{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:40:27Z","timestamp":1769582427847,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s12032-014-0303-2","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T09:37:20Z","timestamp":1414661840000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Upregulation of microRNA-31 associates with a poor prognosis of malignant pleural mesothelioma with sarcomatoid component"],"prefix":"10.1007","volume":"31","author":[{"given":"Shinji","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Nabeshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Shibuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukuru","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"issue":"4","key":"303_CR1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.trsl.2009.01.004","volume":"153","author":"DW Kamp","year":"2009","unstructured":"Kamp DW. Asbestos-induced lung diseases: an update. Transl Res J Lab Clin Med. 2009;153(4):143\u201352.","journal-title":"Transl Res J Lab Clin Med"},{"issue":"1","key":"303_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajim.20246","volume":"49","author":"T Murayama","year":"2006","unstructured":"Murayama T, Takahashi K, Natori Y, Kurumatani N. Estimation of future mortality from pleural malignant mesothelioma in Japan based on an age-cohort model. Am J Ind Med. 2006;49(1):1\u20137.","journal-title":"Am J Ind Med"},{"issue":"12","key":"303_CR3","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1200\/JCO.2008.19.8523","volume":"27","author":"AS Tsao","year":"2009","unstructured":"Tsao AS, Wistuba I, Roth JA, Kindler HL. Malignant pleural mesothelioma. J Clin Oncol. 2009;27(12):2081\u201390.","journal-title":"J Clin Oncol"},{"issue":"6","key":"303_CR4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00428-008-0689-3","volume":"453","author":"S Dacic","year":"2008","unstructured":"Dacic S, Kothmaier H, Land S, Shuai Y, Halbwedl I, Morbini P, et al. Prognostic significance of p16\/cdkn2a loss in pleural malignant mesotheliomas. Virchows Arch. 2008;453(6):627\u201335.","journal-title":"Virchows Arch"},{"issue":"1","key":"303_CR5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1378\/chest.09-1951","volume":"138","author":"S Savic","year":"2010","unstructured":"Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B, et al. Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. Chest. 2010;138(1):137\u201344.","journal-title":"Chest"},{"issue":"4","key":"303_CR6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1309\/AJCPP5R2ZJZKCLWN","volume":"135","author":"SE Monaco","year":"2011","unstructured":"Monaco SE, Shuai Y, Bansal M, Krasinskas AM, Dacic S. The diagnostic utility of p16 FISH and GLUT-1 immunohistochemical analysis in mesothelial proliferations. Am J Clin Pathol. 2011;135(4):619\u201327.","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"303_CR7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cncy.21269","volume":"121","author":"S Matsumoto","year":"2013","unstructured":"Matsumoto S, Nabeshima K, Kamei T, Hiroshima K, Kawahara K, Hata S, et al. Morphology of 9p21 homozygous deletion-positive pleural mesothelioma cells analyzed using fluorescence in situ hybridization and virtual microscope system in effusion cytology. Cancer Cytopathol. 2013;121(8):415\u201322.","journal-title":"Cancer Cytopathol"},{"issue":"1","key":"303_CR8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1309\/AJCPT94JVWIHBKRD","volume":"139","author":"D Wu","year":"2013","unstructured":"Wu D, Hiroshima K, Matsumoto S, Nabeshima K, Yusa T, Ozaki D, et al. Diagnostic usefulness of p16\/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis. Am J Clin Pathol. 