{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:01:25Z","timestamp":1781571685790,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s12032-014-0423-8","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T04:55:24Z","timestamp":1417668924000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of metabolic syndrome and its components on recurrence and survival in early-stage non-small cell lung cancer"],"prefix":"10.1007","volume":"32","author":[{"given":"Ying-Sheng","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-qing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"issue":"5","key":"423_CR1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2353\/ajpath.2006.051090","volume":"169","author":"S Cowey","year":"2006","unstructured":"Cowey S, Hardy RW. The metabolic syndrome: a high-risk state for cancer? Am J Pathol. 2006;169(5):1505\u201322.","journal-title":"Am J Pathol"},{"key":"423_CR2","doi-asserted-by":"crossref","unstructured":"Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel iii) final report. Circulation. 2002;106(25):3143\u2013421.","DOI":"10.1161\/circ.106.25.3143"},{"issue":"2","key":"423_CR3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/MCG.0b013e3182a030c4","volume":"48","author":"R Jinjuvadia","year":"2014","unstructured":"Jinjuvadia R, Patel S, Liangpunsakul S. The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis. J Clin Gastroenterol. 2014;48(2):172\u20137.","journal-title":"J Clin Gastroenterol"},{"issue":"8","key":"423_CR4","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.7314\/APJCP.2012.13.8.3873","volume":"13","author":"V Ulaganathan","year":"2012","unstructured":"Ulaganathan V, Kandiah M, Zalilah MS, et al. Colorectal cancer and its association with the metabolic syndrome: a malaysian multi-centric case\u2013control study. Asian Pac J Cancer Prev. 2012;13(8):3873\u20137.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"423_CR5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/MCG.0b013e3182688c15","volume":"47","author":"R Jinjuvadia","year":"2013","unstructured":"Jinjuvadia R, Lohia P, Jinjuvadia C, et al. The association between metabolic syndrome and colorectal neoplasm: systemic review and meta-analysis. J Clin Gastroenterol. 2013;47(1):33\u201344.","journal-title":"J Clin Gastroenterol"},{"key":"423_CR6","doi-asserted-by":"crossref","unstructured":"Borena W, Edlinger M, Bj\u00f8rge T, et al. Correction: a prospective study on metabolic risk factors and gallbladder cancer in the metabolic syndrome and cancer (Me-Can) collaborative study. PLoS One. 2014;9(7):e102291.","DOI":"10.1371\/journal.pone.0102291"},{"issue":"2","key":"423_CR7","doi-asserted-by":"crossref","first-page":"e89368","DOI":"10.1371\/journal.pone.0089368","volume":"9","author":"W Borena","year":"2014","unstructured":"Borena W, Edlinger M, Bjorge T, et al. A prospective study on metabolic risk factors and gallbladder cancer in the metabolic syndrome and cancer (Me-Can) collaborative study. PLoS One. 2014;9(2):e89368.","journal-title":"PLoS One"},{"issue":"11","key":"423_CR8","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1158\/1055-9965.EPI-11-0715","volume":"20","author":"CM Friedenreich","year":"2011","unstructured":"Friedenreich CM, Biel RK, Lau DC, et al. Case\u2013control study of the metabolic syndrome and metabolic risk factors for endometrial cancer. Cancer Epidemiol Biomarkers Prev. 2011;20(11):2384\u201395.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"423_CR9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/annonc\/mdq464","volume":"22","author":"V Rosato","year":"2011","unstructured":"Rosato V, Zucchetto A, Bosetti C, et al. Metabolic syndrome and endometrial cancer risk. Ann Oncol. 2011;22(4):884\u20139.","journal-title":"Ann Oncol"},{"issue":"1","key":"423_CR10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ygyno.2009.12.029","volume":"117","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Liu Z, Yu X, et al. The association between metabolic abnormality and endometrial cancer: a large case\u2013control study in China. Gynecol Oncol. 2010;117(1):41\u20136.","journal-title":"Gynecol Oncol"},{"issue":"10","key":"423_CR11","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.metabol.2011.03.005","volume":"60","author":"V Rosato","year":"2011","unstructured":"Rosato V, Tavani A, Bosetti C, et al. Metabolic syndrome and pancreatic cancer risk: a case\u2013control study in Italy and meta-analysis. Metabolism. 2011;60(10):1372\u20138.","journal-title":"Metabolism"},{"issue":"4","key":"423_CR12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000341397","volume":"86","author":"Q Wu","year":"2012","unstructured":"Wu Q, Chen G, Wu WM, et al. Metabolic syndrome components and risk factors for pancreatic adenocarcinoma: a case\u2013control study in China. Digestion. 