{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T02:28:37Z","timestamp":1783218517884,"version":"3.54.6"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018778","name":"Al-Azhar University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018778","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME) and have been linked to immunosuppression and poor prognosis. TAMs have been shown to be harmful in ovarian cancer (OC), with a positive correlation between their high levels of tumors and poor overall patient survival. These cells are crucial in the progression and chemoresistance of OC. The primary pro-tumoral role of TAMs is the release of cytokines, chemokines, enzymes, and exosomes that directly enhance the invasion potential and chemoresistance of OC by activating their pro-survival signalling pathways. TAMs play a crucial role in the metastasis of OC in the peritoneum and ascities by assisting in spheroid formation and cancer cell adhesion to the metastatic regions. Furthermore, TAMs interact with tumor protein p53 (TP53), exosomes, and other immune cells, such as stem cells and cancer-associated fibroblasts (CAFs) to support the progression and metastasis of OC. In this review we revisit development, functions and interactions of TAMs in the TME of OC patients to highlight and shed light on challenges and excitement down the road.<\/jats:p>","DOI":"10.1007\/s12032-023-01987-x","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T05:03:11Z","timestamp":1681189391000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Revisiting macrophages in ovarian cancer microenvironment: development, function and interaction"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-7191","authenticated-orcid":false,"given":"Amr Ahmed","family":"El-Arabey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia S.","family":"Alkhalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia T.","family":"Al-Shouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaweya E.","family":"Awadalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba W.","family":"Alhamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taghreed N.","family":"Almanaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah Saif Eldin M.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohnad","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"1987_CR1","doi-asserted-by":"crossref","unstructured":"Puttabyatappa M, Padmanabhan V. 2018 Developmental programming of ovarian functions and dysfunctions. Vitam Horm Academic Press Inc107 377 422","DOI":"10.1016\/bs.vh.2018.01.017"},{"key":"1987_CR2","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","volume":"42","author":"RJ Kurman","year":"2011","unstructured":"Kurman RJ, Shih I-M. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer\u2013shifting the paradigm. Hum Pathol. 2011;42:918\u201331.","journal-title":"Hum Pathol"},{"issue":"1","key":"1987_CR3","doi-asserted-by":"publisher","first-page":"16061","DOI":"10.1038\/nrdp.2016.61","volume":"2","author":"UA Matulonis","year":"2016","unstructured":"Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY. Ovarian cancer. Nat Rev Dis Primers. 2016;2(1):16061.","journal-title":"Nat Rev Dis Primers"},{"key":"1987_CR4","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1158\/0008-5472.CAN-11-3911","volume":"72","author":"EMJJ Berns","year":"2012","unstructured":"Berns EMJJ, Bowtell DD. The changing view of high-grade serous ovarian cancer. Cancer Res. 2012;72:2701\u20134.","journal-title":"Cancer Res"},{"key":"1987_CR5","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1097\/PAS.0b013e31819c4271","volume":"33","author":"E Veras","year":"2009","unstructured":"Veras E, Mao T-L, Ayhan A, Ueda S, Lai H, Hayran M, et al. Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. Am J Surg Pathol. 2009;33:844\u201353.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1987_CR6","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3390\/ijms20040952","volume":"20","author":"M-A Lisio","year":"2019","unstructured":"Lisio M-A, Fu L, Goyeneche A, Gao Z-H, Telleria C. High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints. Int J Mol Sci. 2019;20(4):952.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"1987_CR7","first-page":"649","volume":"43","author":"Z Lu","year":"2014","unstructured":"Lu Z, Chen J. Introduction of WHO classification of tumours of female reproductive organs. Zhonghua Bing Li Xue Za Zhi Chin J Pathol. 2014;43(10):649\u201350.","journal-title":"Zhonghua Bing Li Xue Za Zhi Chin J Pathol"},{"key":"1987_CR8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","volume":"186","author":"RJ Kurman","year":"2016","unstructured":"Kurman RJ, Shih I-M. The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded. Am J Pathol. 