{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:54:05Z","timestamp":1778273645371,"version":"3.51.4"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["R501-LR-RND003-0000001471-0000"],"award-info":[{"award-number":["R501-LR-RND003-0000001471-0000"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-025-03182-6","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:51:43Z","timestamp":1766739103000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenomic landscape of nasopharyngeal carcinoma"],"prefix":"10.1007","volume":"43","author":[{"given":"Saleh Suleiman","family":"Silmi Almohammadin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-8809","authenticated-orcid":false,"given":"Rabiatul Basria","family":"S. M. N. Mydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosle","family":"Bahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denisha","family":"Sivasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-6737","authenticated-orcid":false,"given":"Muhamad Yusri","family":"Musa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"issue":"1","key":"3182_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/epigenomes9010005","volume":"9","author":"AA Baumann","year":"2025","unstructured":"Baumann AA, Buribayev Z, Wolkenhauer O, Salybekov AA, Wolfien M. Epigenomic echoes\u2014decoding genomic and epigenetic instability to distinguish lung cancer types and predict relapse. Epigenomes. 2025;9(1):5. https:\/\/doi.org\/10.3390\/epigenomes9010005.","journal-title":"Epigenomes"},{"issue":"1","key":"3182_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01803-z","volume":"10","author":"X Yu","year":"2024","unstructured":"Yu X, et al. Cancer epigenetics: from laboratory studies and clinical trials to precision medicine. Cell Death Discov. 2024;10(1):28. https:\/\/doi.org\/10.1038\/s41420-024-01803-z.","journal-title":"Cell Death Discov"},{"issue":"10","key":"3182_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105801","volume":"23","author":"IV Bure","year":"2022","unstructured":"Bure IV, Nemtsova MV, Kuznetsova EB. Histone modifications and non-coding RNAs: mutual epigenetic regulation and role in pathogenesis. Int J Mol Sci. 2022;23(10):5801. https:\/\/doi.org\/10.3390\/ijms23105801.","journal-title":"Int J Mol Sci"},{"key":"3182_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.495","author":"M Gu","year":"2024","unstructured":"Gu M, et al. Epigenetic regulation in cancer. MedComm. 2024. https:\/\/doi.org\/10.1002\/mco2.495.","journal-title":"MedComm"},{"issue":"1","key":"3182_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/bfgp\/elx018","volume":"17","author":"LT Kagohara","year":"2018","unstructured":"Kagohara LT, et al. Epigenetic regulation of gene expression in cancer: techniques, resources and analysis. Brief Funct Genomics. 2018;17(1):49\u201363. https:\/\/doi.org\/10.1093\/bfgp\/elx018.","journal-title":"Brief Funct Genomics"},{"issue":"1","key":"3182_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-025-01003-7","volume":"9","author":"HE Marei","year":"2025","unstructured":"Marei HE. Epigenetic regulators in cancer therapy and progression. NPJ Precis Oncol. 2025;9(1):206. https:\/\/doi.org\/10.1038\/s41698-025-01003-7.","journal-title":"NPJ Precis Oncol"},{"issue":"2","key":"3182_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.32607\/actanaturae.11043","volume":"13","author":"IS Kiselev","year":"2021","unstructured":"Kiselev IS, Kulakova OG, Boyko AN, Favorova OO. DNA methylation as an epigenetic mechanism in the development of multiple sclerosis. Acta Naturae. 2021;13(2):45\u201357. https:\/\/doi.org\/10.32607\/actanaturae.11043.","journal-title":"Acta Naturae"},{"issue":"3","key":"3182_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030764","volume":"12","author":"W Zhang","year":"2020","unstructured":"Zhang W, et al. Global DNA hypomethylation in epithelial ovarian cancer: passive demethylation and association with genomic instability. Cancers (Basel). 2020;12(3):764. https:\/\/doi.org\/10.3390\/cancers12030764.","journal-title":"Cancers (Basel)"},{"issue":"4","key":"3182_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10040101","volume":"10","author":"M Thomas","year":"2018","unstructured":"Thomas M, Marcato P. Epigenetic modifications as biomarkers of tumor development, therapy response, and recurrence across the cancer care continuum. Cancers (Basel). 2018;10(4):101. https:\/\/doi.org\/10.3390\/cancers10040101.","journal-title":"Cancers (Basel)"},{"key":"3182_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01150","author":"WJ Locke","year":"2019","unstructured":"Locke WJ, et al. DNA methylation cancer biomarkers: translation to the clinic. Front Genet. 