{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:21:21Z","timestamp":1787959281554,"version":"build-2784847793"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-025-03112-6","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:39:57Z","timestamp":1771947597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dysregulated immune microenvironment in metastatic colorectal cancer"],"prefix":"10.1007","volume":"43","author":[{"given":"Shuaixing","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"3112_CR1","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","volume":"394","author":"E Dekker","year":"2019","unstructured":"Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. Lancet. 2019;394:1467\u201380.","journal-title":"Lancet"},{"issue":"1","key":"3112_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm9010012","volume":"9","author":"S Boussios","year":"2019","unstructured":"Boussios S, Ozturk MA, Moschetta M, Karathanasi A, Zakynthinakis-Kyriakou N, Katsanos KH, et al. The developing story of predictive biomarkers in colorectal cancer. J Pers Med. 2019;9(1):12. https:\/\/doi.org\/10.3390\/jpm9010012.","journal-title":"J Pers Med"},{"issue":"9","key":"3112_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12091534","volume":"12","author":"M Osseis","year":"2022","unstructured":"Osseis M, Nehmeh WA, Rassy N, Derienne J, Noun R, Salloum C, et al. Surgery for T4 colorectal cancer in older patients: determinants of outcomes. J Pers Med. 2022;12(9):1534. https:\/\/doi.org\/10.3390\/jpm12091534.","journal-title":"J Pers Med"},{"key":"3112_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrclinonc.2016.171","volume":"14","author":"CJ Punt","year":"2017","unstructured":"Punt CJ, Koopman M, Vermeulen L. From tumour heterogeneity to advances in precision treatment of colorectal cancer. Nat Rev Clin Oncol. 2017;14:235\u201346.","journal-title":"Nat Rev Clin Oncol"},{"key":"3112_CR5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.25141.1","volume":"9","author":"JA Eddy","year":"2020","unstructured":"Eddy JA, Thorsson V, Lamb AE, Gibbs DL, Heimann C, Yu JX, et al. CRI iAtlas: an interactive portal for immuno-oncology research. F1000Res. 2020;9:1028.","journal-title":"F1000Res"},{"key":"3112_CR6","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","volume":"35","author":"Ru Beibei","year":"2019","unstructured":"Beibei Ru, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wai Chung Wu, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35:4200.","journal-title":"Bioinformatics"},{"key":"3112_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.644637","volume":"12","author":"J Xia","year":"2021","unstructured":"Xia J, Bai P, Fan W, Li Q, Li Y, Wang D, et al. NEPdb: a database of T-cell experimentally-validated neoantigens and pan-cancer predicted neoepitopes for cancer immunotherapy. Front Immunol. 2021;12:644637.","journal-title":"Front Immunol"},{"issue":"1","key":"3112_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139\u201340.","journal-title":"Bioinformatics"},{"issue":"18","key":"3112_CR9","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","volume":"32","author":"Z Gu","year":"2016","unstructured":"Gu Z, Eils R, Schlesner M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016;32(18):2847\u20139.","journal-title":"Bioinformatics"},{"key":"3112_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr988","volume":"40","author":"M Kanehisa","year":"2012","unstructured":"Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012;40:D109.","journal-title":"Nucleic Acids Res"},{"key":"3112_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"H Wickham","year":"2016","unstructured":"Wickham H. ggplot2: Elegant Graphics for Data Analysis. New York: Springer-Verlag; 2016."},{"issue":"Web Server issu","key":"3112_CR12","doi-asserted-by":"publisher","first-page":"W741","DOI":"10.1093\/nar\/gki475","volume":"33","author":"B Zhang","year":"2005","unstructured":"Zhang B, Kirov S, Snoddy J. WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 2005;33(Web Server issue):W741-8.","journal-title":"Nucleic Acids Res"},{"key":"3112_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35096-6","volume":"13","author":"Q Sui","year":"2022","unstructured":"Sui Q, Zhang X, Chen C, et al. Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer. Nat Commun. 