{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:46:19Z","timestamp":1768077979146,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703095"],"award-info":[{"award-number":["81703095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2021jcyj-msxmX0214"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0214"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Top Science and Technology Talent Fund Project of The First Affiliated Hospital of Chongqing Medical University","award":["BJRC2020\u201304"],"award-info":[{"award-number":["BJRC2020\u201304"]}]},{"name":"Innovation Support Program for Overseas Students of Chongqing","award":["cx2018142"],"award-info":[{"award-number":["cx2018142"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-022-01821-w","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T21:02:42Z","timestamp":1664485362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair"],"prefix":"10.1007","volume":"39","author":[{"given":"Yang","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefeng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2440-4053","authenticated-orcid":false,"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"1821_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/300765a0","volume":"300","author":"A de Klein","year":"1982","unstructured":"de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982;300:765\u20137.","journal-title":"Nature"},{"key":"1821_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12943-018-0780-6","volume":"17","author":"S Soverini","year":"2018","unstructured":"Soverini S, Mancini M, Bavaro L, Cavo M, Martinelli G. Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy. Mol Cancer. 2018;17:49.","journal-title":"Mol Cancer"},{"key":"1821_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/306277a0","volume":"306","author":"CR Bartram","year":"1983","unstructured":"Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, Geurts van Kessel A, Bootsma D, Grosveld G, Ferguson-Smith MA, Davies T, Stone M, et al. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1983;306:277\u201380.","journal-title":"Nature"},{"key":"1821_CR4","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s11899-019-00548-2","volume":"14","author":"RE Clark","year":"2019","unstructured":"Clark RE. Tyrosine kinase inhibitor therapy discontinuation for patients with chronic myeloid leukaemia in clinical practice. Curr Hematol Malig Rep. 2019;14:507\u201314.","journal-title":"Curr Hematol Malig Rep"},{"key":"1821_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.ccell.2020.03.006","volume":"37","author":"TP Braun","year":"2020","unstructured":"Braun TP, Eide CA, Druker BJ. Response and resistance to BCR-ABL1-targeted therapies. Cancer Cell. 2020;37:530\u201342.","journal-title":"Cancer Cell"},{"key":"1821_CR6","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646\u201374.","journal-title":"Cell"},{"key":"1821_CR7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s13238-015-0143-7","volume":"6","author":"H Zhou","year":"2015","unstructured":"Zhou H, Xu R. Leukemia stem cells: the root of chronic myeloid leukemia. Protein Cell. 2015;6:403\u201312.","journal-title":"Protein Cell"},{"key":"1821_CR8","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.molcel.2007.11.015","volume":"28","author":"JW Harper","year":"2007","unstructured":"Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell. 2007;28:739\u201345.","journal-title":"Mol Cell"},{"key":"1821_CR9","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3390\/ijms21041177","volume":"21","author":"HD Popp","year":"2020","unstructured":"Popp HD, Kohl V, Naumann N, Flach J, Brendel S, Kleiner H, Weiss C, Seifarth W, Saussele S, Hofmann WK, Fabarius A. DNA damage and DNA damage response in chronic myeloid leukemia. Int J Mol Sci. 2020;21:1177.","journal-title":"Int J Mol Sci"},{"key":"1821_CR10","doi-asserted-by":"publisher","first-page":"3746","DOI":"10.1182\/blood-2004-05-1941","volume":"104","author":"MO Nowicki","year":"2004","unstructured":"Nowicki MO, Falinski R, Koptyra M, Slupianek A, Stoklosa T, Gloc E, Nieborowska-Skorska M, Blasiak J, Skorski T. BCR\/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood. 2004;104:3746\u201353.","journal-title":"Blood"},{"key":"1821_CR11","doi-asserted-by":"publisher","first-page":"8591","DOI":"10.1038\/sj.onc.1206087","volume":"21","author":"T Skorski","year":"2002","unstructured":"Skorski T. BCR\/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability. Oncogene. 