2019. https:\/\/doi.org\/10.3389\/fgene.2019.01150.","journal-title":"Front Genet"},{"key":"3182_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101312","volume":"16","author":"G Shanmugam","year":"2022","unstructured":"Shanmugam G, Rakshit S, Sarkar K. HDAC inhibitors: targets for tumor therapy, immune modulation and lung diseases. Transl Oncol. 2022;16:101312. https:\/\/doi.org\/10.1016\/j.tranon.2021.101312.","journal-title":"Transl Oncol"},{"key":"3182_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1072651","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, et al. Recent progress in DNA methyltransferase inhibitors as anticancer agents. Front Pharmacol. 2022. https:\/\/doi.org\/10.3389\/fphar.2022.1072651.","journal-title":"Front Pharmacol"},{"issue":"1","key":"3182_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-025-10253-7","volume":"44","author":"A Suraweera","year":"2025","unstructured":"Suraweera A, O\u2019Byrne KJ, Richard DJ. Epigenetic drugs in cancer therapy. Cancer Metastasis Rev. 2025;44(1):37. https:\/\/doi.org\/10.1007\/s10555-025-10253-7.","journal-title":"Cancer Metastasis Rev"},{"issue":"3","key":"3182_CR14","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.3892\/ol.2016.4877","volume":"12","author":"P Brockmeyer","year":"2016","unstructured":"Brockmeyer P, Hemmerlein B. Epigenetic modification suppresses proliferation, migration and invasion of urothelial cancer cell lines. Oncol Lett. 2016;12(3):1693\u2013700. https:\/\/doi.org\/10.3892\/ol.2016.4877.","journal-title":"Oncol Lett"},{"issue":"1","key":"3182_CR15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.31557\/apjcb.2023.8.1.75-89","volume":"8","author":"A Pathak","year":"2023","unstructured":"Pathak A, Tomar S, Pathak S. Epigenetics and cancer: a comprehensive review. Asian Pac J Cancer Biol. 2023;8(1):75\u201389. https:\/\/doi.org\/10.31557\/apjcb.2023.8.1.75-89.","journal-title":"Asian Pac J Cancer Biol"},{"issue":"10","key":"3182_CR16","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1158\/2159-8290.CD-24-0296","volume":"14","author":"M Esteller","year":"2024","unstructured":"Esteller M, Dawson MA, Kadoch C, Rassool FV, Jones PA, Baylin SB. The epigenetic hallmarks of cancer. Cancer Discov. 2024;14(10):1783\u2013809. https:\/\/doi.org\/10.1158\/2159-8290.CD-24-0296.","journal-title":"Cancer Discov"},{"issue":"7","key":"3182_CR17","first-page":"1954","volume":"10","author":"N Darwiche","year":"2020","unstructured":"Darwiche N. Epigenetic mechanisms and the hallmarks of cancer: an intimate affair. Am J Cancer Res. 2020;10(7):1954\u201378.","journal-title":"Am J Cancer Res"},{"issue":"11","key":"3182_CR18","doi-asserted-by":"publisher","first-page":"556","DOI":"10.5732\/cjc.014.10170","volume":"33","author":"ML Lung","year":"2014","unstructured":"Lung ML, Cheung AKL, Ko JMY, Lung HL, Cheng Y, Dai W. The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma. Chin J Cancer. 2014;33(11):556\u201368. https:\/\/doi.org\/10.5732\/cjc.014.10170.","journal-title":"Chin J Cancer"},{"key":"3182_CR19","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5878","author":"L Wu","year":"2018","unstructured":"Wu L, Li C, Pan L. Nasopharyngeal carcinoma: a review of current updates. Exp Ther Med. 2018. https:\/\/doi.org\/10.3892\/etm.2018.5878.","journal-title":"Exp Ther Med"},{"key":"3182_CR20","doi-asserted-by":"publisher","unstructured":"Kondo S, et al. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2023;1869(2):166598. https:\/\/doi.org\/10.1016\/j.bbadis.2022.166598.","DOI":"10.1016\/j.bbadis.2022.166598"},{"key":"3182_CR21","unstructured":"Mustofa A, Saputra P, Yunus M. The Role of Food containing Nitrosamine in the Development of Nasopharyngeal Carcinoma: A Literature Review. Iran J Blood Cancer, 2025. [Online]. Available: https:\/\/ijbc.ir"},{"issue":"9","key":"3182_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204568","volume":"13","author":"H-C Fan","year":"2018","unstructured":"Fan H-C, et al. Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. PLoS One. 2018;13(9):e0204568. https:\/\/doi.org\/10.1371\/journal.pone.0204568.","journal-title":"PLoS One"},{"issue":"10","key":"3182_CR23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016582","volume":"7","author":"M Long","year":"2017","unstructured":"Long M, Fu Z, Li P, Nie Z. Cigarette smoking and the risk of nasopharyngeal carcinoma: a meta-analysis of epidemiological studies. BMJ Open. 2017;7(10):e016582. https:\/\/doi.org\/10.1136\/bmjopen-2017-016582.","journal-title":"BMJ Open"},{"issue":"1","key":"3182_CR24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000533193","volume":"16","author":"JCNL da Mota","year":"2023","unstructured":"da Mota JCNL, et al. Impact of methyl-donor micronutrient supplementation on DNA methylation patterns: a systematic review and meta-analysis of in vitro, animal, and human studies. Lifestyle Genomics. 