2016;186:733\u201347.","journal-title":"Am J Pathol"},{"key":"1987_CR9","doi-asserted-by":"crossref","unstructured":"El-Arabey AA, Abdalla M, Abd-Allah AR. GATA3 and stemness of high-grade serous ovarian carcinoma: novel hope for the deadliest type of ovarian cancer [Internet]. Hum Cell. Springer; 2020 [cited 2021 Jan 10]. p. 904\u20136. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32388811\/","DOI":"10.1007\/s13577-020-00368-0"},{"key":"1987_CR10","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1007\/s13577-022-00706-4","volume":"35","author":"AA El-Arabey","year":"2022","unstructured":"El-Arabey AA, Abdalla M. The role of GATA3 in the metastasis of triple-negative breast cancer and high-grade serous ovarian cancer. Hum Cell. 2022;35:1298\u2013300.","journal-title":"Hum Cell"},{"key":"1987_CR11","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","volume":"11","author":"D Singh","year":"2023","unstructured":"Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO global cervical cancer elimination initiative. Lancet Glob Health. 2023;11:e197-206.","journal-title":"Lancet Glob Health"},{"issue":"4","key":"1987_CR12","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/ijc.33588","volume":"149","author":"J Ferlay","year":"2021","unstructured":"Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Pi\u00f1eros M, Znaor A, et al. Cancer statistics for the year 2020: an overview. Int J Cancer. 2021;149(4):778\u201389.","journal-title":"Int J Cancer."},{"key":"1987_CR13","doi-asserted-by":"crossref","unstructured":"Guo S, Deng CX. 2018 Effect of stromal cells in tumor microenvironment on metastasis initiation. Int J Biol Sci Ivyspring International Publisher. 2083\u201393.","DOI":"10.7150\/ijbs.25720"},{"key":"1987_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109539","author":"AA El-Arabey","year":"2020","unstructured":"El-Arabey AA, Denizli M, Kanlikilicer P, Bayraktar R, Ivan C, Rashed M, et al. GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma. Cell Signal. 2020. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109539.","journal-title":"Cell Signal"},{"key":"1987_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010092","author":"D Hirayama","year":"2018","unstructured":"Hirayama D, Iida T, Nakase H. The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19010092.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1987_CR16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40425-017-0257-y","volume":"5","author":"MA Cannarile","year":"2017","unstructured":"Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, R\u00fcttinger D. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J Immunother Cancer. 2017;5(1):53.","journal-title":"J Immunother Cancer"},{"issue":"4","key":"1987_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ccell.2015.02.015","volume":"27","author":"B Ruffell","year":"2015","unstructured":"Ruffell B, Coussens LM. Macrophages and therapeutic resistance in cancer. Cancer Cell. 2015;27(4):462\u201372.","journal-title":"Cancer Cell"},{"key":"1987_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3389\/fonc.2019.00421","volume":"9","author":"H Cheng","year":"2019","unstructured":"Cheng H, Wang Z, Fu L, Xu T. Macrophage polarization in the development and progression of ovarian cancers: An overview. Front Oncol. 2019;9:421.","journal-title":"Front Oncol."},{"key":"1987_CR19","first-page":"49","volume-title":"Pollard JW","author":"R Noy","year":"2014","unstructured":"Noy R. Pollard JW. Tumor-Associated Macrophages: From Mechanisms to therapy. Immunity. cell press; 2014. p. 49\u201361."},{"issue":"10","key":"1987_CR20","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3390\/cancers10100366","volume":"10","author":"V Gupta","year":"2018","unstructured":"Gupta V, Yull F, Khabele D. Bipolar tumor-associated macrophages in ovarian cancer as targets for therapy. Cancers. 2018;10(10):366.","journal-title":"Cancers"},{"issue":"5","key":"1987_CR21","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.3390\/cells9051299","volume":"9","author":"M Nowak","year":"2020","unstructured":"Nowak M, Klink M. The role of tumor-associated macrophages in the progression and chemoresistance of ovarian cancer. Cells. 2020;9(5):1299.","journal-title":"Cells"},{"key":"1987_CR22","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.immuni.2009.03.014","volume":"30","author":"J Rangel-Moreno","year":"2009","unstructured":"Rangel-Moreno J, Moyron-Quiroz JE, Carragher DM, Kusser K, Hartson L, Moquin A, et al. Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens. Immunity. 