{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:55:39Z","timestamp":1771610139852,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1007\/s12032-010-9785-8","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T17:23:06Z","timestamp":1293729786000},"page":"16-24","source":"Crossref","is-referenced-by-count":33,"title":["Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience"],"prefix":"10.1007","volume":"29","author":[{"given":"Robert","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Mun\u00e1rriz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Santaballa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Palomar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Montalar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"9785_CR1","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.ejca.2005.01.029","volume":"41","author":"I Soerjomataram","year":"2005","unstructured":"Soerjomataram I, et al. Risks of second primary breast and urogenital cancer following female breast cancer in the south of The Netherlands, 1972\u20132001. Eur J Cancer. 2005;41:2331\u20137.","journal-title":"Eur J Cancer"},{"key":"9785_CR2","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1016\/j.ejca.2009.08.007","volume":"45","author":"W Lu","year":"2009","unstructured":"Lu W, et al. The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer. Eur J Cancer. 2009;45:3000\u20137.","journal-title":"Eur J Cancer"},{"key":"9785_CR3","first-page":"855","volume":"8","author":"Y Chen","year":"1999","unstructured":"Chen Y, Thompson W, Semenciw R, Mao Y. Epidemiology of contralateral breast cancer. Cancer Epidemiol Biomarkers Prev. 1999;8:855\u201361.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9785_CR4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/01.ede.0000072105.39021.6d","volume":"14","author":"JL Bernstein","year":"2003","unstructured":"Bernstein JL, Lapinski RH, Thakore SS, Doucette J, Thompson WD. The descriptive epidemiology of second primary breast cancer. Epidemiology. 2003;14:552\u20138.","journal-title":"Epidemiology"},{"key":"9785_CR5","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1002\/1097-0142(20000615)88:12<2739::AID-CNCR12>3.0.CO;2-J","volume":"88","author":"DE Heron","year":"2000","unstructured":"Heron DE, Komarnicky LT, Hyslop T, Schwartz GF, Mansfield CM. Bilateral breast carcinoma: risk factors and outcomes for patients with synchronous and metachronous disease. Cancer. 2000;88:2739\u201350.","journal-title":"Cancer"},{"key":"9785_CR6","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1200\/JCO.1993.11.8.1545","volume":"11","author":"EA Healey","year":"1993","unstructured":"Healey EA, et al. Contralateral breast cancer: clinical characteristics and impact on prognosis. J Clin Oncol. 1993;11:1545\u201352.","journal-title":"J Clin Oncol"},{"key":"9785_CR7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/bjs.6553","volume":"96","author":"T Irvine","year":"2009","unstructured":"Irvine T, Allen DS, Gillett C, Hamed H, Fentiman IS. Prognosis of synchronous bilateral breast cancer. Br J Surg. 2009;96:376\u201380.","journal-title":"Br J Surg"},{"key":"9785_CR8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/oxfordjournals.aje.a116565","volume":"136","author":"JB Bernstein","year":"1992","unstructured":"Bernstein JB, Thompson WD, Risch N, Holford TR. Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer. Am J Epidemiol. 1992;136:925\u201336.","journal-title":"Am J Epidemiol"},{"key":"9785_CR9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/sj.bjc.6601042","volume":"89","author":"CI Li","year":"2003","unstructured":"Li CI, Malone KE, Porter PL, Daling JR. Epidemiologic and molecular risk factors for contralateral breast cancer among young women. Br J Cancer. 2003;89:513\u20138.","journal-title":"Br J Cancer"},{"key":"9785_CR10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1417::AID-CNCR7>3.0.CO;2-H","volume":"78","author":"KE Malone","year":"1996","unstructured":"Malone KE, et al. Family history of young women with invasive breast carcinoma. Cancer. 1996;78:1417\u201325.","journal-title":"Cancer"},{"key":"9785_CR11","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0140-6736(97)11423-4","volume":"351","author":"Early Breast Cancer Trialists\u2019 Collaborative Group","year":"1998","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet. 1998;351:1451\u201367.","journal-title":"Lancet"},{"key":"9785_CR12","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0140-6736(98)03301-7","volume":"352","author":"Early Breast Cancer Trialists\u2019 Collaborative Group","year":"1998","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group. Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet. 1998;352:930\u201345.","journal-title":"Lancet"},{"key":"9785_CR13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM199203193261201","volume":"326","author":"JD Boice Jr","year":"1992","unstructured":"Boice JD Jr, et al. Cancer in the contralateral breast after radiotherapy for breast cancer. N Engl J Med. 1992;326:781\u20135.","journal-title":"N Engl J Med"},{"key":"9785_CR14","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1200\/JCO.2007.16.0192","volume":"26","author":"MJ Hooning","year":"2008","unstructured":"Hooning MJ, et al. Roles of radiotherapy and chemotherapy in the development of contralateral breast cancer. J Clin Oncol. 