{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:18:56Z","timestamp":1757621936723,"version":"3.44.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"AstraZeneca Externally Sponsored Research Project","award":["ESR-23-22118"],"award-info":[{"award-number":["ESR-23-22118"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-025-02933-9","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T21:53:01Z","timestamp":1754344381000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardio-oncology in focus: novel molecular signatures of lung adenocarcinoma-driven cardiac cachexia"],"prefix":"10.1007","volume":"42","author":[{"given":"Zhenyang","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongrong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haomin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haolin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"2933_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1161\/CIRCULATIONAHA.124.065473","volume":"150","author":"JJ Moslehi","year":"2024","unstructured":"Moslehi JJ. Cardio-oncology: a new clinical frontier and novel platform for cardiovascular investigation. Circulation. 2024;150:513\u20135. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.065473.","journal-title":"Circulation"},{"key":"2933_CR2","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1002\/ejhf.3340","volume":"26","author":"CG Tocchetti","year":"2024","unstructured":"Tocchetti CG, et al. Cardiovascular toxicities of immune therapies for cancer\u2014a scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology. Eur J Heart Fail. 2024;26:2055\u201376. https:\/\/doi.org\/10.1002\/ejhf.3340.","journal-title":"Eur J Heart Fail"},{"key":"2933_CR3","doi-asserted-by":"publisher","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"VE Baracos","year":"2018","unstructured":"Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH. Cancer-associated cachexia. Nat Rev Dis Primers. 2018;4:17105. https:\/\/doi.org\/10.1038\/nrdp.2017.105.","journal-title":"Nat Rev Dis Primers"},{"key":"2933_CR4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41571-023-00734-5","volume":"20","author":"JM Argil\u00e9s","year":"2023","unstructured":"Argil\u00e9s JM, L\u00f3pez-Soriano FJ, Stemmler B, Busquets S. Cancer-associated cachexia\u2014understanding the tumour macroenvironment and microenvironment to improve management. Nat Rev Clin Oncol. 2023;20:250\u201364. https:\/\/doi.org\/10.1038\/s41571-023-00734-5.","journal-title":"Nat Rev Clin Oncol"},{"key":"2933_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123170","volume":"358","author":"FA Bhat","year":"2024","unstructured":"Bhat FA, et al. Cardio-oncological dialogue: understanding the mechanistic correlation between heart failure and cancer. Life Sci. 2024;358: 123170. https:\/\/doi.org\/10.1016\/j.lfs.2024.123170.","journal-title":"Life Sci"},{"key":"2933_CR6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11912-023-01387-4","volume":"25","author":"N Yegya-Raman","year":"2023","unstructured":"Yegya-Raman N, Berlin E, Feigenberg SJ, Ky B, Sun L. Cardiovascular toxicity and risk mitigation with lung cancer treatment. Curr Oncol Rep. 2023;25:433\u201344. https:\/\/doi.org\/10.1007\/s11912-023-01387-4.","journal-title":"Curr Oncol Rep"},{"key":"2933_CR7","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3892\/or.2018.6453","volume":"40","author":"T Chen","year":"2018","unstructured":"Chen T, et al. Luteolin reduces cancer-induced skeletal and cardiac muscle atrophy in a Lewis lung cancer mouse model. Oncol Rep. 2018;40:1129\u201337. https:\/\/doi.org\/10.3892\/or.2018.6453.","journal-title":"Oncol Rep"},{"key":"2933_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115117","volume":"165","author":"Q Wu","year":"2023","unstructured":"Wu Q, et al. A novel onco-cardiological mouse model of lung cancer-induced cardiac dysfunction and its application in identifying potential roles of tRNA-derived small RNAs. Biomed Pharmacother. 2023;165: 115117. https:\/\/doi.org\/10.1016\/j.biopha.2023.115117.","journal-title":"Biomed Pharmacother"},{"key":"2933_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226440","volume":"14","author":"TE Berent","year":"2019","unstructured":"Berent TE, et al. Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice. PLoS ONE. 2019;14: e0226440. https:\/\/doi.org\/10.1371\/journal.pone.0226440.","journal-title":"PLoS ONE"},{"key":"2933_CR10","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:220. https:\/\/doi.org\/10.1186\/s13059-017-1349-1.","journal-title":"Genome Biol"},{"key":"2933_CR11","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","volume":"20","author":"AS Castanza","year":"2023","unstructured":"Castanza AS, et al. Extending support for mouse data in the molecular signatures database (MSigDB). Nat Methods. 2023;20:1619\u201320. https:\/\/doi.org\/10.1038\/s41592-023-02014-7.","journal-title":"Nat Methods"},{"key":"2933_CR12","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci. 2005;102:15545\u201350. https:\/\/doi.org\/10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci"},{"key":"2933_CR13","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:D638\u201346. https:\/\/doi.org\/10.1093\/nar\/gkac1000.","journal-title":"Nucleic Acids Res"},{"key":"2933_CR14","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504.","journal-title":"Genome Res"},{"key":"2933_CR15","doi-asserted-by":"publisher","first-page":"W199","DOI":"10.1093\/nar\/gkz401","volume":"47","author":"Y Liao","year":"2019","unstructured":"Liao Y, Wang J, Jaehnig EJ, Shi Z, Zhang B. WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs. Nucleic Acids Res. 2019;47:W199\u2013205. https:\/\/doi.org\/10.1093\/nar\/gkz401.","journal-title":"Nucleic Acids Res"},{"key":"2933_CR16","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559. https:\/\/doi.org\/10.1186\/1471-2105-9-559.","journal-title":"BMC