2023;16(1):192\u2013213. https:\/\/doi.org\/10.1159\/000533193.","journal-title":"Lifestyle Genomics"},{"issue":"1","key":"3182_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54070-9","volume":"9","author":"A Mahajan","year":"2019","unstructured":"Mahajan A, Sapehia D, Thakur S, Mohanraj PS, Bagga R, Kaur J. Effect of imbalance in folate and vitamin B12 in maternal\/parental diet on global methylation and regulatory miRNAs. Sci Rep. 2019;9(1):17602. https:\/\/doi.org\/10.1038\/s41598-019-54070-9.","journal-title":"Sci Rep"},{"issue":"1","key":"3182_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1017\/S0007114519002526","volume":"123","author":"J Steluti","year":"2020","unstructured":"Steluti J, Palchetti CZ, Miranda AM, Fisberg RM, Marchioni DM. DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid. Br J Nutr. 2020;123(1):23\u20139. https:\/\/doi.org\/10.1017\/S0007114519002526.","journal-title":"Br J Nutr"},{"key":"3182_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1593394","author":"X Zhang","year":"2025","unstructured":"Zhang X, Assaraf YG, Lin Y. Death-associated protein kinase 1: a double-edged sword in health and disease. Front Immunol. 2025. https:\/\/doi.org\/10.3389\/fimmu.2025.1593394.","journal-title":"Front Immunol"},{"issue":"1","key":"3182_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s43018-024-00876-0","volume":"6","author":"P Ganguli","year":"2025","unstructured":"Ganguli P, et al. Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer. Nat Cancer. 2025;6(1):158\u201374. https:\/\/doi.org\/10.1038\/s43018-024-00876-0.","journal-title":"Nat Cancer"},{"key":"3182_CR29","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2025.1002335","author":"S Singh","year":"2025","unstructured":"Singh S, Nema R, Banerjee M, Kushwah AS. Genetic and epigenetic landscape of O6-methylguanine-DNA methyltransferase (MGMT): implications for DNA repair and cancer therapeutics. Explor Target Antitumor Ther. 2025. https:\/\/doi.org\/10.37349\/etat.2025.1002335.","journal-title":"Explor Target Antitumor Ther"},{"key":"3182_CR30","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.89290","author":"G Mitchell","year":"2025","unstructured":"Mitchell G, Mitchell MG, Akinbo P. The role of the CDH1 gene in the pathogenesis and progression of lobular breast cancer. Cureus. 2025. https:\/\/doi.org\/10.7759\/cureus.89290.","journal-title":"Cureus"},{"issue":"6","key":"3182_CR31","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.31557\/APJCP.2025.26.6.2239","volume":"26","author":"H Thieu","year":"2025","unstructured":"Thieu H, Le T, Lao T. Methylation of tumor suppressor genes on chromosome 9: diagnostic insights from a nasopharyngeal carcinoma in Vietnam. Asian Pac J Cancer Prev. 2025;26(6):2239\u201345. https:\/\/doi.org\/10.31557\/APJCP.2025.26.6.2239.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"3182_CR32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1177\/03936155241268431","volume":"39","author":"TD Lao","year":"2024","unstructured":"Lao TD, Le TAH. Hypermethylation of genes on chromosome 3p as a biomarker for nasopharyngeal carcinoma diagnosis: a Vietnamese case-control study. Int J Biol Markers. 2024;39(3):201\u20138. https:\/\/doi.org\/10.1177\/03936155241268431.","journal-title":"Int J Biol Markers"},{"issue":"1","key":"3182_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-01242-3","volume":"15","author":"W Jiang","year":"2024","unstructured":"Jiang W, Zheng B, Wei H. Recent advances in early detection of nasopharyngeal carcinoma. Discover Oncol. 2024;15(1):365. https:\/\/doi.org\/10.1007\/s12672-024-01242-3.","journal-title":"Discover Oncol"},{"issue":"2","key":"3182_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.21037\/cco.2016.03.06","volume":"5","author":"W Dai","year":"2016","unstructured":"Dai W, Zheng H, Cheung AKL, Lung ML. Genetic and epigenetic landscape of nasopharyngeal carcinoma. Chin Clin Oncol. 2016;5(2):16\u201316. https:\/\/doi.org\/10.21037\/cco.2016.03.06.","journal-title":"Chin Clin Oncol"},{"issue":"31","key":"3182_CR35","doi-asserted-by":"publisher","first-page":"31493","DOI":"10.18632\/oncotarget.5154","volume":"6","author":"I Nawaz","year":"2015","unstructured":"Nawaz I, et al. Integrin \u03b19 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma. Oncotarget. 2015;6(31):31493\u2013507. https:\/\/doi.org\/10.18632\/oncotarget.5154.","journal-title":"Oncotarget"},{"key":"3182_CR36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209852119","author":"Q Zhou","year":"2022","unstructured":"Zhou Q, et al. Epigenetic analysis of cell-free DNA by fragmentomic profiling. Proc Natl Acad Sci USA. 2022. https:\/\/doi.org\/10.1073\/pnas.2209852119.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3182_CR37","doi-asserted-by":"crossref","unstructured":"Paro R, Grossniklaus U, Santoro R, Wutz A. Learning Materials in Biosciences Introduction to Epigenetics, 2021.","DOI":"10.1007\/978-3-030-68670-3"},{"issue":"12","key":"3182_CR38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/cac2.12104","volume":"40","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, et al. ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3. Cancer Commun. 2020;40(12):721\u201337. https:\/\/doi.org\/10.1002\/cac2.12104.","journal-title":"Cancer Commun"},{"issue":"1","key":"3182_CR39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1177\/17246008211065472","volume":"37","author":"TD Lao","year":"2022","unstructured":"Lao TD, Thieu HH, Nguyen DH, Le TAH. Hypermethylation of the RASSF1A gene promoter as the tumor DNA marker for nasopharyngeal carcinoma. Int J Biol Markers. 2022;37(1):31\u20139. https:\/\/doi.org\/10.1177\/17246008211065472.","journal-title":"Int J Biol Markers"},{"key":"3182_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1229862","author":"S Bi","year":"2023","unstructured":"Bi S, Tu Z, Chen D, Zhang S. Histone modifications in embryo implantation and placentation: insights from mouse models. Front Endocrinol (Lausanne). 2023. https:\/\/doi.org\/10.3389\/fendo.2023.1229862.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3182_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2022.03.010","author":"AL Mattei","year":"2022","unstructured":"Mattei AL, Bailly N, Meissner A. DNA methylation: a historical perspective. Trends Genet. 2022. https:\/\/doi.org\/10.1016\/j.tig.2022.03.010.","journal-title":"Trends Genet"},{"key":"3182_CR42","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.canlet.2017.03.029","volume":"396","author":"A Van Tongelen","year":"2017","unstructured":"Van Tongelen A, Loriot A, De Smet C. Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes. Cancer Lett. 2017;396:130\u20137. https:\/\/doi.org\/10.1016\/j.canlet.2017.03.029.","journal-title":"Cancer Lett"},{"issue":"24","key":"3182_CR43","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020682","volume":"99","author":"Z Wu","year":"2020","unstructured":"Wu Z, Zhou T, Sun H-Y. DNA methylation-based diagnostic and prognostic biomarkers of nasopharyngeal carcinoma patients. Medicine. 2020;99(24):e20682. https:\/\/doi.org\/10.1097\/MD.0000000000020682.","journal-title":"Medicine"},{"issue":"7","key":"3182_CR44","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1111\/cas.14431","volume":"111","author":"Y Xu","year":"2020","unstructured":"Xu Y, et al. Combination of RERG and ZNF671 methylation rates in circulating cell-free DNA: a novel biomarker for screening of nasopharyngeal carcinoma. Cancer Sci. 2020;111(7):2536\u201345. https:\/\/doi.org\/10.1111\/cas.14431.","journal-title":"Cancer Sci"},{"key":"3182_CR45","doi-asserted-by":"publisher","first-page":"5","DOI":"10.21037\/anpc-21-9","volume":"6","author":"L Li","year":"2022","unstructured":"Li L, Xie J, Ma B, Chan ATC, Tao Q. CpG methylation as epigenetic biomarkers for nasopharyngeal carcinoma diagnostics. Annals of Nasopharynx Cancer. 2022;6:5\u20135. https:\/\/doi.org\/10.21037\/anpc-21-9.","journal-title":"Annals of Nasopharynx Cancer"},{"key":"3182_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1473706","author":"KS Saini","year":"2024","unstructured":"Saini KS, et al. Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy. Front Oncol. 2024. https:\/\/doi.org\/10.3389\/fonc.2024.1473706.","journal-title":"Front Oncol"},{"issue":"1","key":"3182_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14508-y","volume":"25","author":"Z-H Qin","year":"2025","unstructured":"Qin Z-H, et al. Nasopharyngeal carcinoma detected noninvasively in the real world using three gene methylation analyses from automatically processed bilateral nasal swab samples. BMC Cancer. 2025;25(1):1147. https:\/\/doi.org\/10.1186\/s12885-025-14508-y.","journal-title":"BMC Cancer"},{"issue":"1","key":"3182_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02161-8","volume":"23","author":"G Liu","year":"2025","unstructured":"Liu G, et al. Retinoic acid enhances \u03b3\u03b4 T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion. Cell Commun Signal. 2025;23(1):156. https:\/\/doi.org\/10.1186\/s12964-025-02161-8.","journal-title":"Cell Commun Signal"},{"issue":"1","key":"3182_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12907-1","volume":"24","author":"L Dong","year":"2024","unstructured":"Dong L, Li Y, Song X, Sun C, Song X. SFRP1 mediates cancer-associated fibroblasts to suppress cancer cell proliferation and migration in head and neck squamous cell carcinoma. BMC Cancer. 