{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:37:13Z","timestamp":1787319433034,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Medical Research Project of Sichuan","award":["S23020 and Q23047"],"award-info":[{"award-number":["S23020 and Q23047"]}]},{"DOI":"10.13039\/100012551","name":"Applied Basic Research Program of Sichuan Province","doi-asserted-by":"publisher","award":["25NSFSC2024"],"award-info":[{"award-number":["25NSFSC2024"]}],"id":[{"id":"10.13039\/100012551","id-type":"DOI","asserted-by":"publisher"}]},{"name":"evelopment of Scientific Research Plan of Doctoral Scientific Research Foundation of North Sichuan Medical College","award":["CBY22-ZDA03"],"award-info":[{"award-number":["CBY22-ZDA03"]}]},{"name":"Scientific Research Development Plan Project of Affiliated Hospital of North Sichuan Medical College","award":["2024PTZK004, 2023ZD001 and 2023-2ZD002"],"award-info":[{"award-number":["2024PTZK004, 2023ZD001 and 2023-2ZD002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-025-02634-3","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T04:19:02Z","timestamp":1740197942000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["STM2457 impairs the proliferation of esophageal squamous cell carcinoma by activating DNA damage response through ATM-Chk2 axis"],"prefix":"10.1007","volume":"42","author":[{"given":"Chuanli","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"issue":"1","key":"2634_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12\u201349. https:\/\/doi.org\/10.3322\/caac.21820.","journal-title":"CA Cancer J Clin"},{"key":"2634_CR2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3760\/cma.j.cn112152-20240119-00035","volume":"46","author":"RS Zheng","year":"2024","unstructured":"Zheng RS, Chen R, Han BF, et al. Cancer incidence and mortality in China, 2022. Zhonghua Zhong Liu Za Zhi. 2024;46:221\u201331. https:\/\/doi.org\/10.3760\/cma.j.cn112152-20240119-00035.","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"issue":"1","key":"2634_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41392-020-00323-3","volume":"5","author":"Y-M Yang","year":"2020","unstructured":"Yang Y-M, Hong P, Xu WW, et al. Advances in targeted therapy for esophageal cancer. Signal Transduct Tar. 2020;5(1):229. https:\/\/doi.org\/10.1038\/s41392-020-00323-3.","journal-title":"Signal Transduct Tar"},{"issue":"1","key":"2634_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/nyas.13863","volume":"1434","author":"M Wang","year":"2018","unstructured":"Wang M, Smith JS, Wei W-Q. Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions. Ann Ny Acad Sci. 2018;1434(1):59\u201369. https:\/\/doi.org\/10.1111\/nyas.13863.","journal-title":"Ann Ny Acad Sci"},{"issue":"5","key":"2634_CR5","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-86. https:\/\/doi.org\/10.1002\/ijc.29210.","journal-title":"Int J Cancer"},{"issue":"1","key":"2634_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12943-023-01782-2","volume":"22","author":"H Zhuang","year":"2023","unstructured":"Zhuang H, Yu B, Tao D, et al. The role of m6A methylation in therapy resistance in cancer. Mol Cancer. 2023;22(1):91. https:\/\/doi.org\/10.1186\/s12943-023-01782-2.","journal-title":"Mol Cancer"},{"issue":"1","key":"2634_CR7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/s12964-023-01360-5","volume":"21","author":"Q Jin","year":"2023","unstructured":"Jin Q, Qu H, Quan C. New insights into the regulation of METTL3 and its role in tumors. Cell Commun Signal. 2023;21(1):334. https:\/\/doi.org\/10.1186\/s12964-023-01360-5.","journal-title":"Cell Commun Signal"},{"issue":"8","key":"2634_CR8","doi-asserted-by":"publisher","first-page":"5095","DOI":"10.1007\/s00432-022-04429-9","volume":"149","author":"L Huang","year":"2023","unstructured":"Huang L, Liang D, Zhang Y, et al. METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b. J Cancer Res Clin. 2023;149(8):5095\u2013108. https:\/\/doi.org\/10.1007\/s00432-022-04429-9.","journal-title":"J Cancer Res Clin"},{"issue":"17","key":"2634_CR9","doi-asserted-by":"publisher","first-page":"9656","DOI":"10.3390\/ijms23179656","volume":"23","author":"Y Li","year":"2022","unstructured":"Li Y, Wang N-X, Yin C, et al. RNA editing enzyme ADAR1 regulates METTL3 in an editing dependent manner to promote breast cancer progression via METTL3\/ARHGAP5\/YTHDF1 Axis. Int J Mol Sci. 2022;23(17):9656. https:\/\/doi.org\/10.3390\/ijms23179656.