{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T06:21:49Z","timestamp":1738218109281,"version":"3.34.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-025-02599-3","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T18:32:25Z","timestamp":1737570745000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ameliorative effect of aqueous leaf extract of Pistacia lentiscus L. against oxaliplatin-induced hepatic injury, oxidative stress, and DNA damage in vitro and in vivo"],"prefix":"10.1007","volume":"42","author":[{"given":"Nesrine","family":"Chouikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamia","family":"Benguedouar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanen","family":"Chaabani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Abid Essefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohra","family":"Haouas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriem","family":"Mehdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihem","family":"Safta Skhiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Sifour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"issue":"6","key":"2599_CR1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A. GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries: Global cancer statistics. CA Cancer J Clin. 2018;68(6):394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"2599_CR2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.phymed.2018.12.033","volume":"57","author":"SY Wen","year":"2019","unstructured":"Wen SY, Chen YY, Deng CM, Zhang C, Jiang MM. Nerigoside suppresses colorectal cancer cell growth and metastatic potential through inhibition of ERK\/GSK3\u03b2\/\u03b2-catenin signaling pathway. Phytomedicine. 2019;57:352\u201363.","journal-title":"Phytomedicine"},{"key":"2599_CR3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ctrc.2015.11.002","volume":"4","author":"D Kumaran","year":"2015","unstructured":"Kumaran D, Rupa D, Haresh K, Gupta S, Sharma D, Rath G. Oxaliplatin induced pulmonary toxicity\u2014a rare phenomenon. Cancer Treat Commun. 2015;4:203\u20135.","journal-title":"Cancer Treat Commun"},{"key":"2599_CR4","first-page":"4","volume":"25","author":"E Raymond","year":"1998","unstructured":"Raymond E, Faivre S, Woynarowski JM, Chaney SG. Oxaliplatin: mechanism of action and antineoplastic activity. Pr\u00e9sent\u00e9 \u00e0 Seminars in Oncology. 1998;25:4\u201312.","journal-title":"Pr\u00e9sent\u00e9 \u00e0 Seminars in Oncology"},{"issue":"2","key":"2599_CR5","first-page":"2266","volume":"15","author":"Y Lin","year":"2018","unstructured":"Lin Y, Li Y, Hu X, Liu Z, Chen J, Lu Y, Liuv LS, Zhang Y, Liang R, et al. The hepatoprotective role of reduced glutathione and its underlying mechanism in oxaliplatin-induced acute liver injury. Oncol Lett. 2018;15(2):2266\u201372.","journal-title":"Oncol Lett"},{"issue":"3","key":"2599_CR6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3892\/mco.2015.512","volume":"3","author":"H Tajima","year":"2015","unstructured":"Tajima H, Ohta T, Miyashita T, Nakanuma S, Matoba M, Miyata T, Sakai S, KOkamotoIMakino Kinoshita J, et al. Oxaliplatin-based chemotherapy induces extravasated platelet aggregation in the liver. Mol Clin Oncol. 2015;3(3):555\u20138.","journal-title":"Mol Clin Oncol"},{"issue":"2","key":"2599_CR7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jhep.2013.04.014","volume":"59","author":"SM Robinson","year":"2013","unstructured":"Robinson SM, Mann J, Vasilaki A, Mathers J, Burt AD, Oakley F, White SA, Mann DA. Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. J Hepatol. 2013;59(2):318\u201326.","journal-title":"J Hepatol"},{"issue":"4","key":"2599_CR8","first-page":"01","volume":"2","author":"B Sharma","year":"2013","unstructured":"Sharma B. In vitro antibacterial activity of certain folk medicinal plants from Darjeeling Himalayas used to treat microbial infections. J Pharmacogn Phytochem. 