{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:48:15Z","timestamp":1740138495251,"version":"3.37.3"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-024-02366-w","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:02:03Z","timestamp":1713337323000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-5811","authenticated-orcid":false,"given":"Ahad Amer","family":"Alsaiari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-3368","authenticated-orcid":false,"given":"Amal F.","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-650X","authenticated-orcid":false,"given":"Maha Mahfouz","family":"Bakhuraysah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-9118","authenticated-orcid":false,"given":"Amani A.","family":"Alrehaili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6153-6920","authenticated-orcid":false,"given":"Shatha M.","family":"Algethami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0553-2977","authenticated-orcid":false,"given":"Hayfa Ali","family":"Alsaif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5987-7611","authenticated-orcid":false,"given":"Norah","family":"Al Harthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-1277","authenticated-orcid":false,"given":"Mohammed Ageeli","family":"Hakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"issue":"3","key":"2366_CR1","first-page":"2423","volume":"10","author":"S Manoharan","year":"2010","unstructured":"Manoharan S, Pugalendhi P. Breast cancer: an overview. J Cell Tissue Res. 2010;10(3):2423.","journal-title":"J Cell Tissue Res"},{"issue":"4","key":"2366_CR2","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1158\/1055-9965.EPI-16-0858","volume":"26","author":"LA Torre","year":"2017","unstructured":"Torre LA, et al. Global cancer in women: burden and trends. Cancer Epidemiol Biomark Prev. 2017;26(4):444\u201357.","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"2","key":"2366_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/1097-0029(20010115)52:2<204::AID-JEMT1006>3.0.CO;2-F","volume":"52","author":"J Russo","year":"2001","unstructured":"Russo J, et al. Cancer risk related to mammary gland structure and development. Microsc Res Tech. 2001;52(2):204\u201323.","journal-title":"Microsc Res Tech"},{"issue":"1","key":"2366_CR4","doi-asserted-by":"publisher","first-page":"16545","DOI":"10.1038\/s41598-023-43789-1","volume":"13","author":"A Sahu","year":"2023","unstructured":"Sahu A, et al. In-silico and in-vitro study reveals Ziprasidone as a potential aromatase inhibitor against breast carcinoma. Sci Rep. 2023;13(1):16545.","journal-title":"Sci Rep"},{"issue":"3","key":"2366_CR5","first-page":"275","volume":"8","author":"D Sathish","year":"2016","unstructured":"Sathish D, et al. Medical imaging techniques and computer aided diagnostic approaches for the detection of breast cancer with an emphasis on thermography-a review. Int J Med Eng Inf. 2016;8(3):275\u201399.","journal-title":"Int J Med Eng Inf"},{"issue":"24","key":"2366_CR6","doi-asserted-by":"publisher","first-page":"7988","DOI":"10.1158\/1078-0432.CCR-08-1211","volume":"14","author":"OI Olopade","year":"2008","unstructured":"Olopade OI, et al. Advances in breast cancer: pathways to personalized medicine. Clin Cancer Res. 2008;14(24):7988\u201399.","journal-title":"Clin Cancer Res"},{"issue":"38","key":"2366_CR7","doi-asserted-by":"publisher","first-page":"26766","DOI":"10.1039\/D3RA04873J","volume":"13","author":"M Rana","year":"2023","unstructured":"Rana M, et al. Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole\u2013pyrazoline hybrid derivatives. RSC Adv. 2023;13(38):26766\u201379.","journal-title":"RSC Adv"},{"key":"2366_CR8","first-page":"231","volume":"10","author":"NI Cherny","year":"2018","unstructured":"Cherny NI, Paluch-Shimon S, Berner-Wygoda Y. Palliative care: needs of advanced breast cancer patients. Breast Cancer. 