{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:14:11Z","timestamp":1788880451793,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"RUSA 2.0","award":["F. 24-51\/2014-U"],"award-info":[{"award-number":["F. 24-51\/2014-U"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-026-03238-1","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:38:54Z","timestamp":1770298734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Farnesol induces apoptosis, LC3B\/SQSTM1 mediated regulation of autophagy and downregulates anaerobic Glycolysis through suppression of LDH and PKM in A549 lung adenocarcinoma cells"],"prefix":"10.1007","volume":"43","author":[{"given":"Nagakanni","family":"Muthuvenugopal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soundarya Rani Rajendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indhirakumar","family":"Balakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandima Devi","family":"Kasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"3238_CR1","doi-asserted-by":"publisher","unstructured":"Upadhyay A. Cancer: an unknown territory; rethinking before going ahead. Genes Dis. Sep. 2021;8(5):655\u201361. https:\/\/doi.org\/10.1016\/j.gendis.2020.09.002.","DOI":"10.1016\/j.gendis.2020.09.002"},{"key":"3238_CR2","doi-asserted-by":"publisher","unstructured":"Siddiqui F, Vaqar S, Siddiqui AH. Lung Cancer, Cambridge Handbook of Psychology, Health and Medicine, Second Edition, pp. 605\u2013606, May 2023, https:\/\/doi.org\/10.1017\/CBO9780511543579.138","DOI":"10.1017\/CBO9780511543579.138"},{"key":"3238_CR3","unstructured":"Lung cancer., Accessed. Aug. 28, 2024. [Online]. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lung-cancer"},{"issue":"11","key":"3238_CR4","doi-asserted-by":"publisher","first-page":"e0165973","DOI":"10.1371\/journal.pone.0165973","volume":"11","author":"L Korrodi-Greg\u00f3rio","year":"2016","unstructured":"Korrodi-Greg\u00f3rio L, Soto-Cerrato V, Vitorino R, Fardilha M, P\u00e9rez-Tom\u00e1s R. From proteomic analysis to potential therapeutic targets: functional profile of two lung cancer cell Lines, A549 and SW900, widely studied in Pre-Clinical research. PLoS ONE. 2016;11(11):e0165973. https:\/\/doi.org\/10.1371\/journal.pone.0165973.","journal-title":"PLoS ONE"},{"key":"3238_CR5","unstructured":"Non-Small Cell Lung Cancer Treatment - NCI., Accessed. Aug. 29, 2024. [Online]. Available: https:\/\/www.cancer.gov\/types\/lung\/patient\/non-small-cell-lung-treatment-pdq"},{"key":"3238_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/MODPATHOL.2011.150","volume":"25","author":"WD Travis","year":"2012","unstructured":"Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol. 2012;25:18\u201330. https:\/\/doi.org\/10.1038\/MODPATHOL.2011.150.","journal-title":"Mod Pathol"},{"key":"3238_CR7","doi-asserted-by":"publisher","unstructured":"Xiao Z, et al. The pivotal role of IKK\u03b1 in the development of spontaneous lung squamous cell carcinomas. Cancer Cell. Apr. 2013;23(4):527\u201340. https:\/\/doi.org\/10.1016\/J.CCR.2013.03.009.","DOI":"10.1016\/J.CCR.2013.03.009"},{"key":"3238_CR8","doi-asserted-by":"publisher","unstructured":"Sung H, Global Cancer Statistics. 