{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:16:10Z","timestamp":1781889370692,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s12032-017-1061-8","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T05:14:43Z","timestamp":1511500483000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Volumetric modulated arc therapy (VMAT) to deliver nodal irradiation in breast cancer patients"],"prefix":"10.1007","volume":"35","author":[{"given":"Giuseppe Carlo","family":"Iorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-0687","authenticated-orcid":false,"given":"Pierfrancesco","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Arcadipane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bartoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Rondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Romana","family":"Giglioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Ala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Airoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Donadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Ricardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"1061_CR1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","volume":"378","author":"S Darby","year":"2011","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG), Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials. Lancet. 2011;378:1707\u201316.","journal-title":"Lancet"},{"key":"1061_CR2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12032-013-0518-7","volume":"30","author":"D Cante","year":"2013","unstructured":"Cante D, Franco P, Sciacero P, Girelli G, Marra AM, Pasquino M, et al. Five-year results of a prospective case series of accelerated hypofractionated whole breast radiation with concomitant boost to the tumor bed after conserving surgery for early breast cancer. Med Oncol. 2013;30:518.","journal-title":"Med Oncol"},{"key":"1061_CR3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12032-017-1020-4","volume":"34","author":"D Cante","year":"2017","unstructured":"Cante D, Petrucci E, Sciacero P, Piva C, Ferrario S, et al. Ten-year results of accelerated hypofractionated adjuvant whole-breast radiation with concomitant boost to the lumpectomy cavity after conserving surgery for early breast cancer. Med Oncol. 2017;34:152.","journal-title":"Med Oncol"},{"key":"1061_CR4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s12032-014-0838-2","volume":"31","author":"D Cante","year":"2014","unstructured":"Cante D, Franco P, Sciacero P, Girelli G, Marra AM, Pasquino M, et al. Hypofractionation and concomitant boost to deliver adjuvant whole-breast radiation in ductal carcinoma in situ (DCIS): a subgroup analysis of a prospective case series. Med Oncol. 2014;31:838.","journal-title":"Med Oncol"},{"key":"1061_CR5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000369845","volume":"10","author":"P Franco","year":"2015","unstructured":"Franco P, Cante D, Sciacero P, Girelli G, La Porta MR, Ricardi U. Tumor bed boost integration during whole breast radiotherapy: a review of the current evidence. Breast Care. 2015;10:44\u20139.","journal-title":"Breast Care"},{"key":"1061_CR6","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(14)60488-8","volume":"383","author":"P McGale","year":"2014","unstructured":"EBCTCG (Early Breast Cancer Trialists\u2019 Collaborative Group), McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet Oncol. 2014;383:2127\u201335.","journal-title":"Lancet Oncol"},{"key":"1061_CR7","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1056\/NEJMoa1415369","volume":"373","author":"PM Poortmans","year":"2015","unstructured":"Poortmans PM, Struikmans H, Bartelink H. Regional nodal irradiation in early-stage breast cancer. N Engl J Med. 2015;373:1879\u201380.","journal-title":"N Engl J Med"},{"key":"1061_CR8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/030089161109700414","volume":"97","author":"P Franco","year":"2011","unstructured":"Franco P, Catuzzo P, Cante D, La Porta MR, Sciacero P, Girelli G, et al. TomoDirect: an efficient means to deliver radiation at static angles with tomotherapy. Tumori. 