{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:15:19Z","timestamp":1790813719699,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T00:00:00Z","timestamp":1525478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s12032-018-1144-1","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T07:18:34Z","timestamp":1525504714000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["A review of HPRT and its emerging role in cancer"],"prefix":"10.1007","volume":"35","author":[{"given":"Michelle H.","family":"Townsend","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-6217","authenticated-orcid":false,"given":"Kim L.","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,5]]},"reference":[{"issue":"3","key":"1144_CR1","doi-asserted-by":"publisher","first-page":"16587","DOI":"10.1021\/bc00003a001","volume":"1","author":"J Goodchild","year":"1990","unstructured":"Goodchild J. Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties. Bioconjug Chem. 1990;1(3):165\u201387.","journal-title":"Bioconjug Chem"},{"issue":"1","key":"1144_CR2","doi-asserted-by":"publisher","first-page":"349400","DOI":"10.1146\/annurev.bi.60.070191.002025","volume":"60","author":"Y Kaziro","year":"1991","unstructured":"Kaziro Y, Itoh H, et al. Signal-transducing structure and function of GTP-binding proteins. Ann Rev Biochem 1991;60(1):349\u2013400.","journal-title":"Ann Rev Biochem"},{"issue":"1","key":"1144_CR3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1574-6976.1998.tb00358.x","volume":"22","author":"E Schneider","year":"1998","unstructured":"Schneider E, Hunke S. ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits\/domains. FEMS Microbiol Rev 1998;22(1):1\u201320.","journal-title":"FEMS Microbiol Rev"},{"key":"1144_CR4","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1111\/j.1365-2958.2005.04620.x","volume":"56","author":"L Rajagopal","year":"2005","unstructured":"Rajagopal L, Vo A, Silvestroni A, Rubens CE. Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae. Mol Microbiol. 2005;56:1329\u201346. \n                    https:\/\/doi.org\/10.1111\/j.1365-2958.2005.04620.x\n                    \n                  .","journal-title":"Mol Microbiol"},{"key":"1144_CR5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv047","author":"AN Lane","year":"2015","unstructured":"Lane AN, Fan TW. Regulation of mammalian nucleotide metabolism and biosynthesis. Nucleic Acids Res. 2015. \n                    https:\/\/doi.org\/10.1093\/nar\/gkv047\n                    \n                  .","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"1144_CR6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/00005176-198305000-00018","volume":"2","author":"NS LeLeiko","year":"1983","unstructured":"LeLeiko NS, Bronstein AD, Baliga BS, Munro HN. De novo purine nucleotide synthesis in the rat small and large intestine: effect of dietary protein and purines. J Pediatr Gastroenterol Nutr. 1983;2(2):313\u20139.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"25","key":"1144_CR7","doi-asserted-by":"publisher","first-page":"742835","DOI":"10.1021\/ja00363a037","volume":"105","author":"A Gross","year":"1983","unstructured":"Gross A, Lewis JM, George M. Practical synthesis of 5-phospho-D-ribosyl. alpha.-1-pyrophosphate (PRPP): enzymatic routes from ribose 5-phosphate or ribose. J Am Chem Soc. 1983;105(25):7428\u201335.","journal-title":"J Am Chem Soc"},{"key":"1144_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.01.002","author":"X Tong","year":"2009","unstructured":"Tong X, Zhao F, Thompson CB. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Curr Opin Genet Dev. 2009. \n                    https:\/\/doi.org\/10.1016\/j.gde.2009.01.002\n                    \n                  .","journal-title":"Curr Opin Genet Dev"},{"issue":"46","key":"1144_CR9","first-page":"53953","volume":"28","author":"A Becerra","year":"1998","unstructured":"Becerra A, Lazcano A. The role of gene duplication in the evolution of purine nucleotide salvage pathways. Orig Life Evol Biosph. 