer Res. 2005;65:8912\u20139.","journal-title":"Cancer Res"},{"key":"9267_CR4","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1182\/blood-2006-06-032490","volume":"109","author":"H Modi","year":"2007","unstructured":"Modi H, McDonald T, Chu S. Role of BCR\/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells. Blood. 2007;109:5411\u201321.","journal-title":"Blood"},{"key":"9267_CR5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1182\/asheducation-2007.1.384","volume":"2007","author":"JP Radich","year":"2007","unstructured":"Radich JP. The biology of CML blast crisis. Hematology Am Soc Hematol Educ Program. 2007;2007:384\u201391.","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"9267_CR6","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1200\/JCO.2005.05.531","volume":"23","author":"S Soverini","year":"2005","unstructured":"Soverini S, Martinelli G, Rosti G. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol. 2005;23:4100\u20139.","journal-title":"J Clin Oncol"},{"key":"9267_CR7","first-page":"85","volume":"1765","author":"B Carpenter","year":"2006","unstructured":"Carpenter B, Mackay C, Alnabulsi A. The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression. Biochim Biophys Acta. 2006;1765:85\u2013100.","journal-title":"Biochim Biophys Acta"},{"key":"9267_CR8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/bies.20048","volume":"26","author":"K Bomsztyk","year":"2004","unstructured":"Bomsztyk K, Denisenko O, Ostrowski J. HnRNP K: one protein multiple processes. Bioessays. 2004;26:629\u201338.","journal-title":"Bioessays"},{"key":"9267_CR9","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1128\/MCB.22.7.2255-2266.2002","volume":"22","author":"A Iervolino","year":"2002","unstructured":"Iervolino A, Santilli G, Trotta R, Guerzoni C, Cesi V, Bergamaschi A, et al. hnRNP A1 Nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR\/ABL leukemogenesis. Mol Cell Biol. 2002;22:2255\u201366.","journal-title":"Mol Cell Biol"},{"key":"9267_CR10","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1038\/sj.onc.1207543","volume":"23","author":"P Danilo","year":"2004","unstructured":"Danilo P, Bruno C. Translational regulation by the p210 BCR\/ABL oncoprotein. Oncogene. 2004;23:3222\u20139.","journal-title":"Oncogene"},{"key":"9267_CR11","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cell.2005.09.032","volume":"123","author":"A Moumen","year":"2005","unstructured":"Moumen A, Masterson P, O\u2019Connor MJ. HnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell. 2005;123:1065\u201378.","journal-title":"Cell"},{"key":"9267_CR12","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/MCB.22.13.4535-4543.2002","volume":"22","author":"A Ostareck-Lederer","year":"2002","unstructured":"Ostareck-Lederer A, Ostareck DH, Cans C. c-src-Mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol. 2002;22:4535\u201343.","journal-title":"Mol Cell Biol"},{"key":"9267_CR13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.leukres.2005.12.028","volume":"30","author":"G-R Ruan","year":"2006","unstructured":"Ruan G-R, Qin Y-Z, Chen S-S, Li J-L, Ma X, Chang Y, et al. Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia. Leuk Res. 2006;30:1159\u201365.","journal-title":"Leuk Res"},{"key":"9267_CR14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.leu.2404463","volume":"21","author":"M Pocaly","year":"2007","unstructured":"Pocaly M, Lagarde V, Etienne G, Ribeil J-A, Claverol S, Bonneu M, et al. Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemia. Leukemia. 2007;21:93\u2013101.","journal-title":"Leukemia"},{"key":"9267_CR15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1182\/blood-2004-04-1242","volume":"105","author":"T Kichiro","year":"2005","unstructured":"Kichiro T, Jun YK, Eiji T. The Jab1\/cop9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression. Blood. 2005;105:775\u201383.","journal-title":"Blood"},{"issue":"3","key":"9267_CR16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrc1567","volume":"5","author":"R Ren","year":"2005","unstructured":"Ren R. Mechanism of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005;5(3):172\u201383.","journal-title":"Nat Rev Cancer"},{"key":"9267_CR17","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1073\/pnas.0602402103","volume":"103","author":"HG Wendel","year":"2006","unstructured":"Wendel HG, Stanchina E, Cepero E. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. PNAS. 2006;103:7444\u20139.","journal-title":"PNAS"},{"key":"9267_CR18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/sj.bjc.6603349","volume":"95","author":"B Carpenter","year":"2006","unstructured":"Carpenter B, McKay M, Dundas SR. Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. Br J Cancer. 