{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:19:08Z","timestamp":1782897548094,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-024-02512-4","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T20:46:20Z","timestamp":1727297180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of the mechanisms underlying the anticancer and biological activity of retinoic acid and chitosan nanoparticles containing retinoic acid"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-0177","authenticated-orcid":false,"given":"Murat","family":"Dogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"issue":"3","key":"2512_CR1","first-page":"683","volume":"53","author":"AO Docea","year":"2012","unstructured":"Docea AO, Mitrut P, Grigore D, Pirici D, Calina DC, Gofita E. Immunohistochemical expression of TGF beta (TGF-beta), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas. Rom J Morphol Embryol. 2012;53(3):683\u201392.","journal-title":"Rom J Morphol Embryol"},{"issue":"3","key":"2512_CR2","first-page":"1","volume":"9","author":"B Salehi","year":"2019","unstructured":"Salehi B, Jornet PL, Lopez EPF, Calina D, Sharifi-Rad M, Ramirez-Alarcon K, Forman K, Fernandez M, Martorell M, Setzer WN, et al. Plant-derived bioactives in oral mucosal lesions: a key emphasis to curcumin, lycopene, chamomile, Aloe Vera, green tea and coffee. Prop Biomol. 2019;9(3):1\u201323.","journal-title":"Prop Biomol"},{"key":"2512_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2020.00694","volume":"11","author":"M Sharifi-Rad","year":"2020","unstructured":"Sharifi-Rad M, Kumar NVA, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Fokou PVT, Azzini E, Peluso I, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. 2020;11:1\u201321.","journal-title":"Front Physiol"},{"key":"2512_CR4","first-page":"156","volume":"5","author":"A Ghad","year":"2014","unstructured":"Ghad A, Mahjoub S, Tabandeh F, Talebnia F. Synthesis and optimization of chitosan NPs: potential applications in nanomedicine and biomedical engineering. Casp J Intern Med. 2014;5:156\u201361.","journal-title":"Casp J Intern Med"},{"key":"2512_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40824-018-0133-y","volume":"22","author":"W Park","year":"2018","unstructured":"Park W, Heo YJ, Han DK. New opportunities for NPs in cancer immunotherapy. Biomater Res. 2018;22:24\u201333.","journal-title":"Biomater Res"},{"issue":"1","key":"2512_CR6","first-page":"11","volume":"34","author":"I Jov\u010devska","year":"2020","unstructured":"Jov\u010devska I, Muyldermans S. The therapeutic potential of nanobodies. BioDrugs Clin Immunother Biopharm Gene Ther. 2020;34(1):11\u201326.","journal-title":"BioDrugs Clin Immunother Biopharm Gene Ther"},{"issue":"1","key":"2512_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nri2216","volume":"8","author":"L Zitvogel","year":"2008","unstructured":"Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. Nat Rev Immunol. 2008;8(1):59\u201373.","journal-title":"Nat Rev Immunol"},{"key":"2512_CR8","doi-asserted-by":"crossref","unstructured":"Wang R, Billone PS, Mullett WM. Nanomedicine in action: an overview of cancer nanomedicine on the market and in clinical trials. J Nanomater. 2013;1\u201312","DOI":"10.1155\/2013\/629681"},{"issue":"9","key":"2512_CR9","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.1021\/nn102324e","volume":"4","author":"JH Adair","year":"2010","unstructured":"Adair JH, Parette MP, Altinoglu EI, Kester M. Nanoparticulate alternatives for drug delivery. ACS Nano. 2010;4(9):4967\u201370.","journal-title":"ACS Nano"},{"issue":"131841","key":"2512_CR10","first-page":"1","volume":"268","author":"HB Yekeler","year":"2024","unstructured":"Yekeler HB, Guler E, Beato PS, Priya S, Abobakr FKM, Dogan M, Uner B. Design and in vitro evaluation of curcumin-loaded PLGA NP-embedded sodium alginate\/gelatin 3D printed scaffolds for Alzheimer\u2019s disease. Int J Biol Macromol. 