{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:06:53Z","timestamp":1790183213241,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["2016\/533"],"award-info":[{"award-number":["2016\/533"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FoUU, Region Halland, Sweden"},{"name":"Swedish LUA\/ALF Foundation","award":["ALFGBG-143521"],"award-info":[{"award-number":["ALFGBG-143521"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s12032-018-1122-7","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T07:49:41Z","timestamp":1522914581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of matrix metalloproteinases in tumour invasion: immunohistochemistry of peritoneum from peritoneal carcinomatosis"],"prefix":"10.1007","volume":"35","author":[{"given":"Peter","family":"Falk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"Swartling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Asplund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-0024","authenticated-orcid":false,"given":"Marie-Lois","family":"Ivarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"1122_CR1","volume-title":"Peritoneum, peritoneal healing, and adhesion formation. Peritoneal surgery","author":"GS diZerega","year":"2000","unstructured":"diZerega GS. Peritoneum, peritoneal healing, and adhesion formation. Peritoneal surgery. New York: Springer; 2000."},{"issue":"Suppl 2","key":"1122_CR2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1463-1318.2007.01345.x","volume":"9","author":"JB Wal van der","year":"2007","unstructured":"van der Wal JB, Jeekel J. Biology of the peritoneum in normal homeostasis and after surgical trauma. Colorectal Dis. 2007;9(Suppl 2):9\u201313.","journal-title":"Colorectal Dis"},{"issue":"3","key":"1122_CR3","first-page":"947","volume":"32","author":"FJ Lejeune","year":"2012","unstructured":"Lejeune FJ. Is Surgical Trauma Prometastatic? Anticancer Res. 2012;32(3):947\u201351.","journal-title":"Anticancer Res"},{"key":"1122_CR4","volume-title":"Tissue remodelling proteases as prognostic factors in colon and rectal cancer","author":"M Langenski\u00f6ld","year":"2009","unstructured":"Langenski\u00f6ld M. Tissue remodelling proteases as prognostic factors in colon and rectal cancer. G\u00f6teborg: G\u00f6teborgs universitet; 2009."},{"issue":"8496","key":"1122_CR5","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/S0140-6736(86)91510-2","volume":"1","author":"RJ Heald","year":"1986","unstructured":"Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1(8496):1479\u201382.","journal-title":"Lancet"},{"issue":"5","key":"1122_CR6","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1245\/s10434-013-3461-0","volume":"21","author":"HC Santvoort van","year":"2014","unstructured":"van Santvoort HC, Braam HJ, Spekreijse KR, Koning NR, de Bruin PC, de Vries Reilingh TS, et al. Peritoneal carcinomatosis in t4 colorectal cancer: occurrence and risk factors. Ann Surg Oncol. 2014;21(5):1686\u201391. https:\/\/doi.org\/10.1245\/s10434-013-3461-0 .","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"1122_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ejso.2012.03.001","volume":"38","author":"PH Cashin","year":"2012","unstructured":"Cashin PH, Graf W, Nygren P, Mahteme H. Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis: prognosis and treatment of recurrences in a cohort study. Eur J Surg Oncol. 2012;38(6):509\u201315. https:\/\/doi.org\/10.1016\/j.ejso.2012.03.001 .","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"1122_CR8","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1245\/s10434-012-2784-6","volume":"20","author":"JO Pelz","year":"2013","unstructured":"Pelz JO, Vetterlein M, Grimmig T, Kerscher AG, Moll E, Lazariotou M, et al. Hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis: role of heat shock proteins and dissecting effects of hyperthermia. Ann Surg Oncol. 2013;20(4):1105\u201313. https:\/\/doi.org\/10.1245\/s10434-012-2784-6 .","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"1122_CR9","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1093\/carcin\/20.5.749","volume":"20","author":"ZS Zeng","year":"1999","unstructured":"Zeng ZS, Cohen AM, Guillem JG. Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis. Carcinogenesis. 1999;20(5):749\u201355.","journal-title":"Carcinogenesis"},{"issue":"23","key":"1122_CR10","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1007\/s00018-011-0763-x","volume":"68","author":"H Hua","year":"2011","unstructured":"Hua H, Li M, Luo T, Yin Y, Jiang Y. Matrix metalloproteinases in tumorigenesis: an evolving paradigm. Cell Mol Life Sci. 2011;68(23):3853\u201368. https:\/\/doi.org\/10.1007\/s00018-011-0763-x .","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1122_CR11","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3390\/cancers6010366","volume":"6","author":"AH Said","year":"2014","unstructured":"Said AH, Raufman JP, Xie G. The role of matrix metalloproteinases in colorectal cancer. Cancers. 2014;6(1):366\u201375. https:\/\/doi.org\/10.3390\/cancers6010366 .","journal-title":"Cancers"},{"issue":"2","key":"1122_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1634\/theoncologist.5-2-108","volume":"5","author":"E Sunami","year":"2000","unstructured":"Sunami E, Tsuno N, Osada T, Saito S, Kitayama J, Tomozawa S, et al. MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer. Oncologist. 