Bioinformatics"},{"key":"2933_CR17","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","volume":"26","author":"G Yu","year":"2010","unstructured":"Yu G, et al. GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics. 2010;26:976\u20138. https:\/\/doi.org\/10.1093\/bioinformatics\/btq064.","journal-title":"Bioinformatics"},{"key":"2933_CR18","doi-asserted-by":"publisher","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","volume":"50","author":"JA Castro-Mondragon","year":"2022","unstructured":"Castro-Mondragon JA, et al. JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2022;50:D165\u201373. https:\/\/doi.org\/10.1093\/nar\/gkab1113.","journal-title":"Nucleic Acids Res"},{"key":"2933_CR19","doi-asserted-by":"publisher","first-page":"W234","DOI":"10.1093\/nar\/gkz240","volume":"47","author":"G Zhou","year":"2019","unstructured":"Zhou G, et al. NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis. Nucleic Acids Res. 2019;47:W234\u201341. https:\/\/doi.org\/10.1093\/nar\/gkz240.","journal-title":"Nucleic Acids Res"},{"key":"2933_CR20","doi-asserted-by":"publisher","first-page":"D127","DOI":"10.1093\/nar\/gkz757","volume":"48","author":"Y Chen","year":"2020","unstructured":"Chen Y, Wang X. miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res. 2020;48:D127\u201331. https:\/\/doi.org\/10.1093\/nar\/gkz757.","journal-title":"Nucleic Acids Res"},{"key":"2933_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13059-019-1629-z","volume":"20","author":"W Liu","year":"2019","unstructured":"Liu W, Wang X. Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data. Genome Biol. 2019;20:18. https:\/\/doi.org\/10.1186\/s13059-019-1629-z.","journal-title":"Genome Biol"},{"key":"2933_CR22","doi-asserted-by":"publisher","first-page":"W169","DOI":"10.1093\/nar\/gkt393","volume":"41","author":"MD Paraskevopoulou","year":"2013","unstructured":"Paraskevopoulou MD, et al. DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows. Nucleic Acids Res. 2013;41:W169\u201373. https:\/\/doi.org\/10.1093\/nar\/gkt393.","journal-title":"Nucleic Acids Res"},{"key":"2933_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206239","volume":"13","author":"C Sticht","year":"2018","unstructured":"Sticht C, De La Torre C, Parveen A, Gretz N. miRWalk: an online resource for prediction of microRNA binding sites. PLoS ONE. 2018;13: e0206239. https:\/\/doi.org\/10.1371\/journal.pone.0206239.","journal-title":"PLoS ONE"},{"key":"2933_CR24","doi-asserted-by":"publisher","first-page":"6998","DOI":"10.1038\/s41598-017-07236-2","volume":"7","author":"LN Moraes","year":"2017","unstructured":"Moraes LN, et al. Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia. Sci Rep. 2017;7:6998. https:\/\/doi.org\/10.1038\/s41598-017-07236-2.","journal-title":"Sci Rep"},{"key":"2933_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s10555-020-09869-8","volume":"39","author":"S Ausoni","year":"2020","unstructured":"Ausoni S, Calamelli S, Sacc\u00e0 S, Azzarello G. How progressive cancer endangers the heart: an intriguing and underestimated problem. Cancer Metastasis Rev. 2020;39:535\u201352. https:\/\/doi.org\/10.1007\/s10555-020-09869-8.","journal-title":"Cancer Metastasis Rev"},{"key":"2933_CR26","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.3892\/or.2017.5542","volume":"37","author":"Y Belloum","year":"2017","unstructured":"Belloum Y, Rannou-Bekono F, Favier FB. Cancer-induced cardiac cachexia: pathogenesis and impact of physical activity (Review). Oncol Rep. 2017;37:2543\u201352. https:\/\/doi.org\/10.3892\/or.2017.5542.","journal-title":"Oncol Rep"},{"key":"2933_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/cells11060990","author":"S Saha","year":"2022","unstructured":"Saha S, Singh PK, Roy P, Kakar SS. Cardiac cachexia: unaddressed aspect in cancer patients. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11060990.","journal-title":"Cells"},{"key":"2933_CR28","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12944-023-01967-0","volume":"22","author":"Y Qu","year":"2023","unstructured":"Qu Y, et al. A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic changes. Lipids Health Dis. 2023;22:211. https:\/\/doi.org\/10.1186\/s12944-023-01967-0.","journal-title":"Lipids Health Dis"},{"key":"2933_CR29","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s10741-019-09784-3","volume":"24","author":"M Rolfe","year":"2019","unstructured":"Rolfe M, Kamel A, Ahmed MM, Kramer J. Pharmacological management of cardiac cachexia: a review of potential therapy options. Heart Fail Rev. 2019;24:617\u201323. https:\/\/doi.org\/10.1007\/s10741-019-09784-3.","journal-title":"Heart Fail Rev"},{"key":"2933_CR30","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/toxsci\/kfu038","volume":"139","author":"R Luisier","year":"2014","unstructured":"Luisier R, et al. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. Toxicol Sci. 2014;139:501\u201311. https:\/\/doi.org\/10.1093\/toxsci\/kfu038.","journal-title":"Toxicol Sci"},{"key":"2933_CR31","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1111\/febs.14466","volume":"285","author":"CE Hughes","year":"2018","unstructured":"Hughes CE, Nibbs RJB. A guide to chemokines and their receptors. FEBS J. 2018;285:2944\u201371. https:\/\/doi.org\/10.1111\/febs.14466.","journal-title":"FEBS J"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02933-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-025-02933-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-02933-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:26:23Z","timestamp":1757348783000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-025-02933-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["2933"],"URL":"https:\/\/doi.org\/10.1007\/s12032-025-02933-9","relation":{},"ISSN":["1559-131X"],"issn-type":[{"type":"electronic","value":"1559-131X"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"25 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"406"}}