{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:49:49Z","timestamp":1792097389167,"version":"4.4.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-026-03366-8","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:57:29Z","timestamp":1787986649000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuro\u2013immune crosstalk in lung cancer brain metastasis: mechanisms, therapeutic targets, and translational opportunities"],"prefix":"10.1007","volume":"43","author":[{"given":"Zhanhai","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"3366_CR1","doi-asserted-by":"publisher","first-page":"15009","DOI":"10.1038\/nrdp.2015.9","volume":"1","author":"C Gridelli","year":"2015","unstructured":"Gridelli C, Rossi A, Carbone DP, Guarize J, Karachaliou N, Mok T, Petrella F, Spaggiari L, Rosell R. Non-small-cell lung cancer. Nat Rev Dis Primers. 2015;1:15009. https:\/\/doi.org\/10.1038\/nrdp.2015.9.","journal-title":"Nat Rev Dis Primers"},{"key":"3366_CR2","doi-asserted-by":"publisher","first-page":"S103","DOI":"10.3747\/co.25.3733","volume":"25","author":"SM Abdallah","year":"2018","unstructured":"Abdallah SM, Wong A. Brain metastasis in non-small-cell lung cancer: are tyrosine kinase inhibitors and checkpoint inhibitors now viable options? Curr Oncol. 2018;25:S103\u201314. https:\/\/doi.org\/10.3747\/co.25.3733.","journal-title":"Curr Oncol"},{"key":"3366_CR3","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1200\/jco.20.01255","volume":"38","author":"PW Sperduto","year":"2020","unstructured":"Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, et al. Survival in Patients With Brain Metastasis: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient. J Clin Oncol. 2020;38:3773\u201384. https:\/\/doi.org\/10.1200\/jco.20.01255.","journal-title":"J Clin Oncol"},{"key":"3366_CR4","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/j.cell.2023.02.002","volume":"186","author":"F Winkler","year":"2023","unstructured":"Winkler F, Venkatesh HS, Amit M, Batchelor T, Demir IE, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbott D, Platten M, Rolls A, Sloan EK, Wang TC, Wick W, Venkataramani V, Monje M. Cancer neuroscience: State of the field, emerging directions. Cell. 2023;186:1689\u2013707. https:\/\/doi.org\/10.1016\/j.cell.2023.02.002.","journal-title":"Cell"},{"key":"3366_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.ccell.2023.02.012","volume":"41","author":"D Hanahan","year":"2023","unstructured":"Hanahan D, Monje M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell. 2023;41:573\u201380. https:\/\/doi.org\/10.1016\/j.ccell.2023.02.012.","journal-title":"Cancer Cell"},{"key":"3366_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41586-023-06036-1","volume":"617","author":"S Krishna","year":"2023","unstructured":"Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Gonzales N, Sudharshan C, Egladyous R, Almeida A, Zhang N, Molinaro Y, Venkatesh AM, Daniel HS, A. G. S., et al. Glioblastoma remodelling of human neural circuits decreases survival. Nature. 2023;617:599\u2013607. https:\/\/doi.org\/10.1038\/s41586-023-06036-1.","journal-title":"Nature"},{"key":"3366_CR7","doi-asserted-by":"publisher","unstructured":"Pan S, Yin K, Tang Z, Wang S, Chen Z, Wang Y, Zhu H, Han Y, Liu M, Jiang M, Xu N, Zhang G. Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice. Elife. 2021;10. https:\/\/doi.org\/10.7554\/eLife.67535.","DOI":"10.7554\/eLife.67535"},{"issue":"8060","key":"3366_CR8","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/s41586-025-08735-3","volume":"640","author":"V Thiel","year":"2025","unstructured":"Thiel V, Renders S, Panten J, Dross N, Bauer K, Azorin D, Henriques V, Vogel V, Klein C, Lepp\u00e4 AM, Ortega B, Schwickert I, Ourailidis J, Mochayedi I, Mallm J, M\u00fcller-Tidow JP, Monyer C, Neoptolemos H, Hackert J, T., et al. Characterization of single neurons reprogrammed by pancreatic cancer. Nature. 2025;640(8060):1042\u201351. https:\/\/doi.org\/10.1038\/s41586-025-08735-3.","journal-title":"Nature"},{"issue":"8059","key":"3366_CR9","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","volume":"640","author":"X Zhi","year":"2025","unstructured":"Zhi X, Wu F, Qian J, Ochiai Y, Lian G, Malagola E, Zheng B, Tu R, Zeng Y, Kobayashi H, Xia Z, Wang R, Peng Y, Shi Q, Chen D, Ryeom SW, Wang TC. Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis. Nature. 2025;640(8059):802\u201310. https:\/\/doi.org\/10.1038\/s41586-025-08591-1.","journal-title":"Nature"},{"key":"3366_CR10","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1158\/0008-5472.Can-20-2793","volume":"81","author":"DA Silverman","year":"2021","unstructured":"Silverman DA, Martinez VK, Dougherty PM, Myers JN, Calin GA, Amit M. Cancer-Associated Neurogenesis and Nerve-Cancer Cross-talk. Cancer Res. 2021;81:1431\u201340. https:\/\/doi.org\/10.1158\/0008-5472.Can-20-2793.","journal-title":"Cancer Res"},{"key":"3366_CR11","doi-asserted-by":"publisher","first-page":"109475","DOI":"10.1016\/j.celrep.2021.109475","volume":"36","author":"V Martirosian","year":"2021","unstructured":"Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, et al. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021;36:109475. https:\/\/doi.org\/10.1016\/j.celrep.2021.109475.","journal-title":"Cell Rep"},{"key":"3366_CR12","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1111\/cas.15355","volume":"113","author":"T Xiong","year":"2022","unstructured":"Xiong T, He P, Zhou M, Zhong D, Yang T, He W, Xu Z, Chen Z, Liu YW, Dai SS. Glutamate blunts cell-killing effects of neutrophils in tumor microenvironment. Cancer Sci. 2022;113:1955\u201367. https:\/\/doi.org\/10.1111\/cas.15355.","journal-title":"Cancer Sci"},{"key":"3366_CR13","doi-asserted-by":"publisher","first-page":"101594","DOI":"10.1016\/j.tranon.2022.101594","volume":"27","author":"P Chen","year":"2023","unstructured":"Chen P, Li Y, Liu R, Xie Y, Jin Y, Wang M, Yu Z, Wang W, Luo X. Non-small cell lung cancer-derived exosomes promote proliferation, phagocytosis, and secretion of microglia via exosomal microRNA in the metastatic microenvironment. Transl Oncol. 2023;27:101594. https:\/\/doi.org\/10.1016\/j.tranon.2022.101594.","journal-title":"Transl Oncol"},{"key":"3366_CR14","doi-asserted-by":"publisher","first-page":"4549","DOI":"10.1038\/s41467-024-48740-0","volume":"15","author":"X Ruan","year":"2024","unstructured":"Ruan X, Yan W, Cao M, Daza RAM, Fong MY, Yang K, Wu J, Liu X, Palomares M, Wu X, Li A, Chen Y, Jandial R, Spitzer NC, Hevner RF, Wang SE. Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis. Nat Commun. 2024;15:4549. https:\/\/doi.org\/10.1038\/s41467-024-48740-0.","journal-title":"Nat Commun"},{"issue":"5","key":"3366_CR15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41422-024-00946-z","volume":"34","author":"Q Xu","year":"2024","unstructured":"Xu Q, Cao Y, Kong F, Liu J, Chen X, Zhao Y, Lai CH, Zhou X, Hu H, Fu W, Chen J, Yang J. Multiple cancer cell types release LIF and Gal3 to hijack neural signals. Cell Res. 2024;34(5):345\u201354. https:\/\/doi.org\/10.1038\/s41422-024-00946-z.","journal-title":"Cell Res"},{"key":"3366_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41568-023-00556-8","volume":"23","author":"C Magnon","year":"2023","unstructured":"Magnon C, Hondermarck H. The neural addiction of cancer. Nat Rev Cancer. 2023;23:317\u201334. https:\/\/doi.org\/10.1038\/s41568-023-00556-8.","journal-title":"Nat Rev Cancer"},{"key":"3366_CR17","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.cmet.2022.04.003","volume":"34","author":"SA Best","year":"2022","unstructured":"Best SA, Gubser PM, Sethumadhavan S, Kersbergen A, Negr\u00f3n Abril YL, Goldford J, Sellers K, Abeysekera W, Garnham AL, McDonald JA, Weeden CE, Anderson D, Pirman D, Roddy TP, Creek DJ, Kallies A, Kingsbury G, Sutherland KD. Glutaminase inhibition impairs CD8 T cell activation in STK11-\/Lkb1-deficient lung cancer. Cell Metab. 2022;34:874\u2013e8876. https:\/\/doi.org\/10.1016\/j.cmet.2022.04.003.","journal-title":"Cell Metab"},{"issue":"5","key":"3366_CR18","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41422-025-01098-4","volume":"35","author":"K Wang","year":"2025","unstructured":"Wang K, Ni B, Xie Y, Li Z, Yuan L, Meng C, Zhao T, Gao S, Huang C, Wang H, Ma Y, Zhou T, Feng Y, Chang A, Yang C, Yu J, Yu W, Zang F, Zhang Y, et al. Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells. Cell Res. 2025;35(5):362\u201380. https:\/\/doi.org\/10.1038\/s41422-025-01098-4.","journal-title":"Cell Res"},{"key":"3366_CR19","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41591-025-03530-z","volume":"31","author":"S Tagore","year":"2025","unstructured":"Tagore S, Caprio L, Amin AD, Bestak K, Luthria K, D\u2019Souza E, Barrera I, Melms JC, Wu S, Abuzaid S, Wang Y, Jakubikova V, Koch P, Brodtman DZ, Bawa B, Deshmukh SK, Ebel L, Ibarra-Arellano MA, Jaiswal A, et al. Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastasis. Nat Med. 2025;31:1351\u201363. https:\/\/doi.org\/10.1038\/s41591-025-03530-z.","journal-title":"Nat Med"},{"key":"3366_CR20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.devcel.2024.01.010","volume":"59","author":"K Ishibashi","year":"2024","unstructured":"Ishibashi K, Ichinose T, Kadokawa R, Mizutani R, Iwabuchi S, Togi S, Ura H, Tange S, Shinjo K, Nakayama J, Nanjo S, Niida Y, Kondo Y, Hashimoto S, Sahai E, Yano S, Nakada M, Hirata E. Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR. Dev Cell. 2024;59:579\u2013e5946. https:\/\/doi.org\/10.1016\/j.devcel.2024.01.010.","journal-title":"Dev Cell"},{"key":"3366_CR21","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s12272-024-01487-0","volume":"47","author":"IJ Yeo","year":"2024","unstructured":"Yeo IJ, Yu JE, Kim SH, Kim DH, Jo M, Son DJ, Yun J, Han SB, Hong JT. TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level. Arch Pharm Res. 2024;47:341\u201359. https:\/\/doi.org\/10.1007\/s12272-024-01487-0.","journal-title":"Arch Pharm Res"},{"key":"3366_CR22","doi-asserted-by":"publisher","first-page":"eadh5548","DOI":"10.1126\/science.adh5548","volume":"384","author":"AE Whiteley","year":"2024","unstructured":"Whiteley AE, Ma D, Wang L, Yu SY, Yin C, Price TT, Simon BG, Xu KR, Marsh KA, Brockman ML, Prioleau TM, Zhou KI, Cui X, Fecci PE, Jeck WR, McCall CM, Neff JL, Sipkins DA. Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science. 