{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:06:08Z","timestamp":1789506368719,"version":"build-2803163510"},"reference-count":182,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-025-02740-2","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T13:50:33Z","timestamp":1747317033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Natural sesquiterpene lactones in prostate cancer therapy: mechanisms and sources"],"prefix":"10.1007","volume":"42","author":[{"given":"Keshav","family":"Kaushal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devesh U.","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anakha","family":"Sony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswin","family":"Viswanath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V. N. L.","family":"Chaitanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avijit","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"2740_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.14740\/wjon1191","volume":"10","author":"P Rawla","year":"2019","unstructured":"Rawla P. Epidemiology of prostate cancer. World J Oncol. 2019;10:63\u201389.","journal-title":"World J Oncol"},{"key":"2740_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.5534\/wjmh.210070","volume":"40","author":"N Hinata","year":"2022","unstructured":"Hinata N, Fujisawa M. Racial differences in prostate cancer characteristics and cancer-specific mortality: an overview. World J Mens Health. 2022;40:217.","journal-title":"World J Mens Health"},{"key":"2740_CR3","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1002\/cncr.34433","volume":"128","author":"JW Lillard","year":"2022","unstructured":"Lillard JW, Moses KA, Mahal BA, George DJ. Racial disparities in Black men with prostate cancer: a literature review. Cancer. 2022;128:3787\u201395.","journal-title":"Cancer"},{"key":"2740_CR4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/B978-0-12-374984-0.00191-1","volume-title":"Cancer Susceptibility Brenner\u2019s Encyclopedia of Genetics","author":"LM Mulligan","year":"2013","unstructured":"Mulligan LM. Cancer Susceptibility Brenner\u2019s Encyclopedia of Genetics. Amsterdam: Elsevier; 2013. p. 420\u20132."},{"key":"2740_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13053-015-0038-x","volume":"13","author":"H Cavanagh","year":"2015","unstructured":"Cavanagh H, Rogers KMA. The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers. Hered Cancer Clin Pract. 2015;13:16.","journal-title":"Hered Cancer Clin Pract"},{"key":"2740_CR6","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.drudis.2021.12.021","volume":"27","author":"S Wang","year":"2022","unstructured":"Wang S, Yang Q, Deng L, Lei Q, Yang Y, Ma P, et al. An overview of cancer drugs approved through expedited approval programs and orphan medicine designation globally between 2011 and 2020. Drug Discov Today. 2022;27:1236\u201350.","journal-title":"Drug Discov Today"},{"key":"2740_CR7","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.3390\/app10093001","volume":"10","author":"L Moujir","year":"2020","unstructured":"Moujir L, Callies O, Sousa PMC, Sharopov F, Seca AML. Applications of sesquiterpene lactones: a review of some potential success cases. Appl Sci. 2020;10:3001.","journal-title":"Appl Sci"},{"key":"2740_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111687","volume":"183","author":"M Hossain","year":"2019","unstructured":"Hossain M, Das U, Dimmock JR. Recent advances in \u03b1, \u03b2-unsaturated carbonyl compounds as mitochondrial toxins. Eur J Med Chem. 2019;183: 111687.","journal-title":"Eur J Med Chem"},{"key":"2740_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/247685","volume":"2015","author":"B Ivanescu","year":"2015","unstructured":"Ivanescu B, Miron A, Corciova A. Sesquiterpene lactones from Artemisia Genus: biological activities and methods of analysis. J Anal Methods Chem. 2015;2015:1\u201321.","journal-title":"J Anal Methods Chem"},{"key":"2740_CR10","doi-asserted-by":"publisher","first-page":"3492","DOI":"10.3390\/molecules27113492","volume":"27","author":"LC Laurella","year":"2022","unstructured":"Laurella LC, Mirakian NT, Garcia MN, Grasso DH, S\u00fclsen VP, Papademetrio DL. Sesquiterpene lactones as promising candidates for cancer therapy: focus on pancreatic cancer. Molecules. 2022;27:3492.","journal-title":"Molecules"},{"key":"2740_CR11","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.3390\/nu15092088","volume":"15","author":"P Pandey","year":"2023","unstructured":"Pandey P, Khan F, Seifeldin SA, Alshaghdali K, Siddiqui S, Abdelwadoud ME, et al. Targeting Wnt\/\u03b2-catenin pathway by flavonoids: implication for cancer therapeutics. Nutrients. 2023;15:2088.","journal-title":"Nutrients"},{"key":"2740_CR12","first-page":"4568964","volume":"209","author":"E Butturini","year":"2019","unstructured":"Butturini E, Carcereri De Prati A, Boriero D, Mariotto S. Natural sesquiterpene lactones enhance chemosensitivity of tumor cells through redox regulation of STAT3 signaling. Oxid Med Cell Longev. 2019;209:4568964.","journal-title":"Oxid Med Cell Longev"},{"key":"2740_CR13","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1593\/neo.13706","volume":"15","author":"Q Chang","year":"2013","unstructured":"Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, et al. The IL-6\/JAK\/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia. 2013;15:848\u201362.","journal-title":"Neoplasia"},{"key":"2740_CR14","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.18632\/oncotarget.13153","volume":"8","author":"X Cheng","year":"2017","unstructured":"Cheng X, Liu YQ, Wang GZ, Yang LN, Lu YZ, Li XC, et al. Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor. Oncotarget. 2017;8:2681\u201393.","journal-title":"Oncotarget"},{"key":"2740_CR15","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1016\/S0968-0896(99)00195-9","volume":"7","author":"P R\u00fcngeler","year":"1999","unstructured":"R\u00fcngeler P, Castro V, Mora G, G\u00f6ren N, Vichnewski W, Pahl HL, et al. Inhibition of transcription factor NF-\u03baB by sesquiterpene lactones: a proposed molecular mechanism of action. Bioorg Med Chem. 1999;7:2343\u201352.","journal-title":"Bioorg Med Chem"},{"key":"2740_CR16","first-page":"5436","volume":"27","author":"G Ioele","year":"2022","unstructured":"Ioele G, Chieffallo M, Occhiuzzi MA, De Luca M, Garofalo A, Ragno G, et al. Anticancer drugs: recent strategies to improve stability profile. Pharmacokin Pharmacodyn Prop Mol. 2022;27:5436.","journal-title":"Pharmacokin Pharmacodyn Prop Mol"},{"key":"2740_CR17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"2740_CR18","doi-asserted-by":"publisher","first-page":"12797","DOI":"10.3390\/ijms241612797","volume":"24","author":"G Rafikova","year":"2023","unstructured":"Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J. Prostate cancer: genetics, epigenetics and the need for immunological biomarkers. Int J Mol Sci. 2023;24:12797.","journal-title":"Int J Mol Sci"},{"key":"2740_CR19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/cac2.12143","volume":"41","author":"N Li","year":"2021","unstructured":"Li N, Wu P, Shen Y, Yang C, Zhang L, Chen Y, et al. Predictions of mortality related to four major cancers in China, 2020 to 2030. Cancer Commun. 2021;41:404\u201313.","journal-title":"Cancer Commun"},{"key":"2740_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12906-016-1517-y","volume":"17","author":"M Shoaib","year":"2017","unstructured":"Shoaib M, Shah I, Ali N, Adhikari A, Tahir MN, Shah SWA, et al. Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem. BMC Complement Altern Med. 2017;17:27.","journal-title":"BMC Complement Altern Med"},{"key":"2740_CR21","doi-asserted-by":"publisher","first-page":"891652","DOI":"10.3389\/fonc.2022.891652","volume":"12","author":"TB Emran","year":"2022","unstructured":"Emran TB, Shahriar A, Mahmud AR, Rahman T, Abir MH, Siddiquee MFR, Ahmed H, Rahman N, Nainu F, Wahyudin E, Mitra S. Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches. Front Oncol. 2022;12:891652.","journal-title":"Front Oncol"},{"key":"2740_CR22","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20:200\u201316.","journal-title":"Nat Rev Drug Discov"},{"key":"2740_CR23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s00253-015-7128-6","volume":"100","author":"M Majdi","year":"2016","unstructured":"Majdi M, Ashengroph M, Abdollahi MR. Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies. Appl Microbiol Biotechnol. 2016;100:1041\u201359.","journal-title":"Appl Microbiol Biotechnol"},{"key":"2740_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065030","volume":"8","author":"AM Ramirez","year":"2013","unstructured":"Ramirez AM, Saillard N, Yang T, Franssen MCR, Bouwmeester HJ, Jongsma MA. Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS ONE. 2013;8: e65030.","journal-title":"PLoS ONE"},{"key":"2740_CR25","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.2174\/1381612826666200116151522","volume":"26","author":"MA Ansari","year":"2020","unstructured":"Ansari MA, Badrealam KF, Alam A, Tufail S, Khalique G, Equbal MJ, et al. Recent nano-based therapeutic intervention of bioactive sesquiterpenes: prospects in cancer therapeutics. Curr Pharm Des. 2020;26:1138\u201344.","journal-title":"Curr Pharm Des"},{"key":"2740_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/13102818.2010.10817819","volume":"24","author":"J Mateji\u0107","year":"2010","unstructured":"Mateji\u0107 J, \u0160arac Z, Ran\u0111elovi\u0107 V. Pharmacological activity of sesquiterpene lactones. Biotechnol Biotechnol Equip. 2010;24:95\u2013100.","journal-title":"Biotechnol Biotechnol Equip"},{"key":"2740_CR27","doi-asserted-by":"publisher","first-page":"12780","DOI":"10.3390\/ijms140612780","volume":"14","author":"M Chadwick","year":"2013","unstructured":"Chadwick M, Trewin H, Gawthrop F, Wagstaff C. Sesquiterpenoids lactones: benefits to plants and people. Int J Mol Sci. 2013;14:12780\u2013805.","journal-title":"Int J Mol Sci"},{"key":"2740_CR28","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.3390\/molecules27031142","volume":"27","author":"A Pa\u00e7o","year":"2022","unstructured":"Pa\u00e7o A, Br\u00e1s T, Santos JO, Sampaio P, Gomes AC, Duarte MF. Anti-inflammatory and immunoregulatory action of sesquiterpene lactones. Molecules. 2022;27:1142.","journal-title":"Molecules"},{"key":"2740_CR29","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.3390\/molecules28114379","volume":"28","author":"A Parafiniuk","year":"2023","unstructured":"Parafiniuk A, Kromer K, Fleszar MG, Kreitschitz A, Wi\u015bniewski J, Gamian A. Localization of sesquiterpene lactones biosynthesis in flowers of arnica taxa. Molecules. 2023;28:4379.","journal-title":"Molecules"},{"key":"2740_CR30","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.3390\/molecules26175347","volume":"26","author":"A Kaur","year":"2021","unstructured":"Kaur A, Kaur S, Jandrotia R, Singh H, Batish D, Kohli R, et al. Parthenin: a Sesquiterpene lactone with multifaceted biological activities: insights and prospects. Molecules. 2021;26:5347.","journal-title":"Molecules"},{"key":"2740_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.24326\/as.2021.3.4","volume":"76","author":"M Sozoniuk","year":"2021","unstructured":"Sozoniuk M. Genetic background of sesquiterpene lactones biosynthesis in Asteraceae. A Rev Agron Sci. 2021;76:49\u201360.","journal-title":"A Rev Agron Sci"},{"key":"2740_CR32","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3390\/pharmaceutics13070991","volume":"13","author":"MS Matos","year":"2021","unstructured":"Matos MS, Anast\u00e1cio JD, Nunes dos Santos C. Sesquiterpene lactones: promising natural compounds to fight inflammation. Pharmaceutics. 2021;13:991.","journal-title":"Pharmaceutics"},{"key":"2740_CR33","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S1572-5995(06)80030-X","volume":"33","author":"TJ Schmidt","year":"2006","unstructured":"Schmidt TJ. Structure-activity relationships of sesquiterpene lactones. Stud Nat Prod Chem. 2006;33:309\u201392.","journal-title":"Stud Nat Prod Chem"},{"key":"2740_CR34","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1080\/17460441.2023.2147920","volume":"17","author":"IA Cheikh","year":"2022","unstructured":"Cheikh IA, El-Baba C, Youssef A, Saliba NA, Ghantous A, Darwiche N. Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention. Expert Opin Drug Discov. 2022;17:1377\u2013405.","journal-title":"Expert Opin Drug Discov"},{"key":"2740_CR35","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1039\/C9NP00049F","volume":"37","author":"RRA Freund","year":"2020","unstructured":"Freund RRA, Gobrecht P, Fischer D, Arndt H-D. Advances in chemistry and bioactivity of parthenolide. Nat Prod Rep. 2020;37:541\u201365.","journal-title":"Nat Prod Rep"},{"key":"2740_CR36","doi-asserted-by":"publisher","first-page":"1371002","DOI":"10.3389\/fphar.2024.1371002","volume":"15","author":"CY Hsu","year":"2024","unstructured":"Hsu CY, Rajabi S, Hamzeloo-Moghadam M, Kumar A, Maresca M, Ghildiyal P. Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis. Front Pharmacol. 2024;15:1371002.","journal-title":"Front Pharmacol"},{"key":"2740_CR37","doi-asserted-by":"crossref","unstructured":"Mehdikhani F, Hajimehdipoor H, Tansaz M, Maresca M, Rajabi S. Sesquiterpene Lactones as Promising Phytochemicals to Cease Metastatic Propagation of Cancer. Biomolecules [Internet]. 2025 [cited 2025 Apr 13];15. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/40001571\/","DOI":"10.3390\/biom15020268"},{"key":"2740_CR38","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/pros.20931","volume":"69","author":"BT Kawasaki","year":"2009","unstructured":"Kawasaki BT, Hurt EM, Kalathur M, Duhagon MA, Milner JA, Kim YS, et al. Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: an integrated molecular profiling approach. Prostate. 2009;69:827\u201337.","journal-title":"Prostate"},{"key":"2740_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107904","volume":"9","author":"C Scarponi","year":"2014","unstructured":"Scarponi C, Butturini E, Sestito R, Madonna S, Cavani A, Mariotto S, et al. Inhibition of inflammatory and proliferative responses of human keratinocytes exposed to the sesquiterpene lactones dehydrocostuslactone and costunolide. PLoS ONE. 2014;9: e107904.","journal-title":"PLoS ONE"},{"key":"2740_CR40","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.2147\/OTT.S256833","volume":"13","author":"Z Qu","year":"2020","unstructured":"Qu Z, Lin Y, Mok DK-W, Bian Q, Tai WC-S, Chen S. Brevilin A, a natural sesquiterpene lactone inhibited the growth of triple-negative breast cancer cells via Akt\/mTOR and STAT3 signaling pathways. Onco Targets Ther. 2020;13:5363\u201373.","journal-title":"Onco Targets Ther"},{"key":"2740_CR41","doi-asserted-by":"publisher","first-page":"627","DOI":"10.4062\/biomolther.2023.210","volume":"32","author":"S An","year":"2024","unstructured":"An S, Chun J, Lee J, Kim YS, Noh M, Ko H. Unraveling stereochemical structure-activity relationships of sesquiterpene lactones for inhibitory effects on STAT3 activation. Biomol Ther (Seoul). 2024;32:627\u201334.","journal-title":"Biomol Ther (Seoul)"},{"key":"2740_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2020.103513","volume":"81","author":"X Ma","year":"2021","unstructured":"Ma X, Wu K, Xu A, Jiao P, Li H, Xing L. The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling. Environ Toxicol Pharmacol. 2021;81: 103513.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"6","key":"2740_CR43","first-page":"1033","volume":"28","author":"S Hayashi","year":"2011","unstructured":"Hayashi S, Koshiba K, Hatashita M, Sato T, Jujo Y, Suzuki R, Tanaka Y, Shioura H. Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-\u03baB inhibitor, in human prostate cancer androgen-independent cell lines. Int J Mol Med. 2011;28(6):1033\u201342.","journal-title":"Int J Mol Med"},{"key":"2740_CR44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cbi.2015.08.015","volume":"240","author":"SH Lone","year":"2015","unstructured":"Lone SH, Bhat KA, Khuroo MA. Arglabin: from isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180\u201398.","journal-title":"Chem Biol Interact"},{"key":"2740_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/4568964","volume":"2019","author":"E Butturini","year":"2019","unstructured":"Butturini E, Carcereri de Prati A, Boriero D, Mariotto S. Natural sesquiterpene lactones enhance chemosensitivity of tumor cells through redox regulation of STAT3 signaling. Oxid Med Cell Longev. 2019;2019:1\u201316.","journal-title":"Oxid Med Cell Longev"},{"key":"2740_CR46","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.3390\/biomedicines9101325","volume":"9","author":"C Bailly","year":"2021","unstructured":"Bailly C. Anticancer targets and signaling pathways activated by britannin and related pseudoguaianolide sesquiterpene lactones. Biomedicines. 2021;9:1325.","journal-title":"Biomedicines"},{"key":"2740_CR47","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/cancers11010034","volume":"11","author":"Y-A Chen","year":"2018","unstructured":"Chen Y-A, Tzeng DTW, Huang Y-P, Lin C-J, Lo U-G, Wu C-L, et al. Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K\/AKT and MAPK signaling pathways. Cancers. 