2024;268(131841):1\u201314.","journal-title":"Int J Biol Macromol"},{"issue":"128635","key":"2512_CR11","first-page":"1","volume":"258","author":"E G\u00fcler","year":"2023","unstructured":"G\u00fcler E, Yekeler HB, Parviz G, Ayd\u0131n S, Asghar A, Do\u011fan M, \u0130kram F. Vitamin B12-loaded chitosan-based NP-embedded polymeric nanofibers for sublingual and transdermal applications: two alternative application routes for vitamin B12. Int J Biol Macromol. 2023;258(128635):1\u201316.","journal-title":"Int J Biol Macromol"},{"key":"2512_CR12","first-page":"339","volume":"7","author":"B Mansoori","year":"2017","unstructured":"Mansoori B, Mohammadi A, Davudian S, Shirjang S, Baradaran B. The different mechanisms of cancer drug resistance: a brief review. Tabriz Univ Med Sci. 2017;7:339\u201348.","journal-title":"Tabriz Univ Med Sci"},{"key":"2512_CR13","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.3390\/cancers6031769","volume":"6","author":"M Longacre","year":"2014","unstructured":"Longacre M, Snyder N, Sarkar S. Drug resistance in cancer: an overview. Cancers (Basel). 2014;6:1769\u201392.","journal-title":"Cancers (Basel)"},{"key":"2512_CR14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.5732\/cjc.011.10326","volume":"31","author":"X Xue","year":"2012","unstructured":"Xue X, Liang XJ. Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology. Chin J Cancer. 2012;31:100\u20139.","journal-title":"Chin J Cancer"},{"issue":"118464","key":"2512_CR15","first-page":"1","volume":"272","author":"A Narmani","year":"2021","unstructured":"Narmani A, Jafari SM. Chitosan-based nanodelivery systems for cancer therapy. Recent Adv Carbohydr Polym. 2021;272(118464):1\u201313.","journal-title":"Recent Adv Carbohydr Polym"},{"key":"2512_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/1750-3841.14439","volume":"84","author":"A Singh","year":"2019","unstructured":"Singh A, Benjakul S, Prodpran T. Ultrasound assisted extraction of chitosan from squid pen: molecular characterization and fat binding capacity. J Food Sci. 2019;84:224\u201334.","journal-title":"J Food Sci"},{"key":"2512_CR17","first-page":"1","volume":"111","author":"A Mittal","year":"2020","unstructured":"Mittal A, Singh A, Benjakul S, Prodpran T, Nilsuwan K, Huda N, Caba KDL. Composite films based on chitosan and epigallocatechin gallate grafted chitosan: characterization, antioxidant and antimicrobial activities. Food Hydrocol. 2020;111:1\u201310.","journal-title":"Food Hydrocol"},{"issue":"2","key":"2512_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics15020515","volume":"15","author":"AV Yagolovich","year":"2023","unstructured":"Yagolovich AV, Gasparian ME, Dolgikh DA. Recent advances in the development of nanodelivery systems targeting the Trail death receptor pathway. Pharmaceutics. 2023;15(2):1\u201337.","journal-title":"Pharmaceutics"},{"issue":"18","key":"2512_CR19","doi-asserted-by":"publisher","first-page":"18797","DOI":"10.1002\/cam4.6502","volume":"12","author":"S Ashique","year":"2023","unstructured":"Ashique S, Garg A, Hussain A, Farid A, Kumar P, Taghizadeh-Hesary F. Nanodelivery systems: an efficient and target-specific approach for drug-resistant cancers. Cancer Med. 2023;12(18):18797\u2013825.","journal-title":"Cancer Med"},{"key":"2512_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2022.100050","volume":"7","author":"MW El-Maadawy","year":"2022","unstructured":"El-Maadawy MW, Mohamed RR, Hanna DH. Preparation of carrageenan\/chitosan-based (N, N, N-trimeth (yl chitosan chloride) silver nanocomposites as pH sensitive carrier for effective controlled curcumin delivery in cancer cells. OpenNano. 2022;7: 100050.","journal-title":"OpenNano"},{"key":"2512_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123364","volume":"231","author":"DH Hanna","year":"2023","unstructured":"Hanna DH, El-Mazaly MH, Mohamed RR. Synthesis of biodegradable antimicrobial pH-sensitive silver nanocomposites reliant on chitosan and carrageenan derivatives for 5-fluorouracil drug delivery toward HCT116 cancer cells. Int J Biol Macromol. 2023;231: 123364.","journal-title":"Int J Biol Macromol"},{"key":"2512_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.intimp.2013.10.027","volume":"18","author":"F Alizadeh","year":"2014","unstructured":"Alizadeh F, Bolhassani A, Khavari A, Bathaie SZ, Naji T, Bidgoli SA. Retinoids and their biological effects against cancer. Int Immunopharmacol. 