2024;384:eadh5548. https:\/\/doi.org\/10.1126\/science.adh5548.","journal-title":"Science"},{"key":"3366_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","volume":"33","author":"BW Renz","year":"2018","unstructured":"Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, et al. \u03b22 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. Cancer Cell. 2018;33:75\u2013e907. https:\/\/doi.org\/10.1016\/j.ccell.2017.11.007.","journal-title":"Cancer Cell"},{"key":"3366_CR24","doi-asserted-by":"publisher","unstructured":"Sirico A, Simonelli S, Pignatiello S, Fulgione C, Sarno L, Chiuso F, Maruotti GM, Sansone M, Guida M, Insabato L. BDNF and NGF expression in preneoplastic cervical disease according to HIV status. Int J Mol Sci. 2023;24. https:\/\/doi.org\/10.3390\/ijms241310729.","DOI":"10.3390\/ijms241310729"},{"key":"3366_CR25","doi-asserted-by":"publisher","first-page":"108522","DOI":"10.1016\/j.pharmthera.2023.108522","volume":"250","author":"SU Khan","year":"2023","unstructured":"Khan SU, Fatima K, Malik F, Kalkavan H, Wani A. Cancer metastasis: Molecular mechanisms and clinical perspectives. Pharmacol Ther. 2023;250:108522. https:\/\/doi.org\/10.1016\/j.pharmthera.2023.108522.","journal-title":"Pharmacol Ther"},{"issue":"9","key":"3366_CR26","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1111\/cas.16241","volume":"115","author":"K Ishibashi","year":"2024","unstructured":"Ishibashi K, Hirata E. Multifaceted interactions between cancer cells and glial cells in brain metastasis. Cancer Sci. 2024;115(9):2871\u20138. https:\/\/doi.org\/10.1111\/cas.16241.","journal-title":"Cancer Sci"},{"key":"3366_CR27","doi-asserted-by":"publisher","unstructured":"Radin DP, Tsirka SE. Interactions between tumor cells, neurons, and microglia in the glioma microenvironment. Int J Mol Sci. 2020;21. https:\/\/doi.org\/10.3390\/ijms21228476.","DOI":"10.3390\/ijms21228476"},{"key":"3366_CR28","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nature18268","volume":"533","author":"Q Chen","year":"2016","unstructured":"Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, Jacob L, Patwa R, Shah H, Xu K, Cross JR, Massagu\u00e9 J. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016;533:493\u20138. https:\/\/doi.org\/10.1038\/nature18268.","journal-title":"Nature"},{"key":"3366_CR29","doi-asserted-by":"publisher","unstructured":"Wu SY, Xing F, Sharma S, Wu K, Tyagi A, Liu Y, Zhao D, Deshpande RP, Shiozawa Y, Ahmed T, Zhang W, Chan M, Ruiz J, Lycan TW, Dothard A, Watabe K. Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function. J Exp Med. 2020;217. https:\/\/doi.org\/10.1084\/jem.20191131.","DOI":"10.1084\/jem.20191131"},{"issue":"10","key":"3366_CR30","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.ccell.2024.08.015","volume":"42","author":"S Gan","year":"2024","unstructured":"Gan S, Macalinao DG, Shahoei SH, Tian L, Jin X, Basnet H, Bibby C, Muller JT, Atri P, Seffar E, Chatila W, Karacay A, Chanda P, Hadjantonakis AK, Schultz N, Brogi E, Bale TA, Moss NS, Murali R, et al. Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain. Cancer Cell. 2024;42(10):1693\u2013e171224. https:\/\/doi.org\/10.1016\/j.ccell.2024.08.015.","journal-title":"Cancer Cell"},{"key":"3366_CR31","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1038\/s41556-023-01273-y","volume":"25","author":"KT Evans","year":"2023","unstructured":"Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodr\u00edguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA. Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis. Nat Cell Biol. 2023;25:1848\u201359. https:\/\/doi.org\/10.1038\/s41556-023-01273-y.","journal-title":"Nat Cell Biol"},{"key":"3366_CR32","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s43018-023-00519-w","volume":"4","author":"O Adler","year":"2023","unstructured":"Adler O, Zait Y, Cohen N, Blazquez R, Doron H, Monteran L, Scharff Y, Shami T, Mundhe D, Glehr G, Kanner AA, Horn S, Yahalom V, Haferkamp S, Hutchinson JA, Bleckmann A, Nahary L, Benhar I, Katz Y, S., et al. Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2. Nat Cancer. 2023;4:401\u201318. https:\/\/doi.org\/10.1038\/s43018-023-00519-w.","journal-title":"Nat Cancer"},{"key":"3366_CR33","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/glia.23520","volume":"67","author":"M Brandao","year":"2019","unstructured":"Brandao M, Simon T, Critchley G, Giamas G. Astrocytes, the rising stars of the glioblastoma microenvironment. Glia. 2019;67:779\u201390. https:\/\/doi.org\/10.1002\/glia.23520.","journal-title":"Glia"},{"key":"3366_CR34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13073-018-0567-9","volume":"10","author":"J Yuan","year":"2018","unstructured":"Yuan J, Levitin HM, Frattini V, Bush EC, Boyett DM, Samanamud J, Ceccarelli M, Dovas A, Zanazzi G, Canoll P, Bruce JN, Lasorella A, Iavarone A, Sims PA. Single-cell transcriptome analysis of lineage diversity in high-grade glioma. Genome Med. 2018;10:57. https:\/\/doi.org\/10.1186\/s13073-018-0567-9.","journal-title":"Genome Med"},{"key":"3366_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09370-8","author":"EN Baruch","year":"2025","unstructured":"Baruch EN, Gleber-Netto FO, Nagarajan P, Rao X, Akhter S, Eichwald T, Xie T, Balood M, Adewale A, Naara S, Sathishkumar HN, Islam S, McCarthy W, Mattson BJ, Ferrarotto R, Wong MK, Davies MA, Jindal S, Basu S, et al. Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-09370-8.","journal-title":"Nature"},{"key":"3366_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11481-019-09891-w","volume":"15","author":"MB Nilsson","year":"2020","unstructured":"Nilsson MB, Le X, Heymach JV. \u03b2-Adrenergic Signaling in Lung Cancer: A Potential Role for Beta-Blockers. J Neuroimmune Pharmacol. 