1998;28(4\u20136):539\u201353.","journal-title":"Orig Life Evol Biosph"},{"issue":"1","key":"1144_CR10","doi-asserted-by":"publisher","first-page":"12748","DOI":"10.1146\/annurev.ge.19.120185.001015","volume":"19","author":"JT Stout","year":"1985","unstructured":"Stout JT, Caskey CT. Hprt: gene structure, expression, and mutation. Ann Rev Genet. 1985;19(1):127\u201348","journal-title":"Ann Rev Genet"},{"key":"1144_CR11","doi-asserted-by":"crossref","unstructured":"Caskey CT, Kruh GD. (1979) The HPRT locus review. Cell 1979;16(1):1\u20139.","DOI":"10.1016\/0092-8674(79)90182-X"},{"key":"1144_CR12","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1073\/pnas.80.3.870","volume":"80","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Tarr GE, Kelley WN. Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. Proc Natl Acad Sci USA. 1983;80:870\u20133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1144_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0092-8674(94)90301-8","volume":"78","author":"JC Eads","year":"1994","unstructured":"Eads JC, Xu Y, Grubmeyer C. The crystal structure with bound GMP of human phosphoribosyltransferase. Cell 1994;78:325\u201334.","journal-title":"Cell"},{"key":"1144_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jmb.2005.05.061","volume":"351","author":"DT Keough","year":"2005","unstructured":"Keough DT, Brereton IM, De Jersey J, Guddat LW. The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. J Mol Biol. 2005;351:170\u201381. \n                    https:\/\/doi.org\/10.1016\/j.jmb.2005.05.061\n                    \n                  .","journal-title":"J Mol Biol"},{"key":"1144_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2016.03.007","author":"N Zhang","year":"2016","unstructured":"Zhang N, Gong X, Lu M, et al. Crystal structures of Apo and GMP bound hypoxanthine\u2014guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis. J Struct Biol. 2016. \n                    https:\/\/doi.org\/10.1016\/j.jsb.2016.03.007\n                    \n                  .","journal-title":"J Struct Biol"},{"key":"1144_CR16","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1128\/MCB.3.6.1086","volume":"3","author":"JC Fuscoe","year":"1983","unstructured":"Fuscoe JC, Fenwick IRG, Ledbetter IDH, Caskey CT. Deletion and amplification of the HGPRT locus in Chinese hamster cells. Mol Cell Biol 1983;3:1086\u201396.","journal-title":"Mol Cell Biol"},{"key":"1144_CR17","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1073\/pnas.80.3.870","volume":"80","author":"JM Wilson","year":"1983","unstructured":"Wilson JM, Tarrt GE, Kelley WN. Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. Proc Natl Acad Sci USA. 1983;80:870\u20133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1144_CR18","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1093\/nar\/14.7.3103","volume":"14","author":"SH Kim","year":"1986","unstructured":"Kim SH, Moores JC, David D, et al. The organization of the human HPRT gene. Nucleic Acids Res. 1986;14:3103\u201318.","journal-title":"Nucleic Acids Res"},{"key":"1144_CR19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0092-8674(86)90766-X","volume":"44","author":"DW Melton","year":"1986","unstructured":"Melton DW, Mcewan C, Reid AM, Mckie B. Expression of the mouse HPRT gene: deletional analysis of the promoter region of an X-chromosome linked housekeeping gene. Cell 1986;44:319\u201328.","journal-title":"Cell"},{"key":"1144_CR20","doi-asserted-by":"publisher","first-page":"6977","DOI":"10.1073\/pnas.78.11.6977","volume":"78","author":"CT Caskey","year":"1981","unstructured":"Caskey CT. In vitro translation of hypoxanthine\/guanine phosphoribosyltransferase mRNA: characterization of a mouse neuroblastoma cell line that has elevated levels of hypoxanthine\/guanine phosphoribosyltransferase protein. Proc Natl Acad Sci USA. 1981;78:6977\u201380.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1144_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0925-4439(99)00103-9","volume":"1500","author":"E Zoref-Shani","year":"2000","unstructured":"Zoref-Shani E, Frishberg Y, Bromberg Y. Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations. BBA Mol Basis Dis. 2000;1500:197\u2013203.","journal-title":"BBA Mol Basis Dis"},{"key":"1144_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470015902.a0001457.pub2","volume-title":"Lesch\u2013Nyhan syndrome","author":"WL Nyhan","year":"2012","unstructured":"Nyhan WL, Diego S. (2012) Lesch\u2013Nyhan syndrome. Wiley, Chichester, pp.\u00a01\u20136. \n                    https:\/\/doi.org\/10.1002\/9780470015902.a0001457.pub2\n                    \n                  ."},{"key":"1144_CR23","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cca.2015.04.018","volume":"447","author":"E Kostalova","year":"2015","unstructured":"Kostalova E, Pavelka K, Vlaskova H, et al. Hyperuricemia and gout due to deficiency of hypoxanthine\u2014guanine phosphoribosyltransferase in female carriers: new insight to differential diagnosis.. Clin Chim Acta. 2015;447:121. \n                    https:\/\/doi.org\/10.1016\/j.cca.2015.04.018\n                    \n                  .","journal-title":"Clin Chim Acta"},{"key":"1144_CR24","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1073\/pnas.80.15.4709","volume":"80","author":"AD Miller","year":"1983","unstructured":"Miller AD, Jollyt DJ, Friedmannt T, Verma IM. A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT Proc Natl Acad Sci USA. 1983;80:4709\u201313..","journal-title":"Proc Natl Acad Sci USA"},{"key":"1144_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/00005792-200103000-00003","volume":"80","author":"JOMA Rcas","year":"2001","unstructured":"Rcas JOMA, U\u00f1o ANSB, Eill PAON. The spectrum of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency clinical experience based on 22 patients from 18 Spanish families. Medicine 2001;80:102\u201312.","journal-title":"Medicine"},{"key":"1144_CR26","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1126\/science.155.3770.1682","volume":"155","author":"JE Seegmiller","year":"2016","unstructured":"Seegmiller JE, Rosenbloom FM, Kelley WN. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science 2016;155:1682\u20134.","journal-title":"Science"},{"key":"1144_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1172-2-48","volume":"10","author":"RJ Torres","year":"2007","unstructured":"Torres RJ, Puig JG. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome. Orphanet J Rare Dis 2007;10:1\u201310. \n                    https:\/\/doi.org\/10.1186\/1750-1172-2-48\n                    \n                  .","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"1144_CR28","doi-asserted-by":"publisher","first-page":"18895","DOI":"10.1172\/JCI112275","volume":"77","author":"JM Wilson","year":"1986","unstructured":"Wilson JM, Stout JT, Palella TD, Davidson BL, Kelley WN, Caskey CT. A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. J Clin Invest. 1986;77(1):188\u201395","journal-title":"J Clin Invest"},{"key":"1144_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1073-8","author":"KK Jagarlamudi","year":"2015","unstructured":"Jagarlamudi KK, Hansson LO, Eriksson S. Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker. BMC Cancer. 2015. \n                    https:\/\/doi.org\/10.1186\/s12885-015-1073-8\n                    \n                  .","journal-title":"BMC Cancer"},{"key":"1144_CR30","unstructured":"Alegre MM, Grose J. Thymidine kinase 1: diagnostic and prognostic significance in malignancy, Doctoral dissertation, Brigham Young University, Provo; 2013."},{"key":"1144_CR31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.canlet.2011.10.025","volume":"316","author":"S Aufderklamm","year":"2012","unstructured":"Aufderklamm S, Todenh\u00f6fer T, Gakis G, et al. Thymidine kinase and cancer monitoring. Cancer Lett. 2012;316:6\u201310. \n                    https:\/\/doi.org\/10.1016\/j.canlet.2011.10.025\n                    \n                  .","journal-title":"Cancer Lett"},{"key":"1144_CR32","first-page":"145","volume":"13","author":"HX Li","year":"2005","unstructured":"Li HX, Lei DS, Wang XQ, et al. Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer. Oncol Rep. 2005;13:145\u20139..","journal-title":"Oncol Rep"},{"key":"1144_CR33","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/sj.leu.2404536","volume":"21","author":"KL O\u2019Neill","year":"2007","unstructured":"O\u2019Neill KL, Zhang F, Li H, et al. Thymidine kinase 1\u2014a prognostic and diagnostic indicator in ALL and AML patients. Leukemia 2007;21:560\u20133. \n                    https:\/\/doi.org\/10.1038\/sj.leu.2404536\n                    \n                  .","journal-title":"Leukemia"},{"key":"1144_CR34","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/172460080001500203","volume":"15","author":"Q He","year":"2000","unstructured":"He Q, Zou L, Zhang PA, et al. The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody. Int J Biol Mark. 2000;15:139\u201346.","journal-title":"Int J Biol Mark"},{"key":"1144_CR35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1515\/cclm-2012-0162","volume":"51","author":"B Nisman","year":"2013","unstructured":"Nisman B, Allweis T, Kadouri L, et al. Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients. Clin Chem Lab Med. 2013;51:439\u201347. \n                    https:\/\/doi.org\/10.1515\/cclm-2012-0162","journal-title":"Clin Chem Lab Med"},{"key":"1144_CR36","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/03009730802688835","volume":"114","author":"L Carlsson","year":"2009","unstructured":"Carlsson L, Larsson A, Lindman H. Elevated levels of thymidine kinase 1 peptide in serum from patients with breast cancer. Ups J Med Sci. 2009;114:116\u201320. \n                    https:\/\/doi.org\/10.1080\/03009730802688835\n                    \n                  .","journal-title":"Ups J Med Sci"},{"key":"1144_CR37","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/jcla.21587","volume":"226","author":"M Bolayirli","year":"2013","unstructured":"Bolayirli M, Papila C, Korkmaz GG, et al. Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy. J Clin Lab Anal. 2013;226:220\u20136. \n                    https:\/\/doi.org\/10.1002\/jcla.21587\n                    \n                  .","journal-title":"J Clin Lab Anal"},{"key":"1144_CR38","first-page":"2145","volume":"34","author":"MM Alegre","year":"2014","unstructured":"Alegre MM, Weyant MJ, Bennett DT, et al. Serum detection of thymidine kinase 1 as a means of early detection of lung cancer. Anticancer Res. 2014;34:2145\u201352.","journal-title":"Anticancer Res"},{"key":"1144_CR39","first-page":"8","volume":"25","author":"F Zhang","year":"2001","unstructured":"Zhang F, Li H, Pendleton AR, et al. Thymidine kinase 1 immunoassay: a potential marker for breast cancer. Cancer Detect Prev. 2001;25:8\u201315.","journal-title":"Cancer Detect Prev"},{"key":"1144_CR40","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/15257771003738535","volume":"29","author":"E He","year":"2010","unstructured":"He E, Xu XH, Guan H, et al. Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin\u2019s lymphoma. Nucleosides Nucleotides Nucleic Acids. 2010;29:352\u20138. \n                    https:\/\/doi.org\/10.1080\/15257771003738535\n                    \n                  .","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"1144_CR41","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/carcin\/bgx009","volume":"38","author":"Y-J Chang","year":"2017","unstructured":"Chang Y-J, Tseng C-Y, Lin P-Y, et al. Acute exposure to DEHP metabolite, MEHP cause genotoxicity, mutagenesis and carcinogenicity in mammalian Chinese hamster ovary cells. Carcinogenesis 2017;38:336\u201345. \n                    https:\/\/doi.org\/10.1093\/carcin\/bgx009\n                    \n                  .","journal-title":"Carcinogenesis"},{"key":"1144_CR42","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mrgentox.2017.03.001","volume":"816\u2013817","author":"J Gobrecht","year":"2017","unstructured":"Gobrecht J, McDyre C, Comotto J, Reynolds M. Induction of cytotoxic and genotoxic damage following exposure of V79 cells to cadmium chloride. Mutat Res Toxicol Environ Mutagen. 