2013;2(4):01\u20134.","journal-title":"J Pharmacogn Phytochem"},{"key":"2599_CR9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.indcrop.2014.06.035","volume":"61","author":"F Dahmoune","year":"2014","unstructured":"Dahmoune F, Spigno G, Moussi K, Remini H, Cherbal A, Madani K. Pistacia lentiscus leaves as a source of phenolic compounds: microwave-assisted extraction optimized and compared with ultrasound-assisted and conventional solvent extraction. Ind Crops Prod. 2014;61:31\u201340.","journal-title":"Ind Crops Prod"},{"key":"2599_CR10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpba.2013.01.026","volume":"77","author":"C Rodr\u00edguez-P\u00e9rez","year":"2013","unstructured":"Rodr\u00edguez-P\u00e9rez C, Quirantes-Pin\u00e9 R, Amessis-Ouchemoukh N, Madani K, Segura-Carretero A, Fern\u00e1ndez-Gutierrez A. A metabolite-profiling approach allows the identification of new compounds from Pistacia lentiscus leaves. J Pharm Biomed Anal. 2013;77:167\u201374.","journal-title":"J Pharm Biomed Anal"},{"issue":"3","key":"2599_CR11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jfda.2016.03.002","volume":"24","author":"C Mehenni","year":"2016","unstructured":"Mehenni C, Atmani-Kilani D, Dumar\u00e7ay S, G\u00e9rardin Perrin D, P, Atmani D. Hepatoprotective and antidiabetic effects of Pistacia lentiscus leaf and fruit extracts. J Food Drug Anal. 2016;24(3):653\u201369.","journal-title":"J Food Drug Anal"},{"key":"2599_CR12","unstructured":"Nshimiyimana DS, He Q. Radical scavenging capacity of Rwandan CTC tea polyphenols extracted using microwave assisted extraction. Pak. J. Nutr. 2010."},{"issue":"3","key":"2599_CR13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","volume":"16","author":"VL Singleton","year":"1965","unstructured":"Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965;16(3):144\u201358.","journal-title":"Am J Enol Vitic"},{"issue":"22","key":"2599_CR14","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1021\/jf0343074","volume":"51","author":"DO Kim","year":"2003","unstructured":"Kim DO, Chun OK, Kim YJ, Moon HY, Lee CY. Quantification of polyphenolics and their antioxidant capacity in fresh plums. J Agric Food Chem. 2003;51(22):6509\u201315.","journal-title":"J Agric Food Chem"},{"key":"2599_CR15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00385058","volume":"72","author":"S Mole","year":"1987","unstructured":"Mole S, Waterman P. A critical analysis of techniques for measuring tannins in ecological studies. I techniques for chemically defining tannins. Oecologia. 1987;72:137\u201347.","journal-title":"Oecologia"},{"issue":"9\u201310","key":"2599_CR16","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26(9\u201310):1231\u20137.","journal-title":"Free Radic Biol Med"},{"key":"2599_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosman","year":"1983","unstructured":"Mosman T. Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J Immunol Meth. 1983;65:55\u201363.","journal-title":"J Immunol Meth"},{"key":"2599_CR18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.96104s3465","volume":"104","author":"AR Collins","year":"1996","unstructured":"Collins AR, Dusinska M, Gedik CM, Stetina R. Oxidative damage to DNA: do we have a reliable biomarker? Environ Health Perspect. 1996;104:465\u20139.","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2599_CR19","first-page":"73","volume":"8","author":"E Hakimizadeh","year":"2021","unstructured":"Hakimizadeh E, Kaeidi A, Hassanshahi J, Mehrbani M, Rahmani MR, Fatemi I. Ameliorating effect of pistachio hydroalcoholic extract on cisplatin-induced nephrotoxicity in mice. Res J Pharmacogn. 2021;8(1):73\u20139.","journal-title":"Res J Pharmacogn"},{"issue":"24","key":"2599_CR20","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1111\/bph.13646","volume":"173","author":"RM McQuade","year":"2016","unstructured":"McQuade RM, Carbone SE, Stojanovska V, Rahman A, Gwynne RM, Robinson AM, Goodman CA, Bornstein JC, Nurgali K. Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice. Br J Pharmacol. 2016;173(24):3502\u201321.","journal-title":"Br J Pharmacol"},{"issue":"6","key":"2599_CR21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0165-7992(82)90171-3","volume":"104","author":"R Schlegel","year":"1982","unstructured":"Schlegel R, MacGregor JT. The persistence of micronuclei in peripheral blood erythrocytes: detection of chronic chromosome breakage in mice. Mutat Res Lett. 1982;104(6):367\u20139.","journal-title":"Mutat Res Lett"},{"issue":"1","key":"2599_CR22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70\u20137.","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"2599_CR23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351\u20138.","journal-title":"Anal Biochem"},{"issue":"1","key":"2599_CR24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1034\/j.1600-0773.2003.920106.x","volume":"92","author":"M Iqbal","year":"2003","unstructured":"Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol. 2003;92(1):33\u20138.","journal-title":"Pharmacol. Toxicol"},{"key":"2599_CR25","unstructured":"Clairborne A. Assay of catalase. Hand Book Methods Oxyg. Free Radic. Res. 1985: 283\u2011284."