2018;10:231\u201343.","journal-title":"Breast Cancer"},{"key":"2366_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s42250-023-00607-5","volume":"6","author":"SO Famuyiwa","year":"2023","unstructured":"Famuyiwa SO, et al. Comprehensive computational studies of naturally occurring kuguacins as antidiabetic agents by targeting visfatin. Chem Afr. 2023;6:1\u201313.","journal-title":"Chem Afr"},{"issue":"2","key":"2366_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.gendis.2018.05.001","volume":"5","author":"Y Feng","year":"2018","unstructured":"Feng Y, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 2018;5(2):77\u2013106.","journal-title":"Genes Dis"},{"issue":"1","key":"2366_CR11","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41467-017-02293-7","volume":"9","author":"BD Page","year":"2018","unstructured":"Page BD, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat Commun. 2018;9(1):250.","journal-title":"Nat Commun"},{"issue":"41","key":"2366_CR12","doi-asserted-by":"publisher","first-page":"7318","DOI":"10.1021\/bi400852h","volume":"52","author":"KM Lamb","year":"2013","unstructured":"Lamb KM, et al. Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase. Biochemistry. 2013;52(41):7318\u201326.","journal-title":"Biochemistry"},{"issue":"23","key":"2366_CR13","doi-asserted-by":"publisher","first-page":"8030","DOI":"10.1021\/jm2008634","volume":"54","author":"T Ishikawa","year":"2011","unstructured":"Ishikawa T, et al. Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)\/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo [3, 2-d] pyrimidine scaffold. J Med Chem. 2011;54(23):8030\u201350.","journal-title":"J Med Chem"},{"issue":"48","key":"2366_CR14","doi-asserted-by":"publisher","first-page":"46265","DOI":"10.1074\/jbc.M207135200","volume":"277","author":"J Stamos","year":"2002","unstructured":"Stamos J, Sliwkowski MX, Eigenbrot C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem. 2002;277(48):46265\u201372.","journal-title":"J Biol Chem"},{"issue":"suppl 1","key":"2366_CR15","first-page":"392","volume":"39","author":"PW Rose","year":"2010","unstructured":"Rose PW, et al. The RCSB Protein Data Bank: redesigned web site and web services. Nucl Acids Res. 2010;39(suppl 1):392\u2013401.","journal-title":"Nucl Acids Res"},{"key":"2366_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135701","volume":"1287","author":"M Rana","year":"2023","unstructured":"Rana M, et al. Synthesis, single crystal, TD-DFT, molecular dynamics simulation and DNA binding studies of carbothioamide analog. J Mol Struct. 2023;1287: 135701.","journal-title":"J Mol Struct"},{"key":"2366_CR17","volume-title":"Protein preparation wizard. Epik","author":"S Release","year":"2023","unstructured":"Release S. Protein preparation wizard. Epik. New York: Schr\u00f6dinger LLC; 2023."},{"key":"2366_CR18","volume-title":"Maestro","author":"L Schr\u00f6dinger","year":"2023","unstructured":"Schr\u00f6dinger L. Maestro. New York: Schr\u00f6dinger; 2023."},{"issue":"2","key":"2366_CR19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/prot.10613","volume":"55","author":"MP Jacobson","year":"2004","unstructured":"Jacobson MP, et al. A hierarchical approach to all-atom protein loop prediction. Proteins. 2004;55(2):351\u201367.","journal-title":"Proteins"},{"key":"2366_CR20","volume-title":"Prime","author":"S Release","year":"2023","unstructured":"Release S. Prime. New York: Schr\u00f6dinger LLC; 2023."},{"key":"2366_CR21","volume-title":"Epik","author":"S Release","year":"2023","unstructured":"Release S. Epik. New York: Schr\u00f6dinger; 2023."},{"issue":"4","key":"2366_CR22","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/prot.20660","volume":"61","author":"H Li","year":"2005","unstructured":"Li H, Robertson AD, Jensen JH. Very fast empirical prediction and rationalization of protein pKa values. Proteins. 