2006;95:921\u20137.","journal-title":"Br J Cancer"},{"key":"9267_CR19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ng791","volume":"30","author":"D Perrotti","year":"2002","unstructured":"Perrotti D, Cesi V, Trotta R. BCR-ABL suppresses C\/EBPalpha expression through inhibitory action of hnRNP E2. Nat Genet. 2002;30:48\u201358.","journal-title":"Nat Genet"},{"key":"9267_CR20","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1182\/blood-2005-09-3732","volume":"107","author":"M Notari","year":"2006","unstructured":"Notari M, Neviani P, Santhanam R, Blaser BW, Chang J-S, Galietta A, et al. AMAPK\/HNRPK pathway controls BCR\/ABL oncogenic potential by regulating MYC mRNA translation. Blood. 2006;107:2507\u201316.","journal-title":"Blood"},{"key":"9267_CR21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/leu.2008.27","volume":"22","author":"JA McCubrey","year":"2008","unstructured":"McCubrey JA, Steelman LS, Abrams SL, Bertrand FE, Ludwig DE, B\u00e4secke J, et al. Targeting survival cascades induced by activation of Ras\/Raf\/MEK\/ERK, PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways for effective leukemia therapy. Leukemia. 2008;22:708\u201322.","journal-title":"Leukemia"},{"key":"9267_CR22","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1411546","volume":"258","author":"CM Crews","year":"1992","unstructured":"Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992;258:478\u201380.","journal-title":"Science"},{"key":"9267_CR23","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/j.1460-2075.1994.tb06424.x","volume":"13","author":"DR Alessi","year":"1994","unstructured":"Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, et al. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J. 1994;13:1610\u20139.","journal-title":"EMBO J"},{"key":"9267_CR24","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0896-6273(94)90438-3","volume":"12","author":"LB Rosen","year":"1994","unstructured":"Rosen LB, Ginty DD, Weber MJ, Greenberg ME. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron. 1994;12:1207\u201321.","journal-title":"Neuron"},{"key":"9267_CR25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","volume":"77","author":"S Cowley","year":"1994","unstructured":"Cowley S, Paterson H, Kemp P, Marshall CJ. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell. 1994;77:841\u201352.","journal-title":"Cell"},{"key":"9267_CR26","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/S0021-9258(17)37680-9","volume":"269","author":"CJ Vlahos","year":"1994","unstructured":"Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H\u20131-benzopyran-4-one (LY294002). J Biol Chem. 1994;269:5241\u20138.","journal-title":"J Biol Chem"},{"key":"9267_CR27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/379645a0","volume":"379","author":"N Meydan","year":"1996","unstructured":"Meydan N, Grunberger T, Dadi H. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature. 1996;379:645\u20138.","journal-title":"Nature"},{"key":"9267_CR28","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1182\/blood-2003-01-0137","volume":"102","author":"S Meshinchi","year":"2003","unstructured":"Meshinchi S, Stirewalt DL, Alonzo TA, Zhang Q, Sweetser DA, Woods WG. Activating mutations of RTK\/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood. 2003;102:1474\u20139.","journal-title":"Blood"},{"key":"9267_CR29","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.2174\/1381612054546842","volume":"11","author":"M Milella","year":"2005","unstructured":"Milella M, Precupanu CM, Gregorj C, Ricciardi MR, Petrucci MT, Kornblau SM, et al. Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects. Curr Pharm Des. 2005;11:2779\u201395.","journal-title":"Curr Pharm Des"},{"key":"9267_CR30","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1046\/j.1365-2141.2001.02653.x","volume":"112","author":"C Gambacorti-Passerini","year":"2001","unstructured":"Gambacorti-Passerini C, Barni R, Marchesi E, Verga M, Rossi M, Rossi F, et al. Sensitivity of the abl inhibitor STI571 in fresh leukaemic cells obtained from chronic myelogenous leukaemia patients in different stages of the disease. Br J Haematol. 2001;112:972\u20134.","journal-title":"Br J Haematol"},{"key":"9267_CR31","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1182\/blood-2005-10-4110","volume":"107","author":"D Ye","year":"2006","unstructured":"Ye D, Wolff N, Li L. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Blood. 2006;107:4917\u201325.","journal-title":"Blood"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-009-9267-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-009-9267-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-009-9267-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T08:42:32Z","timestamp":1633768952000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-009-9267-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["9267"],"URL":"https:\/\/doi.org\/10.1007\/s12032-009-9267-z","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]}}}