2024;24(1):1165. https:\/\/doi.org\/10.1186\/s12885-024-12907-1.","journal-title":"BMC Cancer"},{"issue":"1","key":"3182_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-87038-z","volume":"15","author":"Y Jiang","year":"2025","unstructured":"Jiang Y, et al. Multi-omic analyses reveal aberrant DNA methylation patterns and the associated biomarkers of nasopharyngeal carcinoma and its cancer stem cells. Sci Rep. 2025;15(1):9733. https:\/\/doi.org\/10.1038\/s41598-025-87038-z.","journal-title":"Sci Rep"},{"key":"3182_CR51","unstructured":"Lao D et al. Identification and validation of the hypermethylation biomarkers on ZMYND10 promoter in nasopharyngeal carcinoma biopsies from Vietnamese patients. Int J Environ Engineering-IJEE. 2017;4(1)"},{"issue":"9","key":"3182_CR52","doi-asserted-by":"publisher","first-page":"6035","DOI":"10.3390\/curroncol29090475","volume":"29","author":"X Liu","year":"2022","unstructured":"Liu X, et al. Nasopharyngeal carcinoma progression: accumulating genomic instability and persistent Epstein\u2013Barr virus infection. Curr Oncol. 2022;29(9):6035\u201352. https:\/\/doi.org\/10.3390\/curroncol29090475.","journal-title":"Curr Oncol"},{"issue":"2","key":"3182_CR53","doi-asserted-by":"publisher","first-page":"152","DOI":"10.2478\/rjim-2025-0005","volume":"63","author":"IE Hotoboc","year":"2025","unstructured":"Hotoboc IE, et al. The association between DNA methylation status and Epstein-Barr virus infection in laryngeal carcinomas. Rom J Intern Med. 2025;63(2):152\u201362. https:\/\/doi.org\/10.2478\/rjim-2025-0005.","journal-title":"Rom J Intern Med"},{"key":"3182_CR54","doi-asserted-by":"publisher","unstructured":"- H, et al. First Indonesian nasopharyngeal cancer whole epigenome sequencing identify tumour suppressor CpG methylation. Biologics. Jan. 2025;19:1\u201313. https:\/\/doi.org\/10.2147\/BTT.S490382","DOI":"10.2147\/BTT.S490382"},{"issue":"2","key":"3182_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2025.103495","volume":"73","author":"Y Xu","year":"2025","unstructured":"Xu Y, Cao X, Zhou H, Xu H, Chen B, Bai H. Identifying potential prognosis markers in relapsed multiple myeloma via integrated bioinformatics analysis and biological experiments. Curr Res Transl Med. 2025;73(2):103495. https:\/\/doi.org\/10.1016\/j.retram.2025.103495.","journal-title":"Curr Res Transl Med"},{"key":"3182_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.70054","author":"LJ Chu","year":"2025","unstructured":"Chu LJ, et al. Plasma POSTN derived from bile proteome is a promising biomarker for cholangiocarcinoma with efficacy comparable and complementary to CA19.9. United Eur Gastroenterol J. 2025. https:\/\/doi.org\/10.1002\/ueg2.70054.","journal-title":"United Eur Gastroenterol J"},{"key":"3182_CR57","doi-asserted-by":"publisher","unstructured":"Kai J, Huang H, Su J, Chen Q. Identification of shared immune infiltration characteristic molecules in dermatomyositis and nasopharyngeal carcinoma using bioinformatics, Skin Research and Technology. 2024;30(8).\u00a0https:\/\/doi.org\/10.1111\/srt.13871","DOI":"10.1111\/srt.13871"},{"issue":"5","key":"3182_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296034","volume":"19","author":"X Zhong","year":"2024","unstructured":"Zhong X, et al. Explore the shared molecular mechanism between dermatomyositis and nasopharyngeal cancer by bioinformatic analysis. PLoS One. 2024;19(5):e0296034. https:\/\/doi.org\/10.1371\/journal.pone.0296034.","journal-title":"PLoS One"},{"key":"3182_CR59","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B978-0-323-91909-8.00019-0","volume-title":"Handbook of Epigenetics","author":"L Vanzan","year":"2023","unstructured":"Vanzan L, Sklias A, Boskovic M, Herceg Z, Murr R, Suter DM. Mechanisms of Histone Modifications. In: Handbook of Epigenetics. Elsevier; 2023. p. 27\u201354. https:\/\/doi.org\/10.1016\/B978-0-323-91909-8.00019-0."},{"issue":"1","key":"3182_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01918-w","volume":"9","author":"W Yao","year":"2024","unstructured":"Yao W, Hu X, Wang X. Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases. Signal Transduct Target Ther. 2024;9(1):232. https:\/\/doi.org\/10.1038\/s41392-024-01918-w.","journal-title":"Signal Transduct Target Ther"},{"key":"3182_CR61","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.292","author":"R Liu","year":"2023","unstructured":"Liu R, et al. Post-translational modifications of histones: mechanisms, biological functions, and therapeutic targets. MedComm (Beijing). 2023. https:\/\/doi.org\/10.1002\/mco2.292.","journal-title":"MedComm (Beijing)"},{"issue":"8_Supplement_1","key":"3182_CR62","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1158\/1538-7445.AM2025-211","volume":"85","author":"LS Dittman Chung","year":"2025","unstructured":"Dittman Chung LS, et al. Abstract 211: Epstein-Barr virus (EBV)\u2012human host chromatin interactions rearrange spatial DNA genome organisation and hijack KDM5B to distant metastasis proneness in EBV-associated nasopharyngeal carcinoma (NPC). Cancer Res. 2025;85(8_Supplement_1):211\u2013211. https:\/\/doi.org\/10.1158\/1538-7445.AM2025-211.","journal-title":"Cancer Res"},{"issue":"3","key":"3182_CR63","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41418-024-01257-x","volume":"31","author":"B Zhang","year":"2024","unstructured":"Zhang B, et al. Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16\/TOP2A axis. Cell Death Differ. 2024;31(3):309\u201321. https:\/\/doi.org\/10.1038\/s41418-024-01257-x.","journal-title":"Cell Death Differ"},{"issue":"1","key":"3182_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5005-2","volume":"18","author":"KLM Chua","year":"2018","unstructured":"Chua KLM, et al. Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC. BMC Cancer. 2018;18(1):1095. https:\/\/doi.org\/10.1186\/s12885-018-5005-2.","journal-title":"BMC Cancer"},{"key":"3182_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.605777","author":"M-X Zhang","year":"2021","unstructured":"Zhang M-X, Wang L, Zeng L, Tu Z-W. LCN2 is a potential biomarker for radioresistance and recurrence in nasopharyngeal carcinoma. Front Oncol. 2021. https:\/\/doi.org\/10.3389\/fonc.2020.605777.","journal-title":"Front Oncol"},{"issue":"1","key":"3182_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01773-0","volume":"16","author":"X Yin","year":"2024","unstructured":"Yin X, Li J, Zhao J, Zheng W, Zhang A, Ma J. Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification. Clin Epigenetics. 2024;16(1):162. https:\/\/doi.org\/10.1186\/s13148-024-01773-0.","journal-title":"Clin Epigenetics"},{"issue":"4","key":"3182_CR67","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/17501911.2025.2460900","volume":"17","author":"M Zhu","year":"2025","unstructured":"Zhu M, et al. A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer. Epigenomics. 2025;17(4):263\u201379. https:\/\/doi.org\/10.1080\/17501911.2025.2460900.","journal-title":"Epigenomics"},{"key":"3182_CR68","doi-asserted-by":"publisher","DOI":"10.1080\/29933935.2024.2419069","author":"N Varshney","year":"2024","unstructured":"Varshney N, Pandey RK, Mishra A, Kumar S, Jha HC. Aurora kinase A: integrating insights into cancer, inflammation, and infectious diseases. Gut Microbes Reports. 2024. https:\/\/doi.org\/10.1080\/29933935.2024.2419069.","journal-title":"Gut Microbes Reports"},{"key":"3182_CR69","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-5029369\/v1","author":"Z-H Qin","year":"2024","unstructured":"Qin Z-H, et al. Noninvasive detection of early nasopharyngeal carcinoma based on three gene methylation analysis in bilateral nasal swab samples processed automatically. Oct 22. 2024. https:\/\/doi.org\/10.21203\/rs.3.rs-5029369\/v1","journal-title":"Oct 22"},{"issue":"50","key":"3182_CR70","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036583","volume":"102","author":"T Qian","year":"2023","unstructured":"Qian T, Zhou Z, Zhang Q, Liou Y-L, Zhou H. SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: a reflection of potential minimally invasive biomarkers for early screening of nasopharyngeal cancer. Medicine. 2023;102(50):e36583. https:\/\/doi.org\/10.1097\/MD.0000000000036583.","journal-title":"Medicine"},{"issue":"6","key":"3182_CR71","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/s41418-018-0208-2","volume":"26","author":"Y Li","year":"2019","unstructured":"Li Y, et al. EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma. Cell Death Differ. 2019;26(6):1089\u2013106. https:\/\/doi.org\/10.1038\/s41418-018-0208-2.","journal-title":"Cell Death Differ"},{"key":"3182_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1529239","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Wang H, Zhan Z, Gan L, Bai O. Mechanisms of HDACs in cancer development. Front Immunol. 2025. https:\/\/doi.org\/10.3389\/fimmu.2025.1529239.","journal-title":"Front Immunol"},{"key":"3182_CR73","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.bbrc.2022.11.102","volume":"640","author":"M Tanaka","year":"2023","unstructured":"Tanaka M, Harada H, Kimura H. The role of H3K9me3 in oral squamous cell carcinoma. Biochem Biophys Res Commun. 2023;640:56\u201363. https:\/\/doi.org\/10.1016\/j.bbrc.2022.11.102.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"3182_CR74","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20200032","volume":"65","author":"H Yan","year":"2021","unstructured":"Yan H, Bu P. Non-coding RNA in cancer. Essays Biochem. 2021;65(4):625\u201339. https:\/\/doi.org\/10.1042\/EBC20200032.","journal-title":"Essays Biochem"},{"issue":"5","key":"3182_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051245","volume":"12","author":"X-Z Zhang","year":"2020","unstructured":"Zhang X-Z, Liu H, Chen S-R. Mechanisms of long non-coding RNAs in cancers and their dynamic regulations. Cancers (Basel). 2020;12(5):1245. https:\/\/doi.org\/10.3390\/cancers12051245.