},{"issue":"3","key":"2599_CR26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469\u201374.","journal-title":"Eur J Biochem"},{"key":"2599_CR27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","volume":"105","author":"L Floh\u00e9","year":"1984","unstructured":"Floh\u00e9 L, G\u00fcnzler WA. Assays of glutathione peroxidase. Methods in enzymology,. 1984;105:114\u201320.","journal-title":"Methods in enzymology,"},{"issue":"22","key":"2599_CR28","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249(22):7130\u20139.","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"2599_CR29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1\u20132):248\u201354.","journal-title":"Anal Biochem"},{"key":"2599_CR30","volume-title":"Histology: a text and atlas (2^","author":"M Ross","year":"1989","unstructured":"Ross M, Reith E, Romrell L. Histology: a text and atlas (2^. nd. Baltim: Williams Wilkins; 1989.","edition":"nd"},{"issue":"4","key":"2599_CR31","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2559.2010.03511.x","volume":"56","author":"L Rubbia-Brandt","year":"2010","unstructured":"Rubbia-Brandt L, Lauwers GY, Wang H, Majno PE, Tanabe K, Zhu AX, Brezault C, Soubrane O, Abdalla EK, Vauthey JN, et al. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology. 2010;56(4):430\u20139.","journal-title":"Histopathology"},{"key":"2599_CR32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.indcrop.2019.05.062","volume":"137","author":"LL .AzibPistacia lentiscus","year":"2019","unstructured":".AzibPistacia lentiscus LL, et al. leaves extract and its major phenolic compounds reverse aluminium-induced neurotoxicity in mice. Ind Crops Prod. 2019;137:576\u201384.","journal-title":"Ind Crops Prod"},{"key":"2599_CR33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3923\/ajps.2012.131.136","volume":"11","author":"A Cherbal","year":"2012","unstructured":"Cherbal A, Kebieche M, Madani K. El-Adawi, H. Extraction and valorization of phenolic compounds of leaves of Algerian Pistacia lentiscus. Asian J Plant Sci. 2012;11:131\u20136.","journal-title":"Asian J Plant Sci"},{"issue":"1","key":"2599_CR34","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jksus.2018.05.010","volume":"3","author":"M Barbouchi","year":"2020","unstructured":"Barbouchi M, Elamrani K, El Idrissi M. A comparative study on phytochemical screening, quantification of phenolic contents and antioxidant properties of different solvent extracts from various parts of Pistacia lentiscus L. J King Saud Univ-Sci. 2020;3(1):302\u20136.","journal-title":"J King Saud Univ-Sci"},{"issue":"5","key":"2599_CR35","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jpba.2006.04.002","volume":"41","author":"M Naczk","year":"2006","unstructured":"Naczk M, Shahidi F. Phenolics in cereals, fruits and vegetables: occurrence, extraction and analysis. J Pharm Biomed Anal. 2006;41(5):1523\u201342.","journal-title":"J Pharm Biomed Anal"},{"issue":"3","key":"2599_CR36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/mnfr.201100441","volume":"56","author":"JT Pierson","year":"2012","unstructured":"Pierson JT, Dietzgen RG, Shaw PN, Roberts-Thomson SJ, Monteith GR, Gidley MJ. Major Australian tropical fruits biodiversity: bioactive compounds and their bioactivities. Mol Nutr Food Res. 2012;56(3):357\u201387.","journal-title":"Mol Nutr Food Res"},{"key":"2599_CR37","first-page":"133","volume":"7","author":"AI Ghenima","year":"2015","unstructured":"Ghenima AI, Idir M, Nadjet MG, Samia MA, Mihoub ZM, Karim H. In vitro evaluation of biological activities of Pistacia lentiscus aqueous extract. Int J Pharm Pharm Sci. 2015;7:133\u20139.","journal-title":"Int J Pharm Pharm Sci"},{"issue":"9","key":"2599_CR38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14715\/cmb\/2017.63.9.16","volume":"63","author":"M Yemmen","year":"2017","unstructured":"Yemmen M, Landolsi A, Hamida JB, M\u00e9graud F, Ayadi MT. Antioxidant activities, anticancer activity and polyphenolics profile, of leaf, fruit and stem extracts of Pistacia lentiscus from Tunisia. Cell Mol Biol. 2017;63(9):87\u201395.","journal-title":"Cell Mol Biol"},{"issue":"5","key":"2599_CR39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/cosmetics9050094","volume":"9","author":"H Mechqoq","year":"2022","unstructured":"Mechqoq H, Hourfane S, El Yaagoubi M, El Hamdaoui A, Msanda Fda Silva Almeida JRG, El Joao Rocha M, Aouad N. Phytochemical screening, and in vitro evaluation of the antioxidant and dermocosmetic activities of four Moroccan plants: Halimium antiatlanticum, Adenocarpus artemisiifolius, Pistacia lentiscus and Leonotis nepetifolia. Cosmetics. 