{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:36:40Z","timestamp":1791005800646,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer-related lymphedema (BCRL) remains a challenging condition impacting function and quality of life. Complete decongestive therapy (CDT) is the current standard of care, necessitating a comprehensive review of its impact. This paper presents a systematic review (SR) of SRs on CDT\u2019s efficacy in BCRL, and the components of manual lymph drainage (MLD) and exercise. A literature search yielded 13 SRs published between January 2018 and March 2023 meeting inclusion criteria, with varied quality ratings based on the AMSTAR II. A sub-analysis of CDT investigated the within group effect size estimations on volume in different stages of lymphedema. While a moderate quality SR indicated support for CDT in volume reduction, other SRs on the topic were of critically low quality. Larger effect sizes for CDT were found for later stage BCRL. The impact of MLD as a component of CDT demonstrated no additional volume benefit in a mix of moderate to low quality SRs. Similarly, exercise\u2019s role in volume reduction in CDT was limited, although it demonstrated some benefit in pain and quality of life. A rapid review of trials published January 2021\u2013March 2023 reinforced these findings. Variability in CDT delivery and outcomes remained. These findings underscore the need to standardize staging criteria and outcome measures in research and practice. Future research should focus on refining interventions, determining clinically important differences in outcomes, and standardizing measures to improve evidence-based BCRL management. Current evidence supports CDT\u2019s efficacy in BCRL. MLD and exercise as components of CDT have limited support for volume reduction.<\/jats:p>","DOI":"10.1007\/s12032-024-02421-6","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T22:02:27Z","timestamp":1729634547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effectiveness of complete decongestive therapy for upper extremity breast cancer-related lymphedema: a review of systematic reviews"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-1313","authenticated-orcid":false,"given":"Laura","family":"Gilchrist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-8113","authenticated-orcid":false,"given":"Kim","family":"Levenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-6719","authenticated-orcid":false,"given":"Claire C.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-7719","authenticated-orcid":false,"given":"Linda","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"2421_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s00520-022-07508-2","volume":"31","author":"A Shen","year":"2023","unstructured":"Shen A, Lu Q, Fu X, Wei X, Zhang L, Bian J, Qiang W, Pang D. Risk factors of unilateral breast cancer-related lymphedema: an updated systematic review and meta-analysis of 84 cohort studies. Support Care Cancer. 2023;31:18. https:\/\/doi.org\/10.1007\/s00520-022-07508-2.","journal-title":"Support Care Cancer"},{"issue":"5","key":"2421_CR2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1089\/lrb.2018.0063","volume":"17","author":"J Douglass","year":"2019","unstructured":"Douglass J, Kelly-Hope L. Comparison of staging systems to assess lymphedema caused by cancer therapies, lymphatic filariasis, and podoconiosis. Lymphat Res Biol. 2019;17(5):550\u20136. https:\/\/doi.org\/10.1089\/lrb.2018.0063.","journal-title":"Lymphat Res Biol"},{"issue":"1","key":"2421_CR3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41523-021-00276-y","volume":"7","author":"MG J\u00f8rgensen","year":"2021","unstructured":"J\u00f8rgensen MG, Toyserkani NM, Hansen FG, Bygum A, S\u00f8rensen JA. The impact of lymphedema on health-related quality of life up to 10 years after breast cancer treatment. NPJ Breast Cancer. 2021;7(1):70. https:\/\/doi.org\/10.1038\/s41523-021-00276-y.","journal-title":"NPJ Breast Cancer"},{"issue":"5","key":"2421_CR4","doi-asserted-by":"publisher","first-page":"e664","DOI":"10.1016\/j.clbc.2022.01.013","volume":"22","author":"Y Lin","year":"2022","unstructured":"Lin Y, Yang Y, Zhang X, Li W, Li H, Mu D. Manual lymphatic drainage for breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials. Clin Breast Cancer. 