2017;816\u2013817:12\u20137. \n                    https:\/\/doi.org\/10.1016\/j.mrgentox.2017.03.001\n                    \n                  .","journal-title":"Mutat Res Toxicol Environ Mutagen"},{"key":"1144_CR43","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0027-5107(92)90186-6","volume":"266","author":"S Grist","year":"1992","unstructured":"Grist S, McCarron M, Kutlaca A, et al. In vivo human somatic mutation: frequency and spectrum with age. Mutat Res. 1992;266:189\u201396. \n                    https:\/\/doi.org\/10.1016\/0027-5107(92)90186-6\n                    \n                  .","journal-title":"Mutat Res"},{"key":"1144_CR44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0165-1218(93)90069-P","volume":"319","author":"H Hirota","year":"1993","unstructured":"Hirota H, Kubota M, Hashimoto H, et al. Analysis of hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia. Mutat Res Toxicol. 1993;319:113\u201320.","journal-title":"Mutat Res Toxicol"},{"key":"1144_CR45","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0165-1161(94)90053-1","volume":"313","author":"DR Robinson","year":"1994","unstructured":"Robinson DR, Albertini RJ, Neill O, Finette B, Sala-trepat M, Moustacchi E, et al. An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets. Mutat Res. 1994;313:227\u201347.","journal-title":"Mutat Res"},{"key":"1144_CR46","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0027-5107(79)90140-4","volume":"61","author":"GH Strauss","year":"1979","unstructured":"Strauss GH, Albertini RJ. Enumeration of 6-thioguanine-resistant peripheral blood lymphocytes in man as a potential test for somatic cell mutations arising in vivo. Mutat Res Mol Mech Mutagen. 1979;61:353\u201379. \n                    https:\/\/doi.org\/10.1016\/0027-5107(79)90140-4\n                    \n                  .","journal-title":"Mutat Res Mol Mech Mutagen"},{"key":"1144_CR47","doi-asserted-by":"publisher","first-page":"6617","DOI":"10.1073\/pnas.79.21.6617","volume":"79","author":"RJ Albertini","year":"1982","unstructured":"Albertini RJ, Castle KL, Borcherding WR. T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood. Proc Natl Acad Sci USA. 1982;79:6617\u201321. \n                    https:\/\/doi.org\/10.1073\/pnas.79.21.6617\n                    \n                  .","journal-title":"Proc Natl Acad Sci USA"},{"key":"1144_CR48","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2307\/3431307","volume":"94","author":"PJE Compton","year":"1991","unstructured":"Compton PJE, Hooper K, Smith MT. Human somatic mutation assays as biomarkers of carcinogenesis. Environ Health Perspect. 1991;94:135\u201341.","journal-title":"Environ Health Perspect"},{"key":"1144_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1383-5742(01)00064-3","volume":"489","author":"RJ Albertini","year":"2001","unstructured":"Albertini RJ. HPRT mutations in humans: biomarkers for mechanistic studies. Mutat Res Rev Mutat Res. 2001;489:1\u201316.","journal-title":"Mutat Res Rev Mutat Res"},{"key":"1144_CR50","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/carcin\/20.3.437","volume":"20","author":"S Hou","year":"1999","unstructured":"Hou S, Yang K, Nyberg F, et al. Hprt mutant frequency and aromatic DNA adduct level in non-smoking and smoking lung cancer patients and population controls. Carcinogenesis 1999;20:437\u201344.","journal-title":"Carcinogenesis"},{"key":"1144_CR51","doi-asserted-by":"crossref","unstructured":"Branda RF, Sullivan LM, O\u2019neill JP, Falta MT, Nicklas JA, Hirsch B, Vacek PM, Albertini RJ, Vacek PM, Albertini RJ. Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations. 1993;285:267\u201379.","DOI":"10.1016\/0027-5107(93)90115-V"},{"key":"1144_CR52","first-page":"711","volume":"7","author":"M Sawada","year":"1998","unstructured":"Sawada M, Kubota M, Lin YW, Watanabe K, Koishi S, Usami I, et al. Prospective study of mutant frequencies at the hprt and T-cell receptor gene loci in pediatric cancer patients during chemotherapy. Cancer Epidemiol Biomarkers. 