{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:46:48Z","timestamp":1784882808404,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"2021 Medical and Health Research Project of Heilongjiang Provincial Health Commission","award":["No.: 20210909010355"],"award-info":[{"award-number":["No.: 20210909010355"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-026-03278-7","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:23:59Z","timestamp":1769768639000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The upregulated RNA circ_0060055 regulates the proliferation, invasion and apoptosis of pancreatic cancer cells through spongy miR-1298-5p"],"prefix":"10.1007","volume":"43","author":[{"given":"Liguo","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ming","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"3278_CR1","doi-asserted-by":"crossref","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 Apr 4. doi: 10.3322\/caac.21834. Epub ahead of print. PMID: 38572751.","DOI":"10.3322\/caac.21834"},{"issue":"1","key":"3278_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7\u201333. https:\/\/doi.org\/10.3322\/caac.21708.","journal-title":"CA Cancer J Clin"},{"issue":"18","key":"3278_CR3","doi-asserted-by":"publisher","first-page":"7635","DOI":"10.18632\/aging.204310","volume":"14","author":"S Jiang","year":"2022","unstructured":"Jiang S, Fagman JB, Ma Y, Liu J, Vihav C, Engstrom C, Liu B, Chen C. A comprehensive review of pancreatic cancer and its therapeutic challenges. Aging. 2022;14(18):7635\u201349. https:\/\/doi.org\/10.18632\/aging.204310. Epub 2022 Sep 28. PMID: 36173644; PMCID: PMC9550249.","journal-title":"Aging"},{"issue":"1","key":"3278_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.clcc.2022.11.001","volume":"22","author":"R Ayasun","year":"2023","unstructured":"Ayasun R, Saridogan T, Gaber O, Sahin IH. Systemic therapy for patients with pancreatic cancer: current approaches and opportunities for novel avenues toward precision medicine. Clin Colorectal Cancer. 2023;22(1):2\u201311. https:\/\/doi.org\/10.1016\/j.clcc.2022.11.001.","journal-title":"Clin Colorectal Cancer"},{"issue":"2","key":"3278_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/13543784.2019.1557145","volume":"28","author":"S Chandana","year":"2019","unstructured":"Chandana S, Babiker HM, Mahadevan D. Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC). Expert Opin Investig Drugs. 2019;28(2):161\u201377. https:\/\/doi.org\/10.1080\/13543784.2019.1557145.","journal-title":"Expert Opin Investig Drugs"},{"issue":"11","key":"3278_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15112923","volume":"15","author":"L Mercanti","year":"2023","unstructured":"Mercanti L, Sindaco M, Mazzone M, Di Marcantonio MC, Piscione M, Muraro R, et al. PDAC, the influencer cancer: cross-talk with tumor microenvironment and connected potential therapy strategies. Cancers (Basel). 2023;15(11):2923. https:\/\/doi.org\/10.3390\/cancers15112923.","journal-title":"Cancers (Basel)"},{"key":"3278_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-031621-024600","volume":"18","author":"MH Sherman","year":"2023","unstructured":"Sherman MH, Beatty GL. Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance. Annu Rev Pathol. 2023;18:123\u201348. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-031621-024600.","journal-title":"Annu Rev Pathol"},{"key":"3278_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115217","volume":"165","author":"Z He","year":"2023","unstructured":"He Z, Zhu Q. Circular RNAs: emerging roles and new insights in human cancers. Biomed Pharmacother. 2023;165:115217. https:\/\/doi.org\/10.1016\/j.biopha.2023.115217.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"3278_CR9","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cell.2018.12.021","volume":"176","author":"JN Vo","year":"2019","unstructured":"Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, et al. The landscape of circular RNA in cancer. Cell. 2019;176(4):869-881.e13. https:\/\/doi.org\/10.1016\/j.cell.2018.12.021.","journal-title":"Cell"},{"issue":"7441","key":"3278_CR10","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333\u20138. https:\/\/doi.org\/10.1038\/nature11928.","journal-title":"Nature"},{"issue":"3","key":"3278_CR11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nsmb.2959","volume":"22","author":"Z Li","year":"2015","unstructured":"Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256\u201364. https:\/\/doi.org\/10.1038\/nsmb.2959.","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"3278_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12943-020-01196-4","volume":"19","author":"X Guo","year":"2020","unstructured":"Guo X, Zhou Q, Su D, Luo Y, Fu Z, Huang L, Li Z, Jiang D, Kong Y, Li Z, Chen R, Chen C. Circular RNA circbfar promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p\/MET\/Akt axis. Mol Cancer. 