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Y.T. has received honoraria from AstraZeneca, Eisai, Pfizer, Allergan, Johnson & Johnson. T.S and A.O. have received research funding AstraZeneca, Eisai, Ono, Kyowa Hakko, Daiichi-Sankyo, Taiho, Chugai, Nippon Kayaku, Bayer, MSD, Nihon-Mediphysics, Hamamatsu-photonics and Parexel on the other studies. S.N. has been an advisor for AstraZeneca, Novartis and Taiho, has received honoraria from Sysmex, AstraZeneca, Chugai, Nippon Kayaku, Novartis and Takeda, and has received research funding from Sysmex, AstraZeneca, Chugai, Daiichi-Sankyo, Eisai, Nippon Kayaku, Novartis, Ono, Pfizer, Taiho and Takeda on the other studies. S.N. hold the joint patents with Sysmex on subjects not related to this study. M.D. and M.K. are employees of Sysmex Corporation. The other Authors do not declare any conflict of interest related to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the institutional review boards of all participating institutions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all patients included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"54"}}