2020;15:27\u201336. https:\/\/doi.org\/10.1007\/s11481-019-09891-w.","journal-title":"J Neuroimmune Pharmacol"},{"key":"3366_CR37","doi-asserted-by":"publisher","first-page":"e29915","DOI":"10.1371\/journal.pone.0029915","volume":"7","author":"HA Al-Wadei","year":"2012","unstructured":"Al-Wadei HA, Al-Wadei MH, Schuller HM. Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention. PLoS ONE. 2012;7:e29915. https:\/\/doi.org\/10.1371\/journal.pone.0029915.","journal-title":"PLoS ONE"},{"key":"3366_CR38","doi-asserted-by":"publisher","unstructured":"Al Khashali H, Darweesh B, Ray R, Haddad B, Wozniak C, Ranzenberger R, Goel S, Khalil J, Guthrie J, Heyl D, Evans HG. Regulation of vascular endothelial growth factor signaling by nicotine in a manner dependent on acetylcholine-and\/or \u03b2-adrenergic-receptors in human lung cancer cells. Cancers (Basel). 2023;15. https:\/\/doi.org\/10.3390\/cancers15235500.","DOI":"10.3390\/cancers15235500"},{"issue":"Suppl 2","key":"3366_CR39","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1016\/s0169-5002(01)00346-4","volume":"34","author":"W Nikli\u0144ska","year":"2001","unstructured":"Nikli\u0144ska W, Burzykowski T, Chyczewski L, Nikli\u0144ski J. Expression of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC): association with p53 gene mutation and prognosis. Lung Cancer. 2001;34(Suppl 2):S59\u201364. https:\/\/doi.org\/10.1016\/s0169-5002(01)00346-4.","journal-title":"Lung Cancer"},{"key":"3366_CR40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41698-023-00370-3","volume":"7","author":"SK Alam","year":"2023","unstructured":"Alam SK, Wang L, Zhu Z, Hoeppner LH. IKK\u03b1 promotes lung adenocarcinoma growth through ERK signaling activation via DARPP-32-mediated inhibition of PP1 activity. NPJ Precis Oncol. 2023;7:33. https:\/\/doi.org\/10.1038\/s41698-023-00370-3.","journal-title":"NPJ Precis Oncol"},{"key":"3366_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41388-021-02028-5","volume":"41","author":"SK Alam","year":"2022","unstructured":"Alam SK, Zhang Y, Wang L, Zhu Z, Hernandez CE, Zhou Y, Yang N, Lei J, Chen X, Zeng L, Klein MA, Hoeppner LH. DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma. Oncogene. 2022;41:83\u201398. https:\/\/doi.org\/10.1038\/s41388-021-02028-5.","journal-title":"Oncogene"},{"key":"3366_CR42","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1002\/1878-0261.13608","volume":"18","author":"CE Grant","year":"2024","unstructured":"Grant CE, Flis AL, Toulabi L, Zingone A, Rossi E, Aploks K, Sheppard H, Ryan BM. DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC. Mol Oncol. 2024;18:1631\u201348. https:\/\/doi.org\/10.1002\/1878-0261.13608.","journal-title":"Mol Oncol"},{"key":"3366_CR43","doi-asserted-by":"publisher","first-page":"15444","DOI":"10.1038\/s41598-024-65835-2","volume":"14","author":"A Klupczynska-Gabryszak","year":"2024","unstructured":"Klupczynska-Gabryszak A, Daskalaki E, Wheelock CE, Kasprzyk M, Dyszkiewicz W, Grabicki M, Brajer-Luftmann B, Pawlak M, Kokot ZJ, Matysiak J. Metabolomics-based search for lung cancer markers among patients with different smoking status. Sci Rep. 2024;14:15444. https:\/\/doi.org\/10.1038\/s41598-024-65835-2.","journal-title":"Sci Rep"},{"key":"3366_CR44","doi-asserted-by":"publisher","first-page":"e13272","DOI":"10.7717\/peerj.13272","volume":"10","author":"K Liu","year":"2022","unstructured":"Liu K, Li J, Long T, Wang Y, Yin T, Long J, Shen Y, Cheng L. Changes in serum amino acid levels in non-small cell lung cancer: a case-control study in Chinese population. PeerJ. 2022;10:e13272. https:\/\/doi.org\/10.7717\/peerj.13272.","journal-title":"PeerJ"},{"key":"3366_CR45","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1158\/0008-5472.Can-20-0617","volume":"81","author":"W Guo","year":"2021","unstructured":"Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, et al. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2021;81:552\u201366. https:\/\/doi.org\/10.1158\/0008-5472.Can-20-0617.","journal-title":"Cancer Res"},{"key":"3366_CR46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11306-023-02045-3","volume":"19","author":"JW Lee","year":"2023","unstructured":"Lee JW, Lee H, Chun YS, Ahn J, Moon JY, Kim DK, Cho SK, Choi HK. Characterization of chemoresistant human non-small cell lung cancer cells by metabolic and lipidomic profiling. Metabolomics. 2023;19:80. https:\/\/doi.org\/10.1007\/s11306-023-02045-3.","journal-title":"Metabolomics"},{"key":"3366_CR47","doi-asserted-by":"publisher","unstructured":"Balakrishna P, George S, Hatoum H, Mukherjee S. Serotonin pathway in cancer. Int J Mol Sci. 2021;22. https:\/\/doi.org\/10.3390\/ijms22031268.","DOI":"10.3390\/ijms22031268"},{"key":"3366_CR48","doi-asserted-by":"publisher","first-page":"1901191","DOI":"10.1155\/2021\/1901191","volume":"2021","author":"JR Chen","year":"2021","unstructured":"Chen JR, Huang MS, Lee YC, Lin MH, Yang YF. Potential Clinical Value of 5-Hydroxytryptamine Receptor 3\u00a0C as a Prognostic Biomarker for Lung Cancer. J Oncol. 