2008;26:5561\u20138.","journal-title":"J Clin Oncol"},{"key":"9785_CR15","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1200\/JCO.2006.08.8575","volume":"24","author":"JL Khatcheressian","year":"2006","unstructured":"Khatcheressian JL, et al. American Society of Clinical Oncology. American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting. J Clin Oncol. 2006;24:5091\u20137.","journal-title":"J Clin Oncol"},{"key":"9785_CR16","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/sj.bjc.6604065","volume":"97","author":"DA Montgomery","year":"2007","unstructured":"Montgomery DA, Krupa K, Cooke TG. Follow-up in breast cancer: does routine clinical examination improve outcome? A systematic review of the literature. Br J Cancer. 2007;97:1632\u201341.","journal-title":"Br J Cancer"},{"key":"9785_CR17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10549-008-0023-4","volume":"114","author":"WL Lu","year":"2009","unstructured":"Lu WL, et al. Impact on survival of early detection of isolated breast recurrences after the primary treatment for breast cancer: a meta-analysis. Breast Cancer Res Treat. 2009;114:403\u201312.","journal-title":"Breast Cancer Res Treat"},{"key":"9785_CR18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s11606-007-0471-2","volume":"23","author":"TS Field","year":"2008","unstructured":"Field TS, et al. Under utilization of surveillance mammography among older breast cancer survivors. J Gen Intern Med. 2008;23:158\u201363.","journal-title":"J Gen Intern Med"},{"key":"9785_CR19","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/cncr.21893","volume":"106","author":"CA Doubeni","year":"2006","unstructured":"Doubeni CA, et al. Patterns and predictors of mammography utilization among breast cancer survivors. Cancer. 2006;106:2482\u20138.","journal-title":"Cancer"},{"key":"9785_CR20","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/1097-0142(19910401)67:7<1844::AID-CNCR2820670705>3.0.CO;2-W","volume":"67","author":"WAM Mellink","year":"1991","unstructured":"Mellink WAM, et al. The contribution of routine follow-up mammography to an early detection of asynchronous contralateral breast cancer. Cancer. 1991;67:1844\u201352.","journal-title":"Cancer"},{"key":"9785_CR21","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s002680010171","volume":"24","author":"J Kollias","year":"2000","unstructured":"Kollias J, et al. Value of contralateral surveillance mammography for primary breast cancer follow-up. World J Surg. 2000;24:983\u20137.","journal-title":"World J Surg"},{"key":"9785_CR22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/jnci\/djh097","volume":"96","author":"SM Swain","year":"2004","unstructured":"Swain SM, et al. Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer. J Natl Cancer Inst. 2004;96:516\u201323.","journal-title":"J Natl Cancer Inst"},{"key":"9785_CR23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1075-122X.2005.21579.x","volume":"11","author":"A Stark","year":"2005","unstructured":"Stark A, Lu M, Mackowiak P, Linden M. Concordance of the hormone receptors and correlation of HER-2\/neu overexpression of the metachronous cancers of contralateral breasts. Breast J. 2005;11:183\u20137.","journal-title":"Breast J"},{"key":"9785_CR24","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1200\/JCO.2005.04.076","volume":"23","author":"G Arpino","year":"2005","unstructured":"Arpino G, Weiss HL, Clark GM, Hilsenbeck SG, Osborne CK. Hormone receptor status of a contralateral breast cancer is independent of the receptor status of the first primary in patients not receiving adjuvant tamoxifen. J Clin Oncol. 2005;23:4687\u201394.","journal-title":"J Clin Oncol"},{"key":"9785_CR25","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/jnci\/93.13.1008","volume":"93","author":"CI Li","year":"2002","unstructured":"Li CI, Malone KE, Weiss NS, Daling JR. Tamoxifen therapy for primary breast cancer and risk of contralateral breast cancer. J Natl Cancer Inst. 2002;93:1008\u201313.","journal-title":"J Natl Cancer Inst"},{"key":"9785_CR26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/sj.bjc.6600746","volume":"88","author":"R Kaas","year":"2002","unstructured":"Kaas R, et al. The influence of tamoxifen treatment on the estrogen receptor in metachronous contralateral breast cancer. Br J Cancer. 2002;88:707\u201310.","journal-title":"Br J Cancer"},{"key":"9785_CR27","first-page":"3427","volume":"8","author":"T Bachleitner-Hofmann","year":"2002","unstructured":"Bachleitner-Hofmann T, et al. Pattern of hormone receptor status of secondary contralateral breast cancer in patients receiving adjuvant tamoxifen. Clin Cancer Res. 2002;8:3427\u201332.","journal-title":"Clin Cancer Res"},{"key":"9785_CR28","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.1996.14.9.2584","volume":"14","author":"T Kuukasjarvi","year":"1996","unstructured":"Kuukasjarvi T, Kononen J, Helin H, Holli K, Isola J. Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy. J Clin Oncol. 