2014;18:43\u20139.","journal-title":"Int Immunopharmacol"},{"key":"2512_CR23","first-page":"42","volume":"5","author":"R Tang","year":"2017","unstructured":"Tang R, Liang C, Shangguan J, Guo S. The effects of all-trans retinoic acid on vasculogen ic mimicry formation ability in CD133+ glioma stem cells and its mechanisms. J Biosci Med. 2017;5:42\u201354.","journal-title":"J Biosci Med"},{"key":"2512_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.physbeh.2017.03.040","volume":"176","author":"P Bunney","year":"2017","unstructured":"Bunney P, Zink AHA. Retinoids and rex inoids in cancer prevention: from laboratory to clinic. Physiol Behav. 2017;176:139\u201348.","journal-title":"Physiol Behav"},{"key":"2512_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcab.2020.101670","volume":"27","author":"T Taskin","year":"2020","unstructured":"Taskin T, Dogan M, Yilmaz BN, Senkardes I. Phytochemical screening and evaluation of antioxidant, enzyme inhibition, anti-proliferative and calcium oxalate anti-crystallization activities of Micromeria fruticosa spp. brachycalyx and Rhus coriaria. Biocatal Agric Biotechnol. 2020;27:1\u20137.","journal-title":"Biocatal Agric Biotechnol"},{"issue":"1","key":"2512_CR26","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4","volume":"63","author":"P Calvo","year":"1997","unstructured":"Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan-polyethylene oxide NPs as protein carriers. J Appl Polym Sci. 1997;63(1):125\u201332.","journal-title":"J Appl Polym Sci"},{"issue":"1","key":"2512_CR27","first-page":"1","volume":"7","author":"T Wikanta","year":"2012","unstructured":"Wikanta T, Erizal T, Tjahyono T, Sugiyono T. Synthesis of polyvinyl alcohol-chitosan hydrogel and study of its swelling and antibacterial properties. Squalen Bull Mar Fish Postharvest Biotechnol. 2012;7(1):1\u201310.","journal-title":"Squalen Bull Mar Fish Postharvest Biotechnol"},{"key":"2512_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bioorg.2018.11.036","volume":"84","author":"DH Hanna","year":"2019","unstructured":"Hanna DH, Saad GR. Encapsulation of ciprofloxacin within modified xanthan gum-chitosan based hydrogel for drug delivery. Bioorg Chem. 2019;84:115\u201324.","journal-title":"Bioorg Chem"},{"key":"2512_CR29","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/172\/1\/012035","volume":"172","author":"N Purbowatiningrum","year":"2017","unstructured":"Purbowatiningrum N, Ismiyarto EF. Cinnamomum casia extract encapsulated nanochitosan as antihypercholesterol. IOP Conf Ser Mater Sci Eng. 2017;172: 012035.","journal-title":"IOP Conf Ser Mater Sci Eng"},{"key":"2512_CR30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.colsurfb.2015.03.050","volume":"130","author":"HJ Han","year":"2015","unstructured":"Han HJ, Lee JS, Park SA, Ahn JB, Lee HG. Extraction optimization and nanoencapsulation of jujube pulp and seed for enhancing antioxidant activity. Colloids Surf B. 2015;130:93\u2013100.","journal-title":"Colloids Surf B"},{"issue":"8","key":"2512_CR31","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.31557\/APJCP.2021.22.8.2587","volume":"22","author":"A Pourgholi","year":"2021","unstructured":"Pourgholi A, Dadashpour M, Mousapour A, Amandi AF, Zarghami N. Anticancer potential of silibinin loaded polymeric nanoparticles against breast cancer cells: insight into the apoptotic genes targets. Asian Pac J Cancer Prev. 2021;22(8):2587.","journal-title":"Asian Pac J Cancer Prev"},{"key":"2512_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101673","volume":"57","author":"MHA Elella","year":"2020","unstructured":"Elella MHA, Sabaa M, Hanna DH, Abdel-Aziz MM, Mohamed RR. Antimicrobial pH-sensitive protein carrier based on modified xanthan gum. J Drug Deliv Sci Technol. 2020;57: 101673.