{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:48:07Z","timestamp":1773323287042,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T00:00:00Z","timestamp":1285286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s12032-010-9685-y","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T15:50:09Z","timestamp":1285257009000},"page":"1311-1318","source":"Crossref","is-referenced-by-count":15,"title":["Epigenetic regulation of retinoic acid receptor \u03b22 gene in the initiation of breast cancer"],"prefix":"10.1007","volume":"28","author":[{"given":"Jingyan","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juntian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,9,24]]},"reference":[{"key":"9685_CR1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1210\/er.19.4.365","volume":"19","author":"C Lopez-Otin","year":"1998","unstructured":"Lopez-Otin C, Diamandis EP. Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. Endocr Rev. 1998;19:365\u201396.","journal-title":"Endocr Rev"},{"key":"9685_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3322\/canjclin.57.1.43","volume":"57","author":"A Jemal","year":"2007","unstructured":"Jemal A, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43\u201366.","journal-title":"CA Cancer J Clin"},{"key":"9685_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21101\/cejph.a3412","volume":"15","author":"J Brtko","year":"2007","unstructured":"Brtko J. Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention. Cent Eur J Public Health. 2007;15:3\u20136.","journal-title":"Cent Eur J Public Health"},{"key":"9685_CR4","first-page":"183","volume":"29","author":"MV Karamouzis","year":"2007","unstructured":"Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG. The molecular basis of retinoids\u2019 use in breast cancer chemoprevention. Cell Oncol. 2007;29:183\u20134.","journal-title":"Cell Oncol"},{"key":"9685_CR5","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.2174\/092986706779026183","volume":"13","author":"B Pavan","year":"2006","unstructured":"Pavan B, Biondi C, Dalpiaz A. Nuclear retinoic acid receptor beta as a tool in chemoprevention trials. Curr Med Chem. 2006;13:3553\u201363.","journal-title":"Curr Med Chem"},{"key":"9685_CR6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0959-437X(96)80085-2","volume":"6","author":"S Minucci","year":"1996","unstructured":"Minucci S, Ozato K. Retinoid receptors in transcriptional regulation. Curr Opin Genet Dev. 1996;6:567\u201374.","journal-title":"Curr Opin Genet Dev"},{"key":"9685_CR7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/j.1460-2075.1989.tb03394.x","volume":"8","author":"H The de","year":"1989","unstructured":"de The H, Marchio A, Tiollais P, Dejean A. Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J. 1989;8:429\u201333.","journal-title":"EMBO J"},{"key":"9685_CR8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0006-291X(92)91112-4","volume":"188","author":"BJ Leede van der","year":"1992","unstructured":"van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT. Genomic organization of the human retinoic acid receptor beta 2. Biochem Biophys Res Commun. 1992;188:695\u2013702.","journal-title":"Biochem Biophys Res Commun"},{"key":"9685_CR9","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1210\/mend-4-11-1727","volume":"4","author":"B Hoffmann","year":"1990","unstructured":"Hoffmann B, et al. A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter. Mol Endocrinol. 1990;4:1727\u201336.","journal-title":"Mol Endocrinol"},{"key":"9685_CR10","first-page":"133","volume":"5","author":"K Swisshelm","year":"1994","unstructured":"Swisshelm K, et al. Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ. 1994;5:133\u201341.","journal-title":"Cell Growth Differ"},{"key":"9685_CR11","first-page":"2135","volume":"55","author":"M Widschwendter","year":"1995","unstructured":"Widschwendter M, Daxenbichler G, Dapunt O, Marth C. Effects of retinoic acid and gamma-interferon on expression of retinoic acid receptor and cellular retinoic acid-binding protein in breast cancer cells. Cancer Res. 1995;55:2135\u20139.","journal-title":"Cancer Res"},{"key":"9685_CR12","first-page":"5663","volume":"54","author":"XK Zhang","year":"1994","unstructured":"Zhang XK, Liu Y, Lee MO, Pfahl M. A specific defect in the retinoic acid response associated with human lung cancer cell lines. Cancer Res. 1994;54:5663\u20139.","journal-title":"Cancer Res"},{"key":"9685_CR13","first-page":"3580","volume":"54","author":"XC Xu","year":"1994","unstructured":"Xu XC, et al. Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues. Cancer Res. 1994;54:3580\u20137.","journal-title":"Cancer Res"},{"key":"9685_CR14","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1073\/pnas.90.3.985","volume":"90","author":"B Houle","year":"1993","unstructured":"Houle B, Rochette-Egly C, Bradley WE. Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci USA. 1993;90:985\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"9685_CR15","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1128\/MCB.16.3.1138","volume":"16","author":"Y Liu","year":"1996","unstructured":"Liu Y, et al. Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol. 1996;16:1138\u201349.","journal-title":"Mol Cell Biol"},{"key":"9685_CR16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/excr.1995.1158","volume":"218","author":"X Lee","year":"1995","unstructured":"Lee X, Si SP, Tsou HC, Peacocke M. Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2. Exp Cell Res. 1995;218:296\u2013304.","journal-title":"Exp Cell Res"},{"key":"9685_CR17","first-page":"2455","volume":"62","author":"SM Sirchia","year":"2002","unstructured":"Sirchia SM, et al. Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res. 2002;62:2455\u201361.","journal-title":"Cancer Res"},{"key":"9685_CR18","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/jnci\/92.10.826","volume":"92","author":"M Widschwendter","year":"2000","unstructured":"Widschwendter M, et al. Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. J Natl Cancer Inst. 2000;92:826\u201332.","journal-title":"J Natl Cancer Inst"},{"key":"9685_CR19","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1365-2559.2009.03289.x","volume":"54","author":"F Liu","year":"2009","unstructured":"Liu F, et al. Increased expression of SDF-1\/CXCR4 is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast. Histopathology. 2009;54:741\u201350.","journal-title":"Histopathology"},{"key":"9685_CR20","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/jnci\/91.21.1847","volume":"91","author":"U Veronesi","year":"1999","unstructured":"Veronesi U, et al. Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst. 1999;91:1847\u201356.","journal-title":"J Natl Cancer Inst"},{"key":"9685_CR21","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM199505253322103","volume":"332","author":"R Lotan","year":"1995","unstructured":"Lotan R, et al. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med. 1995;332:1405\u201310.","journal-title":"N Engl J Med"},{"key":"9685_CR22","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1096\/fasebj.10.9.8801172","volume":"10","author":"J Berard","year":"1996","unstructured":"Berard J, et al. Lung tumors in mice expressing an antisense RARbeta2 transgene. FASEB J. 1996;10:1091\u20137.","journal-title":"FASEB J"},{"key":"9685_CR23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/jnci\/90.8.597","volume":"90","author":"AL Sabichi","year":"1998","unstructured":"Sabichi AL, Hendricks DT, Bober MA, Birrer MJ. Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide. J Natl Cancer Inst. 1998;90:597\u2013605.","journal-title":"J Natl Cancer Inst"},{"key":"9685_CR24","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1126\/science.274.5295.2057","volume":"274","author":"G Deng","year":"1996","unstructured":"Deng G, et al. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science. 1996;274:2057\u20139.","journal-title":"Science"},{"key":"9685_CR25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0002-9440(10)63969-7","volume":"158","author":"Q Yang","year":"2001","unstructured":"Yang Q, et al. Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer. Am J Pathol. 2001;158:299\u2013303.","journal-title":"Am J Pathol"},{"key":"9685_CR26","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.281.5381.1352","volume":"281","author":"M Bix","year":"1998","unstructured":"Bix M, Locksley RM. Independent and epigenetic regulation of the interleukin-4 alleles in CD4\u00a0+\u00a0T cells. Science. 1998;281:1352\u20134.","journal-title":"Science"},{"key":"9685_CR27","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1126\/science.279.5359.2118","volume":"279","author":"GA Hollander","year":"1998","unstructured":"Hollander GA, et al. Monoallelic expression of the interleukin-2 locus. Science. 1998;279:2118\u201321.","journal-title":"Science"},{"key":"9685_CR28","first-page":"3972","volume":"51","author":"L Hu","year":"1991","unstructured":"Hu L, et al. Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines. Cancer Res. 1991;51:3972\u201381.","journal-title":"Cancer Res"},{"key":"9685_CR29","first-page":"4158","volume":"57","author":"M Widschwendter","year":"1997","unstructured":"Widschwendter M, et al. Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer. Cancer Res. 1997;57:4158\u201361.","journal-title":"Cancer Res"},{"key":"9685_CR30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/5947","volume":"21","author":"PA Jones","year":"1999","unstructured":"Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet. 1999;21:163\u20137.","journal-title":"Nat Genet"},{"key":"9685_CR31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00001813-199701000-00007","volume":"8","author":"S Cote","year":"1997","unstructured":"Cote S, Momparler RL. Activation of the retinoic acid receptor beta gene by 5-aza-2\u2032-deoxycytidine in human DLD-1 colon carcinoma cells. Anticancer Drugs. 1997;8:56\u201361.","journal-title":"Anticancer Drugs"},{"key":"9685_CR32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/jnci\/89.9.602","volume":"89","author":"JD Minna","year":"1997","unstructured":"Minna JD, Mangelsdorf DJ. Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles? J Natl Cancer Inst. 1997;89:602\u20134.","journal-title":"J Natl Cancer Inst"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-010-9685-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-010-9685-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-010-9685-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T21:41:10Z","timestamp":1559684470000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-010-9685-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,24]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["9685"],"URL":"https:\/\/doi.org\/10.1007\/s12032-010-9685-y","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,24]]}}}