1996;14:2584\u20139.","journal-title":"J Clin Oncol"},{"key":"9785_CR29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.7326\/0000605-200911170-00147","volume":"151","author":"HD Nelson","year":"2009","unstructured":"Nelson HD, et al. Systematic review: comparative effectiveness of medications to reduce risk for primary breast cancer. Ann Intern Med. 2009;151:703\u201315.","journal-title":"Ann Intern Med"},{"key":"9785_CR30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0140-6736(03)12342-2","volume":"361","author":"J Cuzick","year":"2003","unstructured":"Cuzick J, et al. Overview of the main outcomes in breast-cancer prevention trials. Lancet. 2003;361:296\u2013300.","journal-title":"Lancet"},{"key":"9785_CR31","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1200\/JCO.2001.19.4.931","volume":"19","author":"B Fisher","year":"2001","unstructured":"Fisher B, et al. Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from the National Surgical Adjuvant Breast and Bowel Project B-23. J Clin Oncol. 2001;19:931\u201342.","journal-title":"J Clin Oncol"},{"key":"9785_CR32","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/cncr.11746","volume":"98","author":"M Baum","year":"2003","unstructured":"Baum M, et al. The ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists\u2019 Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. Cancer. 2003;98:1779\u201381.","journal-title":"Cancer"},{"key":"9785_CR33","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1056\/NEJMoa032312","volume":"349","author":"PE Goss","year":"2003","unstructured":"Goss PE, et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med. 2003;349:1793\u2013802.","journal-title":"N Engl J Med"},{"key":"9785_CR34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2325\/jbcs.12.196","volume":"12","author":"H Takahashi","year":"2005","unstructured":"Takahashi H, et al. The impact of bilateral breast cancer on the prognosis of breast cancer: a comparative study with unilateral breast cancer. Breast Cancer. 2005;12:196\u2013202.","journal-title":"Breast Cancer"},{"key":"9785_CR35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0960-9776(02)00278-3","volume":"12","author":"JJ Jobsen","year":"2003","unstructured":"Jobsen JJ, van der Palen J, Ong F, Meerwaldt JH. Synchronous, bilateral breast cancer: prognostic value and incidence. Breast. 2003;12:83\u20138.","journal-title":"Breast"},{"key":"9785_CR36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1053\/ejso.2002.1266","volume":"28","author":"AR Carmichael","year":"2002","unstructured":"Carmichael AR, Bendall S, Lockerbie L, Prescott R, Bates T. The long-term outcome of synchronous bilateral breast cancer is worse than metachronous or unilateral tumours. Eur J Surg Oncol. 2002;28:388\u201391.","journal-title":"Eur J Surg Oncol"},{"key":"9785_CR37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s10434-999-0102-8","volume":"6","author":"KM Heaton","year":"1999","unstructured":"Heaton KM, et al. Feasibility of breast conservation therapy in metachronous or synchronous bilateral breast cancer. Ann Surg Oncol. 1999;6:102\u20138.","journal-title":"Ann Surg Oncol"},{"key":"9785_CR38","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/1097-0142(20010515)91:10<1845::AID-CNCR1205>3.0.CO;2-Z","volume":"91","author":"LA Newman","year":"2001","unstructured":"Newman LA, et al. A case\u2013control study of unilateral and bilateral breast carcinoma patients. Cancer. 2001;91:1845\u201353.","journal-title":"Cancer"},{"key":"9785_CR39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/1097-0142(19930101)71:1<172::AID-CNCR2820710127>3.0.CO;2-Y","volume":"71","author":"E Robinson","year":"1993","unstructured":"Robinson E, Rennert G, Rennert HS, Neugut AI. Survival of first and second primary breast cancer. Cancer. 1993;71:172\u20136.","journal-title":"Cancer"},{"key":"9785_CR40","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1200\/JCO.2006.10.5056","volume":"25","author":"M Hartman","year":"2007","unstructured":"Hartman M, et al. Incidence and prognosis of synchronous and metachronous bilateral breast cancer. J Clin Oncol. 2007;25:4210\u20136.","journal-title":"J Clin Oncol"},{"key":"9785_CR41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10549-007-9709-2","volume":"110","author":"M Schaapveld","year":"2008","unstructured":"Schaapveld M, et al. The impact of adjuvant therapy on contralateral breast cancer risk and the prognostic significance of contralateral breast cancer: a population based study in the Netherlands. Breast Cancer Res Treat. 2008;110:189\u201397.","journal-title":"Breast Cancer Res Treat"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-010-9785-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-010-9785-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-010-9785-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T02:22:51Z","timestamp":1559442171000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-010-9785-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,31]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["9785"],"URL":"https:\/\/doi.org\/10.1007\/s12032-010-9785-8","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,31]]}}}