{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:48:00Z","timestamp":1793396880375,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s12032-021-01579-7","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:03:00Z","timestamp":1632290580000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of electroporation on anticancer activity of 5-FU and newly synthesized zinc(II) complex in chemotherapy-resistance human brain tumor cells"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-2873","authenticated-orcid":false,"given":"Mehmet E\u015fref","family":"Alk\u0131\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Alan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi","family":"Irtegun Kandemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Buldurun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"1579_CR1","doi-asserted-by":"publisher","first-page":"129946","DOI":"10.1016\/j.molstruc.2021.129946","volume":"1231","author":"B Naureen","year":"2021","unstructured":"Naureen B, Miana GA, Shahid K, Asghar M, Tanveer S, Sarwar A. Iron (III) and zinc (II) monodentate Schiff base metal complexes: synthesis, characterisation and biological activities. J Mol Struct. 2021;1231:129946. https:\/\/doi.org\/10.1016\/j.molstruc.2021.129946.","journal-title":"J Mol Struct"},{"key":"1579_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.saa.2017.01.018","volume":"176","author":"A Rauf","year":"2017","unstructured":"Rauf A, Shah A, Khan AA, Shah AH, Abbasi R, Qureshi IZ, et al. Synthesis, pH dependent photometric and electrochemical investigation, redox mechanism and biological applications of novel Schiff base and its metallic derivatives. Spectrochim Acta A. 2017;176:155\u201367. https:\/\/doi.org\/10.1016\/j.saa.2017.01.018.","journal-title":"Spectrochim Acta A"},{"issue":"7","key":"1579_CR3","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1039\/B307853C","volume":"33","author":"PG Cozzi","year":"2004","unstructured":"Cozzi PG. Metal-Salen Schiff base complexes in catalysis: practical aspects. Chem Soc Rev. 2004;33(7):410\u201321. https:\/\/doi.org\/10.1039\/B307853C.","journal-title":"Chem Soc Rev"},{"issue":"12","key":"1579_CR4","doi-asserted-by":"publisher","first-page":"996","DOI":"10.2174\/1570178616666190315154512","volume":"16","author":"K-C Gan","year":"2019","unstructured":"Gan K-C, Sim K-M, Lim T-M, Teo K-C. Synthesis, cytotoxic, antibacterial and free radical scavenging activities of Schiff bases derived from 1,2,4-triazole. Lett Org Chem. 2019;16(12):996\u20131003. https:\/\/doi.org\/10.2174\/1570178616666190315154512.","journal-title":"Lett Org Chem"},{"issue":"24","key":"1579_CR5","doi-asserted-by":"publisher","first-page":"4398","DOI":"10.1080\/00958972.2010.532871","volume":"63","author":"AA Nejo","year":"2010","unstructured":"Nejo AA, Kolawole GA, Nejo AO. Synthesis, characterization, antibacterial, and thermal studies of unsymmetrical Schiff-base complexes of cobalt(II). J Coord Chem. 2010;63(24):4398\u2013410. https:\/\/doi.org\/10.1080\/00958972.2010.532871.","journal-title":"J Coord Chem"},{"key":"1579_CR6","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.molstruc.2018.12.055","volume":"1181","author":"RH Taha","year":"2019","unstructured":"Taha RH, El-Shafiey ZA, Salman AA, El-Fakharany EM, Mansour MM. Synthesis and characterization of newly synthesized Schiff base ligand and its metal complexes as potent anticancer. J Mol Struct. 