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2634_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13046-021-01880-3","volume":"40","author":"Y Wu","year":"2021","unstructured":"Wu Y, Chang N, Zhang Y, et al. METTL3-mediated m6A mRNA modification of FBXW7 suppresses lung adenocarcinoma. J Exp Clin Cancer Res. 2021;40(1):90. https:\/\/doi.org\/10.1186\/s13046-021-01880-3.","journal-title":"J Exp Clin Cancer Res"},{"key":"2634_CR11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbrc.2021.05.048","volume":"580","author":"J Zou","year":"2021","unstructured":"Zou J, Zhong X, Zhou X, et al. The m6A methyltransferase METTL3 regulates proliferation in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2021;580:48\u201355. https:\/\/doi.org\/10.1016\/j.bbrc.2021.05.048.","journal-title":"Biochem Biophys Res Commun"},{"key":"2634_CR12","doi-asserted-by":"publisher","first-page":"113367","DOI":"10.1016\/j.biopha.2022.113367","volume":"153","author":"R Xu","year":"2022","unstructured":"Xu R, Xiao X, Zhang S, et al. The methyltransferase METTL3-mediated fatty acid metabolism revealed the mechanism of cinnamaldehyde on alleviating steatosis. Biomed Pharmacother. 2022;153:113367. https:\/\/doi.org\/10.1016\/j.biopha.2022.113367.","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"2634_CR13","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.7150\/jca.69406","volume":"13","author":"S Huang","year":"2022","unstructured":"Huang S, Jin M, Lan X, et al. LncRNA AC098934 promotes proliferation and invasion in lung adenocarcinoma cells by combining METTL3 and m6A modifications. J Cancer. 2022;13(8):2662\u201372. https:\/\/doi.org\/10.7150\/jca.69406.","journal-title":"J Cancer"},{"issue":"7860","key":"2634_CR14","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41586-021-03536-w","volume":"593","author":"E Yankova","year":"2021","unstructured":"Yankova E, Blackaby W, Albertella M, et al. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 2021;593(7860):597\u2013601. https:\/\/doi.org\/10.1038\/s41586-021-03536-w.","journal-title":"Nature"},{"issue":"4","key":"2634_CR15","doi-asserted-by":"publisher","first-page":"111530","DOI":"10.1016\/j.celrep.2022.111530","volume":"41","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Teng X, Zhao F, et al. METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep. 2022;41(4):111530. https:\/\/doi.org\/10.1016\/j.celrep.2022.111530.","journal-title":"Cell Rep"},{"issue":"11","key":"2634_CR16","doi-asserted-by":"publisher","first-page":"8852","DOI":"10.3390\/cimb45110555","volume":"45","author":"S Hao","year":"2023","unstructured":"Hao S, Sun H, Sun H, et al. STM2457 inhibits the invasion and metastasis of pancreatic cancer by down-regulating BRAF-activated noncoding RNA N6-methyladenosine modification. Curr Issues Mol Biol. 2023;45(11):8852\u201363. https:\/\/doi.org\/10.3390\/cimb45110555.","journal-title":"Curr Issues Mol Biol"},{"issue":"11","key":"2634_CR17","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1038\/s41388-022-02185-1","volume":"41","author":"Q Xu","year":"2022","unstructured":"Xu Q, Tien Y, Shi Y, et al. METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner. Oncogene. 2022;41(11):1622\u201333. https:\/\/doi.org\/10.1038\/s41388-022-02185-1.","journal-title":"Oncogene"},{"key":"2634_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.placenta.2024.05.135","volume":"153","author":"SC Selvakumar","year":"2024","unstructured":"Selvakumar SC, Preethi KA, Sekar D. MicroRNA-510-3p regulated vascular dysfunction in Preeclampsia by targeting Vascular Endothelial Growth Factor A (VEGFA) and its signaling axis. Placenta. 2024;153:31\u201352. https:\/\/doi.org\/10.1016\/j.placenta.2024.05.135.","journal-title":"Placenta"},{"issue":"2","key":"2634_CR19","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3390\/biom13020243","volume":"13","author":"W Meng","year":"2023","unstructured":"Meng W, Xiao H, Mei P, et al. Critical roles of METTL3 in translation regulation of cancer. Biomolecules. 2023;13(2):243. https:\/\/doi.org\/10.3390\/biom13020243.","journal-title":"Biomolecules"},{"key":"2634_CR20","doi-asserted-by":"publisher","first-page":"114118","DOI":"10.1016\/j.ejmech.2022.114118","volume":"230","author":"P Xu","year":"2022","unstructured":"Xu P, Ge R. Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy. Eur J Med Chem. 2022;230:114118. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114118.","journal-title":"Eur J Med Chem"},{"issue":"1","key":"2634_CR21","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41419-023-06411-w","volume":"15","author":"Y Chen","year":"2024","unstructured":"Chen Y, He Y, Li Z, et al. METTL3 facilitates renal cell carcinoma progression by PLOD2 m6A-methylation under prolonged hypoxia. Cell Death Dis. 2024;15(1):62. https:\/\/doi.org\/10.1038\/s41419-023-06411-w.","journal-title":"Cell Death Dis"},{"key":"2634_CR22","doi-asserted-by":"publisher","first-page":"833694","DOI":"10.3389\/fgene.2022.833694","volume":"13","author":"S Fang","year":"2022","unstructured":"Fang S, Peng B, Wen Y, et al. Transcriptome-wide analysis of RNA N6-methyladenosine modification in adriamycin-resistant acute myeloid leukemia cells. Front Genet. 2022;13:833694. https:\/\/doi.org\/10.3389\/fgene.2022.833694.","journal-title":"Front Genet"},{"issue":"6","key":"2634_CR23","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.jpha.2023.04.009","volume":"13","author":"H Xiao","year":"2023","unstructured":"Xiao H, Zhao R, Meng W, et al. Effects and translatomics characteristics of a small-molecule inhibitor of METTL3 against non-small cell lung cancer. J Pharm Anal. 2023;13(6):625\u201339. https:\/\/doi.org\/10.1016\/j.jpha.2023.04.009.","journal-title":"J Pharm Anal"},{"issue":"1","key":"2634_CR24","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12935-023-03096-1","volume":"23","author":"Q Liu","year":"2023","unstructured":"Liu Q, Qi J, Li W, et al. Therapeutic effect and transcriptome-methylome characteristics of METTL3 inhibition in liver hepatocellular carcinoma. Cancer Cell Int. 2023;23(1):298. https:\/\/doi.org\/10.1186\/s12935-023-03096-1.","journal-title":"Cancer Cell Int"},{"key":"2634_CR25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.placenta.2024.09.018","volume":"158","author":"SC Selvakumar","year":"2024","unstructured":"Selvakumar SC, Preethi KA, Ross K, et al. The emerging role of microRNA-based therapeutics in the treatment of preeclampsia. Placenta. 2024;158:38\u201347. https:\/\/doi.org\/10.1016\/j.placenta.2024.09.018.","journal-title":"Placenta"},{"key":"2634_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.trsl.2023.04.005","volume":"259","author":"X An","year":"2023","unstructured":"An X, Wu W, Yang L, et al. ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression. Transl Res. 2023;259:62\u201371. https:\/\/doi.org\/10.1016\/j.trsl.2023.04.005.","journal-title":"Transl Res"},{"issue":"3","key":"2634_CR27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.7883\/yoken.JJID.2022.454","volume":"76","author":"C Hu","year":"2023","unstructured":"Hu C, Jiao Y. METTL3 inhibitor alleviates the onset of osteomyelitis in mice model by targeting MyD88. Jpn J Infect Dis. 2023;76(3):191\u20136. https:\/\/doi.org\/10.7883\/yoken.JJID.2022.454.","journal-title":"Jpn J Infect Dis"},{"issue":"23","key":"2634_CR28","doi-asserted-by":"publisher","first-page":"7041","DOI":"10.7150\/jca.64061","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang X, Liu P, Zheng X, et al. N6-methyladenosine regulates ATM expression and downstream signaling. J Cancer. 2021;12(23):7041\u201351. https:\/\/doi.org\/10.7150\/jca.64061.","journal-title":"J Cancer"},{"issue":"3","key":"2634_CR29","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.molcel.2020.06.017","volume":"79","author":"C Zhang","year":"2020","unstructured":"Zhang C, Chen L, Peng D, et al. METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation. Mol Cell. 2020;79(3):425-42.e7. https:\/\/doi.org\/10.1016\/j.molcel.2020.06.017.","journal-title":"Mol Cell"},{"key":"2634_CR30","doi-asserted-by":"publisher","first-page":"100881","DOI":"10.1016\/j.drup.2022.100881","volume":"65","author":"ER Smith","year":"2022","unstructured":"Smith ER, Wang JQ, Yang DH, et al. Paclitaxel resistance related to nuclear envelope structural sturdiness. Drug Resist Updat. 