2018;11:34.","journal-title":"Cancers"},{"key":"2740_CR48","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2174\/1871520621666211021143255","volume":"22","author":"A Das","year":"2022","unstructured":"Das A, Agarwal P, Jain GK, Aggarwal G, Lather V, Pandita D. Repurposing drugs as novel triple-negative breast cancer therapeutics. Anticancer Agents Med Chem. 2022;22:515\u201350.","journal-title":"Anticancer Agents Med Chem"},{"key":"2740_CR49","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3390\/cells9061451","volume":"9","author":"S Bose","year":"2020","unstructured":"Bose S, Banerjee S, Mondal A, Chakraborty U, Pumarol J, Croley CR, et al. Targeting the JAK\/STAT signaling pathway using phytocompounds for cancer prevention and therapy. Cells. 2020;9:1451.","journal-title":"Cells"},{"key":"2740_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.780257","author":"K Farmanpour-Kalalagh","year":"2022","unstructured":"Farmanpour-Kalalagh K, Beyraghdar Kashkooli A, Babaei A, Rezaei A, van der Krol AR. Artemisinins in combating viral infections like SARS-CoV-2, inflammation and cancers and options to meet increased global demand. Front Plant Sci. 2022. https:\/\/doi.org\/10.3389\/fpls.2022.780257.","journal-title":"Front Plant Sci"},{"key":"2740_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154032","volume":"99","author":"J Han","year":"2022","unstructured":"Han J, Zhang S, Jiang B, Wang J, Ge X, Wu B, et al. Sesquiterpene lactones from Xanthium sibiricum Patrin alleviate asthma by modulating the Th1\/Th2 balance in a murine model. Phytomedicine. 2022;99: 154032.","journal-title":"Phytomedicine"},{"key":"2740_CR52","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.3390\/biomedicines10112739","volume":"10","author":"R Migheli","year":"2022","unstructured":"Migheli R, Virdis P, Galleri G, Arru C, Lostia G, Coradduzza D, et al. Antineoplastic Properties by proapoptotic mechanisms induction of Inula viscosa and its Sesquiterpene lactones tomentosin and inuviscolide. Biomedicines. 2022;10:2739.","journal-title":"Biomedicines"},{"key":"2740_CR53","doi-asserted-by":"publisher","first-page":"101042831990106","DOI":"10.1177\/1010428319901061","volume":"42","author":"P Virdis","year":"2020","unstructured":"Virdis P, Migheli R, Galleri G, Fancello S, Cadoni MPL, Pintore G, et al. Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line. Tumor Biology. 2020;42:101042831990106.","journal-title":"Tumor Biology"},{"key":"2740_CR54","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1080\/10286020.2017.1302939","volume":"19","author":"TA Mohamed","year":"2017","unstructured":"Mohamed TA, Hegazy M-EF, Abd El Aty AA, Ghabbour HA, Alsaid MS, Shahat AA, et al. Antimicrobial sesquiterpene lactones from Artemisia sieberi. J Asian Nat Prod Res. 2017;19:1093\u2013101.","journal-title":"J Asian Nat Prod Res"},{"key":"2740_CR55","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.3390\/molecules29081866","volume":"29","author":"VuQ Van","year":"2024","unstructured":"Van VuQ, Sayama S, Ando M, Kataoka T. Sesquiterpene lactones containing an \u03b1-methylene-\u03b3-lactone moiety selectively down-regulate the expression of tumor necrosis factor receptor 1 by promoting its ectodomain shedding in human lung adenocarcinoma A549 cells. Molecules. 2024;29:1866.","journal-title":"Molecules"},{"key":"2740_CR56","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.2174\/1871520623666230918140559","volume":"23","author":"MH Abdolmohammadi","year":"2023","unstructured":"Abdolmohammadi MH, Roozbehani M, Hamzeloo-Moghadam M, Heidari F, Fallahian F. Targeting PPAR\u03b3\/ NF-\u03baB signaling pathway by Britannin, a Sesquiterpene lactone from Inula aucheriana DC, in gastric cancer. Anticancer Agents Med Chem. 2023;23:2102\u201310.","journal-title":"Anticancer Agents Med Chem"},{"key":"2740_CR57","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1055\/s-0043-120115","volume":"84","author":"S Choodej","year":"2018","unstructured":"Choodej S, Pudhom K, Mitsunaga T. Inhibition of TNF-\u03b1-induced inflammation by Sesquiterpene lactones from Saussurea lappa and semi-synthetic analogues. Planta Med. 2018;84:329\u201335.","journal-title":"Planta Med"},{"key":"2740_CR58","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/B978-0-444-63931-8.00009-6","volume":"52","author":"AM Seca","year":"2017","unstructured":"Seca AM, Silva AM, Pinto DC. Parthenolide and parthenolide-like sesquiterpene lactones as multiple targets drugs: current knowledge and new developments. Stud Nat Prod Chem. 2017;52:337\u201372.","journal-title":"Stud Nat Prod Chem"},{"key":"2740_CR59","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s13205-024-04050-2","volume":"14","author":"K Velumani","year":"2024","unstructured":"Velumani K, John A, Shaik MR, Hussain SA, Guru A, Issac PK. Exploring sesquiterpene lactone as a dual therapeutic agent for diabetes and oxidative stress: insights into PI3K\/AKT modulation. 3 Biotech. 2024;14:205.","journal-title":"3 Biotech."},{"key":"2740_CR60","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.gendis.2020.07.014","volume":"9","author":"C Yang","year":"2022","unstructured":"Yang C, Zhang L, Huang H, Yuan X, Zhang P, Ye C, et al. Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt\/\u03b2-catenin and MAPKs signaling pathways. Genes Dis. 2022;9:466\u201378.","journal-title":"Genes Dis"},{"key":"2740_CR61","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.biopha.2016.03.031","volume":"80","author":"C Zhang","year":"2016","unstructured":"Zhang C, Lu T, Wang G-D, Ma C, Zhou Y-F. Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells. Biomed Pharmacother. 2016;80:253\u20139.","journal-title":"Biomed Pharmacother"},{"key":"2740_CR62","doi-asserted-by":"publisher","first-page":"5617","DOI":"10.4049\/jimmunol.163.10.5617","volume":"163","author":"SP Hehner","year":"1999","unstructured":"Hehner SP, Hofmann TG, Dr\u00f6ge W, Schmitz ML. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-\u03baB by targeting the I\u03baB kinase complex. J Immunol. 1999;163:5617\u201323.","journal-title":"J Immunol"},{"key":"2740_CR63","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12935-022-02721-9","volume":"22","author":"P Dhyani","year":"2022","unstructured":"Dhyani P, Sati P, Sharma E, Attri DC, Bahukhandi A, Tynybekov B, et al. Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies. Cancer Cell Int. 2022;22:305.","journal-title":"Cancer Cell Int"},{"key":"2740_CR64","doi-asserted-by":"publisher","first-page":"7358","DOI":"10.3390\/molecules27217358","volume":"27","author":"KMSU Imam","year":"2022","unstructured":"Imam KMSU, Tian Y, Xin F, Xie Y, Wen B. Lactucin, a bitter Sesquiterpene from Cichorium intybus, inhibits cancer cell proliferation by downregulating the MAPK and central carbon metabolism pathway. Molecules. 2022;27:7358.","journal-title":"Molecules"},{"key":"2740_CR65","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.3390\/molecules24213822","volume":"24","author":"NKK Ikram","year":"2019","unstructured":"Ikram NKK, Kashkooli AB, Peramuna A, van der Krol AR, Bouwmeester H, Simonsen HT. Insights into heterologous biosynthesis of Arteannuin B and artemisinin in physcomitrella patens. Molecules. 2019;24:3822.","journal-title":"Molecules"},{"key":"2740_CR66","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3390\/ph13080194","volume":"13","author":"M Sztiller-Sikorska","year":"2020","unstructured":"Sztiller-Sikorska M, Czyz M. Parthenolide as cooperating agent for anti-cancer treatment of various malignancies. Pharmaceuticals. 2020;13:194.","journal-title":"Pharmaceuticals"},{"key":"2740_CR67","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12906-019-2462-3","volume":"19","author":"M Mellado","year":"2019","unstructured":"Mellado M, Soto M, Madrid A, Montenegro I, Jara-Guti\u00e9rrez C, Villena J, et al. In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts. BMC Complement Altern Med. 2019;19:53.","journal-title":"BMC Complement Altern Med"},{"key":"2740_CR68","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3390\/ijms24021439","volume":"24","author":"N Carrasco","year":"2023","unstructured":"Carrasco N, Garrido M, Montenegro I, Madrid A, Hartley R, Gonz\u00e1lez I, et al. Antitumoral activity of leptocarpha rivularis flower extracts against gastric cancer cells. Int J Mol Sci. 2023;24:1439.","journal-title":"Int J Mol Sci"},{"key":"2740_CR69","doi-asserted-by":"publisher","first-page":"5768","DOI":"10.3390\/molecules25235768","volume":"25","author":"R Macr\u00ec","year":"2020","unstructured":"Macr\u00ec R, Musolino V, Gliozzi M, Carresi C, Maiuolo J, Nucera S, et al. Ferula L. plant extracts and dose-dependent activity of natural sesquiterpene ferutinin: from antioxidant potential to cytotoxic effects. Molecules. 