2022;22(5):e664\u201373.","journal-title":"Clin Breast Cancer"},{"key":"2421_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/01.REO.0000000000000093","volume":"36","author":"D Tidhar","year":"2018","unstructured":"Tidhar D, Armer J, Stewart B. What is clinically important in lymphedema management? a systematic review. Rehabil Oncol. 2018;36:13\u201327.","journal-title":"Rehabil Oncol"},{"issue":"2","key":"2421_CR6","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/ptj\/86.2.205","volume":"86","author":"R Taylor","year":"2006","unstructured":"Taylor R, Jayasinghe UW, Koelmeyer L, Ung O, Boyages J. Reliability and validity of arm volume measurements for assessment of lymphedema. Phys Ther. 2006;86(2):205\u201314.","journal-title":"Phys Ther"},{"issue":"3","key":"2421_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3390\/healthcare8030285","volume":"8","author":"JM T\u00e1nori-Tapia","year":"2020","unstructured":"T\u00e1nori-Tapia JM, Romero-P\u00e9rez EM, Camberos NA, Horta-Gim MA, N\u00fa\u00f1ez-Oth\u00f3n G, Medina-P\u00e9rez C, de Paz JA. Determination of the minimum detectable change in the total and segmental volumes of the upper limb, evaluated by perimeter measurements. Healthcare (Basel). 2020;8(3):285. https:\/\/doi.org\/10.3390\/healthcare8030285.","journal-title":"Healthcare (Basel)"},{"issue":"12","key":"2421_CR8","doi-asserted-by":"publisher","first-page":"5717","DOI":"10.1007\/s00520-020-05375-3","volume":"28","author":"T De Vrieze","year":"2020","unstructured":"De Vrieze T, Gebruers N, Nevelsteen I, Tjalma WAA, Thomis S, De Groef A, Dams L, Van der Gucht E, Devoogdt N. Physical activity level and age contribute to functioning problems in patients with breast cancer-related lymphedema: a multicentre cross-sectional study. Support Care Cancer. 2020;28(12):5717\u201331.","journal-title":"Support Care Cancer"},{"key":"2421_CR9","doi-asserted-by":"publisher","first-page":"j4008","DOI":"10.1136\/bmj.j4008","volume":"358","author":"BJ Shea","year":"2017","unstructured":"Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, Henry DA. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008. https:\/\/doi.org\/10.1136\/bmj.j4008.","journal-title":"BMJ"},{"issue":"2","key":"2421_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.11124\/JBISRIR-2016-003185","volume":"16","author":"E Jeffs","year":"2018","unstructured":"Jeffs E, Ream E, Taylor C, Bick D. Clinical effectiveness of decongestive treatments on excess arm volume and patient-centered outcomes in women with early breast cancer-related arm lymphedema: a systematic review. JBI Database Syst Rev Implement Rep. 2018;16(2):453\u2013506.","journal-title":"JBI Database Syst Rev Implement Rep"},{"issue":"6","key":"2421_CR11","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s11136-018-1796-5","volume":"27","author":"M M\u00fcller","year":"2018","unstructured":"M\u00fcller M, Klingberg K, Wertli MM, Carreira H. Manual lymphatic drainage and quality of life in patients with lymphoedema and mixed oedema: a systematic review of randomised controlled trials. Qual Life Res. 2018;27(6):1403\u201314.","journal-title":"Qual Life Res"},{"issue":"2","key":"2421_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1097\/NCC.0000000000001061","volume":"46","author":"J Qiao","year":"2023","unstructured":"Qiao J, Yang LN, Kong YH, Huang X, Li Y, Bai DQ. Effect of manual lymphatic drainage on breast cancer-related postmastectomy lymphedema: a meta-analysis of randomized controlled trials. Cancer Nurs. 2023;46(2):159\u201366.","journal-title":"Cancer Nurs"},{"key":"2421_CR13","doi-asserted-by":"crossref","unstructured":"Thompson B, Gaitatzis K, Janse de Jonge X, Blackwell R, Koelmeyer LA. Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature. J Cancer Survivorship Res Pract. 2021;15(2):244\u2013258.","DOI":"10.1007\/s11764-020-00928-1"},{"issue":"5","key":"2421_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.nwh.2021.07.005","volume":"25","author":"A Wanchai","year":"2021","unstructured":"Wanchai A, Armer JM. Manual lymphedema drainage for reducing risk for and managing breast cancer\u2013related lymphedema after breast surgery: a systematic review. Nurs Womens Health. 