2002;21:8591\u2013604.","journal-title":"Oncogene"},{"key":"1821_CR12","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1080\/03093640701859089","volume":"49","author":"T Skorski","year":"2008","unstructured":"Skorski T. BCR\/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma. 2008;49:610\u20134.","journal-title":"Leuk Lymphoma"},{"key":"1821_CR13","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3324\/haematol.2009.014712","volume":"95","author":"TD Kim","year":"2010","unstructured":"Kim TD, T\u00fcrkmen S, Schwarz M, Koca G, Nogai H, Bommer C, D\u00f6rken B, Daniel P, le Coutre P. Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia. Haematologica. 2010;95:582\u20138.","journal-title":"Haematologica"},{"key":"1821_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1089\/10445490050128403","volume":"19","author":"T Ozaki","year":"2000","unstructured":"Ozaki T, Nagase T, Ichimiya S, Seki N, Ohiri M, Nomura N, Takada N, Sakiyama S, Weber BL, Nakagawara A. NFBD1\/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain. DNA Cell Biol. 2000;19:475\u201385.","journal-title":"DNA Cell Biol"},{"key":"1821_CR15","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nature01446","volume":"421","author":"GS Stewart","year":"2003","unstructured":"Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961\u20136.","journal-title":"Nature"},{"key":"1821_CR16","doi-asserted-by":"publisher","first-page":"7414","DOI":"10.1038\/sj.onc.1210553","volume":"26","author":"J Bartkova","year":"2007","unstructured":"Bartkova J, Horejs\u00ed Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, Stucki M, Jackson S, Lukas J, Bartek J. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene. 2007;26:7414\u201322.","journal-title":"Oncogene"},{"key":"1821_CR17","doi-asserted-by":"publisher","first-page":"11200","DOI":"10.1073\/pnas.0802885105","volume":"105","author":"L Wu","year":"2008","unstructured":"Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci USA. 2008;105:11200\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1821_CR18","doi-asserted-by":"publisher","first-page":"22993","DOI":"10.1074\/jbc.M611412200","volume":"282","author":"M Nakanishi","year":"2007","unstructured":"Nakanishi M, Ozaki T, Yamamoto H, Hanamoto T, Kikuchi H, Furuya K, Asaka M, Delia D, Nakagawara A. NFBD1\/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage. J Biol Chem. 2007;282:22993\u20133004.","journal-title":"J Biol Chem"},{"key":"1821_CR19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jop.12558","volume":"46","author":"JH Dave","year":"2017","unstructured":"Dave JH, Vora HH, Ghosh NR, Trivedi TI. Mediator of DNA damage checkpoint protein 1 (MDC1) as a prognostic marker for patients with oral squamous cell carcinoma. J Oral Pathol Med. 2017;46:253\u20138.","journal-title":"J Oral Pathol Med"},{"key":"1821_CR20","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s12094-017-1748-5","volume":"20","author":"X Liu","year":"2018","unstructured":"Liu X, Qiu Z, Wang Z, Zuo W, Gong Z, Liu C, Zeng Q, Qian Y, Jiang L, Li Y, Bu Y, Hu G. NFBD1\/MDC1 participates in the regulation of proliferation and apoptosis in human laryngeal squamous cell carcinoma. Clin Transl Oncol. 2018;20:534\u201341.","journal-title":"Clin Transl Oncol"},{"key":"1821_CR21","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1007\/s13277-015-3063-5","volume":"36","author":"X Liu","year":"2015","unstructured":"Liu X, Dong R, Jiang Z, Wei Y, Li Y, Wei L, Sun H, Li Y, Yang N, Yang Q, Liu Z, Kong B. MDC1 promotes ovarian cancer metastasis by inducing epithelial\u2013mesenchymal transition. Tumour Biol. 2015;36:4261\u20139.","journal-title":"Tumour Biol"},{"key":"1821_CR22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s11010-011-1027-7","volume":"359","author":"C Yuan","year":"2012","unstructured":"Yuan C, Bu Y, Wang C, Yi F, Yang Z, Huang X, Cheng L, Liu G, Wang Y, Song F. NFBD1\/MDC1 is a protein of oncogenic potential in human cervical cancer. Mol Cell Biochem. 