2000;5(2):108\u201314.","journal-title":"Oncologist"},{"issue":"3","key":"1122_CR13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00384-004-0667-4","volume":"20","author":"M Langenskiold","year":"2005","unstructured":"Langenskiold M, Holmdahl L, Falk P, Ivarsson ML. Increased plasma MMP-2 protein expression in lymph node-positive patients with colorectal cancer. Int J Colorectal Dis. 2005;20(3):245\u201352.","journal-title":"Int J Colorectal Dis"},{"issue":"6","key":"1122_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00384-008-0452-x","volume":"23","author":"A Solberg","year":"2008","unstructured":"Solberg A, Holmdahl L, Falk P, Palmgren I, Ivarsson ML. A local imbalance between MMP and TIMP may have an implication on the severity and course of appendicitis. Int J Colorectal Dis. 2008;23(6):611\u20138.","journal-title":"Int J Colorectal Dis"},{"issue":"8","key":"1122_CR15","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3109\/02841860903150510","volume":"48","author":"E Angenete","year":"2009","unstructured":"Angenete E, Oresland T, Falk P, Breimer M, Hultborn R, Ivarsson ML. Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen components. Acta Oncol. 2009;48(8):1144\u201351.","journal-title":"Acta Oncol."},{"issue":"1","key":"1122_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.tice.2016.11.004","volume":"49","author":"JO Baal van","year":"2017","unstructured":"van Baal JO, Van de Vijver KK, Nieuwland R, van Noorden CJ, van Driel WJ, Sturk A, et al. The histophysiology and pathophysiology of the peritoneum. Tissue Cell. 2017;49(1):95\u2013105. https:\/\/doi.org\/10.1016\/j.tice.2016.11.004 .","journal-title":"Tissue Cell"},{"issue":"2","key":"1122_CR17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.47102\/annals-acadmedsg.V32N2p219","volume":"32","author":"DG Jayne","year":"2003","unstructured":"Jayne DG. The molecular biology of peritoneal carcinomatosis from gastrointestinal cancer. Ann Acad Med Singap. 2003;32(2):219\u201325.","journal-title":"Ann Acad Med Singap"},{"issue":"9","key":"1122_CR18","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.ijsu.2013.06.005","volume":"11","author":"P Falk","year":"2013","unstructured":"Falk P, Angenete E, Bergstrom M, Ivarsson ML. TGF-beta1 promotes transition of mesothelial cells into fibroblast phenotype in response to peritoneal injury in a cell culture model. Int J Surg. 2013;11(9):977\u201382. https:\/\/doi.org\/10.1016\/j.ijsu.2013.06.005 .","journal-title":"Int J Surg"},{"issue":"3","key":"1122_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1046\/j.1440-1843.2002.00404.x","volume":"7","author":"SE Mutsaers","year":"2002","unstructured":"Mutsaers SE. Mesothelial cells: their structure, function and role in serosal repair. Respirology. 2002;7(3):171\u201391.","journal-title":"Respirology"},{"issue":"11","key":"1122_CR20","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1046\/j.1365-2168.1998.00859.x","volume":"85","author":"ML Ivarsson","year":"1998","unstructured":"Ivarsson ML, Bergstrom M, Eriksson E, Risberg B, Holmdahl L. Tissue markers as predictors of postoperative adhesions. Br J Surg. 1998;85(11):1549\u201354.","journal-title":"Br J Surg"},{"issue":"Suppl 2","key":"1122_CR21","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.fertnstert.2005.03.078","volume":"84","author":"CJ Sikkink","year":"2005","unstructured":"Sikkink CJ, Reijnen MM, Falk P, van Goor H, Holmdahl L. Influence of monocyte-like cells on the fibrinolytic activity of peritoneal mesothelial cells and the effect of sodium hyaluronate. Fertil Steril. 2005;84(Suppl 2):1072\u20137.","journal-title":"Fertil Steril"},{"issue":"6","key":"1122_CR22","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/S0015-0282(01)02875-8","volume":"76","author":"N Chegini","year":"2001","unstructured":"Chegini N, Kotseos K, Zhao Y, Ma C, McLean F, Diamond MP, et al. Expression of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertil Steril. 2001;76(6):1212\u20139.","journal-title":"Fertil Steril"},{"key":"1122_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/bjs.1800600412","volume":"60","author":"AT Raftery","year":"1973","unstructured":"Raftery AT. Regeneration of parietal and visceral peritoneum. A light microscopical study. Br J Surg. 1973;60:293\u20139.","journal-title":"Br J Surg"},{"key":"1122_CR24","first-page":"375","volume":"115","author":"AT Raftery","year":"1973","unstructured":"Raftery AT. Regeneration of parietal and visceral peritoneum: an electron microscopical study. J Anat. 1973;115:375\u201392.","journal-title":"J Anat"},{"issue":"5","key":"1122_CR25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.humpath.2015.01.014","volume":"46","author":"P Desmeules","year":"2015","unstructured":"Desmeules P, Trudel D, Turcotte S, Sirois J, Plante M, Gregoire J, et al. Prognostic significance of TIMP-2, MMP-2, and MMP-9 on high-grade serous ovarian carcinoma using digital image analysis. Hum Pathol. 2015;46(5):739\u201345. https:\/\/doi.org\/10.1016\/j.humpath.2015.01.014 .","journal-title":"Hum Pathol"},{"issue":"6","key":"1122_CR26","first-page":"634","volume":"3","author":"T Takeuchi","year":"2010","unstructured":"Takeuchi T, Iwasaki S, Miyazaki J, Nozaki Y, Takahashi M, Ono M, et al. Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane. Int J Clin Exp Pathol. 2010;3(6):634\u20139.","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-018-1122-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-018-1122-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-018-1122-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T19:13:21Z","timestamp":1720206801000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-018-1122-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["1122"],"URL":"https:\/\/doi.org\/10.1007\/s12032-018-1122-7","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,5]]},"assertion":[{"value":"14 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The sampling of human peritoneal tissue was approved by the Local Ethics Committee (University of Gothenburg, Dnr: \u00d6728-03), in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"64"}}