2022;9(5):94.","journal-title":"Cosmetics."},{"key":"2599_CR40","unstructured":"Cefali, L.C., Ataide, J.A., Moriel, P., Foglio, M.A., Mazzola, P. G. 2017. Antioxidant Activity and Potentially Safe Profile of Leaf Extracts from Pistacia Lentiscus L. (Anacardiaceae)."},{"issue":"3","key":"2599_CR41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.eujim.2015.03.009","volume":"7","author":"S Remila","year":"2015","unstructured":"Remila S, Atmani-Kilani D, Delemasure S, Connat JL, Azib L, Richard T, Atmani D. Antioxidant, cytoprotective, anti-inflammatory and anticancer activities of Pistacia lentiscus (Anacardiaceae) leaf and fruit extracts. Eur J Integr Med. 2015;7(3):274\u201386.","journal-title":"Eur J Integr Med"},{"issue":"3","key":"2599_CR42","first-page":"144","volume":"2","author":"Y Huang","year":"2013","unstructured":"Huang Y, Li L. DNA crosslinking damage and cancer-a tale of friend and foe. Transl Cancer Res. 2013;2(3):144.","journal-title":"Transl Cancer Res"},{"issue":"172\u2013173","key":"2599_CR43","first-page":"233","volume":"43","author":"M Fenech","year":"1985","unstructured":"Fenech M, Morley A. Solutions to the kinetic problem in the micronucleus assay. Cytobios. 1985;43(172\u2013173):233\u201346.","journal-title":"Cytobios"},{"issue":"6","key":"2599_CR44","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.fct.2011.03.016","volume":"49","author":"I Aquino","year":"2011","unstructured":"Aquino I, Perazzo FF, Maistro EL. Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice. Food Chem Toxicol. 2011;49(6):1335\u20139.","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"2599_CR45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1534735406298302","volume":"6","author":"P Venkatesh","year":"2007","unstructured":"Venkatesh P, Shantala B, Jagetia GC, Rao KK, Baliga MS. Modulation of doxorubicin-induced genotoxicity by Aegle marmelos in mouse bone marrow: a micronucleus study. Integr Cancer Ther. 2007;6(1):42\u201353.","journal-title":"Integr Cancer Ther"},{"issue":"4","key":"2599_CR46","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/01480545.2016.1252918","volume":"40","author":"AP de Souza","year":"2017","unstructured":"de Souza AP, Lehmann M, Dihl RR. Comparative study on the induction of complex genomic alterations after exposure of mammalian cells to carboplatin and oxaliplatin. Drug Chem Toxicol. 2017;40(4):410\u20135.","journal-title":"Drug Chem Toxicol"},{"issue":"5","key":"2599_CR47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1248\/cpb.c18-00809","volume":"67","author":"MA Ganaie","year":"2019","unstructured":"Ganaie MA, Jan BL, Khan TH, Alharthy KM, Sheikh IA. The protective effect of naringenin on oxaliplatin-induced genotoxicity in mice. Chem Pharm Bull (Tokyo). 2019;67(5):433\u20138.","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"2599_CR48","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","volume":"740","author":"S Dasari","year":"2014","unstructured":"Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014;740:364\u201378.","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"2599_CR49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","volume":"4","author":"V Lobo","year":"2010","unstructured":"Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4(8):118.","journal-title":"Pharmacogn Rev"},{"issue":"2","key":"2599_CR50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/01635581.2020.1749289","volume":"73","author":"A Sassi","year":"2021","unstructured":"Sassi A, Boubaker J, Loussaief A, Jomaa K, Ghedira K, Chekir-Ghedira L. Protective effect of chrysin, a dietary flavone against genotoxic and oxidative damage induced by mitomycin C in Balb\/C mice. Nutr Cancer. 