2021;2021:1901191. https:\/\/doi.org\/10.1155\/2021\/1901191.","journal-title":"J Oncol"},{"key":"3366_CR49","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1021\/acsptsci.3c00138","volume":"7","author":"K Arunrungvichian","year":"2024","unstructured":"Arunrungvichian K, Vajragupta O, Hayakawa Y, Pongrakhananon V. Targeting Alpha7 Nicotinic Acetylcholine Receptors in Lung Cancer: Insights, Challenges, and Therapeutic Strategies. ACS Pharmacol Transl Sci. 2024;7:28\u201341. https:\/\/doi.org\/10.1021\/acsptsci.3c00138.","journal-title":"ACS Pharmacol Transl Sci"},{"key":"3366_CR50","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13046-025-03315-9","volume":"44","author":"M Xie","year":"2025","unstructured":"Xie M, Qin H, Liu L, Wu J, Zhao Z, Zhao Y, Fang Y, Yu X, Su C. GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer. J Exp Clin Cancer Res. 2025;44:61. https:\/\/doi.org\/10.1186\/s13046-025-03315-9.","journal-title":"J Exp Clin Cancer Res"},{"key":"3366_CR51","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41419-021-04485-y","volume":"13","author":"XW Zhang","year":"2022","unstructured":"Zhang XW, Li L, Hu WQ, Hu MN, Tao Y, Hu H, Miao XK, Yang WL, Zhu Q, Mou LY. Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR. Cell Death Dis. 2022;13:41. https:\/\/doi.org\/10.1038\/s41419-021-04485-y.","journal-title":"Cell Death Dis"},{"key":"3366_CR52","doi-asserted-by":"publisher","unstructured":"Ricci A, Salvucci C, Castelli S, Carraturo A, de Vitis C, Ascanio D, M. Adenocarcinomas of the lung and neurotrophin system: a review. Biomedicines. 2022;10. https:\/\/doi.org\/10.3390\/biomedicines10102531.","DOI":"10.3390\/biomedicines10102531"},{"key":"3366_CR53","doi-asserted-by":"publisher","unstructured":"Dorandish S, Atali S, Ray R, Khashali A, Coleman H, Guthrie KL, Heyl J, D., Evans HG. Differences in the relative abundance of ProBDNF and mature BDNF in A549 and H1299 human lung cancer cell media. Int J Mol Sci. 2021;22. https:\/\/doi.org\/10.3390\/ijms22137059.","DOI":"10.3390\/ijms22137059"},{"key":"3366_CR54","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/imm.13581","volume":"168","author":"Q Yu","year":"2023","unstructured":"Yu Q, Wang Y, Yi G, Yang W, Chen K, Tan X, Zhang X, Xu Z, Yang Z, Peng Y. BDNF is a prognostic biomarker involved in immune infiltration of lung adenocarcinoma and is associated with brain metastasis. Immunology. 2023;168:320\u201330. https:\/\/doi.org\/10.1111\/imm.13581.","journal-title":"Immunology"},{"key":"3366_CR55","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1007\/s00432-022-04365-8","volume":"149","author":"M Malekan","year":"2023","unstructured":"Malekan M, Nezamabadi SS, Samami E, Mohebalizadeh M, Saghazadeh A, Rezaei N. BDNF and its signaling in cancer. J Cancer Res Clin Oncol. 2023;149:2621\u201336. https:\/\/doi.org\/10.1007\/s00432-022-04365-8.","journal-title":"J Cancer Res Clin Oncol"},{"key":"3366_CR56","doi-asserted-by":"publisher","unstructured":"Ray R, Goel S, Khashali A, Darweesh H, Haddad B, Wozniak B, Ranzenberger C, Khalil R, Guthrie J, Heyl J, D., Evans HG. Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and \u03b2-Adrenergic Receptor Ligands. Biomedicines. 2023;11. https:\/\/doi.org\/10.3390\/biomedicines11092555.","DOI":"10.3390\/biomedicines11092555"},{"key":"3366_CR57","doi-asserted-by":"publisher","unstructured":"Sierra-Rodero B, Cruz-Berm\u00fadez A, Nadal E, Garitaonaind\u00eda Y, Insa A, Mosquera J, Casal-Rubio J, D\u00f3mine M, Majem M, Rodriguez-Abreu D, Martinez-Marti A, De Castro Carpe\u00f1o J, Cobo M, L\u00f3pez Vivanco G, Del Barco E, Bernab\u00e9 Caro R, Vi\u00f1olas N, Aranda B, Viteri I, S., et al. Clinical and molecular parameters associated to pneumonitis development in non-small-cell lung cancer patients receiving chemoimmunotherapy from NADIM trial. J Immunother Cancer. 2021;9. https:\/\/doi.org\/10.1136\/jitc-2021-002804.","DOI":"10.1136\/jitc-2021-002804"},{"key":"3366_CR58","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/s1359-6101(03)00061-3","volume":"14","author":"GW Hoyle","year":"2003","unstructured":"Hoyle GW. Neurotrophins and lung disease. Cytokine Growth Factor Rev. 2003;14:551\u20138. https:\/\/doi.org\/10.1016\/s1359-6101(03)00061-3.","journal-title":"Cytokine Growth Factor Rev"},{"key":"3366_CR59","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2183\/pjab.98.008","volume":"98","author":"M Takahashi","year":"2022","unstructured":"Takahashi M. RET receptor signaling: Function in development, metabolic disease, and cancer. Proc Jpn Acad Ser B Phys Biol Sci. 2022;98:112\u201325. https:\/\/doi.org\/10.2183\/pjab.98.008.","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"3366_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2017.12.021","volume":"128","author":"R Roskoski Jr","year":"2018","unstructured":"Roskoski R Jr., Sadeghi-Nejad A. Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers. Pharmacol Res. 2018;128:1\u201317. https:\/\/doi.org\/10.1016\/j.phrs.2017.12.021.","journal-title":"Pharmacol Res"},{"key":"3366_CR61","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12575-023-00192-4","volume":"25","author":"L Ye","year":"2023","unstructured":"Ye L, Wu Y, Zhou J, Xie M, Zhang Z, Su C. Influence of Exosomes on Astrocytes in the Pre-Metastatic Niche of Lung Cancer Brain Metastasis. Biol Proced Online. 