2019;1181:536\u201345. https:\/\/doi.org\/10.1016\/j.molstruc.2018.12.055.","journal-title":"J Mol Struct"},{"issue":"16","key":"1579_CR7","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.3390\/MOLECULES25163584","volume":"25","author":"PA Ajibade","year":"2020","unstructured":"Ajibade PA, Andrew FP, Botha NL, Solomane N. Synthesis, crystal structures and anticancer studies of morpholinyldithiocarbamato Cu(II) and Zn(II) complexes. Molecules. 2020;25(16):3584. https:\/\/doi.org\/10.3390\/MOLECULES25163584.","journal-title":"Molecules"},{"key":"1579_CR8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/J.CANLET.2020.09.028","volume":"496","author":"H Wang","year":"2021","unstructured":"Wang H, Zhou H, Xu J, Lu Y, Ji X, Yao Y, et al. Different T-cell subsets in glioblastoma multiforme and targeted immunotherapy. Cancer Lett. 2021;496:134\u201343. https:\/\/doi.org\/10.1016\/J.CANLET.2020.09.028.","journal-title":"Cancer Lett"},{"key":"1579_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/S41419-019-1477-5","author":"G Mazor","year":"2019","unstructured":"Mazor G, Levin L, Picard D, Ahmadov U, Car\u00e9n H, Borkhardt A, et al. The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Cell Death Dis. 2019. https:\/\/doi.org\/10.1038\/S41419-019-1477-5.","journal-title":"Cell Death Dis"},{"issue":"8","key":"1579_CR10","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3390\/MOLECULES25081947","volume":"25","author":"AB \u021aigu","year":"2020","unstructured":"\u021aigu AB, Toma V-A, Mo\u021b AC, Jurj A, Moldovan CS, Fischer-Fodor E, et al. The synergistic antitumor effect of 5-fluorouracil combined with allicin against lung and colorectal carcinoma cells. Molecules. 2020;25(8):1947. https:\/\/doi.org\/10.3390\/MOLECULES25081947.","journal-title":"Molecules"},{"issue":"5","key":"1579_CR11","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/NRC1074","volume":"3","author":"DB Longley","year":"2003","unstructured":"Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330\u20138. https:\/\/doi.org\/10.1038\/NRC1074.","journal-title":"Nat Rev Cancer"},{"issue":"18","key":"1579_CR12","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.7150\/JCA.20196","volume":"8","author":"H Yang","year":"2017","unstructured":"Yang H, Huang S, Wei Y, Cao S, Pi C, Feng T, et al. Curcumin enhances the anticancer effect of 5-fluorouracil against gastric cancer through down-regulation of COX-2 and NF-\u03baB signaling pathways. J Cancer. 2017;8(18):3697\u2013706. https:\/\/doi.org\/10.7150\/JCA.20196.","journal-title":"J Cancer"},{"issue":"3","key":"1579_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/S11243-018-0285-6","volume":"44","author":"A Popovi\u0107","year":"2019","unstructured":"Popovi\u0107 A, Nikoli\u0107 M, Mijajlovi\u0107 M, Ratkovi\u0107 Z, Jevti\u0107 V, Trifunovi\u0107 SR, et al. DNA binding and antitumor activities of zinc(II) complexes with some S-alkenyl derivatives of thiosalicylic acid. Transit Met Chem. 2019;44(3):219\u201328. https:\/\/doi.org\/10.1007\/S11243-018-0285-6.","journal-title":"Transit Met Chem"},{"issue":"13","key":"1579_CR14","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1016\/j.poly.2008.04.009","volume":"27","author":"D Kovala-Demertzi","year":"2008","unstructured":"Kovala-Demertzi D, Alexandratos A, Papageorgiou A, Yadav PN, Dalezis P, Demertzis MA. Synthesis, characterization, crystal structures, in vitro and in vivo antitumor activity of palladium(II) and zinc(II) complexes with 2-formyl and 2-acetyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone. Polyhedron. 2008;27(13):2731\u20138. https:\/\/doi.org\/10.1016\/j.poly.2008.04.009.","journal-title":"Polyhedron"},{"issue":"24","key":"1579_CR15","doi-asserted-by":"publisher","first-page":"5814","DOI":"10.3390\/MOLECULES25245814","volume":"25","author":"M Porchia","year":"2020","unstructured":"Porchia M, Pellei M, Del Bello F, Santini C. Zinc complexes with nitrogen donor ligands as anticancer agents. Molecules. 