2021;73(2):329\u201338.","journal-title":"Nutr Cancer"},{"issue":"25","key":"2599_CR51","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1021\/acs.jafc.0c02604","volume":"68","author":"X Wu","year":"2020","unstructured":"Wu X, Xue L, Tata A, Song M, Neto CC, Xiao H. Bioactive components of polyphenol-rich and non-polyphenol-rich cranberry fruit extracts and their chemopreventive effects on colitis-associated colon cancer. J Agric Food Chem. 2020;68(25):6845\u201353.","journal-title":"J Agric Food Chem"},{"issue":"1\u20132","key":"2599_CR52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-8741(02)00241-6","volume":"83","author":"S Janakat","year":"2002","unstructured":"Janakat S, Al-Merie H. Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca. J Ethnopharmacol. 2002;83(1\u20132):135\u20138.","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"2599_CR53","first-page":"2020","volume":"42","author":"X Zou","year":"2018","unstructured":"Zou X, Wang Y, Peng C, Wang B, Niu Z, Li Z, Niu J. Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury. Int J Mol Med. 2018;42(4):2020\u201330.","journal-title":"Int J Mol Med"},{"key":"2599_CR54","first-page":"1927","volume":"3","author":"N Bano","year":"2019","unstructured":"Bano N, Beg AE, Hameed K, bin FayyazSadaf TR. Hepatoprotective effects of ethanolic extract of Boerhaavia diffusa against oxaliplatin induced hepatotoxicity in albino rats. Pak J Pharm Sci. 2019;3:1927.","journal-title":"Pak J Pharm Sci"},{"issue":"31","key":"2599_CR55","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1200\/JCO.2006.05.8156","volume":"24","author":"T Aloia","year":"2006","unstructured":"Aloia T, Sebagh M, Plasse M, Karam V, L\u00e9vi F, Giacchetti S, Azoulay D, Bismuth H, Castaing D, Adam R. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol. 2006;24(31):4983\u201390.","journal-title":"J Clin Oncol"},{"issue":"3","key":"2599_CR56","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3892\/mco.2015.512","volume":"3","author":"H Tajima","year":"2015","unstructured":"Tajima H, Ohta T, Miyashita T, Nakanuma S, Matoba M, Miyata T, Sakai S, Okamoto K, Makino I, Kinoshita J. Oxaliplatin-based chemotherapy induces extravasated platelet aggregation in the liver. Mol Clin Oncol. 2015;3(3):555\u20138.","journal-title":"Mol Clin Oncol"},{"key":"2599_CR57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1423-0127-19-26","volume":"19","author":"A Rezazadeh","year":"2012","unstructured":"Rezazadeh A, Yazdanparast R, Molaei M. Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress. J Biomed Sci. 2012;19:1\u20138.","journal-title":"J Biomed Sci"},{"issue":"5","key":"2599_CR58","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3109\/0886022X.2011.577546","volume":"33","author":"MI Waly","year":"2011","unstructured":"Waly MI, Al Moundhri MS, Ali BH. Effect of curcumin on cisplatin-and oxaliplatin-induced oxidative stress in human embryonic kidney (HEK) 293 cells. Ren Fail. 2011;33(5):518\u201323.","journal-title":"Ren Fail"},{"key":"2599_CR59","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00709-015-0821-6","volume":"253","author":"M Waseem","year":"2016","unstructured":"Waseem M, Parvez S. Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin. Protoplasma. 2016;253:417\u201330.","journal-title":"Protoplasma"},{"key":"2599_CR60","doi-asserted-by":"crossref","unstructured":"Bertram C, Hass R. Cellular responses to reactive oxygen species-induced DNA damage and aging. 2008.","DOI":"10.1515\/BC.2008.031"},{"key":"2599_CR61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fct.2020.111190","volume":"138","author":"FM Kandemir","year":"2020","unstructured":"Kandemir FM, Y\u0131ld\u0131r\u0131m S, Kucukler S, Caglayan C, Darendelio\u011flu E, Dortbudak MB. Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: a multi-biomarker approach. Food Chem Toxicol. 2020;138:111\u201390.","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"2599_CR62","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1139\/cjpp-2020-0134","volume":"99","author":"BB Lemos","year":"2021","unstructured":"Lemos BB, da Motta KP, Paltian JJ, Reis AS, Bl\u00f6dorn GB, Soares MP, Alves D, Luchese C, Wilhelm EA. Role of 7-chloro-4-(phenylselanyl) quinoline in the treatment of oxaliplatin-induced hepatic toxicity in mice. Can J Physiol Pharmacol. 2021;99(4):378\u201388.","journal-title":"Can J Physiol Pharmacol"},{"issue":"10","key":"2599_CR63","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1139\/cjpp-2021-0090","volume":"99","author":"KP da Motta","year":"2021","unstructured":"da Motta KP, Lemos BB, Paltian JJ, dos Reis AS, Bl\u00f6dorn GB, Alves D, Luchese C, Wilhelm EA. 7-Chloro-4-(phenylselanyl) quinoline reduces renal oxidative stress induced by oxaliplatin in mice. Can J Physiol Pharmacol. 