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA Cancer J Clin, vol. 71, no. 3, pp. 209\u2013249, May 2021. https:\/\/doi.org\/10.3322\/CAAC.21660","DOI":"10.3322\/CAAC.21660"},{"key":"3238_CR9","doi-asserted-by":"publisher","unstructured":"Cagle PT, Allen TC, Olsen RJ. Lung Cancer Biomarkers: Present Status and Future Developments, Arch Pathol Lab Med, vol. 137, no. 9, pp. 1191\u20131198, Sep. 2013, https:\/\/doi.org\/10.5858\/ARPA.2013-0319-CR","DOI":"10.5858\/ARPA.2013-0319-CR"},{"key":"3238_CR10","doi-asserted-by":"publisher","unstructured":"Larsen JE, Minna JD. Molecular biology of lung cancer: clinical implications. Clin Chest Med. Dec. 2011;32(4):703. https:\/\/doi.org\/10.1016\/J.CCM.2011.08.003.","DOI":"10.1016\/J.CCM.2011.08.003"},{"key":"3238_CR11","doi-asserted-by":"publisher","unstructured":"Liu G et al. Feb., Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer, Int J Mol Sci, vol. 18, no. 2, p. 367, 2017, https:\/\/doi.org\/10.3390\/IJMS18020367","DOI":"10.3390\/IJMS18020367"},{"key":"3238_CR12","doi-asserted-by":"publisher","unstructured":"Luo M, et al. Wogonoside induces apoptosis in human non-small cell lung cancer A549 cells by promoting mitochondria dysfunction. Biomed Pharmacother. Oct. 2018;106:593\u20138. https:\/\/doi.org\/10.1016\/J.BIOPHA.2018.06.077.","DOI":"10.1016\/J.BIOPHA.2018.06.077"},{"key":"3238_CR13","doi-asserted-by":"publisher","unstructured":"Wang S, Hu Y, Yan Y, Cheng Z, Liu T. Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS-mediated mitochondrial-dependent pathway. BMC Complement Altern Med. Aug. 2018;18(1):1\u201311. https:\/\/doi.org\/10.1186\/S12906-018-2300-Z\/FIGURES\/7.","DOI":"10.1186\/S12906-018-2300-Z\/FIGURES\/7"},{"key":"3238_CR14","doi-asserted-by":"publisher","unstructured":"Kiruthiga C, Devi KP, Nabavi SM, Bishayee A. Autophagy: A potential therapeutic target of polyphenols in hepatocellular carcinoma. Cancers 2020. Feb. 2020;12(3):562. https:\/\/doi.org\/10.3390\/CANCERS12030562. Page 562.","DOI":"10.3390\/CANCERS12030562"},{"key":"3238_CR15","doi-asserted-by":"publisher","unstructured":"Deng H, et al. Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing MtDNA damage. Cell Mol Life Sci. Aug. 2022;79(8). https:\/\/doi.org\/10.1007\/S00018-022-04453-5.","DOI":"10.1007\/S00018-022-04453-5"},{"key":"3238_CR16","doi-asserted-by":"publisher","unstructured":"Zhou D, Duan Z, Li Z, Ge F, Wei R, Kong L. The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment, Front Pharmacol, vol. 13, p. 1091779, Dec. 2022, https:\/\/doi.org\/10.3389\/FPHAR.2022.1091779","DOI":"10.3389\/FPHAR.2022.1091779"},{"key":"3238_CR17","doi-asserted-by":"publisher","unstructured":"Xu JQ, et al. Targeting Glycolysis in non-small cell lung cancer: promises and challenges. Front Pharmacol. Nov. 2022;13:1037341. https:\/\/doi.org\/10.3389\/FPHAR.2022.1037341.","DOI":"10.3389\/FPHAR.2022.1037341"},{"key":"3238_CR18","doi-asserted-by":"publisher","unstructured":"Talukder MEK, et al. Molecular docking, QSAR, and simulation analyses of EGFR-targeting phytochemicals in non-small cell lung cancer. J Mol Struct. Feb. 2025;1321:139924. https:\/\/doi.org\/10.1016\/J.MOLSTRUC.2024.139924.","DOI":"10.1016\/J.MOLSTRUC.2024.139924"},{"key":"3238_CR19","doi-asserted-by":"crossref","unstructured":"Aljabali AAA et al. Aug., Phytochemicals in Cancer Therapy: A Structured Review of Mechanisms, Challenges, and Progress in Personalized Treatment, Chem Biodivers, vol. 22, no. 8, p. e202402479, 2025, doi: 10.1002\/CBDV.202402479;WGROUP:STRING:PUBLICATION.","DOI":"10.1002\/cbdv.202402479"},{"key":"3238_CR20","doi-asserted-by":"publisher","unstructured":"Chimento A, D\u2019Amico M, De Luca A, Conforti FL, Pezzi