2023;25:5. https:\/\/doi.org\/10.1186\/s12575-023-00192-4.","journal-title":"Biol Proced Online"},{"key":"3366_CR62","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1186\/s12935-021-02263-6","volume":"21","author":"LY Ye","year":"2021","unstructured":"Ye LY, Sun LX, Zhong XH, Chen XS, Hu S, Xu RR, Zeng XN, Xie WP, Kong H. The structure of blood-tumor barrier and distribution of chemotherapeutic drugs in non-small cell lung cancer brain metastasis. Cancer Cell Int. 2021;21:556. https:\/\/doi.org\/10.1186\/s12935-021-02263-6.","journal-title":"Cancer Cell Int"},{"key":"3366_CR63","doi-asserted-by":"publisher","first-page":"216146","DOI":"10.1016\/j.canlet.2023.216146","volume":"561","author":"W Xu","year":"2023","unstructured":"Xu W, Patel N, Deng Y, Ding S, Wang T, Zhang H. Extracellular vesicle-derived LINC00482 induces microglial M2 polarization to facilitate brain metastasis of NSCLC. Cancer Lett. 2023;561:216146. https:\/\/doi.org\/10.1016\/j.canlet.2023.216146.","journal-title":"Cancer Lett"},{"key":"3366_CR64","doi-asserted-by":"publisher","first-page":"169","DOI":"10.14336\/ad.2023.0514","volume":"15","author":"Y Feng","year":"2024","unstructured":"Feng Y, Hu X, Zhang Y, Wang Y. The Role of Microglia in Brain Metastasis: Mechanisms and Strategies. Aging Dis. 2024;15:169\u201385. https:\/\/doi.org\/10.14336\/ad.2023.0514.","journal-title":"Aging Dis"},{"key":"3366_CR65","doi-asserted-by":"publisher","unstructured":"Souza VGP, Telkar N, Lam WL, Reis PP. Comprehensive analysis of lung adenocarcinoma and brain metastasis through integrated single-cell transcriptomics. Int J Mol Sci. 2024;25. https:\/\/doi.org\/10.3390\/ijms25073779.","DOI":"10.3390\/ijms25073779"},{"key":"3366_CR66","doi-asserted-by":"publisher","unstructured":"Chen Y, Zhang A, Wang J, Pan H, Liu L, Li R. Refining Lung Cancer Brain Metastasis Models for Spatiotemporal Dynamic Research and Personalized Therapy. Cancers (Basel). 2025;17. https:\/\/doi.org\/10.3390\/cancers17091588.","DOI":"10.3390\/cancers17091588"},{"key":"3366_CR67","doi-asserted-by":"publisher","first-page":"4193541","DOI":"10.1155\/2020\/4193541","volume":"2020","author":"M Lombardi","year":"2020","unstructured":"Lombardi M, D\u2019Ascanio M, Scarpino S, Scozzi D, Giordano M, Costarelli L, Raj ER, Mancini R, Cardillo G, Cardaci V, Innammorato M, Vecchione A, Ricci A. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. Biomed Res Int. 2020;2020:4193541. https:\/\/doi.org\/10.1155\/2020\/4193541.","journal-title":"Biomed Res Int"},{"key":"3366_CR68","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.1038\/s41467-022-33365-y","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Abdo R, Iosef C, Kaneko T, Cecchini M, Han VK, Li SS. The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis. Nat Commun. 2022;13:5983. https:\/\/doi.org\/10.1038\/s41467-022-33365-y.","journal-title":"Nat Commun"},{"key":"3366_CR69","doi-asserted-by":"publisher","unstructured":"Zhao Y, Zhang D, Meng B, Zhang Y, Ma S, Zeng J, Wang X, Peng T, Gong X, Zhai R, Dong L, Jiang Y, Dai X, Fang X, Jia W. Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastasis from lung adenocarcinomas. Cancer Lett. 2024;217262. https:\/\/doi.org\/10.1016\/j.canlet.2024.217262.","DOI":"10.1016\/j.canlet.2024.217262"},{"key":"3366_CR70","doi-asserted-by":"publisher","first-page":"e2306348","DOI":"10.1002\/advs.202306348","volume":"11","author":"M Tang","year":"2024","unstructured":"Tang M, Xu M, Wang J, Liu Y, Liang K, Jin Y, Duan W, Xia S, Li G, Chu H, Liu W, Wang Q. Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape. Adv Sci (Weinh). 2024;11:e2306348. https:\/\/doi.org\/10.1002\/advs.202306348.","journal-title":"Adv Sci (Weinh)"},{"key":"3366_CR71","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1080\/15548627.2021.1872187","volume":"17","author":"A Wani","year":"2021","unstructured":"Wani A, Al Rihani SB, Sharma A, Weadick B, Govindarajan R, Khan SU, Sharma PR, Dogra A, Nandi U, Reddy CN, Bharate SS, Singh G, Bharate SB, Vishwakarma RA, Kaddoumi A, Kumar A. Crocetin promotes clearance of amyloid-\u03b2 by inducing autophagy via the STK11\/LKB1-mediated AMPK pathway. Autophagy. 2021;17:3813\u201332. https:\/\/doi.org\/10.1080\/15548627.2021.1872187.","journal-title":"Autophagy"},{"key":"3366_CR72","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s41591-018-0044-4","volume":"24","author":"N Priego","year":"2018","unstructured":"Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Mart\u00ednez L, Mart\u00ednez-Saez E, Ram\u00f3n Y, Cajal S, Meg\u00edas D, Hern\u00e1ndez-Encinas E, Blanco-Aparicio C, Mart\u00ednez L, Zarzuela E, Mu\u00f1oz J, Fustero-Torre C, Pi\u00f1eiro-Y\u00e1\u00f1ez E, Hern\u00e1ndez-La\u00edn A, et al. STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis. Nat Med. 2018;24:1024\u201335. https:\/\/doi.org\/10.1038\/s41591-018-0044-4.","journal-title":"Nat Med"},{"key":"3366_CR73","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1038\/s41556-023-01241-6","volume":"25","author":"F Qu","year":"2023","unstructured":"Qu F, Brough SC, Michno W, Madubata CJ, Hartmann GG, Puno A, Drainas AP, Bhattacharya D, Tomasich E, Lee MC, Yang D, Kim J, Peiris-Pag\u00e8s M, Simpson KL, Dive C, Preusser M, Toland A, Kong C, Das M, et al. Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis. Nat Cell Biol. 2023;25:1506\u201319. https:\/\/doi.org\/10.1038\/s41556-023-01241-6.","journal-title":"Nat Cell Biol"},{"key":"3366_CR74","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1158\/1541-7786.Mcr-24-0265","volume":"22","author":"GG Hartmann","year":"2024","unstructured":"Hartmann GG, Sage J. Small Cell Lung Cancer Neuronal Features and Their Implications for Tumor Progression, Metastasis, and Therapy. Mol Cancer Res. 2024;22:787\u201395. https:\/\/doi.org\/10.1158\/1541-7786.Mcr-24-0265.","journal-title":"Mol Cancer Res"},{"key":"3366_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12964-023-01302-1","volume":"22","author":"SU Khan","year":"2024","unstructured":"Khan SU, Fatima K, Aisha S, Malik F. Unveiling the mechanisms and challenges of cancer drug resistance. Cell Commun Signal. 2024;22:109. https:\/\/doi.org\/10.1186\/s12964-023-01302-1.","journal-title":"Cell Commun Signal"},{"key":"3366_CR76","doi-asserted-by":"publisher","first-page":"101533","DOI":"10.1016\/j.xcrm.2024.101533","volume":"5","author":"L Wang","year":"2024","unstructured":"Wang L, Li C, Zhan H, Li S, Zeng K, Xu C, Zou Y, Xie Y, Zhan Z, Yin S, Zeng Y, Chen X, Lv G, Han Z, Zhou D, Zhou D, Yang Y, Zhou A. Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity. Cell Rep Med. 2024;5:101533. https:\/\/doi.org\/10.1016\/j.xcrm.2024.101533.","journal-title":"Cell Rep Med"},{"key":"3366_CR77","doi-asserted-by":"publisher","first-page":"217739","DOI":"10.1016\/j.canlet.2025.217739","volume":"624","author":"S Shovlin","year":"2025","unstructured":"Shovlin S, Young LS, Vare\u0161lija D. Hormonal and neuronal interactions shaping the brain metastatic microenvironment. Cancer Lett. 2025;624:217739. https:\/\/doi.org\/10.1016\/j.canlet.2025.217739.","journal-title":"Cancer Lett"},{"key":"3366_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09434-9","author":"V Sakthivelu","year":"2025","unstructured":"Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Caiaffa I, Ibruli M, Weber O, Maresch J, Bebber R, C. M., et al. Functional synapses between neurons and small cell lung cancer. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-09434-9.","journal-title":"Nature"},{"key":"3366_CR79","doi-asserted-by":"publisher","first-page":"121855","DOI":"10.1016\/j.lfs.2023.121855","volume":"330","author":"HT Chien","year":"2023","unstructured":"Chien HT, Li CY, Su WH, Chang KC, Chen CS, Liu YT, Chen CY, Dai CY, Wang SC. Multi-omics profiling of chemotactic characteristics of brain microglia and astrocytoma. Life Sci. 2023;330:121855. https:\/\/doi.org\/10.1016\/j.lfs.2023.121855.","journal-title":"Life Sci"},{"key":"3366_CR80","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41591-023-02255-1","volume":"29","author":"D Sturm","year":"2023","unstructured":"Sturm D, Capper D, Andreiuolo F, Gessi M, K\u00f6lsche C, Reinhardt A, Sievers P, Wefers AK, Ebrahimi A, Suwala AK, Gielen GH, Sill M, Schrimpf D, Stichel D, Hovestadt V, Daenekas B, Rode A, Hamelmann S, Previti C, et al. Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology. Nat Med. 2023;29:917\u201326. https:\/\/doi.org\/10.1038\/s41591-023-02255-1.","journal-title":"Nat Med"},{"key":"3366_CR81","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s43018-022-00491-x","volume":"4","author":"S Garcia-Recio","year":"2023","unstructured":"Garcia-Recio S, Hinoue T, Wheeler GL, Kelly BJ, Garrido-Castro AC, Pascual T, De Cubas AA, Xia Y, Felsheim BM, McClure MB, Rajkovic A, Karaesmen E, Smith MA, Fan C, Ericsson PIG, Sanders ME, Creighton CJ, Bowen J, Leraas K, et al. Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis. Nat Cancer. 2023;4:128\u201347. https:\/\/doi.org\/10.1038\/s43018-022-00491-x.","journal-title":"Nat Cancer"},{"key":"3366_CR82","doi-asserted-by":"publisher","first-page":"eadn4306","DOI":"10.1126\/sciadv.adn4306","volume":"10","author":"X Wang","year":"2024","unstructured":"Wang X, Sun Q, Liu T, Lu H, Lin X, Wang W, Liu Y, Huang Y, Huang G, Sun H, Chen Q, Wang J, Tian D, Yuan F, Liu L, Wang B, Gu Y, Liu B, Chen L. Single-cell multi-omics sequencing uncovers region-specific plasticity of glioblastoma for complementary therapeutic targeting. Sci Adv. 2024;10:eadn4306. https:\/\/doi.org\/10.1126\/sciadv.adn4306.","journal-title":"Sci Adv"},{"key":"3366_CR83","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1093\/neuonc\/noad017","volume":"25","author":"Z Wang","year":"2023","unstructured":"Wang Z, Wang Y, Chang M, Wang Y, Liu P, Wu J, Wang G, Tang X, Hui X, Liu P, Guo X, Xing B, Wang Y, Han Z, Ma W. Single-cell transcriptomic analyses provide insights into the cellular origins and drivers of brain metastasis from lung adenocarcinoma. Neuro Oncol. 2023;25:1262\u201374. https:\/\/doi.org\/10.1093\/neuonc\/noad017.","journal-title":"Neuro Oncol"},{"key":"3366_CR84","doi-asserted-by":"publisher","first-page":"e1101","DOI":"10.1002\/ctm2.1101","volume":"12","author":"HF Sun","year":"2022","unstructured":"Sun HF, Li LD, Lao IW, Li X, Xu BJ, Cao YQ, Jin W. Single-cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastasis. Clin Transl Med. 2022;12:e1101. https:\/\/doi.org\/10.1002\/ctm2.1101.","journal-title":"Clin Transl Med"},{"key":"3366_CR85","doi-asserted-by":"publisher","first-page":"e2203699","DOI":"10.1002\/advs.202203699","volume":"10","author":"Y Zou","year":"2023","unstructured":"Zou Y, Ye F, Kong Y, Hu X, Deng X, Xie J, Song C, Ou X, Wu S, Wu L, Xie Y, Tian W, Tang Y, Wong CW, Chen ZS, Xie X, Tang H. The Single-Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastasis of Breast Cancer. Adv Sci (Weinh). 