2021;25(5):377\u201383.","journal-title":"Nurs Womens Health"},{"issue":"1","key":"2421_CR15","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1007\/s10549-018-4725-y","volume":"170","author":"FT Baumann","year":"2018","unstructured":"Baumann FT, Reike A, Reimer V, Schumann M, Hallek M, Taaffe DR, Newton RU, Galvao DA. Effects of physical exercise on breast cancer-related secondary lymphedema: a systematic review. Breast Cancer Res Treat. 2018;170(1):2018.","journal-title":"Breast Cancer Res Treat"},{"issue":"49","key":"2421_CR16","doi-asserted-by":"publisher","first-page":"e23192","DOI":"10.1097\/MD.0000000000023192","volume":"99","author":"M Liang","year":"2020","unstructured":"Liang M, Chen Q, Peng K, Deng L, He L, Hou Y, Zhang Y, Guo J, Mei Z, Li L. Manual lymphatic drainage for lymphedema in patients after breast cancer surgery: a systematic review and meta-analysis of randomized controlled trials. Medicine. 2020;99(49):e23192.","journal-title":"Medicine"},{"issue":"4","key":"2421_CR17","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1002\/nop2.1518","volume":"10","author":"Y Lin","year":"2023","unstructured":"Lin Y, Chen Y, Liu R, Cao B. Effect of exercise on rehabilitation of breast cancer surgery patients: a systematic review and meta-analysis of randomized controlled trials. Nurs Open. 2023;10(4):2030\u201343.","journal-title":"Nurs Open"},{"issue":"5","key":"2421_CR18","doi-asserted-by":"publisher","first-page":"E171","DOI":"10.1188\/20.ONF.E171-E189","volume":"47","author":"L Lytvyn","year":"2020","unstructured":"Lytvyn L, Zeraatkar D, Anbari AB, Ginex PK, Zoratti M, Niburski K, Sadeghirad B, Siedler M, Thabane L, Morgan RL. Conservative intervention strategies for adult cancer-related lymphedema: a systematic review and network meta-analysis. Oncol Nurs Forum. 2020;47(5):E171\u201389.","journal-title":"Oncol Nurs Forum"},{"issue":"5","key":"2421_CR19","first-page":"YE01","volume":"15","author":"M Naik","year":"2021","unstructured":"Naik M, Nayak P, Kumar KUD. Effect of physiotherapy in the prevention and relief of secondary lymphedema in subjects with postoperative breast cancer\u2014a systematic review of randomised controlled trials. J Clin Diagn Res. 2021;15(5):YE01\u20135.","journal-title":"J Clin Diagn Res"},{"issue":"2","key":"2421_CR20","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.apmr.2021.06.027","volume":"103","author":"FB Rangon","year":"2022","unstructured":"Rangon FB, da Silva J, Dibai-Filho AV, Guirro RRJ, Guirro ECO. Effects of complex physical therapy and multimodal approaches on lymphedema secondary to breast cancer: a systematic review and meta-analysis of randomized controlled trials. Arch Phys Med Rehabil. 2022;103(2):353\u201363.","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"2421_CR21","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1097\/COC.0000000000000355","volume":"41","author":"TD Smile","year":"2018","unstructured":"Smile TD, Tendulkar R, Schwarz G, Arthur D, Grobmyer S, Valente S, Vicini F, Shah C. A review of treatment for breast cancer-related lymphedema: paradigms for clinical practice. Am J Clin Oncol Cancer Clin Trials. 2018;41(2):178\u201390.","journal-title":"Am J Clin Oncol Cancer Clin Trials"},{"issue":"2","key":"2421_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1023\/B:BREA.0000032978.67677.9f","volume":"86","author":"ML McNeely","year":"2004","unstructured":"McNeely ML, Magee DJ, Lees AW, Bagnall KM, Haykowsky M, Hanson J. The addition of manual lymph drainage to compression therapy for breast cancer related lymphedema: a randomized controlled trial. Breast Cancer Res Treat. 2004;86(2):95\u2013106.","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"2421_CR23","first-page":"25","volume":"43","author":"S Haghighat","year":"2010","unstructured":"Haghighat S, Lotfi-Tokaldany M, Yunesian M, Akbari ME, Nazemi F, Weiss J. Comparing two treatment methods for post mastectomy lymphedema: complex decongestive therapy alone and in combination with intermittent pneumatic compression. Lymphology. 