2020;25(24):5814. https:\/\/doi.org\/10.3390\/MOLECULES25245814.","journal-title":"Molecules"},{"issue":"19","key":"1579_CR16","doi-asserted-by":"publisher","first-page":"6768","DOI":"10.1039\/C3DT50367D","volume":"42","author":"BS Mendiguchia","year":"2013","unstructured":"Mendiguchia BS, Pucci D, Mastropietro TF, Ghedini M, Crispini A. Non-classical anticancer agents: on the way to water soluble zinc(ii) heteroleptic complexes. Dalton Trans. 2013;42(19):6768. https:\/\/doi.org\/10.1039\/C3DT50367D.","journal-title":"Dalton Trans"},{"issue":"3","key":"1579_CR17","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1515\/RAON-2017-0034","volume":"51","author":"S Kranjc","year":"2017","unstructured":"Kranjc S, Cemazar M, Sersa G, Scancar J, Grabner S. In vitro and in vivo evaluation of electrochemotherapy with trans-platinum analogue trans-[PtCl2(3-Hmpy)2]. Radiol Oncol. 2017;51(3):295\u2013306. https:\/\/doi.org\/10.1515\/RAON-2017-0034.","journal-title":"Radiol Oncol"},{"issue":"02","key":"1579_CR18","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4149\/NEO_2018_170329N227","volume":"65","author":"M Fiorentzis","year":"2018","unstructured":"Fiorentzis M, Kalirai H, Katopodis P, Seitz B, Viestenz A, Coupland SE. Electrochemotherapy with bleomycin and cisplatin enhances cytotoxicity in primary and metastatic uveal melanoma cell lines in vitro. Neoplasma. 2018;65(02):210\u20135. https:\/\/doi.org\/10.4149\/NEO_2018_170329N227.","journal-title":"Neoplasma"},{"key":"1579_CR19","doi-asserted-by":"publisher","first-page":"153303381878532","DOI":"10.1177\/1533033818785329","volume":"17","author":"U Probst","year":"2018","unstructured":"Probst U, Fuhrmann I, Beyer L, Wiggermann P. Electrochemotherapy as a new modality in interventional oncology: a review. Technol Cancer Res Treat. 2018;17:153303381878532. https:\/\/doi.org\/10.1177\/1533033818785329.","journal-title":"Technol Cancer Res Treat"},{"key":"1579_CR20","first-page":"195","volume-title":"Tumors of the central nervous system","author":"M Linnert","year":"2011","unstructured":"Linnert M, Agerholm-Larsen B, Mahmood F, Iversen HK, Gehl J. Electrochemotherapy for primary and secondary brain tumors. In: Hayat MA, editor. Tumors of the central nervous system, vol. 3. Dordrecht: Springer, Netherlands; 2011. p. 195\u2013206."},{"key":"1579_CR21","doi-asserted-by":"publisher","first-page":"129402","DOI":"10.1016\/J.MOLSTRUC.2020.129402","volume":"1226","author":"ME Alk\u0131\u015f","year":"2021","unstructured":"Alk\u0131\u015f ME, Kele\u015ftem\u00fcr \u00dc, Alan Y, Turan N, Buldurun K. Cobalt and ruthenium complexes with pyrimidine based schiff base: synthesis, characterization, anticancer activities and electrochemotherapy efficiency. J Mol Struct. 2021;1226:129402. https:\/\/doi.org\/10.1016\/J.MOLSTRUC.2020.129402.","journal-title":"J Mol Struct"},{"issue":"2","key":"1579_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1053\/j.seminoncol.2019.04.002","volume":"46","author":"LG Campana","year":"2019","unstructured":"Campana LG, Miklav\u010di\u010d D, Bertino G, Marconato R, Valpione S, Imarisio I, et al. Electrochemotherapy of superficial tumors\u2014current status. Semin Oncol. 2019;46(2):173\u201391. https:\/\/doi.org\/10.1053\/j.seminoncol.2019.04.002.","journal-title":"Semin Oncol"},{"key":"1579_CR23","doi-asserted-by":"crossref","unstructured":"Sersa G, Cemazar M, Snoj M (2009) Electrochemotherapy of tumours. Curr Oncol. 16(2):34\u20135. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2669236","DOI":"10.3747\/co.v16i2.368"},{"issue":"6","key":"1579_CR24","doi-asserted-by":"publisher","first-page":"pdb.prot095505","DOI":"10.1101\/pdb.prot095505","volume":"2018","author":"P Kumar","year":"2018","unstructured":"Kumar P, Nagarajan A, Uchil PD. Analysis of cell viability by the MTT assay. Cold Spring Harb Protoc. 2018;2018(6):pdb.prot095505. https:\/\/doi.org\/10.1101\/pdb.prot095505.","journal-title":"Cold Spring Harb Protoc."},{"key":"1579_CR25","first-page":"41","volume-title":"Nanoparticle-mediated targeted delivery of antiretrovirals to the brain. Methods in enzymology","author":"SD Mahajan","year":"2012","unstructured":"Mahajan SD, Law W-C, Aalinkeel R, Reynolds J, Nair BB, Yong K-T, et al. Nanoparticle-mediated targeted delivery of antiretrovirals to the brain. Methods in enzymology. Amsterdam: Elsevier; 2012. p. 41\u201360."},{"key":"1579_CR26","doi-asserted-by":"publisher","first-page":"129842","DOI":"10.1016\/j.molstruc.2020.129842","volume":"1229","author":"H Kargar","year":"2021","unstructured":"Kargar H, Ardakani AA, Tahir MN, Ashfaq M, Munawar KS. Synthesis, spectral characterization, crystal structure determination and antimicrobial activity of Ni(II), Cu(II) and Zn(II) complexes with the Schiff base ligand derived from 3,5-dibromosalicylaldehyde. J Mol Struct. 2021;1229:129842. https:\/\/doi.org\/10.1016\/j.molstruc.2020.129842.","journal-title":"J Mol Struct"},{"issue":"1","key":"1579_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.poly.2012.07.041","volume":"45","author":"TA Yousef","year":"2012","unstructured":"Yousef TA, Abu El-Reash GM, El Morshedy RM. Quantum chemical calculations, experimental investigations and DNA studies on (E)-2-((3-hydroxynaphthalen-2-yl)methylene)-N-(pyridin-2-yl)hydrazinecarbothioamide and its Mn(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes. Polyhedron. 2012;45(1):71\u201385. https:\/\/doi.org\/10.1016\/j.poly.2012.07.041.","journal-title":"Polyhedron"},{"key":"1579_CR28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.molstruc.2017.12.075","volume":"1157","author":"AK El-Sawaf","year":"2018","unstructured":"El-Sawaf AK, El-Essawy F, Nassar AA, El-Samanody E-SA. Synthesis, spectral, thermal and antimicrobial studies on cobalt(II), nickel(II), copper(II), zinc(II) and palladium(II) complexes containing thiosemicarbazone ligand. J Mol Struct. 2018;1157:381\u201394. https:\/\/doi.org\/10.1016\/j.molstruc.2017.12.075.","journal-title":"J Mol Struct."},{"key":"1579_CR29","doi-asserted-by":"publisher","first-page":"127860","DOI":"10.1016\/J.MOLSTRUC.2020.127860","volume":"1208","author":"SM El-Medani","year":"2020","unstructured":"El-Medani SM, Makhlouf AA, Moustafa H, Afifi MA, Haukka M, Ramadan RM. Spectroscopic, crystal structural, theoretical and biological studies of phenylacetohydrazide Schiff base derivatives and their copper complexes. J Mol Struct. 2020;1208:127860. https:\/\/doi.org\/10.1016\/J.MOLSTRUC.2020.127860.","journal-title":"J Mol Struct"},{"issue":"4","key":"1579_CR30","doi-asserted-by":"publisher","first-page":"415","DOI":"10.2298\/JSC0804415S","volume":"73","author":"C Sp\u00eenu","year":"2008","unstructured":"Sp\u00eenu C, Pleniceanu M, Tigae C. Biologically active new Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of N-(2-thienylmethylene)methanamine. J Serb Chem Soc. 2008;73(4):415\u201321. https:\/\/doi.org\/10.2298\/JSC0804415S.","journal-title":"J Serb Chem Soc"},{"key":"1579_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/439848","volume":"2013","author":"P Jeslin Kanaga Inba","year":"2013","unstructured":"Jeslin Kanaga Inba P, Annaraj B, Thalamuthu S, Neelakantan MA. Cu(II), Ni(II), and Zn(II) complexes of Salan-type