2012;86(4):294\u2013301.","journal-title":"Digestion"},{"issue":"8","key":"423_CR13","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s10552-012-0002-2","volume":"23","author":"KW Reeves","year":"2012","unstructured":"Reeves KW, McLaughlin V, Fredman L, et al. Components of metabolic syndrome and risk of breast cancer by prognostic features in the study of osteoporotic fractures cohort. Cancer Causes Control. 2012;23(8):1241\u201351.","journal-title":"Cancer Causes Control"},{"key":"423_CR14","doi-asserted-by":"crossref","first-page":"168797","DOI":"10.1155\/2013\/168797","volume":"2013","author":"GA Thomas","year":"2013","unstructured":"Thomas GA, Alvarez-Reeves M, Lu L, et al. Effect of exercise on metabolic syndrome variables in breast cancer survivors. Int J Endocrinol. 2013;2013:168797.","journal-title":"Int J Endocrinol"},{"issue":"9","key":"423_CR15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/gutjnl-2011-300551","volume":"61","author":"MG O\u2019Doherty","year":"2012","unstructured":"O\u2019Doherty MG, Freedman ND, Hollenbeck AR, et al. A prospective cohort study of obesity and risk of oesophageal and gastric adenocarcinoma in the NIH\u2013AARP diet and health study. Gut. 2012;61(9):1261\u20138.","journal-title":"Gut"},{"issue":"10","key":"423_CR16","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1002\/ijc.21638","volume":"118","author":"RJ MacInnis","year":"2006","unstructured":"MacInnis RJ, English DR, Hopper JL, et al. Body size and composition and the risk of gastric and oesophageal adenocarcinoma. Int J Cancer. 2006;118(10):2628\u201331.","journal-title":"Int J Cancer"},{"issue":"2","key":"423_CR17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/aje\/kwn109","volume":"168","author":"GC Kabat","year":"2008","unstructured":"Kabat GC, Kim M, Hunt JR, et al. Body mass index and waist circumference in relation to lung cancer risk in the women\u2019s health initiative. Am J Epidemiol. 2008;168(2):158\u201369.","journal-title":"Am J Epidemiol"},{"issue":"5","key":"423_CR18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/aje\/kwg179","volume":"158","author":"A Lindgren","year":"2003","unstructured":"Lindgren A, Pukkala E, Nissinen A, et al. Blood pressure, smoking, and the incidence of lung cancer in hypertensive men in North Karelia, Finland. Am J Epidemiol. 2003;158(5):442\u20137.","journal-title":"Am J Epidemiol"},{"issue":"11","key":"423_CR19","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.2337\/dc12-0336","volume":"35","author":"K Esposito","year":"2012","unstructured":"Esposito K, Chiodini P, Colao A, et al. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402\u201311.","journal-title":"Diabetes Care"},{"issue":"3","key":"423_CR20","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/annonc\/mdp344","volume":"21","author":"JS Lee","year":"2010","unstructured":"Lee JS, Cho SI, Park HS. Metabolic syndrome and cancer-related mortality among korean men and women. Ann Oncol. 2010;21(3):640\u20135.","journal-title":"Ann Oncol"},{"issue":"10","key":"423_CR21","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.ejca.2009.01.031","volume":"45","author":"JR Jaggers","year":"2009","unstructured":"Jaggers JR, Sui X, Hooker SP, et al. Metabolic syndrome and risk of cancer mortality in men. Eur J Cancer. 2009;45(10):1831\u20138.","journal-title":"Eur J Cancer"},{"issue":"3","key":"423_CR22","doi-asserted-by":"crossref","first-page":"e89965","DOI":"10.1371\/journal.pone.0089965","volume":"9","author":"XL Wei","year":"2014","unstructured":"Wei XL, Qiu MZ, Lin HX, et al. Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. PLoS One. 2014;9(3):e89965.","journal-title":"PLoS One"},{"issue":"8","key":"423_CR23","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.metabol.2009.11.019","volume":"59","author":"CE Matthews","year":"2010","unstructured":"Matthews CE, Sui X, LaMonte MJ, et al. Metabolic syndrome and risk of death from cancers of the digestive system. Metabolism. 2010;59(8):1231\u20139.","journal-title":"Metabolism"},{"issue":"8","key":"423_CR24","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/cncr.27923","volume":"119","author":"Y Yang","year":"2013","unstructured":"Yang Y, Mauldin PD, Ebeling M, et al. Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients. Cancer. 2013;119(8):1512\u201320.","journal-title":"Cancer"},{"issue":"1","key":"423_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.amjsurg.2009.05.005","volume":"200","author":"Z Shen","year":"2010","unstructured":"Shen Z, Ye Y, Bin L, et al. Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis. Am J Surg. 2010;200(1):59\u201363.","journal-title":"Am J Surg"},{"issue":"3","key":"423_CR26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.clinre.2013.11.009","volume":"38","author":"EH Kim","year":"2014","unstructured":"Kim EH, Lee H, Chung H, et al. Impact of metabolic syndrome on oncologic outcome after radical gastrectomy for gastric cancer. Clin Res Hepatol Gastroenterol. 2014;38(3):372\u20138.","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"1","key":"423_CR27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ijc.21812","volume":"119","author":"P Pasanisi","year":"2006","unstructured":"Pasanisi P, Berrino F, De Petris M, et al. Metabolic syndrome as a prognostic factor for breast cancer recurrences. Int J Cancer. 2006;119(1):236\u20138.","journal-title":"Int J Cancer"},{"issue":"2","key":"423_CR28","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/bcr2856","volume":"13","author":"SW Oh","year":"2011","unstructured":"Oh SW, Park CY, Lee ES, et al. Adipokines, insulin resistance, metabolic syndrome, and breast cancer recurrence: a cohort study. Breast Cancer Res. 2011;13(2):R34.","journal-title":"Breast Cancer Res"},{"key":"423_CR29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1756-9966-32-9","volume":"32","author":"YZ Xiang","year":"2013","unstructured":"Xiang YZ, Xiong H, Cui ZL, et al. The association between metabolic syndrome and the risk of prostate cancer, high-grade prostate cancer, advanced prostate cancer, prostate cancer-specific mortality and biochemical recurrence. J Exp Clin Cancer Res. 2013;32:9.","journal-title":"J Exp Clin Cancer Res"},{"issue":"9","key":"423_CR30","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/JTO.0b013e31829cf942","volume":"8","author":"SE Dahlberg","year":"2013","unstructured":"Dahlberg SE, Schiller JH, Bonomi PB, et al. Body mass index and its association with clinical outcomes for advanced non-small-cell lung cancer patients enrolled on eastern cooperative oncology group clinical trials. J Thorac Oncol. 2013;8(9):1121\u20137.","journal-title":"J Thorac Oncol"},{"issue":"4","key":"423_CR31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/ejcts\/ezs135","volume":"42","author":"S Attaran","year":"2012","unstructured":"Attaran S, McShane J, Whittle I, et al. A propensity-matched comparison of survival after lung resection in patients with a high versus low body mass index. Eur J Cardiothorac Surg. 2012;42(4):653\u20138.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"3","key":"423_CR32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.lungcan.2011.07.019","volume":"75","author":"J Varlotto","year":"2012","unstructured":"Varlotto J, Medford-Davis LN, Recht A, et al. Confirmation of the role of diabetes in the local recurrence of surgically resected non-small cell lung cancer. Lung Cancer. 2012;75(3):381\u201390.","journal-title":"Lung Cancer"},{"key":"423_CR33","doi-asserted-by":"crossref","unstructured":"Vargas T, Moreno-Rubio J, Herranz J, et al. Genes associated with metabolic syndrome predict disease-free survival in stage ii colorectal cancer patients. A novel link between metabolic dysregulation and colorectal cancer. Mol Oncol. 2014;8(8):1469\u201381.","DOI":"10.1016\/j.molonc.2014.05.015"},{"issue":"1","key":"423_CR34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10549-011-1790-x","volume":"131","author":"SV Colonna","year":"2012","unstructured":"Colonna SV, Douglas Case L, Lawrence JA. A retrospective review of the metabolic syndrome in women diagnosed with breast cancer and correlation with estrogen receptor. Breast Cancer Res Treat. 2012;131(1):325\u201331.","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"423_CR35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1463-1318.2011.02562.x","volume":"14","author":"LA Healy","year":"2012","unstructured":"Healy LA, Howard JM, Ryan AM, et al. Metabolic syndrome and leptin are associated with adverse pathological features in male colorectal cancer patients. Colorectal Dis. 2012;14(2):157\u201365.","journal-title":"Colorectal Dis"},{"issue":"4","key":"423_CR36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.clon.2010.02.001","volume":"22","author":"LA Healy","year":"2010","unstructured":"Healy LA, Ryan AM, Carroll P, et al. Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer. Clin Oncol (R Coll Radiol). 2010;22(4):281\u20138.","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-014-0423-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-014-0423-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-014-0423-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T00:15:57Z","timestamp":1566087357000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-014-0423-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["423"],"URL":"https:\/\/doi.org\/10.1007\/s12032-014-0423-8","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]},"article-number":"423"}}