2010;43(1):25\u201333.","journal-title":"Lymphology"},{"issue":"30","key":"2421_CR24","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1200\/JCO.2012.45.7192","volume":"31","author":"IS Dayes","year":"2013","unstructured":"Dayes IS, Whelan TJ, Julian JA, Parpia S, Pritchard KI, D\u2019Souza DP, Kligman L, Reise D, LeBlanc L, McNeely ML, Manchul L, Wiernikowski J, Levine MN. Randomized trial of decongestive lymphatic therapy for the treatment of lymphedema in women with breast cancer. J Clin Oncol. 2013;31(30):3758\u201363.","journal-title":"J Clin Oncol"},{"key":"2421_CR25","doi-asserted-by":"publisher","first-page":"690","DOI":"10.5535\/arm.2013.37.5.690","volume":"37","author":"JM Hwang","year":"2013","unstructured":"Hwang JM, Hwang JH, Kim TW, Lee SY, Chang HJ, Chu IH. Long-term effects of complex decongestive therapy in breast cancer patients with arm lymphedema after axillary dissection. Ann Rehabil Med. 2013;37:690\u20137.","journal-title":"Ann Rehabil Med"},{"issue":"3","key":"2421_CR26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s12282-013-0481-3","volume":"22","author":"H Uzkeser","year":"2015","unstructured":"Uzkeser H, Karatay S, Erdemci B, Koc M, Senel K. Efficacy of manual lymphatic drainage and intermittent pneumatic compression pump use in the treatment of lymphedema after mastectomy: a randomized controlled trial. Breast Cancer. 2015;22(3):300\u20137. https:\/\/doi.org\/10.1007\/s12282-013-0481-3. (Epub 2013 Aug 8).","journal-title":"Breast Cancer"},{"issue":"10","key":"2421_CR27","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1038\/s41416-018-0306-4","volume":"119","author":"M Tambour","year":"2018","unstructured":"Tambour M, Holt M, Speyer A, Christensen R, Gram B. Manual lymphatic drainage adds no further volume reduction to complete decongestive therapy on breast cancer-related lymphoedema: a multicentre, randomised, single-blind trial. Br J Cancer. 2018;119(10):1215\u201322. https:\/\/doi.org\/10.1038\/s41416-018-0306-4.","journal-title":"Br J Cancer"},{"issue":"5","key":"2421_CR28","first-page":"1405","volume":"19","author":"RPC Luz","year":"2018","unstructured":"Luz RPC, Simao Haddad CA, Rizzi SKLA, Elias S, Nazario ACP, Facina G. Complex therapy physical alone or associated with strengthening exercises in patients with lymphedema after breast cancer treatment: a controlled clinical trial. Asian Pacific J Cancer Prevent. 2018;19(5):1405\u201310.","journal-title":"Asian Pacific J Cancer Prevent"},{"key":"2421_CR29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1177\/0269215519888792","volume":"34","author":"E Tastaban","year":"2020","unstructured":"Tastaban E, Soyder A, Aydin E, Sendur OF, Turan Y, Ture M, Bilgen M. Role of intermittent pneumatic compression in the treatment of breast cancer-related lymphoedema: a randomized controlled trial. Clin Rehabil. 2020;34:220\u20138.","journal-title":"Clin Rehabil"},{"key":"2421_CR30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.breast.2012.12.018","volume":"22","author":"SF Liao","year":"2013","unstructured":"Liao SF, Li SH, Huang HY, Chen ST, Kuo SJ, Chen DR, Wei TS. The efficacy of complex decongestive physiotherapy (CDP) in breast cancer-related lymphedema (BCRL). Breast. 2013;22:703\u20136.","journal-title":"Breast"},{"key":"2421_CR31","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1188\/13.ONF.383-393","volume":"40","author":"SH Ridner","year":"2013","unstructured":"Ridner SH, Poage-Hooper E, Kanar C, Doersam JK, Bond SM, Dietrich MS. A pilot randomized trial evaluating low level laser as an alternative treatment to manual lymphatic drainage for breast cancer-related lymphedema. Oncol Nurs Forum. 2013;40:383\u201393.","journal-title":"Oncol Nurs Forum"},{"issue":"11","key":"2421_CR32","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1002\/cncr.10976","volume":"95","author":"A Szuba","year":"2002","unstructured":"Szuba A, Achalu R, Rockson SG. Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compression. Cancer. 