{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:27:24Z","timestamp":1782538044667,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770531"],"award-info":[{"award-number":["81770531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12032-020-01439-w","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T08:05:48Z","timestamp":1605513948000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Iron overload is related to muscle wasting in patients with cachexia of gastric cancer: using quantitative proteome analysis"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-5952","authenticated-orcid":false,"given":"Da","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsudum","family":"Mamtawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-9210","authenticated-orcid":false,"given":"Xinying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"1439_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.21147\/j.issn.1000-9604.2018.03.01","volume":"30","author":"L Yang","year":"2018","unstructured":"Yang L, Zheng R, Wang N, Yuan Y, Liu S, Li H, et al. Incidence and mortality of stomach cancer in China, 2014. Chin J Cancer Res. 2018;30:291\u20138.","journal-title":"Chin J Cancer Res"},{"key":"1439_CR2","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.3748\/wjg.v22.i8.2403","volume":"22","author":"A Digklia","year":"2016","unstructured":"Digklia A, Wagner AD. Advanced gastric cancer: current treatment landscape and future perspectives. World J Gastroenterol. 2016;22:2403\u201314.","journal-title":"World J Gastroenterol"},{"key":"1439_CR3","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1080\/01635581.2015.1073753","volume":"67","author":"L Sun","year":"2015","unstructured":"Sun L, Quan XQ, Yu S. An epidemiological survey of cachexia in advanced cancer patients and analysis on its diagnostic and treatment status. Nutr Cancer. 2015;67:1056\u201362.","journal-title":"Nutr Cancer"},{"key":"1439_CR4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev-med-061509-131248","volume":"62","author":"S Dodson","year":"2011","unstructured":"Dodson S, Baracos VE, Jatoi A, Evans WJ, Cella D, Dalton JT, et al. Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies. Annu Rev Med. 2011;62:265\u201379.","journal-title":"Annu Rev Med"},{"key":"1439_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12:489\u201395.","journal-title":"Lancet Oncol"},{"key":"1439_CR6","doi-asserted-by":"publisher","first-page":"e3164","DOI":"10.1097\/MD.0000000000003164","volume":"95","author":"C-L Zhuang","year":"2016","unstructured":"Zhuang C-L, Huang D-D, Pang W-Y, Zhou C-J, Wang S-L, Lou N, et al. Sarcopenia is an independent predictor of severe postoperative complications and long-term survival after radical gastrectomy for gastric cancer. Medicine. 2016;95:e3164.","journal-title":"Medicine"},{"key":"1439_CR7","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1245\/s10434-017-5811-9","volume":"24","author":"K Kudou","year":"2017","unstructured":"Kudou K, Saeki H, Nakashima Y, Edahiro K, Korehisa S, Taniguchi D, et al. Prognostic significance of sarcopenia in patients with esophagogastric junction cancer or upper gastric cancer. Ann Surg Oncol. 2017;24:1804\u201310.","journal-title":"Ann Surg Oncol"},{"key":"1439_CR8","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1038\/s41596-018-0006-9","volume":"13","author":"P Mertins","year":"2018","unstructured":"Mertins P, Tang LC, Krug K, Clark DJ, Gritsenko MA, Chen L, et al. Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry. Nat Protoc. 2018;13:1632\u201361.","journal-title":"Nat Protoc"},{"issue":"Suppl 1","key":"1439_CR9","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1111\/hdi.12542","volume":"21","author":"S Dev","year":"2017","unstructured":"Dev S, Babitt JL. Overview of iron metabolism in health and disease. Hemodial Int. 2017;21(Suppl 1):S6-s20.","journal-title":"Hemodial Int"},{"key":"1439_CR10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jhep.2015.02.031","volume":"63","author":"N Fujiwara","year":"2015","unstructured":"Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, et al. Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. J Hepatol. 2015;63:131\u201340.","journal-title":"J Hepatol"},{"key":"1439_CR11","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/ajcn\/nqz347","volume":"111","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Wang J, Wang X, Gao T, Tian H, Zhou D, et al. The autophagic-lysosomal and ubiquitin proteasome systems are simultaneously activated in the skeletal muscle of gastric cancer patients with cachexia. Am J Clin Nutr. 2020;111:570\u20139.","journal-title":"Am J Clin Nutr"},{"key":"1439_CR12","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1056\/NEJMra1004967","volume":"366","author":"RE Fleming","year":"2012","unstructured":"Fleming RE, Ponka P. Iron overload in human disease. N Engl J Med. 2012;366:348\u201359.","journal-title":"N Engl J Med"},{"key":"1439_CR13","doi-asserted-by":"publisher","first-page":"1559s","DOI":"10.3945\/ajcn.117.155804","volume":"106","author":"GJ Anderson","year":"2017","unstructured":"Anderson GJ, Frazer DM. Current understanding of iron homeostasis. Am J Clin Nutr. 2017;106:1559s-s1566.","journal-title":"Am J Clin Nutr"},{"key":"1439_CR14","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/mus.20808","volume":"36","author":"M Altun","year":"2007","unstructured":"Altun M, Edstrom E, Spooner E, Flores-Moralez A, Bergman E, Tollet-Egnell P, et al. Iron load and redox stress in skeletal muscle of aged rats. Muscle Nerve. 2007;36:223\u201333.","journal-title":"Muscle Nerve"},{"key":"1439_CR15","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1113\/expphysiol.2008.046045","volume":"94","author":"TF Reardon","year":"2009","unstructured":"Reardon TF, Allen DG. Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance. Exp Physiol. 2009;94:720\u201330.","journal-title":"Exp Physiol"},{"key":"1439_CR16","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jtemb.2016.01.011","volume":"35","author":"Y Ikeda","year":"2016","unstructured":"Ikeda Y, Imao M, Satoh A, Watanabe H, Hamano H, Horinouchi Y, et al. Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3\u2013E3 ubiquitin ligase-dependent pathway. J Trace Elem Med Biol. 2016;35:66\u201376.","journal-title":"J Trace Elem Med Biol"},{"key":"1439_CR17","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/ng1658","volume":"37","author":"RS Ohgami","year":"2005","unstructured":"Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37:1264\u20139.","journal-title":"Nat Genet"},{"key":"1439_CR18","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1126\/science.1104742","volume":"306","author":"E Nemeth","year":"2004","unstructured":"Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090\u20133.","journal-title":"Science"},{"key":"1439_CR19","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1016\/j.jnutbio.2011.12.002","volume":"23","author":"F Du","year":"2012","unstructured":"Du F, Qian ZM, Gong Q, Zhu ZJ, Lu L, Ke Y. The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells. J Nutr Biochem. 2012;23:1694\u2013700.","journal-title":"J Nutr Biochem"},{"key":"1439_CR20","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1158\/0008-5472.CAN-14-3804","volume":"75","author":"Z Gu","year":"2015","unstructured":"Gu Z, Wang H, Xia J, Yang Y, Jin Z, Xu H, et al. Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. Cancer Res. 2015;75:2211\u201321.","journal-title":"Cancer Res"},{"key":"1439_CR21","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3892\/ol.2015.3363","volume":"10","author":"D Xue","year":"2015","unstructured":"Xue D, Zhou CX, Shi YB, Lu H, He XZ. Decreased expression of ferroportin in prostate cancer. Oncol Lett. 2015;10:913\u20136.","journal-title":"Oncol Lett"},{"key":"1439_CR22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc3495","volume":"13","author":"SV Torti","year":"2013","unstructured":"Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer. 2013;13:342\u201355.","journal-title":"Nat Rev Cancer"},{"key":"1439_CR23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/ijms20010095","volume":"20","author":"Y Wang","year":"2018","unstructured":"Wang Y, Yu L, Ding J, Chen Y. Iron metabolism in cancer. Int J Mol Sci. 2018;20:95.","journal-title":"Int J Mol Sci."},{"key":"1439_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","volume":"1275","author":"PM Harrison","year":"1996","unstructured":"Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta. 1996;1275:161\u2013203.","journal-title":"Biochim Biophys Acta"},{"key":"1439_CR25","doi-asserted-by":"publisher","first-page":"33352","DOI":"10.1074\/jbc.271.52.33352","volume":"271","author":"P Rucker","year":"1996","unstructured":"Rucker P, Torti FM, Torti SV. Role of H and L subunits in mouse ferritin. J Biol Chem. 1996;271:33352\u20137.","journal-title":"J Biol Chem"},{"key":"1439_CR26","doi-asserted-by":"publisher","first-page":"e90105","DOI":"10.1371\/journal.pone.0090105","volume":"9","author":"TH Kim","year":"2014","unstructured":"Kim TH, Hwang HJ, Kim SH. Relationship between serum ferritin levels and sarcopenia in Korean females aged 60 years and older using the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008\u20132009. PLoS ONE. 2014;9:e90105.","journal-title":"PLoS ONE"},{"key":"1439_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1053\/j.jrn.2016.01.011","volume":"26","author":"C Nakagawa","year":"2016","unstructured":"Nakagawa C, Inaba M, Ishimura E, Yamakawa T, Shoji S, Okuno S. Association of increased serum ferritin with impaired muscle strength\/quality in hemodialysis patients. J Ren Nutr. 2016;26:253\u20137.","journal-title":"J Ren Nutr"},{"key":"1439_CR28","first-page":"1141","volume":"39","author":"LW Oberley","year":"1979","unstructured":"Oberley LW, Buettner GR. Role of superoxide dismutase in cancer: a review. Cancer Res. 1979;39:1141\u20139.","journal-title":"Cancer Res"},{"key":"1439_CR29","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/35030140","volume":"407","author":"P Huang","year":"2000","unstructured":"Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature. 2000;407:390\u20135.","journal-title":"Nature"},{"key":"1439_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","volume":"30","author":"HJ Forman","year":"2009","unstructured":"Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009;30:1\u201312.","journal-title":"Mol Aspects Med"},{"key":"1439_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","volume":"524","author":"D Tsikas","year":"2017","unstructured":"Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem. 2017;524:13\u201330.","journal-title":"Anal Biochem"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-020-01439-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12032-020-01439-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-020-01439-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T16:37:18Z","timestamp":1606927038000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12032-020-01439-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,16]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1439"],"URL":"https:\/\/doi.org\/10.1007\/s12032-020-01439-w","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,16]]},"assertion":[{"value":"16 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There are no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of the Jinling hospital (Approval No. 2017NZKY-003-01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involved in human rights"}}],"article-number":"113"}}