2020;25:5768.","journal-title":"Molecules"},{"key":"2740_CR70","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1021\/np500768s","volume":"78","author":"AJ Robles","year":"2015","unstructured":"Robles AJ, Peng J, Hartley RM, Lee B, Mooberry SL. Melampodium leucanthum, a source of cytotoxic Sesquiterpenes with antimitotic activities. J Nat Prod. 2015;78:388\u201395.","journal-title":"J Nat Prod"},{"key":"2740_CR71","first-page":"4418","volume":"24","author":"A Wajs-Bonikowska","year":"2019","unstructured":"Wajs-Bonikowska A, Malarz J, Stojakowska A. Composition of essential oils from roots and aerial parts of Carpesium divaricatum, a traditional herbal medicine and wild edible plant from south-east Asia. Grown in Poland Mol. 2019;24:4418.","journal-title":"Grown in Poland Mol"},{"key":"2740_CR72","doi-asserted-by":"publisher","first-page":"4644","DOI":"10.3390\/molecules26154644","volume":"26","author":"N K\u0142eczek","year":"2021","unstructured":"K\u0142eczek N, Malarz J, Gierlikowska B, Skalniak \u0141, Galanty A, Kiss AK, et al. Germacranolides from Carpesium divaricatum: some new data on cytotoxic and anti-inflammatory activity. Molecules. 2021;26:4644.","journal-title":"Molecules"},{"key":"2740_CR73","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1515\/hc-2022-0012","volume":"28","author":"N-N Shi","year":"2022","unstructured":"Shi N-N, Hou C-C, Liu Y, Li K-Y, Mi S-D, Tong B-L, et al. Chemical constituents of plants from the genus Carpesium. Heterocycl Comm. 2022;28:95\u2013123.","journal-title":"Heterocycl Comm"},{"key":"2740_CR74","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00606-004-0272-6","volume":"253","author":"B Gemeinholzer","year":"2005","unstructured":"Gemeinholzer B, Bachmann K. Examining morphological and molecular diagnostic character states of Cichorium intybus L. (Asteraceae) and C. spinosum L. Plant Syst Evol. 2005;253:105\u201323.","journal-title":"Plant Syst Evol"},{"key":"2740_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/579319","volume":"2013","author":"RA Street","year":"2013","unstructured":"Street RA, Sidana J, Prinsloo G. Cichorium intybus\u202f: traditional uses, phytochemistry, pharmacology, and toxicology. Evid-Based Complementary Alternat Med. 2013;2013:1\u201313.","journal-title":"Evid-Based Complementary Alternat Med"},{"key":"2740_CR76","doi-asserted-by":"publisher","first-page":"12061","DOI":"10.3390\/app122312061","volume":"12","author":"B Malik","year":"2022","unstructured":"Malik B, Dar FA, Pirzadah TB, Zari A, Zari TA, Alharby HF, et al. Molecular and phytochemical characterizations of Cichorium intybus L. in diverse ecogeographical regions of kashmir himalaya. Appl Sci. 2022;12:12061.","journal-title":"Appl Sci"},{"key":"2740_CR77","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jep.2006.03.003","volume":"107","author":"A Weso\u0142owska","year":"2006","unstructured":"Weso\u0142owska A, Nikiforuk A, Michalska K, Kisiel W, Chojnacka-W\u00f3jcik E. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. J Ethnopharmacol. 2006;107:254\u20138.","journal-title":"J Ethnopharmacol"},{"key":"2740_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113377","volume":"203","author":"X Meng","year":"2022","unstructured":"Meng X, Lv H, Ding X, Jian T, Guo D, Feng X, et al. Sesquiterpene lactones with anti-inflammatory and cytotoxic activities from the roots of Cichorium intybus. Phytochemistry. 2022;203: 113377.","journal-title":"Phytochemistry"},{"key":"2740_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113411","volume":"203","author":"M Fattahian","year":"2022","unstructured":"Fattahian M, Ghanadian M, Zolfaghari B, Aghaei M, Zulfiqar F, Khan IA, et al. Phytochemical analysis of Artemisia kopetdaghensis: Sesquiterpene lactones with proapoptotic activity against prostate cancer cells. Phytochemistry. 2022;203: 113411.","journal-title":"Phytochemistry"},{"key":"2740_CR80","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1049\/mnl.2020.0387","volume":"15","author":"ME Taghavizadeh Yazdi","year":"2020","unstructured":"Taghavizadeh Yazdi ME, Darroudi M, Amiri MS, Hosseini HA, Nourbakhsh F, Mashreghi M, et al. Anticancer, antimicrobial, and dye degradation activity of biosynthesised silver nanoparticle using Artemisia kopetdaghensis. Micro Nano Lett. 2020;15:1046\u201350.","journal-title":"Micro Nano Lett"},{"key":"2740_CR81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3349\/ymj.2015.56.1.16","volume":"56","author":"U-S Ha","year":"2015","unstructured":"Ha U-S, Bae WJ, Kim SJ, Il YB, Hong SH, Lee JY, et al. Anthocyanin induces apoptosis of DU-145 Cells in vitro and inhibits xenograft growth of prostate cancer. Yonsei Med J. 2015;56:16.","journal-title":"Yonsei Med J"},{"key":"2740_CR82","doi-asserted-by":"publisher","first-page":"1169629","DOI":"10.3389\/fphar.2023.1169629","volume":"14","author":"S Khatib","year":"2023","unstructured":"Khatib S, Sobeh M, Faraloni C, Bouissane L. Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence. Front Pharmacol. 2023;14:1169629.","journal-title":"Front Pharmacol"},{"key":"2740_CR83","doi-asserted-by":"publisher","first-page":"286","DOI":"10.12991\/marupj.300357","volume":"21","author":"A \u015een","year":"2017","unstructured":"\u015een A, Bing\u00f6l \u00d6zakp\u0131nar \u00d6, Birteks\u00f6z Tan S, K\u00fclt\u00fcr \u015e, Uras F, Biti\u015f L. Endemik Tanacetum argenteum subsp. argenteum bitkisinin toprak \u00fcst\u00fc k\u0131s\u0131mlar\u0131ndan elde edilen ekstrelerin biyolojik aktiviteleri. Marmara Pharm J. 2017;21:286\u2013286.","journal-title":"Marmara Pharm J."},{"issue":"3","key":"2740_CR84","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4274\/tjps.42714","volume":"14","author":"G Albayrak","year":"2017","unstructured":"Albayrak G, Nalbantsoy A, Baykan S. In vitro cytotoxic and anti-inflammatory activities of Tanacetum argenteum (Lam.) Willd. Subsp. argenteum extract. Turkish J Pharm Sci. 2017;14(3):231.","journal-title":"Turkish J Pharm Sci"},{"key":"2740_CR85","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.phytol.2014.10.003","volume":"11","author":"IE Orhan","year":"2015","unstructured":"Orhan IE, Tosun F, G\u00fclp\u0131nar AR, Kartal M, Duran A, Mihoglugil F, et al. LC\u2013MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxa. Phytochem Lett. 2015;11:347\u201352.","journal-title":"Phytochem Lett"},{"key":"2740_CR86","doi-asserted-by":"crossref","unstructured":"Szypu\u0142a WJ, Pietrosiuk A. 2021 Biology, Phytochemistry, Pharmacology, and Biotechnology of European Ferns, Club Mosses, and Horsetails: A Review. 2021. p. 605\u201360.","DOI":"10.1007\/978-3-030-74779-4_19"},{"key":"2740_CR87","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.3390\/molecules19033345","volume":"19","author":"D-D Zhao","year":"2014","unstructured":"Zhao D-D, Zhao Q-S, Liu L, Chen Z-Q, Zeng W-M, Lei H, et al. Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity. Molecules. 2014;19:3345\u201355.","journal-title":"Molecules"},{"key":"2740_CR88","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/molecules23071652","volume":"23","author":"T Zhang","year":"2018","unstructured":"Zhang T, Wang L, Duan D-H, Zhang Y-H, Huang S-X, Chang Y. Cytotoxicity-guided isolation of two new phenolic derivatives from dryopteris fragrans (L.) Schott. Molecules. 2018;23:1652.","journal-title":"Molecules"},{"key":"2740_CR89","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00044-021-02828-0","volume":"31","author":"F Zhang","year":"2022","unstructured":"Zhang F, Lai Q, Lai W, Li M, Jin X, Ye L. Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies. Med Chem Res. 2022;31:165\u201376.","journal-title":"Med Chem Res"},{"key":"2740_CR90","doi-asserted-by":"publisher","first-page":"5744","DOI":"10.3390\/molecules28155744","volume":"28","author":"RH Abdallah","year":"2023","unstructured":"Abdallah RH, Al-Saleem MSM, Abdel-Mageed WM, Al-Attar A-SR, Shehata YM, Abdel-Fattah DM, et al. LCMS\/MS phytochemical profiling, molecular, pathological, and immune-histochemical studies on the anticancer properties of annona muricata. Molecules. 2023;28:5744.","journal-title":"Molecules"},{"key":"2740_CR91","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/molecules26010067","volume":"26","author":"I Montenegro","year":"2020","unstructured":"Montenegro I, Moreira J, Ram\u00edrez I, Dorta F, S\u00e1nchez E, Alfaro JF, et al. Chemical composition, antioxidant and anticancer activities of leptocarpha rivularis DC flower extracts. Molecules. 2020;26:67.","journal-title":"Molecules"},{"key":"2740_CR92","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.cbi.2015.11.006","volume":"242","author":"C Bosio","year":"2015","unstructured":"Bosio C, Tomasoni G, Mart\u00ednez R, Olea AF, Carrasco H, Villena J. Cytotoxic and apoptotic effects of leptocarpin, a plant-derived sesquiterpene lactone, on human cancer cell lines. Chem Biol Interact. 