2002;95(11):2260\u20137.","journal-title":"Cancer"},{"key":"2421_CR33","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.jpainsymman.2015.06.017","volume":"50","author":"T Gradalski","year":"2015","unstructured":"Gradalski T, Ochalek K, Kurpiewska J. Complex decongestive lymphatic therapy with or without vodder II manual lymph drainage in more severe chronic postmastectomy upper limb lymphedema: a randomized noninferiority prospective study. J Pain Symptom Manage. 2015;50:750\u20137.","journal-title":"J Pain Symptom Manage"},{"issue":"6","key":"2421_CR34","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1089\/lrb.2019.0003","volume":"17","author":"G Ergin","year":"2019","unstructured":"Ergin G, \u015eahino\u011flu E, Karadibak D, Yavuz\u015fen T. Effectiveness of kinesio taping on anastomotic regions in patients with breast cancer-related lymphedema: a randomized controlled pilot study. Lymphat Res Biol. 2019;17(6):655\u201360.","journal-title":"Lymphat Res Biol"},{"issue":"2","key":"2421_CR35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/lrb.2020.0049","volume":"19","author":"EI Sen","year":"2021","unstructured":"Sen EI, Arman S, Zure M, Yavuz H, Sindel D, Oral A. Manual lymphatic drainage may not have an additional effect on the intensive phase of breast cancer-related lymphedema: a randomized controlled trial. Lymphatic Res Biol. 2021;19(2):141\u201350.","journal-title":"Lymphatic Res Biol"},{"issue":"4","key":"2421_CR36","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3109\/21679169.2014.959048","volume":"16","author":"DO Odebiyi","year":"2014","unstructured":"Odebiyi DO, Aborowa AT, Sokunbi OG, Aweto HA, Ajekigbe AT. Effects of exercise and oedema massage on fatigue level and quality of life of female breast cancer patients. Eur J Physiother. 2014;16(4):238\u201345.","journal-title":"Eur J Physiother"},{"issue":"3","key":"2421_CR37","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/028418600750013186","volume":"39","author":"L Andersen","year":"2000","unstructured":"Andersen L, Hojris I, Erlandsen M, Andersen J. Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage: a randomized study. Acta Oncol. 2000;39(3):399\u2013405.","journal-title":"Acta Oncol"},{"key":"2421_CR38","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1007\/s00520-015-3005-1","volume":"24","author":"Y Cho","year":"2016","unstructured":"Cho Y, Do J, Jung S, Kwon O, Jeon JY. Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection. Support Care Cancer. 2016;24:2047\u201357.","journal-title":"Support Care Cancer"},{"key":"2421_CR39","first-page":"73","volume":"8","author":"MK Gol","year":"2020","unstructured":"Gol MK, Aghamohamadi D. Effect of massage therapy with and without elastic bandaging on pain, edema, and shoulder dysfunction after modified radical mastectomy: a clinical trial. Int J Womens Health Reprod Sci. 2020;8:73\u20138.","journal-title":"Int J Womens Health Reprod Sci"},{"issue":"4","key":"2421_CR40","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1046\/j.1365-2354.2002.00312.x","volume":"11","author":"AF Williams","year":"2002","unstructured":"Williams AF, Vadgama A, Franks PJ, Mortimer PS. A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema. Eur J Cancer Care (Engl). 2002;11(4):254\u201361.","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"1","key":"2421_CR41","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12906-016-1330-7","volume":"16","author":"A Loudon","year":"2016","unstructured":"Loudon A, Barnett T, Piller N, Immink MA, Visentin D, Williams AD. The effects of yoga on shoulder and spinal actions for women with breast cancer-related lymphoedema of the arm: a randomised controlled pilot study. BMC Complement Altern Med. 2016;16(1):343.","journal-title":"BMC Complement Altern Med"},{"key":"2421_CR42","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ejon.2019.08.008","volume":"42","author":"N Pasyar","year":"2019","unstructured":"Pasyar N, Barshan Tashnizi N, Mansouri P, Tahmasebi S. Effect of yoga exercise on the quality of life and upper extremity volume among women with breast cancer related lymphedema: a pilot study. Eur J Oncol Nurs. 2019;42:103\u20139.","journal-title":"Eur J Oncol Nurs"},{"issue":"1","key":"2421_CR43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.5014\/ajot.64.1.59","volume":"64","author":"MK