2012;359:333\u201346.","journal-title":"Mol Cell Biochem"},{"key":"1821_CR23","first-page":"22","volume":"38","author":"HL Zhu","year":"2007","unstructured":"Zhu HL, Liu T, Meng WT, Jia YQ. Establishment of an Imatinib resistance cell line K562R and its resistant principia. Sichuan Da Xue Xue Bao Yi Xue. 2007;38:22\u20136.","journal-title":"Sichuan Da Xue Xue Bao Yi Xue"},{"key":"1821_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000110","volume":"4","author":"N Bennardo","year":"2008","unstructured":"Bennardo N, Cheng A, Huang N, Stark JM. Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 2008;4: e1000110.","journal-title":"PLoS Genet"},{"key":"1821_CR25","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1101\/gad.13.20.2633","volume":"13","author":"AJ Pierce","year":"1999","unstructured":"Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 1999;13:2633\u20138.","journal-title":"Genes Dev"},{"key":"1821_CR26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/nrc2147","volume":"7","author":"JV Melo","year":"2007","unstructured":"Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer. 2007;7:441\u201353.","journal-title":"Nat Rev Cancer"},{"key":"1821_CR27","doi-asserted-by":"publisher","first-page":"10512","DOI":"10.1074\/jbc.TM117.000374","volume":"293","author":"NR Pannunzio","year":"2018","unstructured":"Pannunzio NR, Watanabe G, Lieber MR. Nonhomologous DNA end-joining for repair of DNA double-strand breaks. J Biol Chem. 2018;293:10512\u201323.","journal-title":"J Biol Chem"},{"key":"1821_CR28","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1667\/RR3123.1","volume":"179","author":"R Taleei","year":"2013","unstructured":"Taleei R, Nikjoo H. The non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks: I. A mathematical model. Radiat Res. 2013;179:530\u20139.","journal-title":"Radiat Res"},{"key":"1821_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nrm.2017.48","volume":"18","author":"HHY Chang","year":"2017","unstructured":"Chang HHY, Pannunzio NR, Adachi N, Lieber MR. Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol. 2017;18:495\u2013506.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1821_CR30","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2015.10.040","volume":"60","author":"MJ O\u2019Connor","year":"2015","unstructured":"O\u2019Connor MJ. Targeting the DNA damage response in cancer. Mol Cell. 2015;60:547\u201360.","journal-title":"Mol Cell"},{"key":"1821_CR31","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.molcel.2014.08.002","volume":"55","author":"H Ghezraoui","year":"2014","unstructured":"Ghezraoui H, Piganeau M, Renouf B, Renaud JB, Sallmyr A, Ruis B, Oh S, Tomkinson AE, Hendrickson EA, Giovannangeli C, Jasin M, Brunet E. Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. Mol Cell. 2014;55:829\u201342.","journal-title":"Mol Cell"},{"key":"1821_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0304-3835(02)00692-4","volume":"193","author":"FV Rassool","year":"2003","unstructured":"Rassool FV. DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia. Cancer Lett. 2003;193:1\u20139.","journal-title":"Cancer Lett"},{"key":"1821_CR33","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1089\/dna.2021.0239","volume":"40","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Dai H, Wang Y, Liang Y, Feng W, Yuan Y. Targeting FEN1 suppresses the proliferation of chronic myeloid leukemia cells through regulating alternative end-joining pathways. DNA Cell Biol. 2021;40:1101\u201311.","journal-title":"DNA Cell Biol"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-022-01821-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-022-01821-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-022-01821-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T20:35:14Z","timestamp":1667334914000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-022-01821-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1821"],"URL":"https:\/\/doi.org\/10.1007\/s12032-022-01821-w","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"assertion":[{"value":"2 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research conformed to the standard stipulated by the Declaration of Helsinki and was performed with the approval of the Ethics Committee of Chongqing Medical University (ID:2022059).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"226"}}