2015;242:415\u201321.","journal-title":"Chem Biol Interact"},{"key":"2740_CR93","doi-asserted-by":"publisher","first-page":"608649","DOI":"10.3389\/fphar.2020.608649","volume":"11","author":"P Sonigra","year":"2021","unstructured":"Sonigra P, Meena M. Metabolic profile, bioactivities, and variations in the chemical constituents of essential oils of the Ferula Genus (Apiaceae). Front Pharmacol. 2021;11:608649.","journal-title":"Front Pharmacol"},{"key":"2740_CR94","doi-asserted-by":"publisher","first-page":"10717","DOI":"10.3390\/ijms221910717","volume":"22","author":"SV Luca","year":"2021","unstructured":"Luca SV, Gawe\u0142-B\u0119ben K, Strz\u0119pek-Gom\u00f3\u0142ka M, Jumabayeva A, Sakipova Z, Xiao J, et al. Liquid-liquid chromatography separation of guaiane-type sesquiterpene lactones from ferula penninervis Regel and Schmalh and evaluation of their in vitro cytotoxic and melanin inhibitory potential. Int J Mol Sci. 2021;22:10717.","journal-title":"Int J Mol Sci"},{"key":"2740_CR95","doi-asserted-by":"publisher","first-page":"9002","DOI":"10.3390\/molecules17089002","volume":"17","author":"G Yan","year":"2012","unstructured":"Yan G, Ji L, Luo Y, Hu Y. Preparative isolation and purification of three sesquiterpenoid lactones from eupatorium lindleyanum DC. by high-speed counter-current chromatography. Molecules. 2012;17:9002\u20139.","journal-title":"Molecules"},{"key":"2740_CR96","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1039\/c39720000137","volume":"3","author":"NH Fischer","year":"1972","unstructured":"Fischer NH, Wiley R, Wander JD. Melampodin, a new germacranolide from Melampodium leucanthum Torr. and Gray var. leucanthum (compositae). J Chem Soc Chem Commun. 1972;3:137\u20139.","journal-title":"J Chem Soc Chem Commun"},{"key":"2740_CR97","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/ptr.2286","volume":"22","author":"L Delmulle","year":"2008","unstructured":"Delmulle L, Vanden BT, De KD, Vandenabeele P. Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop ( Humulus lupulus L.) induces a caspase-independent form of cell death. Phytother Res. 2008;22:197\u2013203.","journal-title":"Phytother Res"},{"key":"2740_CR98","doi-asserted-by":"publisher","first-page":"234","DOI":"10.4103\/0973-1296.66942","volume":"6","author":"A Trendafilova","year":"2010","unstructured":"Trendafilova A, Chanev C, Todorova M. Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots. Pharmacogn Mag. 2010;6:234.","journal-title":"Pharmacogn Mag"},{"key":"2740_CR99","first-page":"167","volume":"13","author":"X Liu","year":"2021","unstructured":"Liu X, Li H, Wang S, Zhang J, Liu D. Sesquiterpene lactones of aucklandia lappa: pharmacology, pharmacokinetics, toxicity, and structure\u2013activity relationship. Chin Herb Med. 2021;13:167\u201376.","journal-title":"Chin Herb Med"},{"key":"2740_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100263","volume":"7","author":"M Talebi","year":"2023","unstructured":"Talebi M, Khoramjouy M, Feizi A, Ali Z, Khan IA, Ayatollahi NA, et al. Novel multi-target therapeutic potential of the genus Inula: advances and opportunities for neuroprotection. Pharmacol Res - Modern Chin Med. 2023;7: 100263.","journal-title":"Pharmacol Res - Modern Chin Med"},{"key":"2740_CR101","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.781033","author":"Y Cai","year":"2021","unstructured":"Cai Y, Gao K, Peng B, Xu Z, Peng J, Li J, et al. Alantolactone: a natural plant extract as a potential therapeutic agent for cancer. Front Pharmacol. 2021. https:\/\/doi.org\/10.3389\/fphar.2021.781033.","journal-title":"Front Pharmacol"},{"key":"2740_CR102","doi-asserted-by":"publisher","first-page":"551","DOI":"10.4103\/1735-5362.301340","volume":"15","author":"G Babaei","year":"2020","unstructured":"Babaei G, Khadem Ansari M, Aziz S-G, Bazl M. Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells through STAT3 signaling pathway. Res Pharm Sci. 2020;15:551.","journal-title":"Res Pharm Sci"},{"key":"2740_CR103","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s11418-020-01462-1","volume":"75","author":"S Okubo","year":"2021","unstructured":"Okubo S, Ohta T, Fujita H, Shoyama Y, Uto T. Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells. J Nat Med. 2021;75:240\u20135.","journal-title":"J Nat Med"},{"key":"2740_CR104","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1016\/j.juro.2010.12.091","volume":"185","author":"J-L Hsu","year":"2011","unstructured":"Hsu J-L, Pan S-L, Ho Y-F, Hwang T-L, Kung F-L, Guh J-H. Costunolide induces apoptosis through nuclear calcium 2+ overload and DNA damage response in human prostate cancer. J Urol. 2011;185:1967\u201374.","journal-title":"J Urol"},{"key":"2740_CR105","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1055\/s-0029-1185362","volume":"75","author":"N Perry","year":"2009","unstructured":"Perry N, Burgess E, Rodr\u00edguez Guiti\u00e1n M, Romero Franco R, L\u00f3pez Mosquera E, Smallfield B, et al. Sesquiterpene lactones in Arnica montana\u202f: helenalin and dihydrohelenalin chemotypes in Spain. Planta Med. 2009;75:660\u20136.","journal-title":"Planta Med"},{"key":"2740_CR106","doi-asserted-by":"publisher","first-page":"133","DOI":"10.31557\/APJCP.2023.24.1.133","volume":"24","author":"A Barkhordari","year":"2023","unstructured":"Barkhordari A, Jafari-Gharabaghlou D, Turk Z, Zarghami N. Potential anti-cancer effect of helenalin as a natural bioactive compound on the growth and telomerase gene expression in breast cancer cell line. Asian Pac J Cancer Prev. 2023;24:133\u201340.","journal-title":"Asian Pac J Cancer Prev"},{"key":"2740_CR107","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.3390\/ph14121258","volume":"14","author":"H Mun","year":"2021","unstructured":"Mun H, Townley HE. Mechanism of action of the sesquiterpene compound helenalin in rhabdomyosarcoma cells. Pharmaceuticals. 2021;14:1258.","journal-title":"Pharmaceuticals"},{"key":"2740_CR108","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/1472-6882-12-93","volume":"12","author":"CB Lim","year":"2012","unstructured":"Lim CB, Fu PY, Ky N, Zhu HS, Feng X, Li J, et al. NF-\u03baB p65 repression by the sesquiterpene lactone, helenalin, contributes to the induction of autophagy cell death. BMC Complement Altern Med. 2012;12:93.","journal-title":"BMC Complement Altern Med"},{"key":"2740_CR109","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.tiv.2012.10.014","volume":"27","author":"JH Jang","year":"2013","unstructured":"Jang JH, Iqbal T, Min K, Kim S, Park J-W, Son E-I, et al. Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma. Toxicol In Vitro. 2013;27:588\u201396.","journal-title":"Toxicol In Vitro"},{"key":"2740_CR110","doi-asserted-by":"publisher","first-page":"e930083","DOI":"10.12659\/MSM.930083","volume":"27","author":"M Yang","year":"2021","unstructured":"Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, Yang Y. Helenalin facilitates reactive oxygen species-mediated apoptosis and cell cycle arrest by targeting thioredoxin reductase-1 in human prostate cancer cells. Med Sci Monit. 2021;27:e930083\u201391.","journal-title":"Med Sci Monit"},{"key":"2740_CR111","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1016\/j.febslet.2006.03.041","volume":"580","author":"F Alimirah","year":"2006","unstructured":"Alimirah F, Chen J, Basrawala Z, Xin H, Choubey D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation. FEBS Lett. 2006;580:2294\u2013300.","journal-title":"FEBS Lett"},{"key":"2740_CR112","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.930083","volume":"27","author":"M Yang","year":"2021","unstructured":"Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, et al. Helenalin facilitates reactive oxygen species-mediated apoptosis and cell cycle arrest by targeting thioredoxin reductase-1 in human prostate cancer cells. Med Sci Monit. 2021;27: e930083.","journal-title":"Med Sci Monit"},{"key":"2740_CR113","doi-asserted-by":"publisher","first-page":"107090","DOI":"10.1016\/j.bioorg.2023.107090","volume":"144","author":"Z Wang","year":"2024","unstructured":"Wang Z, Guo S, Cai Y, Yang Q, Wang Y, Yu X, Sun W, Qiu S, Li X, Guo Y, Xie Y. Decoding active compounds and molecular targets of herbal medicine by high-throughput metabolomics technology: a systematic review. Bioorg Chem. 2024;144:107090.","journal-title":"Bioorg Chem"},{"key":"2740_CR114","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3389\/fphar.2016.00472","volume":"7","author":"MF Elsebai","year":"2016","unstructured":"Elsebai MF, Mocan A, Atanasov AG. Cynaropicrin: a comprehensive research review and therapeutic potential as an anti-hepatitis C virus agent. Front Pharmacol. 2016;7:472.","journal-title":"Front Pharmacol"},{"key":"2740_CR115","doi-asserted-by":"publisher","first-page":"103937","DOI":"10.1016\/j.jff.2020.103937","volume":"69","author":"A Zayed","year":"2020","unstructured":"Zayed A, Serag A, Farag MA. Cynara cardunculus L.: outgoing and potential trends of phytochemical, industrial, nutritive and medicinal merits. J Funct Foods. 