2020;19(1):83. https:\/\/doi.org\/10.1186\/s12943-020-01196-4. PMID: 32375768; PMCID: PMC7201986.","journal-title":"Mol Cancer"},{"issue":"1","key":"3278_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12943-020-01205-6","volume":"19","author":"Y Kong","year":"2020","unstructured":"Kong Y, Li Y, Luo Y, Zhu J, Zheng H, Gao B, Guo X, Li Z, Chen R, Chen C. circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p\/PIK3R1\/VEGF-C axis in pancreatic cancer. Mol Cancer. 2020;19(1):82. https:\/\/doi.org\/10.1186\/s12943-020-01205-6. PMID: 32366257; PMCID: PMC7197141.","journal-title":"Mol Cancer"},{"issue":"1","key":"3278_CR14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s13046-021-02063-w","volume":"40","author":"T Yang","year":"2021","unstructured":"Yang T, Shen P, Chen Q, Wu P, Yuan H, Ge W, Meng L, Huang X, Fu Y, Zhang Y, Hu W, Miao Y, Lu Z, Jiang K. FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600\/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. J Exp Clin Cancer Res. 2021;40(1):261. https:\/\/doi.org\/10.1186\/s13046-021-02063-w. PMID: 34416910; PMCID: PMC8377879.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"3278_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12943-021-01400-z","volume":"20","author":"Z Rong","year":"2021","unstructured":"Rong Z, Shi S, Tan Z, Xu J, Meng Q, Hua J, Liu J, Zhang B, Wang W, Yu X, Liang C. Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294\/c-Myc axis. Mol Cancer. 2021;20(1):106. https:\/\/doi.org\/10.1186\/s12943-021-01400-z. PMID: 34419070; PMCID: PMC8379744.","journal-title":"Mol Cancer"},{"issue":"11","key":"3278_CR16","first-page":"5610","volume":"13","author":"X Wangpu","year":"2023","unstructured":"Wangpu X, Zhao J, Yu C, Yu S, Wang H, Yuan Z, Huang X. CircATP13A1 (hsa_circ_0000919) promotes cell proliferation and metastasis and inhibits cell apoptosis in pancreatic ductal adenocarcinoma via the miR-186\/miR-326\/HMGA2 axis: implications for novel therapeutic targets. Am J Cancer Res. 2023;13(11):5610\u201325. PMID: 38058810; PMCID: PMC10695776.","journal-title":"Am J Cancer Res"},{"issue":"1","key":"3278_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bbrc.2018.12.088","volume":"509","author":"Y Xu","year":"2019","unstructured":"Xu Y, Yao Y, Gao P, Cui Y. Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294. Biochem Biophys Res Commun. 2019;509(1):29\u2013142. https:\/\/doi.org\/10.1016\/j.bbrc.2018.12.088.","journal-title":"Biochem Biophys Res Commun"},{"issue":"24","key":"3278_CR18","doi-asserted-by":"publisher","first-page":"11937","DOI":"10.18632\/aging.102519","volume":"11","author":"Z Pan","year":"2019","unstructured":"Pan Z, Lin J, Wu D, He X, Wang W, Hu X, et al. Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p\/HMGA2 axis in esophageal squamous cell carcinoma. Aging Albany NY. 2019;11(24):11937\u201354. https:\/\/doi.org\/10.18632\/aging.102519.","journal-title":"Aging Albany NY"},{"key":"3278_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2147\/CMAR.S280307","volume":"13","author":"T Zhang","year":"2021","unstructured":"Zhang T, Li M, Lu H, Peng T. Up-regulation of circEIF6 contributes to pancreatic cancer development through targeting miR-557\/SLC7A11\/PI3K\/AKT signaling. Cancer Manag Res. 2021;13:12\u2013258. https:\/\/doi.org\/10.2147\/CMAR.S280307.","journal-title":"Cancer Manag Res"},{"issue":"3","key":"3278_CR20","doi-asserted-by":"publisher","first-page":"5827","DOI":"10.1080\/21655979.2022.2036406","volume":"13","author":"T Huang","year":"2022","unstructured":"Huang T, Wang Y, Li M, Wang W, Qi Z, Li J. Circular RNA hsa_circ_0119412 contributes to tumorigenesis of gastric cancer via the regulation of the miR-1298-5p\/zinc finger BED-type containing 3 (ZBED3) axis. Bioengineered. 2022;13(3):5827\u201342. https:\/\/doi.org\/10.1080\/21655979.2022.2036406.","journal-title":"Bioengineered"},{"issue":"24","key":"3278_CR21","doi-asserted-by":"publisher","first-page":"6319","DOI":"10.1158\/1078-0432.CCR-18-1270","volume":"24","author":"X Chen","year":"2018","unstructured":"Chen X, Chen RX, Wei WS, Li YH, Feng ZH, Tan L, et al. PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging mir-30c to induce epithelial-mesenchymal transition. Clin Cancer Res. 2018;24(24):6319\u201330. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-1270.","journal-title":"Clin Cancer Res"},{"issue":"12","key":"3278_CR22","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","volume":"185","author":"CX Liu","year":"2022","unstructured":"Liu CX, Chen LL. Circular RNAs: characterization, cellular roles, and applications. Cell. 2022;185(12):2016\u201334. https:\/\/doi.org\/10.1016\/j.cell.2022.04.021.","journal-title":"Cell"},{"issue":"4","key":"3278_CR23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/15384101.2021.1874684","volume":"20","author":"X Han","year":"2021","unstructured":"Han X, Fang Y, Chen P, Xu Y, Zhou W, Rong Y, Li JA, Chen W, Lou W. Upregulated circrna hsa_circ_0071036 promotes tumourigenesis of pancreatic cancer by sponging miR-489 and predicts unfavorable characteristics and prognosis. Cell Cycle. 2021;20(4):369\u201382. Epub 2021 Jan 28. PMID: 33507122; PMCID: PMC7894420.","journal-title":"Cell Cycle"},{"issue":"6","key":"3278_CR24","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1159\/000453186","volume":"40","author":"H Li","year":"2016","unstructured":"Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Circular RNA expression profile of pancreatic ductal adenocarcinoma revealed by microarray. Cell Physiol Biochem. 2016;40(6):1334\u201344. Epub 2016 Dec 19. PMID: 27997903.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"3278_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12282-017-0793-9","volume":"25","author":"HD Zhang","year":"2018","unstructured":"Zhang HD, Jiang LH, Sun DW, Hou JC, Ji ZL. CircRNA: a novel type of biomarker for cancer. Breast Cancer. 2018;25(1):1\u20137. https:\/\/doi.org\/10.1007\/s12282-017-0793-9.","journal-title":"Breast Cancer"},{"issue":"4","key":"3278_CR26","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1016\/j.bbrc.2018.08.007","volume":"503","author":"L Song","year":"2018","unstructured":"Song L, Xiao Y. Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593\/MUC19 signal pathway. Biochem Biophys Res Commun. 2018;503(4):2603\u201310. https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.007.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3278_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03533-x","volume":"12","author":"H Li","year":"2021","unstructured":"Li H, Liu Q, Chen Z, Wu M, Zhang C, Su J, et al. Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p. Cell Death Dis. 2021;12(3):252. https:\/\/doi.org\/10.1038\/s41419-021-03533-x.","journal-title":"Cell Death Dis"},{"key":"3278_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.643362","volume":"11","author":"X Zhang","year":"2021","unstructured":"Zhang X, Li X, Fu X, Yu M, Qin G, Chen G, et al. Circular RNA TAF4B promotes bladder cancer progression by sponging miR-1298-5p and regulating TGFA expression. Front Oncol. 2021;11:643362. https:\/\/doi.org\/10.3389\/fonc.2021.643362.","journal-title":"Front Oncol"},{"issue":"3","key":"3278_CR29","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12921","volume":"22","author":"J Zhang","year":"2021","unstructured":"Zhang J, Hu C, Hu D, Fan Z. MicroRNA-1298-5p inhibits the tumorigenesis of breast cancer by targeting E2F1. Oncol Lett. 2021;22(3):660. https:\/\/doi.org\/10.3892\/ol.2021.12921.","journal-title":"Oncol Lett"},{"issue":"1","key":"3278_CR30","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1080\/21655979.2021.1935064","volume":"12","author":"H Guan","year":"2021","unstructured":"Guan H, Sun C, Gu Y, Li J, Ji J, Zhu Y. Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. Bioengineered. 2021;12(1):2326\u201340. PMID: 34077306; PMCID: PMC8806680.","journal-title":"Bioengineered"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03278-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-026-03278-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03278-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:03:38Z","timestamp":1775649818000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-026-03278-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["3278"],"URL":"https:\/\/doi.org\/10.1007\/s12032-026-03278-7","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"26 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Animal Ethical Care Committee of Qiqihar Medical University, which issued an approval with the designation QMU-AECC-2021-174.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"127"}}