2021;99(10):1102\u201311.","journal-title":"Can J Physiol Pharmacol"},{"key":"2599_CR64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.freeradbiomed.2013.03.019","volume":"61","author":"LDC Mannelli","year":"2013","unstructured":"Mannelli LDC, Zanardelli M, Failli P, Ghelardini C. Oxaliplatin-induced oxidative stress in nervous system-derived cellular models: could it correlate with in vivo neuropathy? Free Radic Biol Med. 2013;61:143\u201350.","journal-title":"Free Radic Biol Med"},{"key":"2599_CR65","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0065-230X(08)60848-9","volume":"29","author":"L Chasseaud","year":"1979","unstructured":"Chasseaud L. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Advances cancer res. 1979;29:175\u2013274.","journal-title":"Advances cancer res"},{"issue":"47","key":"2599_CR66","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","volume":"22","author":"DM Townsend","year":"2003","unstructured":"Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003;22(47):7369\u201375.","journal-title":"Oncogene"},{"issue":"1","key":"2599_CR67","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/epj.epj_44_21","volume":"21","author":"AE Abd Elraheem","year":"2022","unstructured":"Abd Elraheem AE, Ashry M, Ahmed H, Abdel-Wahhab KG, Morsy FA, Abd-Elstar R. Ameliorative effect of costus ethanolic extract against Oxaliplatin-induced hepatotoxicity in adult rats. Egypt Pharm J. 2022;21(1):30.","journal-title":"Egypt Pharm J"},{"issue":"2","key":"2599_CR68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ctrv.2004.12.006","volume":"31","author":"D Kweekel","year":"2005","unstructured":"Kweekel D, Gelderblom H, Guchelaar HJ. Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy. Cancer Treat Rev. 2005;31(2):90\u2013105.","journal-title":"Cancer Treat Rev"},{"issue":"24","key":"2599_CR69","first-page":"5970","volume":"53","author":"L Pendyala","year":"1993","unstructured":"Pendyala L, Creaven P. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res. 1993;53(24):5970\u20136.","journal-title":"Cancer Res"},{"issue":"4","key":"2599_CR70","first-page":"1263","volume":"13","author":"J Shahraki","year":"2014","unstructured":"Shahraki J, Zareh M, Kamalinejad M, Pourahmad J. Cytoprotective effects of hydrophilic and lipophilic extracts of Pistacia vera against oxidative versus carbonyl stress in rat hepatocytes. Iran J Pharm Res IJPR. 2014;13(4):1263.","journal-title":"Iran J Pharm Res IJPR"},{"key":"2599_CR71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01480545.2024.2429615","volume":"26","author":"N Chouikh","year":"2024","unstructured":"Chouikh N, Benguedouar L, Ayad R, Medjahed Z, Bento-Silva A, Duarte N, Sifour M. Phytochemical analysis, antioxidant activity and modulatory effect of aqueous leaf extract of Pistacia lentiscus L on oxaliplatin-induced oxidative stress in isolated rat liver mitochondria. Drug Chem Toxicology. 2024;26:1\u201312.","journal-title":"Drug Chem Toxicology."},{"issue":"4","key":"2599_CR72","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1016\/j.foodchem.2013.06.107","volume":"141","author":"M Utrera","year":"2013","unstructured":"Utrera M, Est\u00e9vez M. Impact of trolox, quercetin, genistein and gallic acid on the oxidative damage to myofibrillar proteins: the carbonylation pathway. Food Chem. 2013;141(4):4000\u20139.","journal-title":"Food Chem"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02599-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-025-02599-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02599-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T03:36:34Z","timestamp":1738208194000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-025-02599-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["2599"],"URL":"https:\/\/doi.org\/10.1007\/s12032-025-02599-3","relation":{},"ISSN":["1559-131X"],"issn-type":[{"type":"electronic","value":"1559-131X"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"18 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental procedure was compliant with internationally accepted protocols and the ethics of laboratory animal care and use as approved by a committee of the Algerian Association of Sciences in Animal Experimentation (No. 8808\/1988) and associated with veterinary medical activities and animal health protection (No. JORA:004\/1988).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"54"}}