2009;30:731\u201343.","journal-title":"Immunity"},{"key":"1987_CR23","first-page":"832","volume":"157","author":"Y Okabe","year":"2014","unstructured":"Okabe Y, Medzhitov R. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell Cell Press. 2014;157:832\u201344.","journal-title":"Cell Cell Press"},{"key":"1987_CR24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191869","author":"A Etzerodt","year":"2020","unstructured":"Etzerodt A, Moulin M, Doktor TK, Delfini M, Mossadegh-Keller N, Bajenoff M, et al. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. J Exp Med. 2020. https:\/\/doi.org\/10.1084\/jem.20191869.","journal-title":"J Exp Med"},{"issue":"10","key":"1987_CR25","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.2217\/imt.13.102","volume":"5","author":"RZ Panni","year":"2013","unstructured":"Panni RZ, Linehan DC, Denardo DG. Targeting tumor-infiltrating macrophages to combat cancer. Immunotherapy. 2013;5(10):1075\u201387.","journal-title":"Immunotherapy"},{"issue":"1","key":"1987_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-016-0542-2","volume":"15","author":"D Lane","year":"2016","unstructured":"Lane D, Matte I, Laplante C, Garde-Granger P, Carignan A, Bessette P, et al. CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling. Mol Cancer. 2016;15(1):1\u201311.","journal-title":"Mol Cancer"},{"key":"1987_CR27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.canlet.2019.12.024","volume":"472","author":"W Liu","year":"2020","unstructured":"Liu W, Wang W, Wang X, Xu C, Zhang N, Di W. Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis. Cancer Lett. 2020;472:59\u201369.","journal-title":"Cancer Lett"},{"issue":"1","key":"1987_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-017-3630-9","volume":"18","author":"T Adhikary","year":"2017","unstructured":"Adhikary T, Wortmann A, Finkernagel F, Lieber S, Nist A, Stiewe T, et al. Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients. BMC Genomics. 2017;18(1):1\u201314.","journal-title":"BMC Genomics"},{"key":"1987_CR29","doi-asserted-by":"crossref","unstructured":"Colvin EK. Tumor-associated macrophages contribute to tumor progression in ovarian cancer [Internet]. Front Oncol. Frontiers Research Foundation; 2014 [cited 2021 Jan 4]. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/24936477\/","DOI":"10.3389\/fonc.2014.00137"},{"issue":"1","key":"1987_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-019-0568-z","volume":"26","author":"Y Chen","year":"2019","unstructured":"Chen Y, Song Y, Du W, Gong L, Chang H, Zou Z. Tumor-associated macrophages: an accomplice in solid tumor progression. J Biomed Sci. 2019;26(1):1\u201313.","journal-title":"J Biomed Sci"},{"issue":"11","key":"1987_CR31","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1172\/JCI87252","volume":"126","author":"M Yin","year":"2016","unstructured":"Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, et al. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. J Clin Investig. 2016;126(11):4157\u201373.","journal-title":"J Clin Investig"},{"key":"1987_CR32","doi-asserted-by":"crossref","unstructured":"Ghoneum A, Afify H, Salih Z, Kelly M, Said N. 2018 Role of tumor microenvironment in the pathobiology of ovarian cancer: Insights and therapeutic opportunities. Cancer Med. Blackwell Publishing Ltd. 5047\u201356","DOI":"10.1002\/cam4.1741"},{"key":"1987_CR33","doi-asserted-by":"crossref","unstructured":"El-Arabey AA, Abdalla M, Abd-Allah AR. SnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors. Int Immunopharmacol [Internet]. Elsevier B.V.; 2020 [cited 2021 Jan 10];86. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32663767\/","DOI":"10.1016\/j.intimp.2020.106758"},{"key":"1987_CR34","doi-asserted-by":"publisher","first-page":"690","DOI":"10.4049\/jimmunol.181.1.690","volume":"181","author":"S-D Ha","year":"2008","unstructured":"Ha S-D, Martins A, Khazaie K, Han J, Chan BMC, Kim SO. Cathepsin B Is Involved in the Trafficking of TNF-\u03b1-Containing Vesicles to the Plasma Membrane in Macrophages. J Immunol. 2008;181:690\u20137.","journal-title":"J Immunol"},{"key":"1987_CR35","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.3892\/ijo.2014.2794","volume":"46","author":"F Meng","year":"2015","unstructured":"Meng F, Li W, Li C, Gao Z, Guo K, Song S. CCL18 promotes epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells in pancreatic ductal adenocarcinoma. Int J Oncol Spandidos Publications. 