2023;10:e2203699. https:\/\/doi.org\/10.1002\/advs.202203699.","journal-title":"Adv Sci (Weinh)"},{"key":"3366_CR86","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/s41590-022-01215-0","volume":"23","author":"AT Yeo","year":"2022","unstructured":"Yeo AT, Rawal S, Delcuze B, Christofides A, Atayde A, Strauss L, Balaj L, Rogers VA, Uhlmann EJ, Varma H, Carter BS, Boussiotis VA, Charest A. Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression. Nat Immunol. 2022;23:971\u201384. https:\/\/doi.org\/10.1038\/s41590-022-01215-0.","journal-title":"Nat Immunol"},{"key":"3366_CR87","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1016\/j.cell.2024.03.029","volume":"187","author":"AC Greenwald","year":"2024","unstructured":"Greenwald AC, Darnell NG, Hoefflin R, Simkin D, Mount CW, Gonzalez Castro LN, Harnik Y, Dumont S, Hirsch D, Nomura M, Talpir T, Kedmi M, Goliand I, Medici G, Laffy J, Li B, Mangena V, Keren-Shaul H, Weller M, et al. Integrative spatial analysis reveals a multi-layered organization of glioblastoma. Cell. 2024;187:2485\u2013e250126. https:\/\/doi.org\/10.1016\/j.cell.2024.03.029.","journal-title":"Cell"},{"key":"3366_CR88","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.ccell.2022.05.009","volume":"40","author":"VM Ravi","year":"2022","unstructured":"Ravi VM, Will P, Kueckelhaus J, Sun N, Joseph K, Sali\u00e9 H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane JK, Neidert N, Follo M, Scherer F, Goeldner JM, Behringer SP, Franco P, Khiat M, Zhang J, Hofmann UG, et al. Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. Cancer Cell. 2022;40:639\u2013e65513. https:\/\/doi.org\/10.1016\/j.ccell.2022.05.009.","journal-title":"Cancer Cell"},{"key":"3366_CR89","doi-asserted-by":"publisher","first-page":"100620","DOI":"10.1016\/j.xcrm.2022.100620","volume":"3","author":"LJ Sudmeier","year":"2022","unstructured":"Sudmeier LJ, Hoang KB, Nduom EK, Wieland A, Neill SG, Schniederjan MJ, Ramalingam SS, Olson JJ, Ahmed R, Hudson WH. Distinct phenotypic states and spatial distribution of CD8\u2009+\u2009T cell clonotypes in human brain metastasis. Cell Rep Med. 2022;3:100620. https:\/\/doi.org\/10.1016\/j.xcrm.2022.100620.","journal-title":"Cell Rep Med"},{"key":"3366_CR90","doi-asserted-by":"publisher","first-page":"5029","DOI":"10.1038\/s41467-023-40271-4","volume":"14","author":"R Arora","year":"2023","unstructured":"Arora R, Cao C, Kumar M, Sinha S, Chanda A, McNeil R, Samuel D, Arora RK, Matthews TW, Chandarana S, Hart R, Dort JC, Biernaskie J, Neri P, Hyrcza MD, Bose P. Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response. Nat Commun. 2023;14:5029. https:\/\/doi.org\/10.1038\/s41467-023-40271-4.","journal-title":"Nat Commun"},{"issue":"9","key":"3366_CR91","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1038\/s42255-024-01118-4","volume":"6","author":"E Buglakova","year":"2024","unstructured":"Buglakova E, Ekel\u00f6f M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Shahraz M, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A, Snaebjornsson MT, Alexandrov T. Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer. Nat Metab. 2024;6(9):1695\u2013711. https:\/\/doi.org\/10.1038\/s42255-024-01118-4.","journal-title":"Nat Metab"},{"key":"3366_CR92","doi-asserted-by":"publisher","first-page":"101345","DOI":"10.1016\/j.xpro.2022.101345","volume":"3","author":"PK Parida","year":"2022","unstructured":"Parida PK, Marquez-Palencia M, Kaushik AK, Kim K, Nair V, Sudderth J, Vu H, Zacharias L, DeBerardinis R, Malladi S. Optimized protocol for stable isotope tracing and steady-state metabolomics in mouse HER2\u2009+\u2009breast cancer brain metastasis. STAR Protoc. 2022;3:101345. https:\/\/doi.org\/10.1016\/j.xpro.2022.101345.","journal-title":"STAR Protoc"},{"key":"3366_CR93","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1111\/cns.14272","volume":"29","author":"J Wen","year":"2023","unstructured":"Wen J, Liu F, Cheng Q, Weygant N, Liang X, Fan F, Li C, Zhang L, Liu Z. Applications of organoid technology to brain tumors. CNS Neurosci Ther. 2023;29:2725\u201343. https:\/\/doi.org\/10.1111\/cns.14272.","journal-title":"CNS Neurosci Ther"},{"key":"3366_CR94","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.cell.2015.02.038","volume":"160","author":"S Chen","year":"2015","unstructured":"Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015;160:1246\u201360. https:\/\/doi.org\/10.1016\/j.cell.2015.02.038.","journal-title":"Cell"},{"key":"3366_CR95","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","volume":"159","author":"RJ Platt","year":"2014","unstructured":"Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014;159:440\u201355. https:\/\/doi.org\/10.1016\/j.cell.2014.09.014.","journal-title":"Cell"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03366-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-026-03366-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03366-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:42:09Z","timestamp":1792096929000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-026-03366-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":95,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["3366"],"URL":"https:\/\/doi.org\/10.1007\/s12032-026-03366-8","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"4 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"260"}}