2011;97:498\u2013502.","journal-title":"Tumori"},{"key":"1061_CR9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.meddos.2017.02.007","volume":"42","author":"A Coffey","year":"2017","unstructured":"Coffey A, Renucci L, Hunzeker A, Lenards N. Whole breast nodal irradiation using supine VMAT and prone 3D planning: a case study. Med Dosim. 2017;42:185\u20139.","journal-title":"Med Dosim"},{"key":"1061_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1748-717X-7-211","volume":"7","author":"VC Borca","year":"2012","unstructured":"Borca VC, Franco P, Catuzzo P, Migliaccio F, Zenone F, Aimonetto S, et al. Does TomoDirect 3DCRT represent a suitable option for post-operative whole breast irradiation? A hypothesis-generating pilot study. Radiat Oncol. 2012;7:211.","journal-title":"Radiat Oncol"},{"key":"1061_CR11","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00432-013-1515-0","volume":"139","author":"P Franco","year":"2013","unstructured":"Franco P, Zeverino M, Migliaccio F, Sciacero P, Cante D, Casanova Borca V, et al. Intensity-modulated adjuvant whole breast radiation delivered with static angle tomotherapy (TomoDirect): a prospective case series. J Cancer Res Clin Oncol. 2013;139:1927\u201336.","journal-title":"J Cancer Res Clin Oncol"},{"key":"1061_CR12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1259\/bjr\/22373346","volume":"84","author":"M Teoh","year":"2011","unstructured":"Teoh M, Clark CH, Wood K, Whitaker S, Nisbet A. Volumetric modulated arc therapy: a review of current literature and clinical use in practice. Br J Radiol. 2011;84:967\u201396.","journal-title":"Br J Radiol"},{"issue":"89","key":"1061_CR13","first-page":"20150832","volume":"2016","author":"P Franco","year":"1060","unstructured":"Franco P, Arcadipane F, Ragona R, Mistrangelo M, Cassoni P, Munoz F, et al. Volumetric modulated arc therapy (VMAT) in the combined modality treatment of anal cancer patients. Br J Radiol. 1060;2016(89):20150832.","journal-title":"Br J Radiol"},{"key":"1061_CR14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12032-016-0821-1","volume":"33","author":"F Arcadipane","year":"2016","unstructured":"Arcadipane F, Franco P, De Colle C, Rondi N, Di Muzio J, Pelle E, et al. Hypofractionation with no boost after breast conservation in early-stage breast cancer patients. Med Oncol. 2016;33:108.","journal-title":"Med Oncol"},{"key":"1061_CR15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1148\/radiol.2212010247","volume":"221","author":"CN Madu","year":"2001","unstructured":"Madu CN, Quint DJ, Normolle DP, Marsh RB, Wang EY, Pierce LJ. Definition of the supraclavicular and infraclavicular nodes: implications for three-dimensional CT-based conformal radiation therapy. Radiology. 2001;221:333\u20139.","journal-title":"Radiology"},{"key":"1061_CR16","unstructured":"RTOG Breast Cancer Atlas. Radiation Therapy Oncology Group website. https:\/\/www.rtog.org . Accessed on October 2nd 2017."},{"key":"1061_CR17","unstructured":"Radiation Therapy Oncology Group. Acute radiation morbidity scoring criteria. http:\/\/www.rtog.org . Accessed 2 Oct 2017."},{"key":"1061_CR18","unstructured":"National Cancer Institute Cancer Therapy Evaluation Program. Common Toxiity Criteria for Adverse Events. Version 4.02. http:\/\/ctep.cancer.gov . Accessed 2 Oct 2017."},{"key":"1061_CR19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/archsurg.1989.01410020023002","volume":"124","author":"MA Rose","year":"1989","unstructured":"Rose MA, Olivotto IA, Cady B, Koufman C, Osteen R, Silver B, et al. Conservative surgery and radiation therapy for early stage breast cancer: long-term cosmetic results. Arch Surg. 1989;124:153\u20137.","journal-title":"Arch Surg"},{"key":"1061_CR20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.radonc.2007.06.002","volume":"84","author":"P Poortmans","year":"2007","unstructured":"Poortmans P. Evidence-based radiation oncology. Breast Cancer Radiother Oncol. 