2005;61(4):704\u201321.","journal-title":"Proteins"},{"issue":"7","key":"2366_CR23","first-page":"1934578X2211154","volume":"17","author":"S Ahmad","year":"2022","unstructured":"Ahmad S, et al. Multitargeted molecular dynamic understanding of butoxypheser against SARS-CoV-2: An in silico study. Nat Prod Commun. 2022;17(7):1934578X221115499.","journal-title":"Nat Prod Commun"},{"key":"2366_CR24","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/978-981-19-8249-1_13","volume-title":"Protein-based therapeutics","author":"S Ahmad","year":"2023","unstructured":"Ahmad S, et al. Therapeutic protein-based vaccines. In: Protein-based therapeutics. Springer; 2023. p. 355\u201384."},{"issue":"45","key":"2366_CR25","doi-asserted-by":"publisher","first-page":"11225","DOI":"10.1021\/ja9621760","volume":"118","author":"WL Jorgensen","year":"1996","unstructured":"Jorgensen WL, Maxwell DS, Tirado-Rives J. Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids. J Am Chem Soc. 1996;118(45):11225\u201336.","journal-title":"J Am Chem Soc"},{"issue":"6","key":"2366_CR26","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1021\/ja00214a001","volume":"110","author":"WL Jorgensen","year":"1988","unstructured":"Jorgensen WL, Tirado-Rives J. The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. J Am Chem Soc. 1988;110(6):1657\u201366.","journal-title":"J Am Chem Soc"},{"issue":"18","key":"2366_CR27","doi-asserted-by":"publisher","first-page":"6034","DOI":"10.3390\/molecules27186034","volume":"27","author":"R Karwasra","year":"2022","unstructured":"Karwasra R, et al. Macrophage-targeted punicalagin nanoengineering to alleviate methotrexate-induced neutropenia: a molecular docking, DFT, and MD simulation analysis. Molecules. 2022;27(18):6034.","journal-title":"Molecules"},{"key":"2366_CR28","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/978-981-16-9221-5_21","volume-title":"Computational intelligence in oncology","author":"R Karwasra","year":"2022","unstructured":"Karwasra R, et al. The incipient role of computational intelligence in oncology: drug designing, discovery, and development. In: Computational intelligence in oncology. Springer; 2022. p. 369\u201384."},{"issue":"12","key":"2366_CR29","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1080\/07391102.2019.1680435","volume":"38","author":"T Kaul","year":"2019","unstructured":"Kaul T, et al. Probing the effect of a plus 1bp frameshift mutation in protein-DNA interface of domestication gene, NAMB1, in wheat. J Biomol Struct Dyn. 2019;38(12):3633\u201347.","journal-title":"J Biomol Struct Dyn"},{"issue":"80","key":"2366_CR30","doi-asserted-by":"publisher","first-page":"8016","DOI":"10.1126\/scitranslmed.3001862","volume":"3","author":"R Huang","year":"2011","unstructured":"Huang R, et al. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med. 2011;3(80):8016.","journal-title":"Sci Transl Med"},{"key":"2366_CR31","volume-title":"LigPrep","author":"S Release","year":"2023","unstructured":"Release S. LigPrep. New York: Schr\u00f6dinger LLC; 2023."},{"issue":"5","key":"2366_CR32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2174\/0929867330666230309143711","volume":"31","author":"AA Shah","year":"2024","unstructured":"Shah AA, et al. Structure-based virtual screening, molecular docking, molecular dynamics simulation, and metabolic reactivity studies of quinazoline derivatives for their anti-EGFR activity against tumor angiogenesis. Curr Med Chem. 2024;31(5):595\u2013619.","journal-title":"Curr Med Chem"},{"key":"2366_CR33","first-page":"1","volume":"2023","author":"AP Singh","year":"2023","unstructured":"Singh AP, et al. Computational screening and MM\/GBSA-based MD simulation studies reveal the high binding potential of FDA-approved drugs against Cutibacterium acnes sialidase. J Biomol Struct Dyn. 2023;2023:1\u201311.","journal-title":"J Biomol Struct Dyn"},{"issue":"21","key":"2366_CR34","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"RA Friesner","year":"2006","unstructured":"Friesner RA, et al. Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein\u2212ligand complexes. J Med Chem. 2006;49(21):6177\u201396.","journal-title":"J Med Chem"},{"key":"2366_CR35","volume-title":"Glide","author":"S Release","year":"2023","unstructured":"Release S. Glide. New York: Schr\u00f6dinger; 2023."},{"issue":"14","key":"2366_CR36","doi-asserted-by":"publisher","first-page":"6633","DOI":"10.1080\/07391102.2022.2110158","volume":"41","author":"YS Alghamdi","year":"2023","unstructured":"Alghamdi YS, et al. Unveiling the multitargeted potential of N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine (NSL-CG) against SARS CoV-2: a virtual screening and molecular dynamics simulation study. J Biomol Struct Dyn. 2023;41(14):6633\u201342.","journal-title":"J Biomol Struct Dyn"},{"issue":"14","key":"2366_CR37","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.3390\/molecules27144391","volume":"27","author":"NA Alturki","year":"2022","unstructured":"Alturki NA, et al. In-silico screening and molecular dynamics simulation of drug bank experimental compounds against SARS-CoV-2. Molecules. 2022;27(14):4391.","journal-title":"Molecules"},{"issue":"4","key":"2366_CR38","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3390\/medicina58040515","volume":"58","author":"A Alzamami","year":"2022","unstructured":"Alzamami A, et al. Hemi-Babim and fenoterol as potential inhibitors of MPro and papain-like protease against SARS-CoV-2: an in-silico study. Medicina. 2022;58(4):515.","journal-title":"Medicina"},{"issue":"9","key":"2366_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s13205-023-03730-9","volume":"13","author":"R Bhati","year":"2023","unstructured":"Bhati R, et al. Structural\u2013functional analysis and molecular characterization of arsenate reductase from Enterobacter cloacae RSC3 for arsenic biotransformation. 3 Biotech. 2023;13(9):305.","journal-title":"3 Biotech"},{"issue":"4","key":"2366_CR40","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"CA Lipinski","year":"2004","unstructured":"Lipinski CA. Lead-and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol. 2004;1(4):337\u201341.","journal-title":"Drug Discov Today Technol"},{"key":"2366_CR41","volume-title":"QikProp","author":"S Release","year":"2023","unstructured":"Release S. QikProp. New York: Schr\u00f6dinger LLC; 2023."},{"issue":"9","key":"2366_CR42","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1080\/07391102.2022.2060308","volume":"41","author":"S Ahmad","year":"2023","unstructured":"Ahmad S, et al. Reporting dinaciclib and theodrenaline as a multitargeted inhibitor against SARS-CoV-2: an in-silico study. J Biomol Struct Dyn. 2023;41(9):4013\u201323.","journal-title":"J Biomol Struct Dyn"},{"key":"2366_CR43","first-page":"1","volume":"2023","author":"S Ahmad","year":"2023","unstructured":"Ahmad S, Raza K. Identification of 5-nitroindazole as a multitargeted inhibitor for CDK and transferase kinase in lung cancer: a multisampling algorithm-based structural study. Mol Divers. 2023;2023:1\u201314.","journal-title":"Mol Divers"},{"key":"2366_CR44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2023.2291541","volume":"2023","author":"S Ahmad","year":"2023","unstructured":"Ahmad S, et al. Multisampling-based docking reveals Imidazolidinyl urea as a multitargeted inhibitor for lung cancer: an optimisation followed multi-simulation and in-vitro study. J Biomol Struct Dyn. 2023;2023:1\u201318.","journal-title":"J Biomol Struct Dyn"},{"key":"2366_CR45","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/B978-0-323-90608-1.00001-0","volume-title":"Computer Aided Drug Design (CADD): from ligand-based methods to structure-based approaches","author":"MK Tripathi","year":"2022","unstructured":"Tripathi MK, et al. Fundamentals of molecular modeling in drug design. In: Computer Aided Drug Design (CADD): from ligand-based methods to structure-based approaches. Elsevier; 2022. p. 125\u201355."