2020;69:103937.","journal-title":"J Funct Foods."},{"key":"2740_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.605184","author":"D Zheng","year":"2021","unstructured":"Zheng D, Zhu Y, Shen Y, Xiao S, Yang L, Xiang Y, et al. Cynaropicrin shows antitumor progression potential in colorectal cancer through mediation of the LIFR\/STATs axis. Front Cell Dev Biol. 2021. https:\/\/doi.org\/10.3389\/fcell.2020.605184.","journal-title":"Front Cell Dev Biol"},{"key":"2740_CR117","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2174\/1871530318666180928153241","volume":"19","author":"SM Lepore","year":"2019","unstructured":"Lepore SM, Maggisano V, Lombardo GE, Maiuolo J, Mollace V, Bulotta S, et al. Antiproliferative effects of cynaropicrin on anaplastic thyroid cancer cells. Endocr Metab Immune Disord Drug Targets. 2019;19:59\u201366.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"2740_CR118","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s42826-019-0030-0","volume":"35","author":"J-H Kang","year":"2019","unstructured":"Kang J-H, Jang Y-S, Lee HJ, Lee C-Y, Shin DY, Oh SH. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Lab Anim Res. 2019;35:30.","journal-title":"Lab Anim Res"},{"key":"2740_CR119","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3390\/biomedicines10071583","volume":"10","author":"R Rotondo","year":"2022","unstructured":"Rotondo R, Oliva MA, Arcella A. The sesquiterpene lactone cynaropicrin manifests strong cytotoxicity in glioblastoma cells U-87 MG by induction of oxidative stress. Biomedicines. 2022;10:1583.","journal-title":"Biomedicines"},{"key":"2740_CR120","doi-asserted-by":"publisher","first-page":"5501","DOI":"10.2174\/1381612821666151002112824","volume":"21","author":"N Quynh Doan","year":"2015","unstructured":"Quynh Doan N, Christensen S. Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development. Curr Pharm Des. 2015;21:5501\u201317.","journal-title":"Curr Pharm Des"},{"key":"2740_CR121","doi-asserted-by":"publisher","first-page":"19656","DOI":"10.1074\/jbc.M117.796920","volume":"292","author":"P Sehgal","year":"2017","unstructured":"Sehgal P, Szalai P, Olesen C, Praetorius HA, Nissen P, Christensen SB, et al. Inhibition of the sarco\/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response. J Biol Chem. 2017;292:19656\u201373.","journal-title":"J Biol Chem"},{"key":"2740_CR122","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.exppara.2015.08.017","volume":"159","author":"MC P\u00e9rez-Gordones","year":"2015","unstructured":"P\u00e9rez-Gordones MC, Serrano ML, Rojas H, Mart\u00ednez JC, Uzcanga G, Mendoza M. Presence of a thapsigargin-sensitive calcium pump in Trypanosoma evansi: immunological, physiological, molecular and structural evidences. Exp Parasitol. 2015;159:107\u201317.","journal-title":"Exp Parasitol"},{"key":"2740_CR123","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8833","author":"F Huang","year":"2018","unstructured":"Huang F, Wang P, Wang X. Thapsigargin induces apoptosis of prostate cancer through cofilin-1 and paxillin. Oncol Lett. 2018. https:\/\/doi.org\/10.3892\/ol.2018.8833.","journal-title":"Oncol Lett"},{"key":"2740_CR124","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.2147\/DDDT.S209947","volume":"13","author":"L Wu","year":"2019","unstructured":"Wu L, Huang X, Kuang Y, Xing Z, Deng X, Luo Z. Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study. Drug Des Devel Ther. 2019;13:2787\u201398.","journal-title":"Drug Des Devel Ther"},{"key":"2740_CR125","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.3390\/plants12162940","volume":"12","author":"K Hordiei","year":"2023","unstructured":"Hordiei K, Gontova T, Trumbeckaite S, Yaremenko M, Raudone L. Phenolic composition and antioxidant activity of tanacetum parthenium cultivated in different regions of ukraine: insights into the flavonoids and hydroxycinnamic acids profile. Plants. 2023;12:2940.","journal-title":"Plants"},{"key":"2740_CR126","doi-asserted-by":"publisher","first-page":"302","DOI":"10.7150\/thno.8387","volume":"5","author":"K Liao","year":"2015","unstructured":"Liao K, Xia B, Zhuang Q-Y, Hou M-J, Zhang Y-J, Luo B, et al. Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via Suppression of the NF-\u03baB\/COX-2 pathway. Theranostics. 2015;5:302\u201321.","journal-title":"Theranostics"},{"key":"2740_CR127","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1165\/rcmb.2006-0323OC","volume":"36","author":"A Saadane","year":"2007","unstructured":"Saadane A, Masters S, DiDonato J, Li J, Berger M. Parthenolide inhibits I\u03baB kinase, NF-\u03baB activation, and inflammatory response in cystic fibrosis cells and mice. Am J Respir Cell Mol Biol. 2007;36:728\u201336.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2740_CR128","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1186\/s12935-020-01658-1","volume":"20","author":"X Li","year":"2020","unstructured":"Li X, Huang R, Li M, Zhu Z, Chen Z, Cui L, et al. Parthenolide inhibits the growth of non-small cell lung cancer by targeting epidermal growth factor receptor. Cancer Cell Int. 2020;20:561.","journal-title":"Cancer Cell Int"},{"key":"2740_CR129","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1006\/bbrc.1999.1948","volume":"267","author":"R Sobota","year":"2000","unstructured":"Sobota R, Szwed M, Kasza A, Bugno M, Kordula T. Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family. Biochem Biophys Res Commun. 2000;267:329\u201333.","journal-title":"Biochem Biophys Res Commun"},{"key":"2740_CR130","doi-asserted-by":"publisher","first-page":"e891","DOI":"10.1038\/cddis.2013.415","volume":"4","author":"A D\u2019Anneo","year":"2013","unstructured":"D\u2019Anneo A, Carlisi D, Lauricella M, Puleio R, Martinez R, Di Bella S, et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. a soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 2013;4:e891\u2013e891.","journal-title":"Cell Death Dis"},{"key":"2740_CR131","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.chembiol.2007.06.007","volume":"14","author":"YNV Gopal","year":"2007","unstructured":"Gopal YNV, Arora TS, Van Dyke MW. Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated. Chem Biol. 2007;14:813\u201323.","journal-title":"Chem Biol"},{"key":"2740_CR132","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1124\/jpet.108.147934","volume":"329","author":"Z Liu","year":"2009","unstructured":"Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, et al. Modulation of DNA methylation by a sesquiterpene lactone parthenolide. J Pharmacol Exp Ther. 2009;329:505\u201314.","journal-title":"J Pharmacol Exp Ther"},{"key":"2740_CR133","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11010-013-1822-4","volume":"385","author":"SW Kwak","year":"2014","unstructured":"Kwak SW, Park ES, Lee CS. Parthenolide induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits FAK-mediated cell invasion. Mol Cell Biochem. 2014;385:133\u201344.","journal-title":"Mol Cell Biochem"},{"key":"2740_CR134","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2020.131631","volume":"76","author":"AS Quy","year":"2020","unstructured":"Quy AS, Li X, Male L, Stankovic T, Agathanggelou A, Fossey JS. Aniline-containing derivatives of parthenolide: synthesis and anti-chronic lymphocytic leukaemia activity. Tetrahedron. 2020;76: 131631.","journal-title":"Tetrahedron"},{"key":"2740_CR135","doi-asserted-by":"publisher","first-page":"8213","DOI":"10.1016\/j.tet.2011.07.020","volume":"67","author":"LH Choudhury","year":"2011","unstructured":"Choudhury LH, Parvin T. Recent advances in the chemistry of imine-based multicomponent reactions (MCRs). Tetrahedron. 2011;67:8213\u201328.","journal-title":"Tetrahedron"},{"key":"2740_CR136","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1039\/C9MD00297A","volume":"10","author":"X Li","year":"2019","unstructured":"Li X, Payne DT, Ampolu B, Bland N, Brown JT, Dutton MJ, et al. Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia. Medchemcomm. 2019;10:1379\u201390.","journal-title":"Medchemcomm"},{"key":"2740_CR137","doi-asserted-by":"publisher","first-page":"e2194","DOI":"10.1038\/cddis.2016.94","volume":"7","author":"D Carlisi","year":"2016","unstructured":"Carlisi D, Buttitta G, Di Fiore R, Scerri C, Drago-Ferrante R, Vento R, et al. Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis. Cell Death Dis. 2016;7:e2194\u2013e2194.","journal-title":"Cell Death Dis"},{"key":"2740_CR138","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1158\/1541-7786.MCR-09-0166","volume":"7","author":"K Bray","year":"2009","unstructured":"Bray K, Chen H-Y, Karp CM, May M, Ganesan S, Karantza-Wadsworth V, et al. Bcl-2 modulation to activate apoptosis in prostate cancer. Mol Cancer Res. 2009;7:1487\u201396.","journal-title":"Mol Cancer Res"},{"key":"2740_CR139","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.freeradbiomed.2017.08.001","volume":"112","author":"MS Mendonca","year":"2017","unstructured":"Mendonca MS, Turchan WT, Alpuche ME, Watson CN, Estabrook NC, Chin-Sinex H, et al. DMAPT inhibits NF-\u03baB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017;112:318\u201326.","journal-title":"Free Radic Biol Med"},{"key":"2740_CR140","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.3390\/antiox10121925","volume":"10","author":"S Kumar","year":"2021","unstructured":"Kumar S, Clair D. Radioresistance in prostate cancer: focus on the interplay between NF-\u03baB and SOD. Antioxidants. 2021;10:1925.","journal-title":"Antioxidants"},{"key":"2740_CR141","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.3390\/jcm11195637","volume":"11","author":"L King","year":"2022","unstructured":"King L, Bernaitis N, Christie D, Chess-Williams R, Sellers D, McDermott C, et al. Drivers of radioresistance in prostate cancer. J Clin Med. 2022;11:5637.","journal-title":"J Clin Med"},{"key":"2740_CR142","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1158\/1541-7786.MCR-21-0099","volume":"19","author":"KL Morel","year":"2021","unstructured":"Morel KL, Hamid AA, Clohessy JG, Pandell N, Ellis L, Sweeney CJ. NF-\u03baB blockade with oral administration of dimethylaminoparthenolide (DMAPT), delays prostate cancer resistance to androgen receptor (AR) inhibition and inhibits AR variants. Mol Cancer Res. 2021;19:1137\u201345.","journal-title":"Mol Cancer Res"},{"key":"2740_CR143","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3390\/plants11151905","volume":"11","author":"J Maiuolo","year":"2022","unstructured":"Maiuolo J, Musolino V, Guarnieri L, Macr\u00ec R, Coppoletta AR, Cardamone A, et al. Ferula communis L. (Apiaceae) root acetone-water extract: phytochemical analysis, cytotoxicity and in vitro evaluation of estrogenic properties. Plants. 2022;11:1905.","journal-title":"Plants"},{"key":"2740_CR144","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/horticulturae8070614","volume":"8","author":"P Thiviya","year":"2022","unstructured":"Thiviya P, Gunawardena N, Gamage A, Madhujith T, Merah O. Apiaceae family as a valuable source of biocidal components and their potential uses in agriculture. Horticulturae. 2022;8:614.","journal-title":"Horticulturae"},{"key":"2740_CR145","doi-asserted-by":"publisher","first-page":"e03962","DOI":"10.1016\/j.heliyon.2020.e03962","volume":"6","author":"MdMR Bhuiyan","year":"2020","unstructured":"Bhuiyan MdMR, Bhuiya NMMA, Hasan MdN, Nahar UJ. In vivo and in silico evaluation of antinociceptive activities of seed extract from the Holarrhena antidysenterica plant. Heliyon. 2020;6:e03962.","journal-title":"Heliyon."},{"key":"2740_CR146","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1055\/s-2001-18342","volume":"67","author":"V Hern\u00e1ndez","year":"2001","unstructured":"Hern\u00e1ndez V, del Carmen RM, M\u00e1\u00f1ez S, Prieto J, Giner R, R\u00edos J. A Mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from inula viscosa. Planta Med. 2001;67:726\u201331.","journal-title":"Planta Med"},{"key":"2740_CR147","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1080\/14786410701415681","volume":"21","author":"G Fontana","year":"2007","unstructured":"Fontana G, La Rocca S, Passannanti S, Pia PM. Sesquiterpene compounds from Inula viscosa. Nat Prod Res. 2007;21:824\u20137.","journal-title":"Nat Prod Res"},{"key":"2740_CR148","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.fitote.2007.03.005","volume":"78","author":"S M\u00e1\u00f1ez","year":"2007","unstructured":"M\u00e1\u00f1ez S, Hern\u00e1ndez V, Giner R-M, R\u00edos J-L, del Recio MC. Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa. Fitoterapia. 2007;78:329\u201331.","journal-title":"Fitoterapia"},{"key":"2740_CR149","doi-asserted-by":"publisher","first-page":"5808","DOI":"10.1038\/s41598-022-09763-z","volume":"12","author":"O Tarj\u00e1nyi","year":"2022","unstructured":"Tarj\u00e1nyi O, Haerer J, Vecserny\u00e9s M, Berta G, Stayer-Harci A, Balogh B, et al. Prolonged treatment with the proteasome inhibitor MG-132 induces apoptosis in PC12 rat pheochromocytoma cells. Sci Rep. 2022;12:5808.","journal-title":"Sci Rep"},{"key":"2740_CR150","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.jtcme.2024.03.001","volume":"14","author":"V Livraghi","year":"2024","unstructured":"Livraghi V, Mazza L, Chiappori F, Cardano M, Cazzalini O, Puglisi R, et al. A proteasome-dependent inhibition of SIRT-1 by the resveratrol analogue 4,4\u2032-dihydroxy-trans-stilbene. J Tradit Complement Med. 2024;14:534\u201343.","journal-title":"J Tradit Complement Med"},{"key":"2740_CR151","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.3390\/nano13243166","volume":"13","author":"C Schwarz","year":"2023","unstructured":"Schwarz C, G\u00f6ring J, Gr\u00fcttner C, Hilger I. Intravenous injection of PEI-decorated iron oxide nanoparticles impacts NF-kappaB protein expression in immunologically stressed mice. Nanomaterials. 2023;13:3166.","journal-title":"Nanomaterials"},{"key":"2740_CR152","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s13596-018-0307-0","volume":"18","author":"H Lounis","year":"2018","unstructured":"Lounis H, Bergheim I, Bouhaimi A, Guigonis J-M, Belhamel K. Anti-inflammatory and antioxidant activities of Inula viscosa and Senecio anteuphorbium. Orient Pharm Exp Med. 2018;18:225\u201336.","journal-title":"Orient Pharm Exp Med"},{"key":"2740_CR153","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1055\/s-2007-981567","volume":"73","author":"W Lommen","year":"2007","unstructured":"Lommen W, Elzinga S, Verstappen F, Bouwmeester H. Artemisinin and sesquiterpene precursors in dead and green leaves of Artemisia annua L. Crops Planta Med. 2007;73:1133\u20139.","journal-title":"Crops Planta Med"},{"key":"2740_CR154","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.tips.2008.07.004","volume":"29","author":"S Krishna","year":"2008","unstructured":"Krishna S, Bustamante L, Haynes RK, Staines HM. Artemisinins: their growing importance in medicine. Trends Pharmacol Sci. 2008;29:520\u20137.","journal-title":"Trends Pharmacol Sci"},{"key":"2740_CR155","doi-asserted-by":"publisher","first-page":"4986","DOI":"10.3390\/ijms21144986","volume":"21","author":"A Septembre-Malaterre","year":"2020","unstructured":"Septembre-Malaterre A, Lalarizo Rakoto M, Marodon C, Bedoui Y, Nakab J, Simon E, et al. Artemisia annua, a traditional plant brought to light. Int J Mol Sci. 2020;21:4986.","journal-title":"Int J Mol Sci"},{"key":"2740_CR156","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12964-023-01067-7","volume":"21","author":"M Barman","year":"2023","unstructured":"Barman M, Dandasena D, Suresh A, Bhandari V, Kamble S, Singh S, et al. Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata-transformed cells. Cell Commun Signal. 2023;21:78.","journal-title":"Cell Commun Signal"},{"key":"2740_CR157","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","volume":"27","author":"G-Q Chen","year":"2020","unstructured":"Chen G-Q, Benthani FA, Wu J, Liang D, Bian Z-X, Jiang X. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Cell Death Differ. 2020;27:242\u201354.","journal-title":"Cell Death Differ"},{"key":"2740_CR158","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.lfs.2004.08.020","volume":"76","author":"H Lai","year":"2005","unstructured":"Lai H, Sasaki T, Singh NP, Messay A. Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sci. 2005;76:1267\u201379.","journal-title":"Life Sci"},{"key":"2740_CR159","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.3390\/molecules15031705","volume":"15","author":"PM O\u2019Neill","year":"2010","unstructured":"O\u2019Neill PM, Barton VE, Ward SA. The molecular mechanism of action of artemisinin: the debate continues. Molecules. 2010;15:1705\u201321.","journal-title":"Molecules"},{"key":"2740_CR160","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.3390\/molecules15031378","volume":"15","author":"J Li","year":"2010","unstructured":"Li J, Zhou B. Biological actions of artemisinin: insights from medicinal chemistry studies. Molecules. 2010;15:1378\u201397.","journal-title":"Molecules"},{"key":"2740_CR161","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/nano10091816","volume":"10","author":"L Rueda-Gensini","year":"2020","unstructured":"Rueda-Gensini L, Cifuentes J, Castellanos MC, Puentes PR, Serna JA, Mu\u00f1oz-Camargo C, et al. Tailoring Iron oxide nanoparticles for efficient cellular internalization and endosomal escape. Nanomaterials. 