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We conducted a PROSPERO-registered systematic review (CRD420251142673) to evaluate the prognostic and biological impact of\n                    <jats:italic>ATM<\/jats:italic>\n                    alterations in MDS, AML, and MPN. Ten studies met inclusion criteria. In MDS,\n                    <jats:italic>ATM<\/jats:italic>\n                    alterations showed consistent downregulation, hypermethylation, and a predominance of oncogenic missense mutations, with methylation significantly enriched in cases progressing to AML. In AML, reduced\n                    <jats:italic>ATM<\/jats:italic>\n                    gene expression, often driven by miR-100 or miR-181a, was associated with increased blast proliferation, while the\n                    <jats:italic>ATM<\/jats:italic>\n                    genetic variant rs3092856 correlated with chemoresistance and inferior survival. Evidence in MPN\/CML, although limited, suggests that\n                    <jats:italic>ATM<\/jats:italic>\n                    polymorphisms, such as rs228593, rs3092856 (C4138T), \u22125144A&gt;T (rs228589), c.5753G&gt;C, c.346A&gt;G, c.4060C&gt;A, and the germline variant L2307F, contribute to disease susceptibility and adverse prognostic stratification. Collectively, current evidence supports\n                    <jats:italic>ATM<\/jats:italic>\n                    alterations as clinically relevant biomarkers in myeloid malignancies, although their functional role in disease pathogenesis remains incompletely understood.. Rather than establishing\n                    <jats:italic>ATM<\/jats:italic>\n                    merely as a prognostic marker, future efforts should prioritize the characterization of\n                    <jats:italic>ATM<\/jats:italic>\n                    -related therapeutic vulnerabilities and integrate\n                    <jats:italic>ATM<\/jats:italic>\n                    status into treatment-oriented molecular panels to guide precision-based interventions in myeloid diseases.\n                  <\/jats:p>","DOI":"10.1007\/s12032-026-03378-4","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:41:21Z","timestamp":1790311281000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ATM mutations in myelodysplastic neoplasms, acute myeloid leukemia, and myeloproliferative neoplasms: a systematic review"],"prefix":"10.1007","volume":"43","author":[{"given":"Lucas Oliveira","family":"Laurindo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjori Lima Boblitz","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greyce Luri","family":"Sasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor Caetano","family":"Goes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Rodrigues","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri Vasconcelos","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Feitosa","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"3378_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2016.12.049","volume":"107","author":"J Cadet","year":"2017","unstructured":"Cadet J, Davies KJA, Medeiros MH, Di Mascio P, Wagner JR. 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