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We demonstrate that SCC-4 cells constitutively synthesize and release significant amounts of IL-6, a process that is enhanced by the addition of the TLR2\/TLR6 agonist, Pam2CSK4. The expression of TLR2\/6 and IL-6Ra\/gp130 receptors was also confirmed in SCC-4 cells. Cancerous SCC-4 human tongue cells also have a classic EMT profile, unlike precancerous human tongue DOK cells. We also established that IL-6 is driving<jats:italic>anoikis<\/jats:italic>resistance in an autocrine fashion and that anti-IL-6 neutralising antibodies, anti-IL-6 receptor antibodies and anti-TLR2 receptor antibodies inhibit<jats:italic>anoikis<\/jats:italic>resistance in cancerous SCC-4 human tongue cells<jats:italic>.<\/jats:italic>The data suggest a promising role for anti-IL-6 receptor antibody and anti-TLR2 receptor antibody treatment for oral cancer.<\/jats:p>","DOI":"10.1007\/s12032-022-01664-5","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:03:10Z","timestamp":1651190590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma"],"prefix":"10.1007","volume":"39","author":[{"given":"Marilena","family":"Karavyraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-5161","authenticated-orcid":false,"given":"Richard K.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"1664_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1601-0825.2000.tb00105.x","volume":"6","author":"SR Moore","year":"2000","unstructured":"Moore SR, Johnson NW, Pierce AM, Wilson DF. 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