2013;139(1):39\u201346.","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"303_CR9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281\u201397.","journal-title":"Cell"},{"issue":"10","key":"303_CR10","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.leukres.2013.07.019","volume":"37","author":"T Shibuta","year":"2013","unstructured":"Shibuta T, Honda E, Shiotsu H, Tanaka Y, Vellasamy S, Shiratsuchi M, et al. Imatinib induces demethylation of miR-203 gene: an epigenetic mechanism of anti-tumor effect of imatinib. Leuk Res. 2013;37(10):1278\u201386.","journal-title":"Leuk Res"},{"issue":"11","key":"303_CR11","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1261\/rna.1034808","volume":"14","author":"LX Yan","year":"2008","unstructured":"Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA. 2008;14(11):2348\u201360.","journal-title":"RNA"},{"issue":"2","key":"303_CR12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hed.21713","volume":"34","author":"CJ Liu","year":"2012","unstructured":"Liu CJ, Lin SC, Yang CC, Cheng HW, Chang KW. Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head Neck. 2012;34(2):219\u201324.","journal-title":"Head Neck"},{"issue":"4","key":"303_CR13","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI39566","volume":"120","author":"X Liu","year":"2010","unstructured":"Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, et al. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest. 2010;120(4):1298\u2013309.","journal-title":"J Clin Invest"},{"issue":"5\u20136","key":"303_CR14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000113489","volume":"72","author":"O Slaby","year":"2007","unstructured":"Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, et al. Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology. 2007;72(5\u20136):397\u2013402.","journal-title":"Oncology"},{"issue":"3","key":"303_CR15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12032-009-9269-x","volume":"27","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Guo J, Li D, Xiao B, Miao Y, Jiang Z, et al. Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance. Med Oncol. 2010;27(3):685\u20139.","journal-title":"Med Oncol"},{"issue":"10","key":"303_CR16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s12094-013-1014-4","volume":"15","author":"S Wang","year":"2013","unstructured":"Wang S, Li Q, Wang K, Dai Y, Yang J, Xue S, et al. Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer. Clin Transl Oncol. 2013;15(10):849\u201354.","journal-title":"Clin Transl Oncol"},{"issue":"6","key":"303_CR17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2353\/jmoldx.2010.090169","volume":"12","author":"H Benjamin","year":"2010","unstructured":"Benjamin H, Lebanony D, Rosenwald S, Cohen L, Gibori H, Barabash N, et al. A diagnostic assay based on microRNA expression accurately identifies malignant pleural mesothelioma. J Mol Diagn. 2010;12(6):771\u20139.","journal-title":"J Mol Diagn"},{"issue":"4","key":"303_CR18","doi-asserted-by":"crossref","first-page":"e18232","DOI":"10.1371\/journal.pone.0018232","volume":"6","author":"L Santarelli","year":"2011","unstructured":"Santarelli L, Strafella E, Staffolani S, Amati M, Emanuelli M, Sartini D, et al. Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma. PLoS One. 2011;6(4):e18232.","journal-title":"PLoS One"},{"issue":"1","key":"303_CR19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/modpathol.2011.144","volume":"25","author":"A Fassina","year":"2012","unstructured":"Fassina A, Cappellesso R, Guzzardo V, Dalla Via L, Piccolo S, Ventura L, et al. Epithelial-mesenchymal transition in malignant mesothelioma. Mod Pathol. 2012;25(1):86\u201399.","journal-title":"Mod Pathol"},{"issue":"3","key":"303_CR20","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1165\/rcmb.2009-0060OC","volume":"42","author":"S Busacca","year":"2010","unstructured":"Busacca S, Germano S, De Cecco L, Rinaldi M, Comoglio F, Favero F, et al. MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. Am J Respir Cell Mol Biol. 2010;42(3):312\u20139.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"15","key":"303_CR21","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1158\/1078-0432.CCR-10-3040","volume":"17","author":"T Kubo","year":"2011","unstructured":"Kubo T, Toyooka S, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, et al. Epigenetic silencing of microRNA-34b\/c plays an important role in the pathogenesis of malignant pleural mesothelioma. Clin Cancer Res. 2011;17(15):4965\u201374.","journal-title":"Clin Cancer Res"},{"key":"303_CR22","doi-asserted-by":"crossref","unstructured":"Reid G, Pel ME, Kirschner MB, Cheng YY, Mugridge N, Weiss J, et al. Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma. Ann Oncol. 