2007;84:84\u2013101.","journal-title":"Breast Cancer Radiother Oncol"},{"key":"1061_CR21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1524-4741.2011.01159.x","volume":"17","author":"D Cante","year":"2011","unstructured":"Cante D, Rosa La Porta M, Casanova-Borca V, Sciacero P, Girelli G, Pasquino M, et al. Accelerated hypofractionated adjuvant whole breast radiotherapy with concomitant photon boost after conserving surgery for early stage breast cancer: a prospective evaluation on 463 patients. Breast J. 2011;17:586\u201393.","journal-title":"Breast J"},{"key":"1061_CR22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5301\/tj.5000402","volume":"102","author":"D Cante","year":"2016","unstructured":"Cante D, Franco P, Sciacero P, Girelli G, Pasquino M, Borca Casanova, et al. Hypofractionated whole-breast radiotherapy and concomitant boost after breast conservation in elderly patients. Tumori. 2016;102:196\u2013202.","journal-title":"Tumori"},{"key":"1061_CR23","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/j.breast.2017.06.035","volume":"34","author":"AS Moreno","year":"2017","unstructured":"Moreno AS, Shaitelman SF, Bucholz TA. A clinical perspective on regional irradiation for breast cancer. The Breast. 2017;34:S85\u201390.","journal-title":"The Breast"},{"key":"1061_CR24","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1056\/NEJM199710023371401","volume":"337","author":"M Overgaard","year":"1997","unstructured":"Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med. 1997;337:949\u201355.","journal-title":"N Engl J Med"},{"key":"1061_CR25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1415369","volume":"373","author":"P Poortmans","year":"2015","unstructured":"Poortmans P, Collette S, Kirkove C, Van Limbergen E, Budach V, Struikmans H, et al. Internal mammary and medial supraclavicular irradiation in breast cancer. N Engl J Med. 2015;373:317\u201327.","journal-title":"N Engl J Med"},{"key":"1061_CR26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1056\/NEJMoa1415340","volume":"373","author":"TJ Whelan","year":"2015","unstructured":"Whelan TJ, Olivotto IA, Parulekar WR, Ackerman I, Chua BH, Nabid A, et al. Regional nodal irradiation in early-stage breast cancer. N Engl J Med. 2015;373:307\u201316.","journal-title":"N Engl J Med"},{"key":"1061_CR27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1586\/14737140.2014.883282","volume":"14","author":"B Bari De","year":"2014","unstructured":"De Bari B, Fiorentino A, Arcangeli S, Franco P, D\u2019Angelillo RM, Alongi F. From radiobiology to technology: what is changing in radiotherapy for prostate cancer. Expert Rev Anticancer Ther. 2014;14:553\u201364.","journal-title":"Expert Rev Anticancer Ther"},{"key":"1061_CR28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00432-013-1560-8","volume":"140","author":"P Franco","year":"2014","unstructured":"Franco P, Zeverino M, Migliaccio F, Cante D, Sciecero P, Casanova Borca V, et al. Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics ports of tomotherapy (TomoDirect): a prospective phase II trial. J Cancer Res Clin Oncol. 2014;140:167\u201377.","journal-title":"J Cancer Res Clin Oncol"},{"key":"1061_CR29","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.2147\/OTT.S113119","volume":"10","author":"G Macchia","year":"2017","unstructured":"Macchia G, Deodato F, Cilla S, Cammelli S, Guido A, Ferioli M, et al. Volumetric modulated arc therapy for treatment of solid tumors: current insights. Onco Targets Ther. 2017;10:3755\u201372.","journal-title":"Onco Targets Ther"},{"key":"1061_CR30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijrobp.2009.05.038","volume":"76","author":"CC Popescu","year":"2010","unstructured":"Popescu CC, Olivotto IA, Beckham WA, Ansbacher W, Zavgorodni S, Shaffer R, et al. Volumetric modulated arc therapy improves dosimetry and reduces treatment time compared to conventional intensity-modulated radiotherapy for loco-regional radiotherapy of left-sided breast cancer and internal mammary nodes. Int J Radiat Oncol Biol Phys. 2010;76:287\u201395.","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-017-1061-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-017-1061-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-017-1061-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T15:09:04Z","timestamp":1570374544000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-017-1061-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1061"],"URL":"https:\/\/doi.org\/10.1007\/s12032-017-1061-8","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]},"article-number":"1"}}