McClure","year":"2010","unstructured":"McClure MK, McClure RJ, Day R, Brufsky AM. Randomized controlled trial of the breast cancer recovery program for women with breast cancer-related lymphedema. Am J Occup Ther. 2010;64(1):59\u201372.","journal-title":"Am J Occup Ther"},{"issue":"9","key":"2421_CR44","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1097\/PHM.0000000000000089","volume":"93","author":"ME Letellier","year":"2014","unstructured":"Letellier ME, Towers A, Shimony A, Tidhar D. Breast cancer-related lymphedema: a randomized controlled pilot and feasibility study. Am J Phys Med Rehabil. 2014;93(9):751\u201361. https:\/\/doi.org\/10.1097\/PHM.0000000000000089.","journal-title":"Am J Phys Med Rehabil"},{"issue":"5","key":"2421_CR45","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1177\/1534735413477194","volume":"12","author":"P Cormie","year":"2013","unstructured":"Cormie P, Galv\u00e3o DA, Spry N, Newton RU. Neither heavy nor light load resistance exercise acutely exacerbates lymphedema in breast cancer survivor. Integr Cancer Ther. 2013;12(5):423\u201332. https:\/\/doi.org\/10.1177\/1534735413477194.","journal-title":"Integr Cancer Ther"},{"issue":"4","key":"2421_CR46","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00520-012-1621-6","volume":"21","author":"E Jeffs","year":"2013","unstructured":"Jeffs E, Wiseman T. Randomised controlled trial to determine the benefit of daily home-based exercise in addition to self-care in the management of breast cancer-related lymphoedema: a feasibility study. Support Care Cancer. 2013;21(4):1013\u201323. https:\/\/doi.org\/10.1007\/s00520-012-1621-6.","journal-title":"Support Care Cancer"},{"issue":"12","key":"2421_CR47","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1016\/j.apmr.2010.09.008","volume":"91","author":"DS Kim","year":"2010","unstructured":"Kim DS, Sim YJ, Jeong HJ, Kim GC. Effect of active resistive exercise on breast cancer-related lymphedema: a randomized controlled trial. Arch Phys Med Rehabil. 2010;91(12):1844\u20138. https:\/\/doi.org\/10.1016\/j.apmr.2010.09.008.","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"2421_CR48","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/lrb.2015.0021","volume":"14","author":"SK Bok","year":"2016","unstructured":"Bok SK, Jeon Y, Hwang PS. Ultrasonographic evaluation of the effects of progressive resistive exercise in breast cancer-related lymphedema. Lymphat Res Biol. 2016;14(1):18\u201324. https:\/\/doi.org\/10.1089\/lrb.2015.0021.","journal-title":"Lymphat Res Biol"},{"issue":"11","key":"2421_CR49","doi-asserted-by":"publisher","first-page":"6545","DOI":"10.1007\/s00520-021-06235-4","volume":"29","author":"E Baran","year":"2021","unstructured":"Baran E, \u00d6z\u00e7akar L, \u00d6zg\u00fcl S, Aksoy S, Akbayrak T. Upper limb sensory evaluations and ultrasonographic skin measurements in breast cancer-related lymphedema receiving complex decongestive physiotherapy. Support Care Cancer. 2021;29(11):6545\u201353.","journal-title":"Support Care Cancer"},{"issue":"3","key":"2421_CR50","doi-asserted-by":"publisher","first-page":"e270","DOI":"10.1016\/j.clbc.2021.08.005","volume":"22","author":"P Borman","year":"2022","unstructured":"Borman P, Yaman A, Yasrebi S, P\u0131nar \u0130nanl\u0131 A, Ar\u0131kan DA. Combined complete decongestive therapy reduces volume and improves quality of life and functional status in patients with breast cancer-related lymphedema. Clin Breast Cancer. 2022;22(3):e270\u20137.","journal-title":"Clin Breast Cancer"},{"key":"2421_CR51","doi-asserted-by":"publisher","first-page":"105890","DOI":"10.1016\/j.clinbiomech.2023.105890","volume":"102","author":"F Bilek","year":"2023","unstructured":"Bilek F, Deniz G, Gulkesen A. The effect of complex decongestive therapy on spatio-temporal parameters and balance in women with breast cancer-related upper extremity unilateral lymphedema. Clin Biomech. 