2022;65:100881. https:\/\/doi.org\/10.1016\/j.drup.2022.100881.","journal-title":"Drug Resist Updat"},{"key":"2634_CR31","doi-asserted-by":"publisher","first-page":"115408","DOI":"10.1016\/j.bcp.2022.115408","volume":"208","author":"G Pascual-Pasto","year":"2023","unstructured":"Pascual-Pasto G, Resa-Pares C, Castillo-Ecija H, et al. Low Bcl-2 is a robust biomarker of sensitivity to nab-paclitaxel in Ewing sarcoma. Biochem Pharmacol. 2023;208:115408. https:\/\/doi.org\/10.1016\/j.bcp.2022.115408.","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"2634_CR32","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nrc2803","volume":"10","author":"M Kavallaris","year":"2010","unstructured":"Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer. 2010;10(3):194\u2013204. https:\/\/doi.org\/10.1038\/nrc2803.","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"2634_CR33","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.3390\/genes13071142","volume":"13","author":"J Ramesh","year":"2022","unstructured":"Ramesh J, Thilakan RC, Gopalakrishnan RM, et al. Ginsenoside Rg5 sensitizes paclitaxel-resistant human cervical-adeno-carcinoma cells to paclitaxel-and enhances the anticancer effect of paclitaxel. Genes. 2022;13(7):1142. https:\/\/doi.org\/10.3390\/genes13071142.","journal-title":"Genes"},{"issue":"3","key":"2634_CR34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00280-018-3627-3","volume":"82","author":"X Guo","year":"2018","unstructured":"Guo X, Li S, Zhu X, et al. Lapatinib in combination with paclitaxel plays synergistic antitumor effects on esophageal squamous cancer. Cancer Chemother Pharmacol. 2018;82(3):383\u201394. https:\/\/doi.org\/10.1007\/s00280-018-3627-3.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"11","key":"2634_CR35","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1158\/1535-7163.MCT-12-1178","volume":"12","author":"TL Bush","year":"2013","unstructured":"Bush TL, Payton M, Heller S, et al. AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models. Mol Cancer Ther. 2013;12(11):2356\u201366. https:\/\/doi.org\/10.1158\/1535-7163.MCT-12-1178.","journal-title":"Mol Cancer Ther"},{"issue":"33","key":"2634_CR36","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1038\/s41388-023-02760-0","volume":"42","author":"J Gao","year":"2023","unstructured":"Gao J, Fang Y, Chen J, et al. Methyltransferase like 3 inhibition limits intrahepatic cholangiocarcinoma metabolic reprogramming and potentiates the efficacy of chemotherapy. Oncogene. 2023;42(33):2507\u201320. https:\/\/doi.org\/10.1038\/s41388-023-02760-0.","journal-title":"Oncogene"},{"issue":"1","key":"2634_CR37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13046-023-02638-9","volume":"42","author":"Y Sun","year":"2023","unstructured":"Sun Y, Shen W, Hu S, et al. METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy. J Exp Clin Cancer Res. 2023;42(1):65. https:\/\/doi.org\/10.1186\/s13046-023-02638-9.","journal-title":"J Exp Clin Cancer Res"},{"key":"2634_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14864","author":"L Liu","year":"2024","unstructured":"Liu L, Zhao T, Zheng S, et al. METTL3 inhibitor STM2457 impairs tumor progression and enhances sensitivity to anlotinib in OSCC. Oral Dis. 2024. https:\/\/doi.org\/10.1111\/odi.14864.","journal-title":"Oral Dis"},{"issue":"1","key":"2634_CR39","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12935-022-02715-7","volume":"22","author":"J Chen","year":"2022","unstructured":"Chen J, Li S, Huang Z, et al. METTL3 suppresses anlotinib sensitivity by regulating m6A modification of FGFR3 in oral squamous cell carcinoma. Cancer Cell Int. 2022;22(1):295. https:\/\/doi.org\/10.1186\/s12935-022-02715-7.","journal-title":"Cancer Cell Int"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02634-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-025-02634-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02634-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T09:19:08Z","timestamp":1741252748000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-025-02634-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,22]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["2634"],"URL":"https:\/\/doi.org\/10.1007\/s12032-025-02634-3","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,22]]},"assertion":[{"value":"10 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"82"}}