2015;46:1109\u201320.","journal-title":"Int J Oncol Spandidos Publications"},{"issue":"11","key":"1987_CR36","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1158\/0008-5472.CAN-13-2421","volume":"74","author":"EJ Yeo","year":"2014","unstructured":"Yeo EJ, Cassetta L, Qian BZ, Lewkowich I, Li JF, Stefater JA, et al. Myeloid wnt7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Res. 2014;74(11):2962\u201373.","journal-title":"Cancer Res"},{"issue":"3","key":"1987_CR37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ccr.2013.02.013","volume":"23","author":"M de Palma","year":"2013","unstructured":"de Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell. 2013;23(3):277\u201386.","journal-title":"Cancer Cell"},{"key":"1987_CR38","first-page":"559","volume":"513","author":"OR Colegio","year":"2014","unstructured":"Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature Nature Publ Group. 2014;513:559\u201363.","journal-title":"Nature Nature Publ Group"},{"key":"1987_CR39","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ccr.2013.11.007","volume":"24","author":"A Casazza","year":"2013","unstructured":"Casazza A, Laoui D, Wenes M, Rizzolio S, Bassani N, Mambretti M, et al. Impeding macrophage entry into hypoxic tumor areas by sema3a\/nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell. 2013;24:695\u2013709.","journal-title":"Cancer Cell"},{"key":"1987_CR40","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1158\/2326-6066.CIR-14-0232","volume":"3","author":"SL Shiao","year":"2015","unstructured":"Shiao SL, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. TH2-polarized CD4+ T cells and macrophages limit efficacy of radiotherapy. Cancer Immunol Res. 2015;3:518\u201325.","journal-title":"Cancer Immunol Res"},{"key":"1987_CR41","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1002\/eji.200940288","volume":"40","author":"SC Wong","year":"2010","unstructured":"Wong SC, Puaux AL, Chittezhath M, Shalova I, Kajiji TS, Wang X, et al. Macrophage polarization to a unique phenotype driven by B cells. Eur J Immunol. 2010;40:2296\u2013307.","journal-title":"Eur J Immunol"},{"issue":"12","key":"1987_CR42","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1002\/ijc.31750","volume":"143","author":"HJ Chen","year":"2018","unstructured":"Chen HJ, Huang RL, Liew PL, Su PH, Chen LY, Weng YC, et al. GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells. Int J Cancer. 2018;143(12):3106\u201319.","journal-title":"Int J Cancer"},{"key":"1987_CR43","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.3390\/cancers11081147","volume":"11","author":"K Nakamura","year":"2019","unstructured":"Nakamura K, Sawada K, Kobayashi M, Miyamoto M, Shimizu A, Yamamoto M, et al. Role of the exosome in ovarian cancer progression and its potential as a therapeutic target. Cancers (Basel). 2019;11:1147.","journal-title":"Cancers (Basel)"},{"key":"1987_CR44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13578-019-0282-2","volume":"9","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Liu Y, Liu H, Tang WH. Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019;9:19.","journal-title":"Cell Biosci"},{"key":"1987_CR45","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1002\/ijc.26031","volume":"128","author":"RR Langley","year":"2011","unstructured":"Langley RR, Fidler IJ. The seed and soil hypothesis revisited\u2013the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer. 2011;128:2527\u201335.","journal-title":"Int J Cancer"},{"key":"1987_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-019-0975-5","volume":"18","author":"I Li","year":"2019","unstructured":"Li I, Nabet BY. Exosomes in the tumor microenvironment as mediators of cancer therapy resistance. Mol Cancer. 2019;18:1\u201310.","journal-title":"Mol Cancer"},{"key":"1987_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00792","author":"Y Yao","year":"2019","unstructured":"Yao Y, Xu X-H, Jin L. Macrophage polarization in physiological and pathological pregnancy. Front Immunol. 2019. https:\/\/doi.org\/10.3389\/fimmu.2019.00792.","journal-title":"Front Immunol"},{"key":"1987_CR48","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.trecan.2019.10.007","volume":"5","author":"K Mehla","year":"2019","unstructured":"Mehla K, Singh PK. Metabolic regulation of macrophage polarization in cancer. Trends Cancer. 2019;5:822\u201334.","journal-title":"Trends Cancer"},{"key":"1987_CR49","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.canlet.2018.08.001","volume":"435","author":"X Chen","year":"2018","unstructured":"Chen X, Zhou J, Li X, Wang X, Lin Y, Wang X. Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype. Cancer Lett. 2018;435:80\u201391.","journal-title":"Cancer Lett"},{"key":"1987_CR50","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3892\/or.2017.5697","volume":"38","author":"X Chen","year":"2017","unstructured":"Chen X, Ying X, Wang X, Wu X, Zhu Q, Wang X. Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization. Oncol Rep. 2017;38:522\u20138.","journal-title":"Oncol Rep"},{"key":"1987_CR51","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13046-019-1095-1","volume":"38","author":"X Zhu","year":"2019","unstructured":"Zhu X, Shen H, Yin X, Yang M, Wei H, Chen Q, et al. Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype. J Exp Clin Cancer Res. 2019;38:81.","journal-title":"J Exp Clin Cancer Res"},{"key":"1987_CR52","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ebiom.2018.11.004","volume":"38","author":"P Kanlikilicer","year":"2018","unstructured":"Kanlikilicer P, Bayraktar R, Denizli M, Rashed MH, Ivan C, Aslan B, et al. Corrigendum to \u2018exosomal miRNA confers chemo resistance via targeting Cav1\/p-gp\/M2-type macrophage axis in ovarian cancer.\u2019 EBioMedicine. 2018;38:100\u201312.","journal-title":"EBioMedicine"},{"key":"1987_CR53","doi-asserted-by":"publisher","first-page":"110147","DOI":"10.1016\/j.cellsig.2021.110147","volume":"89","author":"AA El-Arabey","year":"2022","unstructured":"El-Arabey AA, Denizli M, Kanlikilicer P, Bayraktar R, Ivan C, Rashed M, et al. CORRIGENDUM: GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma. Cell Signal. 2022;89:110147.","journal-title":"Cell Signal"},{"key":"1987_CR54","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1007\/s13577-021-00598-w","volume":"34","author":"AA El-Arabey","year":"2021","unstructured":"El-Arabey AA, Abdalla M. GATA3 as a regulator for naughty cancer-associated fibroblasts in the microenvironment of high-grade serous ovarian cancer. Hum Cell. 2021;34:1934\u20136.","journal-title":"Hum Cell"},{"issue":"2","key":"1987_CR55","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.cell.2020.03.013","volume":"181","author":"D Park","year":"2020","unstructured":"Park D, Sahai E, Rullan A. Snapshot: cancer-associated fibroblasts. Cell. 2020;181(2):486\u2013486.","journal-title":"Cell"},{"issue":"9","key":"1987_CR56","doi-asserted-by":"publisher","first-page":"e25563","DOI":"10.4161\/onci.25563","volume":"2","author":"P Chiarugi","year":"2013","unstructured":"Chiarugi P. Cancer-associated fibroblasts and macrophages: Friendly conspirators for malignancy. Oncoimmunology. 2013;2(9):e25563.","journal-title":"Oncoimmunology"},{"key":"1987_CR57","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/cdd.2014.212","volume":"22","author":"L Li","year":"2015","unstructured":"Li L, Ng DSW, Mah WC, Almeida FF, Rahmat SA, Rao VK, et al. A unique role for p53 in the regulation of M2 macrophage polarization. Cell Death Differ Nature Publ Gr. 2015;22:1081\u201393.","journal-title":"Cell Death Differ Nature Publ Gr"},{"key":"1987_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03224-w","author":"T Cooks","year":"2018","unstructured":"Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, et al. Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246. Nat Commun. 2018. https:\/\/doi.org\/10.1038\/s41467-018-03224-w.","journal-title":"Nat Commun"},{"issue":"7","key":"1987_CR59","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3390\/cancers10070219","volume":"10","author":"I Uehara","year":"2018","unstructured":"Uehara I, Tanaka N. Role of p53 in the regulation of the inflammatory tumor microenvironment and tumor suppression. Cancers. 2018;10(7):219.","journal-title":"Cancers"},{"key":"1987_CR60","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1158\/0008-5472.CAN-06-2425","volume":"67","author":"L Weisz","year":"2007","unstructured":"Weisz L, Damalas A, Liontos M, Karakaidos P, Fontemaggi G, Maor-Aloni R, et al. Mutant p53 enhances nuclear factor \u03bab activation by tumor necrosis factor \u03b1 in cancer cells. Cancer Res. 2007;67:2396\u2013401.","journal-title":"Cancer Res"},{"key":"1987_CR61","unstructured":"Harrington BS, Annunziata CM. Nf-\u03bab signaling in ovarian cancer [Internet]. Cancers (Basel). MDPI AG; 2019 [cited 2021 Jan 4]. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31443240\/"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-023-01987-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-023-01987-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-023-01987-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T04:23:51Z","timestamp":1682655831000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-023-01987-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,11]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["1987"],"URL":"https:\/\/doi.org\/10.1007\/s12032-023-01987-x","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,11]]},"assertion":[{"value":"8 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest for this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"142"}}