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"3182_CR76","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jphs.2021.08.002","volume":"147","author":"Z Tang","year":"2021","unstructured":"Tang Z, et al. LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6. J Pharmacol Sci. 2021;147(3):284\u201393. https:\/\/doi.org\/10.1016\/j.jphs.2021.08.002.","journal-title":"J Pharmacol Sci"},{"key":"3182_CR77","doi-asserted-by":"publisher","unstructured":"Suzuki H, Maruyama R, Yamamoto E, Kai M. Epigenetic alteration and MicroRNA dysregulation in cancer. Front Genet. 2013;4. https:\/\/doi.org\/10.3389\/fgene.2013.00258","DOI":"10.3389\/fgene.2013.00258"},{"issue":"15","key":"3182_CR78","doi-asserted-by":"publisher","first-page":"12837","DOI":"10.18632\/oncotarget.3805","volume":"6","author":"N Amodio","year":"2015","unstructured":"Amodio N, et al. miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies. Oncotarget. 2015;6(15):12837\u201361. https:\/\/doi.org\/10.18632\/oncotarget.3805.","journal-title":"Oncotarget"},{"issue":"11","key":"3182_CR79","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3748\/wjg.v30.i11.1497","volume":"30","author":"Q-Y Wei","year":"2024","unstructured":"Wei Q-Y, et al. Micrornas: a novel signature in the metastasis of esophageal squamous cell carcinoma. World J Gastroenterol. 2024;30(11):1497\u2013523. https:\/\/doi.org\/10.3748\/wjg.v30.i11.1497.","journal-title":"World J Gastroenterol"},{"key":"3182_CR80","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.2147\/OTT.S154464","volume":"Volume 11","author":"Z-W Lu","year":"2018","unstructured":"Lu Z-W, et al. MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma. Onco Targets Ther. 2018;Volume 11:1733\u201341. https:\/\/doi.org\/10.2147\/OTT.S154464.","journal-title":"Onco Targets Ther"},{"key":"3182_CR81","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1617198","author":"J Bautista","year":"2025","unstructured":"Bautista J, Lopez-Cortes A. Oncogenic viruses rewire the epigenome in human cancer. Front Cell Infect Microbiol. 2025. https:\/\/doi.org\/10.3389\/fcimb.2025.1617198.","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"3182_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092122","volume":"14","author":"KA Islam","year":"2022","unstructured":"Islam KA, et al. Prognostic biomarkers for survival in nasopharyngeal carcinoma: a systematic review of the literature. Cancers (Basel). 2022;14(9):2122. https:\/\/doi.org\/10.3390\/cancers14092122.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"3182_CR83","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/2211536611666220919144834","volume":"12","author":"T Wardana","year":"2023","unstructured":"Wardana T, et al. Microrna gene signature for predicting mechanisms in nasopharyngeal carcinoma: a case study on the potential application of circulating biomarkers. MicroRNA. 2023;12(1):29\u201344. https:\/\/doi.org\/10.2174\/2211536611666220919144834.","journal-title":"MicroRNA"},{"key":"3182_CR84","doi-asserted-by":"publisher","DOI":"10.2174\/0122115366365058250513110804","author":"C Srinivasan","year":"2025","unstructured":"Srinivasan C, Karthikeyan MC, Jeyaprakash A, Arockiam AJV. AAAGUGC seed-containing miRNAs: master regulators of cancer pathways and therapeutic resistance. MicroRNA. 2025. https:\/\/doi.org\/10.2174\/0122115366365058250513110804.","journal-title":"MicroRNA"},{"issue":"24","key":"3182_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/cells13242060","volume":"13","author":"DL Levitis","year":"2024","unstructured":"Levitis DL, Si J, Ravishankar K, Toborek M, Park M. Identification of stable reference miRNAs for miRNA expression analysis in adult neurogenesis across mouse and human tissues. Cells. 2024;13(24):2060. https:\/\/doi.org\/10.3390\/cells13242060.","journal-title":"Cells"},{"key":"3182_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1299249","author":"H Xu","year":"2024","unstructured":"Xu H, Li W, Wang D. The promising role of mirnas in radioresistance and chemoresistance of nasopharyngeal carcinoma. Front Oncol. 2024. https:\/\/doi.org\/10.3389\/fonc.2024.1299249.","journal-title":"Front Oncol"},{"key":"3182_CR87","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2905179","author":"Y Chen","year":"2024","unstructured":"Chen Y, Xu S, He Y, He L. The role of PTEN in nasopharyngeal carcinoma. Front Biosci-Landmark. 2024. https:\/\/doi.org\/10.31083\/j.fbl2905179.","journal-title":"Front Biosci-Landmark"},{"key":"3182_CR88","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2902080","author":"H Hu","year":"2024","unstructured":"Hu H, Song H, Han B, Zhao H, He J. Tumor-educated platelet RNA and circulating free RNA: emerging liquid biopsy markers for different tumor types. Front Biosci Landmark. 