ligand containing ester groups: synthesis, characterization, electrochemical properties, andIn vitrobiological activities. Bioinorg Chem Appl. 2013;2013:1\u201311. https:\/\/doi.org\/10.1155\/2013\/439848.","journal-title":"Bioinorg Chem Appl"},{"issue":"5","key":"1579_CR32","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.saa.2011.04.064","volume":"79","author":"SEH Etaiw","year":"2011","unstructured":"Etaiw SEH, Abd El-Aziz DM, Abd El-Zaher EH, Ali EA. Synthesis, spectral, antimicrobial and antitumor assessment of Schiff base derived from 2-aminobenzothiazole and its transition metal complexes. Spectrochim Acta A Mol Biomol Spectrosc. 2011;79(5):1331\u20137. https:\/\/doi.org\/10.1016\/j.saa.2011.04.064.","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"issue":"1","key":"1579_CR33","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/J.ARABJC.2017.09.015","volume":"13","author":"A Rauf","year":"2020","unstructured":"Rauf A, Shah A, Munawar KS, Ali S, Nawaz Tahir M, Javed M, et al. Synthesis, physicochemical elucidation, biological screening and molecular docking studies of a Schiff base and its metal(II) complexes. Arab J Chem. 2020;13(1):1130\u201341. https:\/\/doi.org\/10.1016\/J.ARABJC.2017.09.015.","journal-title":"Arab J Chem"},{"issue":"5","key":"1579_CR34","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1007\/s10895-017-2118-y","volume":"27","author":"N Revathi","year":"2017","unstructured":"Revathi N, Sankarganesh M, Rajesh J, Raja JD. Biologically active cu(II), co(II), Ni(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DNA binding, antioxidant, antibacterial and in vitro anticancer studies. J Fluoresc. 2017;27(5):1801\u201314. https:\/\/doi.org\/10.1007\/s10895-017-2118-y.","journal-title":"J Fluoresc"},{"issue":"9","key":"1579_CR35","doi-asserted-by":"publisher","first-page":"e108166","DOI":"10.1371\/JOURNAL.PONE.0108166","volume":"9","author":"SY Lee","year":"2014","unstructured":"Lee SY, Slagle-Webb B, Rizk E, Patel A, Miller PA, Sung S-S, et al. Characterization of a novel anti-cancer compound for astrocytomas. PLoS ONE. 2014;9(9):e108166. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0108166.","journal-title":"PLoS ONE"},{"issue":"8","key":"1579_CR36","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1039\/c9mt00124g","volume":"11","author":"P Yu","year":"2019","unstructured":"Yu P, Deng J, Cai J, Zhang Z, Zhang J, Hamid Khan M, et al. Anticancer and biological properties of a Zn-2,6-diacetylpyridine bis(thiosemicarbazone) complex. Metallomics. 2019;11(8):1372\u201386. https:\/\/doi.org\/10.1039\/c9mt00124g.","journal-title":"Metallomics"},{"key":"1579_CR37","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.molstruc.2016.10.099","volume":"1130","author":"MA Arafath","year":"2017","unstructured":"Arafath MA, Adam F, Razali MR, Ahmed Hassan LE, Ahamed MBK, Majid AMSA. Synthesis, characterization and anticancer studies of Ni(II), Pd(II) and Pt(II) complexes with Schiff base derived from N-methylhydrazinecarbothioamide and 2-hydroxy-5-methoxy-3-nitrobenzaldehyde. J Mol Struct. 2017;1130:791\u20138. https:\/\/doi.org\/10.1016\/j.molstruc.2016.10.099.","journal-title":"J Mol Struct"},{"key":"1579_CR38","first-page":"6","volume":"11","author":"M Ta\u015fpinar","year":"2019","unstructured":"Ta\u015fpinar M, Denizler FN, G\u00fcven M, Y\u00fcksek V, \u00c7etin S, Dede S. The cytotoxic effect of 5-FU and celastrol on glioblastoma. Van Health Sciences J. 2019;11:6\u201310.","journal-title":"Van Health Sciences J"},{"issue":"1","key":"1579_CR39","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/J.cbi.2013.08.008","volume":"206","author":"A-M Gao","year":"2013","unstructured":"Gao A-M, Ke Z-P, Shi F, Sun G-C, Chen H. Chrysin enhances sensitivity of BEL-7402\/ADM cells to doxorubicin by suppressing PI3K\/Akt\/Nrf2 and ERK\/Nrf2 pathway. Chem Biol Interact. 