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"4","key":"2512_CR33","doi-asserted-by":"publisher","first-page":"659","DOI":"10.33808\/clinexphealthsci.972180","volume":"11","author":"D Ta\u015fk\u0131n","year":"2021","unstructured":"Ta\u015fk\u0131n D, Do\u011fan M, Ermano\u011flu M, Arabaci T. Achillea goniocephala extract loaded into nanochitosan: in vitro cytotoxic and antioxidant activity. Clin Exp Health Sci. 2021;11(4):659\u201366.","journal-title":"Clin Exp Health Sci"},{"issue":"4","key":"2512_CR34","first-page":"479","volume":"42","author":"M Do\u011fan","year":"2020","unstructured":"Do\u011fan M, Karademir M. Effect of captopril on the oxidative damage caused by pentylenetetrazole in the SHSY-5Y human neuroblastoma cell line. Cumhuriyet Med J. 2020;42(4):479\u201383.","journal-title":"Cumhuriyet Med J"},{"key":"2512_CR35","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s12032-022-01820-x","volume":"11","author":"M Dogan","year":"2022","unstructured":"Dogan M. Assessment of mechanism involved in the apoptotic and anti-cancer activity of Quercetin and Quercetin-loaded chitosan NPs. Med Oncol. 2022;11:176\u201385.","journal-title":"Med Oncol"},{"key":"2512_CR36","doi-asserted-by":"publisher","first-page":"679","DOI":"10.2174\/1871520611313050001","volume":"13","author":"J Chen","year":"2013","unstructured":"Chen J. Recent advance in the studies of \u03b2-glucans for cancer therapy. Anticancer Agents Med Chem. 2013;13:679\u201380.","journal-title":"Anticancer Agents Med Chem"},{"issue":"4","key":"2512_CR37","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1007\/s11033-022-08171-w","volume":"50","author":"D Jafari-Gharabaghlou","year":"2023","unstructured":"Jafari-Gharabaghlou D, Dadashpour M, Khanghah OJ, Salmani-Javan E, Zarghami N. Potentiation of Folate-Functionalized PLGA-PEG nanoparticles loaded with metformin for the treatment of breast cancer: possible clinical application. Mol Biol Rep. 2023;50(4):3023\u201333.","journal-title":"Mol Biol Rep"},{"key":"2512_CR38","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.21873\/anticanres.13480","volume":"39","author":"P Sima","year":"2019","unstructured":"Sima P, Richter J, Vetvicka V. Glucans as new anticancer agents. Anticancer Res. 2019;39:3373\u20138.","journal-title":"Anticancer Res"},{"key":"2512_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"C Guo","year":"2016","unstructured":"Guo C, Li X, Wang R, et al. Association between oxidative DNA Damage and risk of colorectal cancer: sensitive determination of urinary 8-Hydroxy-2\u2032-deoxyguanosine by UPLC-MS\/MS analysis. Sci Rep. 2016;6:1\u20139.","journal-title":"Sci Rep"},{"key":"2512_CR40","first-page":"1559","volume":"15","author":"Z Chen","year":"2018","unstructured":"Chen Z, Zhang B, Gao F, Shi R. Modulation of G2\/M cell cycle arrest and apoptosis by luteolin in human colon cancer cells and xenografts. Oncol Lett. 2018;15:1559\u201365.","journal-title":"Oncol Lett"},{"key":"2512_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"SI Lee","year":"2019","unstructured":"Lee SI, Jeong YJ, Yu AR, Kwak HJ, Cha JY, Kang I, Yeo EJ. Carfilzomib enhances cisplatin-induced apoptosis in SK-NBE(2)-M17 human neuroblastoma cells. Sci Rep. 2019;9:1\u201314.","journal-title":"Sci Rep"},{"issue":"4","key":"2512_CR42","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3329\/bjp.v16i4.54872","volume":"16","author":"AK Filiz","year":"2021","unstructured":"Filiz AK, Joha Z, Yulak F. Mechanism of anti-cancer effect of \u03b2-glucan on SH-SY5Y cell line. Bangladesh J Pharmacol. 2021;16(4):122\u20138.","journal-title":"Bangladesh J Pharmacol"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-024-02512-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-024-02512-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-024-02512-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T14:14:46Z","timestamp":1731507286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-024-02512-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,25]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["2512"],"URL":"https:\/\/doi.org\/10.1007\/s12032-024-02512-4","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,25]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"251"}}