2023;102:105890.","journal-title":"Clin Biomech"},{"issue":"4","key":"2421_CR52","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1089\/lrb.2020.0099","volume":"19","author":"M Corum","year":"2021","unstructured":"Corum M, Basoglu C, Korkmaz MD, Yildirim MA, Ones K. Effectiveness of combined complex decongestive therapy and resistance exercises in the treatment of lymphedema associated with breast cancer and the effect of pain on treatment response. Lymphat Res Biol. 2021;19(4):383\u201390.","journal-title":"Lymphat Res Biol"},{"issue":"3","key":"2421_CR53","doi-asserted-by":"publisher","first-page":"387","DOI":"10.4103\/njcp.njcp_373_19","volume":"24","author":"A Kostanoglu","year":"2021","unstructured":"Kostanoglu A, Tarakci E. Physical therapy enhances functions and quality of life in older patients with breast cancer-related lymphedema: a prospective experimental study. Niger J Clin Pract. 2021;24(3):387\u201392.","journal-title":"Niger J Clin Pract"},{"issue":"2","key":"2421_CR54","doi-asserted-by":"publisher","first-page":"211","DOI":"10.5606\/tftrd.2021.5191","volume":"67","author":"H Ye\u015fil","year":"2021","unstructured":"Ye\u015fil H, Eyig\u00f6r S, \u0130nbat M, Bulut F. The effects of complex decongestive therapy on kinesthetic sense of hands, upper extremity function, and quality of life in patients with breast cancer-related lymphedema. Turk J Phys Med Rehabil. 2021;67(2):211\u20137.","journal-title":"Turk J Phys Med Rehabil"},{"key":"2421_CR55","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3390\/cancers15051545","volume":"15","author":"N Devoogdt","year":"2023","unstructured":"Devoogdt N, Thomis S, De Groef A, Heroes AK, Nevelsteen I, Gebruers N, Tjalma WAA, Belgrado JP, Monten C, Hanssens M, De Vrieze T. The effectiveness of fluoroscopy-guided manual lymph drainage as part of decongestive lymphatic therapy on the superficial lymphatic architecture in patients with breast cancer-related lymphoedema: a randomised controlled trial. Cancers. 2023;15:1545. https:\/\/doi.org\/10.3390\/cancers15051545.","journal-title":"Cancers"},{"key":"2421_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ptj\/pzac137","volume":"102","author":"T De Vrieze","year":"2022","unstructured":"De Vrieze T, Gebruers N, Nevelsteen I, Thomis S, De Groef A, Tjalma WAA, Belgrado JP, Vandermeeren L, Monten C, Hanssens M, Asnong A, Dams L, Van der Gucht E, Heroes AK, Devoogdt N. Does manual lymphatic drainage add value in reducing arm volume in patients with breast cancer-related lymphedema? Phys Ther. 2022;102:1\u201314.","journal-title":"Phys Ther"},{"issue":"2","key":"2421_CR57","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jphys.2022.03.010","volume":"68","author":"T De Vrieze","year":"2022","unstructured":"De Vrieze T, Gebruers N, Nevelsteen I, Fieuws S, Thomis S, De Groef A, Tjalma WA, Belgrado JP, Vandermeeren L, Monten C, Hanssens M, Devoogdt N. Manual lymphatic drainage with or without fluoroscopy guidance did not substantially improve the effect of decongestive lymphatic therapy in people with breast cancer-related lymphoedema (EFforT-BCRL trial): a multicentre randomised trial. J Physiother. 2022;68(2):110\u201322.","journal-title":"J Physiother"},{"issue":"2","key":"2421_CR58","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/lrb.2020.0049","volume":"19","author":"EI Sen","year":"2021","unstructured":"Sen EI, Arman S, Zure M, Yavuz H, Sindel D, Oral A. Manual lymphatic drainage may not have an additional effect on the intensive phase of breast cancer-related lymphedema: a randomized controlled trial. Lymphat Res Biol. 2021;19(2):141\u201350.","journal-title":"Lymphat Res Biol"},{"issue":"4","key":"2421_CR59","first-page":"28","volume":"26","author":"MM Zabojszcz","year":"2022","unstructured":"Zabojszcz MM, Opuchlik M, Opuchlik A, Wloch A, Ridan T. Influence of complex physical therapy on physical fitness and balance in women after unilateral mastectomy due to cancer treatment. Rehabil Med. 2022;26(4):28\u201335.","journal-title":"Rehabil Med"},{"issue":"1","key":"2421_CR60","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/01893697-201432010-00003","volume":"32","author":"C Davies","year":"2014","unstructured":"Davies C, Ryans K, Levenhagen K, Perdomo M. Breast Cancer EDGE Task Force outcomes: quality of life and functional outcome measures for secondary lymphedema in breast cancer survivors. Rehabil Oncol. 