2013;24(12):3128\u201335.","DOI":"10.1093\/annonc\/mdt412"},{"issue":"5","key":"303_CR23","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/JTO.0b013e31820db125","volume":"6","author":"V Balatti","year":"2011","unstructured":"Balatti V, Maniero S, Ferracin M, Veronese A, Negrini M, Ferrocci G, et al. MicroRNAs dysregulation in human malignant pleural mesothelioma. J Thorac Oncol. 2011;6(5):844\u201351.","journal-title":"J Thorac Oncol"},{"issue":"9","key":"303_CR24","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1600-0463.2012.02891.x","volume":"120","author":"M Andersen","year":"2012","unstructured":"Andersen M, Grauslund M, Muhammad-Ali M, Ravn J, Sorensen JB, Andersen CB, et al. Are differentially expressed microRNAs useful in the diagnostics of malignant pleural mesothelioma? APMIS. 2012;120(9):767\u20139.","journal-title":"APMIS"},{"issue":"7","key":"303_CR25","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/JTO.0b013e3182572e83","volume":"7","author":"MB Kirschner","year":"2012","unstructured":"Kirschner MB, Cheng YY, Badrian B, Kao SC, Creaney J, Edelman JJ, et al. Increased circulating miR-625-3p: a potential biomarker for patients with malignant pleural mesothelioma. J Thorac Oncol. 2012;7(7):1184\u201391.","journal-title":"J Thorac Oncol"},{"issue":"30","key":"303_CR26","doi-asserted-by":"crossref","first-page":"22809","DOI":"10.1074\/jbc.M110.100354","volume":"285","author":"SV Ivanov","year":"2010","unstructured":"Ivanov SV, Goparaju CM, Lopez P, Zavadil J, Toren-Haritan G, Rosenwald S, et al. Pro-tumorigenic effects of miR-31 loss in mesothelioma. J Biol Chem. 2010;285(30):22809\u201317.","journal-title":"J Biol Chem"},{"key":"303_CR27","volume-title":"Pathology and genetics of tumors of the lung, pleura, thymus and heart","author":"WD Travis","year":"2004","unstructured":"Travis WD, Muller-Hermelink HK, World Health Organization Classification of Tumours. Pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: International Agency for Research on Cancer Press; 2004."},{"issue":"3","key":"303_CR28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2007.10.077","volume":"364","author":"S Masaki","year":"2007","unstructured":"Masaki S, Ohtsuka R, Abe Y, Muta K, Umemura T. Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis. Biochem Biophys Res Commun. 2007;364(3):509\u201314.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"303_CR29","first-page":"1227","volume":"55","author":"Y Sekido","year":"1995","unstructured":"Sekido Y, Pass HI, Bader S, Mew DJ, Christman MF, Gazdar AF, et al. Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res. 1995;55(6):1227\u201331.","journal-title":"Cancer Res"},{"issue":"3","key":"303_CR30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/0008-5472.CAN-10-2164","volume":"71","author":"H Murakami","year":"2011","unstructured":"Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, et al. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res. 2011;71(3):873\u201383.","journal-title":"Cancer Res"},{"issue":"4","key":"303_CR31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ceb.2004.06.003","volume":"16","author":"B Fevrier","year":"2004","unstructured":"Fevrier B, Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol. 2004;16(4):415\u201321.","journal-title":"Curr Opin Cell Biol"},{"issue":"12","key":"303_CR32","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1158\/2159-8290.CD-12-0206","volume":"2","author":"AK Mitra","year":"2012","unstructured":"Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012;2(12):1100\u20138.","journal-title":"Cancer Discov"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-014-0303-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-014-0303-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-014-0303-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T02:31:45Z","timestamp":1559442705000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-014-0303-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,31]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["303"],"URL":"https:\/\/doi.org\/10.1007\/s12032-014-0303-2","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,31]]},"article-number":"303"}}