V, De Amicis F. Resveratrol, Epigallocatechin gallate and Curcumin for cancer therapy: challenges from their Pro-Apoptotic properties. Life. Feb. 2023;13(2):261. https:\/\/doi.org\/10.3390\/LIFE13020261.","DOI":"10.3390\/LIFE13020261"},{"key":"3238_CR21","doi-asserted-by":"publisher","unstructured":"Joo JH, Liao G, Collins JB, Grissom SF, Jetten AM. Farnesol-Induced Apoptosis in Human Lung Carcinoma Cells Is Coupled to the Endoplasmic Reticulum Stress Response, Cancer Res, vol. 67, no. 16, pp. 7929\u20137936, Aug. 2007, https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-0931","DOI":"10.1158\/0008-5472.CAN-07-0931"},{"key":"3238_CR22","doi-asserted-by":"publisher","unstructured":"Maryam A, Mehmood T, Zhang H, Li Y, Khan M, Ma T. Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress, Scientific Reports 2017 7:1, vol. 7, no. 1, p. 6242-, Jul. 2017, https:\/\/doi.org\/10.1038\/s41598-017-06535-y","DOI":"10.1038\/s41598-017-06535-y"},{"key":"3238_CR23","doi-asserted-by":"publisher","unstructured":"Zhang SY, Li XB, Hou SG, Sun Y, Shi YR, Sen Lin S. Cedrol induces autophagy and apoptotic cell death in A549 non-small cell lung carcinoma cells through the P13K\/Akt signaling pathway, the loss of mitochondrial transmembrane potential and the generation of ROS. Int J Mol Med. Jul. 2016;38(1):291\u20139. https:\/\/doi.org\/10.3892\/IJMM.2016.2585.","DOI":"10.3892\/IJMM.2016.2585"},{"key":"3238_CR24","doi-asserted-by":"publisher","unstructured":"Rao CV, Newmark HL, Reddy BS. Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis, Cancer Detect Prev, vol. 26, no. 6, pp. 419\u2013425, Dec. 2002, https:\/\/doi.org\/10.1016\/S0361-090X(02)00119-8","DOI":"10.1016\/S0361-090X(02)00119-8"},{"key":"3238_CR25","doi-asserted-by":"publisher","unstructured":"Jung YY, Hwang ST, Sethi G, Fan L, Arfuso F, Ahn KS. Potential Anti-Inflammatory and Anti-Cancer properties of Farnesol. Molecules. Oct. 2018;23(11):2827. https:\/\/doi.org\/10.3390\/molecules23112827.","DOI":"10.3390\/molecules23112827"},{"key":"3238_CR26","doi-asserted-by":"publisher","unstructured":"Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K\/Akt and MAPK pathways. Accessed: Oct. 25, 2024. [Online]. Available: https:\/\/www.spandidos-publications.com\/https:\/\/doi.org\/10.3892\/ijmm.2014.1679","DOI":"10.3892\/ijmm.2014.1679"},{"key":"3238_CR27","doi-asserted-by":"publisher","unstructured":"Maj E, Filip-Psurska B, Milczarek M, Psurski M, Kutner A, Wietrzyk J. Vitamin\u00ef D derivatives potentiate the anticancer and anti-angiogenic activity of tyrosine kinase inhibitors in combination with cytostatic drugs in an A549 non-small cell lung cancer model, Int J Oncol, Dec. 2017, https:\/\/doi.org\/10.3892\/ijo.2017.4228","DOI":"10.3892\/ijo.2017.4228"},{"key":"3238_CR28","doi-asserted-by":"publisher","unstructured":"Kiruthiga C, Niharika K, Devi KP. Phytol and \u03b1-Bisabolol Synergy Induces Autophagy and Apoptosis in A549 Cells and Additional Molecular Insights through Comprehensive Proteome Analysis via Nano LC-MS\/MS, Anticancer Agents Med Chem, vol. 24, no. 10, pp. 773\u2013788, Jun. 2024, https:\/\/doi.org\/10.2174\/0118715206289038240214102951","DOI":"10.2174\/0118715206289038240214102951"},{"key":"3238_CR29","doi-asserted-by":"publisher","unstructured":"Tamhane VA, et al. Label-free quantitative proteomics of sorghum bicolor reveals the proteins strengthening plant defense against insect pest Chilo partellus. Proteome