},{"key":"2366_CR46","first-page":"1","volume":"2022","author":"MK Yadav","year":"2022","unstructured":"Yadav MK, et al. Predictive modeling and therapeutic repurposing of natural compounds against the receptor-binding domain of SARS-CoV-2. J Biomol Struct Dyn. 2022;2022:1\u201313.","journal-title":"J Biomol Struct Dyn"},{"issue":"18","key":"2366_CR47","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1002\/qua.24481","volume":"113","author":"AD Bochevarov","year":"2013","unstructured":"Bochevarov AD, et al. Jaguar: a high-performance quantum chemistry software program with strengths in life and materials sciences. Int J Quantum Chem. 2013;113(18):2110\u201342.","journal-title":"Int J Quantum Chem"},{"issue":"4","key":"2366_CR48","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1039\/C4CP04399E","volume":"17","author":"MD Ganji","year":"2015","unstructured":"Ganji MD, Hosseini-Khah S, Amini-Tabar Z. Theoretical insight into hydrogen adsorption onto graphene: a first-principles B3LYP-D3 study. Phys Chem Chem Phys. 2015;17(4):2504\u201311.","journal-title":"Phys Chem Chem Phys"},{"issue":"6294","key":"2366_CR49","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/347631a0","volume":"347","author":"M Karplus","year":"1990","unstructured":"Karplus M, Petsko GA. Molecular dynamics simulations in biology. Nature. 1990;347(6294):631\u20139.","journal-title":"Nature"},{"key":"2366_CR50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/978-981-19-9605-4_3","volume-title":"Natural product based drug discovery against human parasites: opportunities and challenges","author":"S Ahmad","year":"2023","unstructured":"Ahmad S, et al. Natural product-based drug designing for treatment of human parasitic diseases. In: Natural product based drug discovery against human parasites: opportunities and challenges. Springer; 2023. p. 37\u201359."},{"key":"2366_CR51","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/B978-0-443-13222-3.00007-1","volume-title":"Computational biology for stem cell research","author":"MK Yadav","year":"2024","unstructured":"Yadav MK, et al. Application of machine learning\u2013based approaches in stem cell research. In: Computational biology for stem cell research. Elsevier; 2024. p. 65\u201376."},{"key":"2366_CR52","doi-asserted-by":"crossref","unstructured":"Bowers KJ, et al. Scalable algorithms for molecular dynamics simulations on commodity clusters. In: Proceedings of the 2006 ACM\/IEEE Conference on supercomputing. 2006.","DOI":"10.1145\/1188455.1188544"},{"issue":"43","key":"2366_CR53","doi-asserted-by":"publisher","first-page":"9954","DOI":"10.1021\/jp003020w","volume":"105","author":"P Mark","year":"2001","unstructured":"Mark P, Nilsson L. Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K. J Phys Chem A. 2001;105(43):9954\u201360.","journal-title":"J Phys Chem A"},{"issue":"1","key":"2366_CR54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/00268977200100031","volume":"23","author":"I McDonald","year":"1972","unstructured":"McDonald I. NpT-ensemble Monte Carlo calculations for binary liquid mixtures. Mol Phys. 1972;23(1):41\u201358.","journal-title":"Mol Phys"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-024-02366-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-024-02366-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-024-02366-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T11:34:21Z","timestamp":1731756861000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-024-02366-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s12032-024-02366-w","relation":{},"ISSN":["1559-131X"],"issn-type":[{"type":"electronic","value":"1559-131X"}],"subject":[],"published":{"date-parts":[[2024,4,17]]},"assertion":[{"value":"3 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing or conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"117"}}