2024. https:\/\/doi.org\/10.31083\/j.fbl2902080.","journal-title":"Front Biosci Landmark"},{"issue":"1","key":"3182_CR89","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-10433-2","volume":"52","author":"Y Wang","year":"2025","unstructured":"Wang Y, Jiang L, Wang J, Huang Y, Dong Y. Utilization of TEP miRNAs in tumor proliferation, diagnostic evaluation, therapeutic intervention, and prognostic assessment. Mol Biol Rep. 2025;52(1):343. https:\/\/doi.org\/10.1007\/s11033-025-10433-2.","journal-title":"Mol Biol Rep"},{"key":"3182_CR90","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ncrna.2025.02.005","volume":"12","author":"Y Shao","year":"2025","unstructured":"Shao Y, Zhang S, Pan Y, Peng Z, Dong Y. miR-135b: a key role in cancer biology and therapeutic targets. Non-coding RNA Res. 2025;12:67\u201380. https:\/\/doi.org\/10.1016\/j.ncrna.2025.02.005.","journal-title":"Non-coding RNA Res"},{"issue":"3","key":"3182_CR91","doi-asserted-by":"publisher","first-page":"591","DOI":"10.32604\/or.2024.050548","volume":"33","author":"A Mohanta","year":"2025","unstructured":"Mohanta A, et al. The regulatory role of ZFAS1\/miRNAs\/mRNAs axis in cancer: a systematic review. Oncol Res. 2025;33(3):591\u2013604. https:\/\/doi.org\/10.32604\/or.2024.050548.","journal-title":"Oncol Res"},{"issue":"1","key":"3182_CR92","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-025-03732-2","volume":"23","author":"M Prasad","year":"2025","unstructured":"Prasad M, Hamsa D, Fareed M, Karobari MI. An update on the molecular mechanisms underlying the progression of miR-21 in oral cancer. World J Surg Oncol. 2025;23(1):73. https:\/\/doi.org\/10.1186\/s12957-025-03732-2.","journal-title":"World J Surg Oncol"},{"key":"3182_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.102216","volume":"51","author":"MS Kishta","year":"2025","unstructured":"Kishta MS, Khamis A, Am H, Elshaar AH, G\u00fcl D. Exploring the tumor-suppressive role of miRNA-200c in head and neck squamous cell carcinoma: potential and mechanisms of exosome-mediated delivery for therapeutic applications. Transl Oncol. 2025;51:102216. https:\/\/doi.org\/10.1016\/j.tranon.2024.102216.","journal-title":"Transl Oncol"},{"key":"3182_CR94","doi-asserted-by":"publisher","unstructured":"Birknerova N et al. Circulating Cell-Free DNA-Based Methylation Pattern in Saliva for Early Diagnosis of Head and Neck Cancer,MDPI. 2022;01.\u00a0https:\/\/doi.org\/10.3390\/cancers14194882","DOI":"10.3390\/cancers14194882"},{"key":"3182_CR95","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-48","author":"SH Hutajulu","year":"2011","unstructured":"Hutajulu SH, et al. Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population. Mol Cancer. 2011. https:\/\/doi.org\/10.1186\/1476-4598-10-48.","journal-title":"Mol Cancer"},{"issue":"12","key":"3182_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166552","volume":"1868","author":"Q Babar","year":"2022","unstructured":"Babar Q, Saeed A, Tabish TA, Pricl S, Townley H, Thorat N. Novel epigenetic therapeutic strategies and targets in cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2022;1868(12):166552. https:\/\/doi.org\/10.1016\/j.bbadis.2022.166552.","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"5","key":"3182_CR97","doi-asserted-by":"publisher","first-page":"101020","DOI":"10.1016\/j.gendis.2023.04.040","volume":"11","author":"D Wang","year":"2024","unstructured":"Wang D, et al. Epigenetics: mechanisms, potential roles, and therapeutic strategies in cancer progression. Genes Dis. 2024;11(5):101020. https:\/\/doi.org\/10.1016\/j.gendis.2023.04.040.","journal-title":"Genes Dis"},{"issue":"1","key":"3182_CR98","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01783-z","volume":"25","author":"M Abdar Esfahani","year":"2025","unstructured":"Abdar Esfahani M, Servatian N, Al-Athari AJH, Khafaja ESM, Rahmani Seraji H, Soleimani Samarkhazan H. The epigenetic revolution in hematology: from benchside breakthroughs to clinical transformations. Clin Exp Med. 2025;25(1):230. https:\/\/doi.org\/10.1007\/s10238-025-01783-z.","journal-title":"Clin Exp Med"},{"issue":"1","key":"3182_CR99","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13148-023-01574-x","volume":"15","author":"Y Hu","year":"2023","unstructured":"Hu Y, et al. Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity. Clin Epigenetics. 2023;15(1):161. https:\/\/doi.org\/10.1186\/s13148-023-01574-x.","journal-title":"Clin Epigenetics"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-03182-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-025-03182-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-025-03182-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T14:47:26Z","timestamp":1770389246000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-025-03182-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":99,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["3182"],"URL":"https:\/\/doi.org\/10.1007\/s12032-025-03182-6","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"77"}}