2014;32(1):7\u201312.","journal-title":"Rehabil Oncol"},{"issue":"1","key":"2421_CR61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/01893697-201432010-00005","volume":"32","author":"M Perdomo","year":"2014","unstructured":"Perdomo M, Davies C, Levenhagen K, Ryans K. Breast Cancer EDGE Task Force outcomes: assessment measures of secondary lymphedema in breast cancer survivors. Rehabil Oncol. 2014;32(1):22\u201335. https:\/\/doi.org\/10.1097\/01893697-201432010-00005.","journal-title":"Rehabil Oncol"},{"issue":"4","key":"2421_CR62","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/TGR.0000000000000082","volume":"31","author":"N Stout","year":"2015","unstructured":"Stout N, Harrington S, Pfalzer L, Fisher M. Breast cancer rehabilitation: clinical examination and outcomes assessment. Geriatr Reabil. 2015;31(4):258\u201372. https:\/\/doi.org\/10.1097\/TGR.0000000000000082.","journal-title":"Geriatr Reabil"},{"issue":"3","key":"2421_CR63","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1097\/01.REO.0000000000000073","volume":"35","author":"K Levenhagen","year":"2017","unstructured":"Levenhagen K, Davies C, Perdomo M, Ryans K, Gilchrist L. Diagnosis of upper-quadrant lymphedema secondary to cancer: clinical practice guideline from the oncology section of APTA. Rehabil Oncol. 2017;35(3):E1\u201318. https:\/\/doi.org\/10.1097\/01.REO.0000000000000073.","journal-title":"Rehabil Oncol."},{"issue":"5","key":"2421_CR64","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/J.JVSV.2017.04.012","volume":"5","author":"RJ Damstra","year":"2017","unstructured":"Damstra RJ, Halk A-B. Dutch working group on lymphedema. The dutch lymphedema guidelines based on the international classification of functioning, disability, and health and the chronic care model. J Vasc Surg Venous Lymphat Disord. 2017;5(5):756\u201365. https:\/\/doi.org\/10.1016\/J.JVSV.2017.04.012.","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"1","key":"2421_CR65","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.AOG.0000444442.04111.c6","volume":"41","author":"DA Doubblestein","year":"2023","unstructured":"Doubblestein DA, Spinelli BA, Goldberg A, Larson CA, Yorke AM. Use of outcome measures by certified lymphedema therapists with survivors of breast cancer with breast cancer\u2013related lymphedema. Rehabil Oncol. 2023;41(1):34\u201346. https:\/\/doi.org\/10.1097\/01.AOG.0000444442.04111.c6.","journal-title":"Rehabil Oncol"},{"key":"2421_CR66","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07298-7","author":"D Doubblestein","year":"2024","unstructured":"Doubblestein D, Koehler L, Anderson E, Scheiman N, Stewart P, Schaverien M, Armer J. Development of a core set of outcome measures to be applied toward breast cancer-related lymphedema core outcome domains. Breast Cancer Res Treat. 2024. https:\/\/doi.org\/10.1007\/s10549-024-07298-7. (Epub ahead of print).","journal-title":"Breast Cancer Res Treat"},{"key":"2421_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07262-5","author":"D Doubblestein","year":"2024","unstructured":"Doubblestein D, Koehler L, Anderson E, Scheiman N, Stewart P, Schaverien M, Armer J. Development of a core outcome set for breast cancer-related lymphedema: a delphi study. Breast Cancer Res Treat. 2024. https:\/\/doi.org\/10.1007\/s10549-024-07262-5. (Epub ahead of print. PMID: 38424364).","journal-title":"Breast Cancer Res Treat"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-024-02421-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-024-02421-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-024-02421-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T09:14:54Z","timestamp":1731489294000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-024-02421-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["2421"],"URL":"https:\/\/doi.org\/10.1007\/s12032-024-02421-6","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"27 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"As a literature-based study, consent to publish is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"No IRB approval was required for this literature-based study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"297"}}