1998;7:711\u20137.","journal-title":"Cancer Epidemiol Biomarkers"},{"issue":"2","key":"1144_CR53","doi-asserted-by":"publisher","first-page":"33743","DOI":"10.1016\/S0027-5107(97)00233-9","volume":"397","author":"M Sawada","year":"1998","unstructured":"Sawada M, Kubota M, Lin Y, Watanabe K. Evaluation of mutant frequencies at the hprt and the T-cell receptor loci in pediatric cancer patients before treatment. Mutat Res Fundam Mol Mech Mutag 1998;397(2):337\u201343.","journal-title":"Mutat Res Fundam Mol Mech Mutag"},{"key":"1144_CR54","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/em.2850190403","volume":"19","author":"RF Branda","year":"1992","unstructured":"Branda RF, O\u2019Neill JP, Jacobson-Kram D, Albertini RJ. Factors influencing mutation at the hprt locus in T-lymphocytes: studies in normal women and women with benign and malignant breast masses. Environ Mol Mutagen. 1992;19:274\u201381.","journal-title":"Environ Mol Mutagen"},{"key":"1144_CR55","first-page":"10918","volume":"332","author":"T Cheng","year":"1995","unstructured":"Cheng T, Christiani DC, Liber HL, Wain JC, Xu X, Wiencke JK, et al. Mutant frequency at the hprt locus in human lymphocytes in a case-control study of lung cancer. Mutat Res Mol Mech Mutag. 1995;332:109\u201318.","journal-title":"Mutat Res Mol Mech Mutag"},{"key":"1144_CR56","doi-asserted-by":"crossref","unstructured":"Duthie SJ, Collins R. (1995) The influence of smoking and diet on the hypoxanthine phosphoribosyltransferase mutant frequency in circulating T lymphocytes from a normal human population. Mutat Res Mol Mech Mutag. 1995;331:55\u201364.","DOI":"10.1016\/0027-5107(95)00051-J"},{"key":"1144_CR57","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0027-5107(88)90109-1","volume":"201","author":"M Hakoda","year":"1988","unstructured":"Hakoda M, Akiyama M, Kyoizumi S, Awa AA. Increased somatic cell mutant frequency in atomic bomb survivors. Mutat Res Mol Mech Mutag. 1988;201:39\u201348.","journal-title":"Mutat Res Mol Mech Mutag"},{"key":"1144_CR58","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0027-5107(94)90303-4","volume":"307","author":"AD Tates","year":"1994","unstructured":"Tates AD, Van Dam FJ, Natarajan AT, Zwinderman AH, Osanto S. Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: a prospective study. Mutat Res. 1994;307:293\u2013306.","journal-title":"Mutat Res"},{"key":"1144_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/carcin\/18.1.1","volume":"18","author":"WE Glaab","year":"1997","unstructured":"Glaab WE, Tindall KR. Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. Carcinogenesis 1997;18:1\u20138.","journal-title":"Carcinogenesis"},{"key":"1144_CR60","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/35065016","volume":"410","author":"B Homey","year":"2001","unstructured":"Homey B, Soto H, Ge N, Catron D, Buchanan ME, Mcclanahan T, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001;410:50\u20136.","journal-title":"Nature"},{"key":"1144_CR61","doi-asserted-by":"publisher","first-page":"19","DOI":"10.5539\/cco.v6n2p19","volume":"6","author":"MH Townsend","year":"2017","unstructured":"Townsend MH, Felsted AM, Ence ZE, Piccolo SR, Robison RA, O\u2019Neill KL. Elevated expression of hypoxanthine guanine phosphoribosyltransferase within malignant tissue. Cancer Clin Oncol. 2017;6:19.","journal-title":"Cancer Clin Oncol"},{"key":"1144_CR62","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.2147\/OTT.S128416","volume":"10","author":"MH Townsend","year":"2017","unstructured":"Townsend MH, Anderson MD, Weagel EG, Velazquez EJ, Weber KS, Robison RA, et al. Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane. Onco Targets Ther. 2017;10:1921\u201332.","journal-title":"Onco Targets Ther"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-018-1144-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-018-1144-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-018-1144-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T10:29:53Z","timestamp":1557138593000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-018-1144-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,5]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1144"],"URL":"https:\/\/doi.org\/10.1007\/s12032-018-1144-1","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,5]]},"assertion":[{"value":"20 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All the authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human and animal participants"}}],"article-number":"89"}}