2013;206(1):100\u20138. https:\/\/doi.org\/10.1016\/J.cbi.2013.08.008.","journal-title":"Chem Biol Interact"},{"issue":"5","key":"1579_CR40","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.biopha.2014.05.005","volume":"68","author":"J Saczko","year":"2014","unstructured":"Saczko J, Kami\u0144ska I, Kotulska M, Bar J, Choroma\u0144ska A, Rembia\u0142kowska N, et al. Combination of therapy with 5-fluorouracil and cisplatin with electroporation in human ovarian carcinoma model in vitro. Biomed Pharmacother. 2014;68(5):573\u201380. https:\/\/doi.org\/10.1016\/j.biopha.2014.05.005.","journal-title":"Biomed Pharmacother"},{"key":"1579_CR41","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1852965","author":"ME Alk\u0131\u015f","year":"2020","unstructured":"Alk\u0131\u015f ME, Buldurun K, Turan N, Alan Y, Y\u0131lmaz \u00dcK, Mantarc\u0131 A. Synthesis, characterization, antiproliferative of pyrimidine based ligand and its Ni(II) and Pd(II) complexes and effectiveness of electroporation. J Biomol Struct Dyn. 2020. https:\/\/doi.org\/10.1080\/07391102.2020.1852965.","journal-title":"J Biomol Struct Dyn"},{"issue":"2","key":"1579_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4155\/FMC.12.201","volume":"5","author":"K Saleem","year":"2013","unstructured":"Saleem K, Wani WA, Haque A, Lone MN, Hsieh M-F, Jairajpuri MA, et al. Synthesis, DNA binding, hemolysis assays and anticancer studies of copper(II), nickel(II) and iron(III) complexes of a pyrazoline-based ligand. Future Med Chem. 2013;5(2):135\u201346. https:\/\/doi.org\/10.4155\/FMC.12.201.","journal-title":"Future Med Chem"},{"issue":"9","key":"1579_CR43","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/sj.bjc.6600606","volume":"87","author":"G Sersa","year":"2002","unstructured":"Sersa G, Krzic M, Sentjurc M, Ivanusa T, Beravs K, Kotnik V, et al. Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin. Br J Cancer. 2002;87(9):1047\u201354. https:\/\/doi.org\/10.1038\/sj.bjc.6600606.","journal-title":"Br J Cancer"},{"issue":"2A","key":"1579_CR44","first-page":"1151","volume":"21","author":"M Cemazar","year":"2001","unstructured":"Cemazar M, Parkins CS, Holder AL, Kranjc S, Chaplin DJ, Sersa G. Cytotoxicity of bioreductive drug tirapazamine is increased by application of electric pulses in SA-1 tumours in mice. Anticancer Res. 2001;21(2A):1151\u20136.","journal-title":"Anticancer Res"},{"issue":"4","key":"1579_CR45","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1089\/BIOE.2019.0028","volume":"1","author":"M Cemazar","year":"2019","unstructured":"Cemazar M, Sersa G. Recent advances in electrochemotherapy. Bioelectricity. 2019;1(4):204\u201313. https:\/\/doi.org\/10.1089\/BIOE.2019.0028.","journal-title":"Bioelectricity"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-021-01579-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-021-01579-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-021-01579-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T10:33:46Z","timestamp":1634380426000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-021-01579-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["1579"],"URL":"https:\/\/doi.org\/10.1007\/s12032-021-01579-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-649109\/v1","asserted-by":"object"}]},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,22]]},"assertion":[{"value":"22 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"129"}}