Sci. Dec. 2021;19(1). https:\/\/doi.org\/10.1186\/s12953-021-00173-z.","DOI":"10.1186\/s12953-021-00173-z"},{"key":"3238_CR30","doi-asserted-by":"publisher","unstructured":"Aneesh Kumar A, et al. Proteomics analysis reveals diverse molecular characteristics between endocardial and Aortic-Valvular endothelium. Genes (Basel). Jun. 2021;12:1005. https:\/\/doi.org\/10.3390\/genes12071005.","DOI":"10.3390\/genes12071005"},{"key":"3238_CR31","doi-asserted-by":"publisher","unstructured":"Vineetha RC, Hariharan S, Jaleel A, Chandran M, Nair RH. L-Ascorbic acid and \u03b1-Tocopherol synergistically triggers apoptosis inducing antileukemic effects of arsenic trioxide via oxidative stress in human acute promyelocytic leukemia cells. Front Oncol. Feb. 2020;10:494392. https:\/\/doi.org\/10.3389\/FONC.2020.00065\/BIBTEX.","DOI":"10.3389\/FONC.2020.00065\/BIBTEX"},{"key":"3238_CR32","doi-asserted-by":"publisher","unstructured":"Jafni S, et al. Hesperidin Methyl chalcone reduces extracellular A\u03b2(25\u201335) peptide aggregation and fibrillation and also protects neuro 2a cells from A\u03b2(25\u201335) induced neuronal dysfunction. Bioorg Med Chem. Dec. 2023;96:117536. https:\/\/doi.org\/10.1016\/J.BMC.2023.117536.","DOI":"10.1016\/J.BMC.2023.117536"},{"key":"3238_CR33","doi-asserted-by":"publisher","unstructured":"Panda M, Tripathi SK, Biswal BK. Plumbagin promotes mitochondrial mediated apoptosis in gefitinib sensitive and resistant A549 lung cancer cell line through enhancing reactive oxygen species generation, Mol Biol Rep, vol. 47, no. 6, pp. 4155\u20134168, Jun. 2020, https:\/\/doi.org\/10.1007\/s11033-020-05464-w","DOI":"10.1007\/s11033-020-05464-w"},{"key":"3238_CR34","doi-asserted-by":"publisher","unstructured":"Balan DJ, Rajavel T, Das M, Sathya S, Jeyakumar M, Devi KP. Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells, Pharmacological Reports, vol. 73, no. 1, pp. 240\u2013254, Feb. 2021, https:\/\/doi.org\/10.1007\/S43440-020-00171-6","DOI":"10.1007\/S43440-020-00171-6"},{"key":"3238_CR35","doi-asserted-by":"publisher","unstructured":"Kiruthiga C, Jaya Balan D, Jafni S, Anandan DP, Devi KP. Phytol and (\u2013)-\u03b1-bisabolol synergistically trigger intrinsic apoptosis through redox and Ca2\u2009+\u2009imbalance in non-small cell lung cancer. Biocatal Agric Biotechnol. Feb. 2024;56:103005. https:\/\/doi.org\/10.1016\/J.BCAB.2023.103005.","DOI":"10.1016\/J.BCAB.2023.103005"},{"key":"3238_CR36","doi-asserted-by":"publisher","unstructured":"Faubert B et al. Oct., Lactate metabolism in human lung tumors, Cell, vol. 171, no. 2, p. 358, 2017, https:\/\/doi.org\/10.1016\/J.CELL.2017.09.019","DOI":"10.1016\/J.CELL.2017.09.019"},{"key":"3238_CR37","doi-asserted-by":"publisher","unstructured":"Augoff K, Hryniewicz-Jankowska A, Tabola R. Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer. Cancer Lett. Mar. 2015;358(1):1\u20137. https:\/\/doi.org\/10.1016\/j.canlet.2014.12.035.","DOI":"10.1016\/j.canlet.2014.12.035"},{"key":"3238_CR38","doi-asserted-by":"publisher","unstructured":"Comandatore A, Franczak M, Smolenski RT, Morelli L, Peters GJ, Giovannetti E. Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers, Semin Cancer Biol, vol. 86, pp. 93\u2013100, Nov. 2022, https:\/\/doi.org\/10.1016\/J.SEMCANCER.2022.09.001","DOI":"10.1016\/J.SEMCANCER.2022.09.001"},{"key":"3238_CR39","doi-asserted-by":"publisher","unstructured":"Al-Salam S, Kandhan K, Sudhadevi M. Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and Inhibition of BCL2. Oncotarget. Apr. 2021;12(9):923. https:\/\/doi.org\/10.18632\/ONCOTARGET.27950.","DOI":"10.18632\/ONCOTARGET.27950"},{"key":"3238_CR40","doi-asserted-by":"publisher","unstructured":"Kanipandian N, Li D, Kannan S. Induction of intrinsic apoptotic signaling pathway in A549 lung cancer cells using silver nanoparticles from Gossypium hirsutum and evaluation of in vivo toxicity. Biotechnol Rep. Sep. 2019;23:e00339. https:\/\/doi.org\/10.1016\/J.BTRE.2019.E00339.","DOI":"10.1016\/J.BTRE.2019.E00339"},{"key":"3238_CR41","doi-asserted-by":"publisher","unstructured":"Madan S, Uttekar B, Chowdhary S, Rikhy R. Mitochondria lead the way: mitochondrial dynamics and function in cellular movements in development and disease. Front Cell Dev Biol. Feb. 2022;9:781933. https:\/\/doi.org\/10.3389\/FCELL.2021.781933.","DOI":"10.3389\/FCELL.2021.781933"},{"key":"3238_CR42","doi-asserted-by":"publisher","unstructured":"Shah MA, Rogoff HA. Implications of reactive oxygen species on cancer formation and its treatment. Semin Oncol. Jun. 2021;48(3):238\u201345. https:\/\/doi.org\/10.1053\/J.SEMINONCOL.2021.05.002.","DOI":"10.1053\/J.SEMINONCOL.2021.05.002"},{"key":"3238_CR43","doi-asserted-by":"publisher","unstructured":"Hinaz ZHF, Pragya S, Ezhilarasan D, Harini KS. Anticancer potential of Farnesol against human osteosarcoma Saos-2 cells and human colorectal carcinoma HCT-116 cells. Cureus. Nov. 2023;15(11):e49372. https:\/\/doi.org\/10.7759\/CUREUS.49372.","DOI":"10.7759\/CUREUS.49372"},{"key":"3238_CR44","doi-asserted-by":"publisher","unstructured":"Panda M, Tripathi SK, Biswal BK. Plumbagin promotes mitochondrial mediated apoptosis in gefitinib sensitive and resistant A549 lung cancer cell line through enhancing reactive oxygen species generation. Mol Biol Rep. Jun. 2020;47(6):4155\u201368. https:\/\/doi.org\/10.1007\/S11033-020-05464-W\/FIGURES\/8.","DOI":"10.1007\/S11033-020-05464-W\/FIGURES\/8"},{"key":"3238_CR45","doi-asserted-by":"publisher","unstructured":"Luo Z, Yao J, Wang Z, Xu J. Mitochondria in endothelial cells angiogenesis and function: current Understanding and future perspectives. J Transl Med. Dec. 2023;21(1):441. https:\/\/doi.org\/10.1186\/S12967-023-04286-1.","DOI":"10.1186\/S12967-023-04286-1"},{"key":"3238_CR46","doi-asserted-by":"publisher","unstructured":"Scheid AD, Beadnell TC, Welch DR. Roles of mitochondria in the hallmarks of metastasis, British Journal of Cancer 2020 124:1, vol. 124, no. 1, pp. 124\u2013135, Nov. 2020, https:\/\/doi.org\/10.1038\/s41416-020-01125-8","DOI":"10.1038\/s41416-020-01125-8"},{"key":"3238_CR47","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.2147\/OTT.S179870","volume":"12","author":"C Liu","year":"2019","unstructured":"Liu C, et al. Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer. Onco Targets Ther. 2019;12:3817. https:\/\/doi.org\/10.2147\/OTT.S179870.","journal-title":"Onco Targets Ther"},{"key":"3238_CR48","doi-asserted-by":"publisher","unstructured":"Wang T, Ma F, li Qian H. Defueling the cancer: ATP synthase as an emerging target in cancer therapy. Mol Ther Oncolytics. Dec. 2021;23:82. https:\/\/doi.org\/10.1016\/J.OMTO.2021.08.015.","DOI":"10.1016\/J.OMTO.2021.08.015"},{"key":"3238_CR49","doi-asserted-by":"publisher","unstructured":"Peng L et al. Jul., PRMT1 promotes Warburg effect by regulating the PKM2\/PKM1 ratio in non-small cell lung cancer, Cell Death & Disease 2024 15:7, vol. 15, no. 7, pp. 1\u201311, 2024, https:\/\/doi.org\/10.1038\/s41419-024-06898-x","DOI":"10.1038\/s41419-024-06898-x"},{"key":"3238_CR50","doi-asserted-by":"publisher","unstructured":"Hao S, et al. The role of transketolase in human cancer progression and therapy. Biomed Pharmacother. Oct. 2022;154:113607. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.113607.","DOI":"10.1016\/J.BIOPHA.2022.113607"},{"key":"3238_CR51","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/bs.acc.2014.12.002","volume":"69","author":"E Alegre","year":"2015","unstructured":"Alegre E, Sammamed M, Fern\u00e1ndez-Land\u00e1zuri S, Zubiri L, Gonz\u00e1lez \u00c1. Circulating biomarkers in malignant melanoma. Adv Clin Chem. 2015;69:47\u201389. https:\/\/doi.org\/10.1016\/bs.acc.2014.12.002.","journal-title":"Adv Clin Chem"},{"key":"3238_CR52","doi-asserted-by":"publisher","unstructured":"Ghanbari Movahed Z, Rastegari-Pouyani M, Mohammadi Mhossein, Mansouri K. Cancer cells change their glucose metabolism to overcome increased ROS: one step from cancer cell to cancer stem cell? Biomed Pharmacother. Apr. 2019;112:108690. https:\/\/doi.org\/10.1016\/J.BIOPHA.2019.108690.","DOI":"10.1016\/J.BIOPHA.2019.108690"},{"key":"3238_CR53","doi-asserted-by":"publisher","unstructured":"Wang S et al. Nov., Prognostic value of lactate dehydrogenase in non-small cell lung cancer patients with brain metastases: a retrospective cohort study, J Thorac Dis, vol. 14, no. 11, pp. 4468\u20134481, 2022, https:\/\/doi.org\/10.21037\/JTD-22-1502\/COIF","DOI":"10.21037\/JTD-22-1502\/COIF"},{"key":"3238_CR54","doi-asserted-by":"publisher","unstructured":"Fu H, et al. Aldolase A promotes proliferation and G1\/S transition via the EGFR\/MAPK pathway in non-small cell lung cancer. Cancer Commun (Lond). Dec. 2018;38(1). https:\/\/doi.org\/10.1186\/S40880-018-0290-3.","DOI":"10.1186\/S40880-018-0290-3"},{"key":"3238_CR55","doi-asserted-by":"publisher","unstructured":"Khaodee W, Inboot N, Udomsom S, Kumsaiyai W, Cressey R. Glucosidase II beta subunit (GluII\u03b2) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner, Cellular oncology (Dordrecht, Netherlands), vol. 40, no. 6, pp. 579\u2013591, Dec. 2017, https:\/\/doi.org\/10.1007\/S13402-017-0349-1","DOI":"10.1007\/S13402-017-0349-1"},{"key":"3238_CR56","doi-asserted-by":"publisher","unstructured":"Ke H, et al. FK506-binding proteins: emerging target and therapeutic opportunity in multiple tumors. Int J Biol Macromol. May 2025;307:141914. https:\/\/doi.org\/10.1016\/J.IJBIOMAC.2025.141914.","DOI":"10.1016\/J.IJBIOMAC.2025.141914"},{"key":"3238_CR57","doi-asserted-by":"publisher","unstructured":"Ye W, et al. Autophagy-Related signatures as prognostic indicators for hepatocellular carcinoma. Front Oncol. Mar. 2022;12:654449. https:\/\/doi.org\/10.3389\/FONC.2022.654449\/FULL.","DOI":"10.3389\/FONC.2022.654449\/FULL"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03238-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-026-03238-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03238-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:04:30Z","timestamp":1775649870000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-026-03238-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["3238"],"URL":"https:\/\/doi.org\/10.1007\/s12032-026-03238-1","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"26 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"134"}}