2022;13:7316.","journal-title":"Nat Commun"},{"key":"3112_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60255-4","volume":"10","author":"GE Idos","year":"2020","unstructured":"Idos GE, Kwok J, Bonthala N, et al. The prognostic implications of tumor infiltrating lymphocytes in colorectal cancer: a systematic review and meta-analysis. Sci Rep. 2020;10:3360.","journal-title":"Sci Rep"},{"issue":"2","key":"3112_CR15","doi-asserted-by":"publisher","DOI":"10.4161\/2162402X.2014.984547","volume":"4","author":"S Punt","year":"2015","unstructured":"Punt S, Langenhoff JM, Putter H, Fleuren GJ, Gorter A, Jordanova ES. The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review. Oncoimmunology. 2015;4(2):e984547.","journal-title":"Oncoimmunology"},{"issue":"4","key":"3112_CR16","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.immuni.2018.03.023","volume":"48","author":"V Thorsson","year":"2018","unstructured":"Thorsson V, Gibbs DL, Brown SD, et al. The Immune Landscape of Cancer [published correction appears in Immunity. 2019 Aug 20;51(2):411-412]. Immunity. 2018;48(4):812-830.e14.","journal-title":"Immunity"},{"issue":"4","key":"3112_CR17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2217\/pme-2021-0128","volume":"19","author":"S Adeleke","year":"2022","unstructured":"Adeleke S, Haslam A, Choy A, Diaz-Cano S, Galante JR, Mikropoulos C, et al. Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls. Per Med. 2022;19(4):277\u201386. https:\/\/doi.org\/10.2217\/pme-2021-0128.","journal-title":"Per Med"},{"issue":"11","key":"3112_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113487","volume":"12","author":"SC Chang","year":"2020","unstructured":"Chang SC, Li AF, Lin PC, et al. Clinicopathological and molecular profiles of sporadic microsatellite unstable colorectal cancer with or without the CpG island methylator phenotype (CIMP). Cancers (Basel). 2020;12(11):3487.","journal-title":"Cancers (Basel)"},{"issue":"24","key":"3112_CR19","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1200\/JCO.2011.38.2994","volume":"30","author":"E Vakiani","year":"2012","unstructured":"Vakiani E, Janakiraman M, Shen R, Sinha R, Zeng Z, Shia J, et al. Comparative genomic analysis of primary versus metastatic colorectal carcinomas. J Clin Oncol. 2012;30(24):2956\u201362.","journal-title":"J Clin Oncol"},{"key":"3112_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111998","volume":"132","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Liu Z, Deng K, Qu H, Zhang Q, Zhou P, et al. Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy. Int Immunopharmacol. 2024;132:111998.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"3112_CR21","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.ccell.2018.03.010","volume":"33","author":"Y Liu","year":"2018","unstructured":"Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, et al. Comparative molecular analysis of gastrointestinal adenocarcinomas. Cancer Cell. 2018;33(4):721-735.e8.","journal-title":"Cancer Cell"},{"issue":"5908","key":"3112_CR22","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1126\/science.1159894","volume":"322","author":"G Faure-Andr\u00e9","year":"2008","unstructured":"Faure-Andr\u00e9 G, Vargas P, Yuseff MI, Heuz\u00e9 M, Diaz J, Lankar D, et al. Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain. Science. 2008;322(5908):1705\u201310.","journal-title":"Science"},{"issue":"1","key":"3112_CR23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nm1699","volume":"14","author":"RJ Buckanovich","year":"2008","unstructured":"Buckanovich RJ, Facciabene A, Kim S, et al. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat Med. 2008;14(1):28\u201336. https:\/\/doi.org\/10.1038\/nm1699.","journal-title":"Nat Med"},{"issue":"8","key":"3112_CR24","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/intimm\/dxs051","volume":"24","author":"CA Wild","year":"2012","unstructured":"Wild CA, Bergmann C, Fritz G, Schuler P, Hoffmann TK, Lotfi R, et al. HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells. Int Immunol. 2012;24(8):485\u201394. https:\/\/doi.org\/10.1093\/intimm\/dxs051.","journal-title":"Int Immunol"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-03112-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-025-03112-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-03112-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:06:56Z","timestamp":1776344816000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-025-03112-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["3112"],"URL":"https:\/\/doi.org\/10.1007\/s12032-025-03112-6","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"9 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Agree.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"158"}}