2020;10:1816.","journal-title":"Nanomaterials"},{"key":"2740_CR162","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1039\/D0CS01127D","volume":"50","author":"M Sousa de Almeida","year":"2021","unstructured":"Sousa de Almeida M, Susnik E, Drasler B, Taladriz-Blanco P, Petri-Fink A, Rothen-Rutishauser B. Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine. Chem Soc Rev. 2021;50:5397\u2013434.","journal-title":"Chem Soc Rev"},{"key":"2740_CR163","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1073\/pnas.0914140107","volume":"107","author":"CHJ Choi","year":"2010","unstructured":"Choi CHJ, Alabi CA, Webster P, Davis ME. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci. 2010;107:1235\u201340.","journal-title":"Proc Natl Acad Sci"},{"key":"2740_CR164","doi-asserted-by":"publisher","first-page":"12095","DOI":"10.1073\/pnas.0406731102","volume":"102","author":"S Kasibhatla","year":"2005","unstructured":"Kasibhatla S, Jessen KA, Maliartchouk S, Wang JY, English NM, Drewe J, et al. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci. 2005;102:12095\u2013100.","journal-title":"Proc Natl Acad Sci"},{"key":"2740_CR165","doi-asserted-by":"publisher","first-page":"133","DOI":"10.12954\/PI.14054","volume":"2","author":"B Lojanapiwat","year":"2014","unstructured":"Lojanapiwat B, Anutrakulchai W, Chongruksut W, Udomphot C. Correlation and diagnostic performance of the prostate-specific antigen level with the diagnosis, aggressiveness, and bone metastasis of prostate cancer in clinical practice. Prostate Int. 2014;2:133\u20139.","journal-title":"Prostate Int"},{"key":"2740_CR166","first-page":"613","volume":"19","author":"F Ahmad","year":"2020","unstructured":"Ahmad F, Sarder A, Gour R, Karna SKL, Arora P, Kartha KPR, et al. Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway. Excli J. 2020;19:613\u20139.","journal-title":"Excli J"},{"key":"2740_CR167","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109955","volume":"125","author":"Q Li","year":"2020","unstructured":"Li Q, Wang Z, Xie Y, Hu H. Antitumor activity and mechanism of costunolide and dehydrocostus lactone: two natural sesquiterpene lactones from the Asteraceae family. Biomed Pharmacother. 2020;125: 109955.","journal-title":"Biomed Pharmacother"},{"key":"2740_CR168","doi-asserted-by":"publisher","first-page":"1","DOI":"10.20892\/j.issn.2095-3941.2022.0006","volume":"19","author":"M Huang","year":"2022","unstructured":"Huang M, Liu C, Shao Y, Zhou S, Hu G, Yin S, et al. Anti-tumor pharmacology of natural products targeting mitosis. Cancer Biol Med. 2022;19:1\u201328.","journal-title":"Cancer Biol Med"},{"key":"2740_CR169","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/medicines8100058","volume":"8","author":"AG Smith","year":"2021","unstructured":"Smith AG, Miles VN, Holmes DT, Chen X, Lei W. Clinical trials, Potential mechanisms, and adverse effects of arnica as an adjunct medication for pain management. Medicines. 2021;8:58.","journal-title":"Medicines"},{"key":"2740_CR170","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.3390\/nu13072158","volume":"13","author":"J Maiuolo","year":"2021","unstructured":"Maiuolo J, Bava I, Carresi C, Gliozzi M, Musolino V, Scarano F, et al. The effects of bergamot polyphenolic fraction, cynara cardunculus, and Olea europea L extract on doxorubicin-induced cardiotoxicity. Nutrients. 2021;13:2158.","journal-title":"Nutrients"},{"key":"2740_CR171","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/ijms22010004","volume":"22","author":"A Jaskulska","year":"2020","unstructured":"Jaskulska A, Janecka AE, Gach-Janczak K. Thapsigargin\u2014from traditional medicine to anticancer drug. Int J Mol Sci. 2020;22:4.","journal-title":"Int J Mol Sci"},{"key":"2740_CR172","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00992","author":"SH Akone","year":"2020","unstructured":"Akone SH, Ntie-Kang F, Stuhldreier F, Ewonkem MB, Noah AM, Mouelle SEM, et al. Natural products impacting DNA methyltransferases and histone deacetylases. Front Pharmacol. 2020. https:\/\/doi.org\/10.3389\/fphar.2020.00992.","journal-title":"Front Pharmacol"},{"key":"2740_CR173","doi-asserted-by":"publisher","first-page":"108124","DOI":"10.1016\/j.bioorg.2025.108124","volume":"155","author":"SS Patrushev","year":"2025","unstructured":"Patrushev SS, Kichkina DO, Moralev AD, Rybalova TV, Krasnov VI, Chernyak EI, et al. Synthesis and exploration of anticancer potential of spirocyclic 1,2,3-triazoline and aziridine derivatives of natural eudesmanolide isoalantolactone. Bioorg Chem. 2025;155:108124.","journal-title":"Bioorg Chem"},{"key":"2740_CR174","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1016\/j.bmcl.2006.05.083","volume":"16","author":"SK Srivastava","year":"2006","unstructured":"Srivastava SK, Abraham A, Bhat B, Jaggi M, Singh AT, Sanna VK, et al. Synthesis of 13-amino costunolide derivatives as anticancer agents. Bioorg Med Chem Lett. 2006;16:4195\u20139.","journal-title":"Bioorg Med Chem Lett"},{"key":"2740_CR175","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1515\/bchm.1997.378.9.951","volume":"378","author":"G Lyss","year":"1997","unstructured":"Lyss G, Schmidt TJ, Merfort I, Helenalin PHL. an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. Biol Chem. 1997;378:951\u201361.","journal-title":"Biol Chem"},{"key":"2740_CR176","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1248\/cpb.c23-00811","volume":"72","author":"K Araki","year":"2024","unstructured":"Araki K, Hara M, Hamada S, Matsumoto T, Nakamura S. Antiproliferative activities of cynaropicrin and related compounds against cancer stem cells. Chem Pharm Bull (Tokyo). 2024;72:200\u20138.","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"2740_CR177","doi-asserted-by":"publisher","first-page":"15410","DOI":"10.1021\/acs.jmedchem.0c01449","volume":"63","author":"Y Ren","year":"2020","unstructured":"Ren Y, Kinghorn AD. Development of potential antitumor agents from the scaffolds of plant-derived terpenoid lactones. J Med Chem. 2020;63:15410\u201348.","journal-title":"J Med Chem"},{"key":"2740_CR178","doi-asserted-by":"publisher","first-page":"111706","DOI":"10.1016\/j.ejmech.2019.111706","volume":"1832","author":"Y Ding","year":"2019","unstructured":"Ding Y, Li S, Ge W, Liu Z, Zhang X, Wang M, et al. Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma. Eur J Med Chem. 2019;1832:111706.","journal-title":"Eur J Med Chem"},{"key":"2740_CR179","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2174\/1874143601004010036","volume":"4","author":"G Abrham","year":"2010","unstructured":"Abrham G, Dovrat S, Bessler H, Grossman S, Nir U, Bergman M. Inhibition of inflammatory cytokine secretion by plant-derived compounds inuviscolide and tomentosin: the role of NF\u03baB and STAT1. Open Pharmacol J. 2010;4:36\u201344.","journal-title":"Open Pharmacol J"},{"key":"2740_CR180","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900240","author":"B Zhang","year":"2020","unstructured":"Zhang B. Artemisinin-derived dimers as potential anticancer agents: Current developments, action mechanisms, and structure-activity relationships. Arch Pharm. 2020. https:\/\/doi.org\/10.1002\/ardp.201900240.","journal-title":"Arch Pharm"},{"key":"2740_CR181","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21114149","volume":"21","author":"A Stupin","year":"2020","unstructured":"Stupin A, Mihalj M, Kolobari\u0107 N, \u0160u\u0161njara P, Kolar L, Mihaljevi\u0107 Z, et al. Anti-inflammatory potential of n-3 polyunsaturated fatty acids enriched hen eggs consumption in improving microvascular endothelial function of healthy individuals-clinical trial. Int J Mol Sci. 2020;21:1\u201320.","journal-title":"Int J Mol Sci"},{"key":"2740_CR182","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.drudis.2010.06.002","volume":"15","author":"A Ghantous","year":"2010","unstructured":"Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N. What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today. 2010;15:668\u201378.","journal-title":"Drug Discov Today"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02740-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-025-02740-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02740-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T15:02:27Z","timestamp":1748703747000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-025-02740-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":182,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2740"],"URL":"https:\/\/doi.org\/10.1007\/s12032-025-02740-2","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"19 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest related to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"212"}}