{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:50:32Z","timestamp":1791273032189,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20519"],"award-info":[{"award-number":["U23A20519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"DOI":"10.1007\/s12032-026-03413-4","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:52:30Z","timestamp":1791269550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism of Coumarin in the anti-liver cancer activity by promoting NK cell activation"],"prefix":"10.1007","volume":"43","author":[{"given":"Jincai","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongliang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaodi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"3413_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01737-7","volume":"22","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Cheng L, Liu L, Li X. NK cells are never alone: crosstalk and communication in tumour microenvironments. Mol Cancer. 2023;22:34. https:\/\/doi.org\/10.1186\/s12943-023-01737-7.","journal-title":"Mol Cancer"},{"key":"3413_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","volume":"18","author":"JA Myers","year":"2021","unstructured":"Myers JA, Miller JS. Exploring the NK cell platform for cancer immunotherapy. Nat Rev Clin Oncol. 2021;18:85\u2013100. https:\/\/doi.org\/10.1038\/s41571-020-0426-7.","journal-title":"Nat Rev Clin Oncol"},{"key":"3413_CR3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41423-021-00808-3","volume":"19","author":"F Fang","year":"2022","unstructured":"Fang F, Xie S, Chen M, Li Y, Yue J, Ma J, et al. Advances in NK cell production. Cell Mol Immunol. 2022;19:460\u201381. https:\/\/doi.org\/10.1038\/s41423-021-00808-3.","journal-title":"Cell Mol Immunol"},{"key":"3413_CR4","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.jhep.2024.01.028","volume":"80","author":"R Xiao","year":"2024","unstructured":"Xiao R, Tian Y, Zhang J, Li N, Qi M, Liu L, et al. Increased Siglec-9\/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy. J Hepatol. 2024;80:792\u2013804. https:\/\/doi.org\/10.1016\/j.jhep.2024.01.028.","journal-title":"J Hepatol"},{"key":"3413_CR5","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.cmet.2025.01.011","volume":"37","author":"H Wei","year":"2025","unstructured":"Wei H, Suo C, Gu X, Shen S, Lin K, Zhu C, et al. AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity. Cell Metab. 2025;37:1103-1118.e1107. https:\/\/doi.org\/10.1016\/j.cmet.2025.01.011.","journal-title":"Cell Metab"},{"key":"3413_CR6","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.20892\/j.issn.2095-3941.2022.0050","volume":"19","author":"H Liu","year":"2022","unstructured":"Liu H, Zhao R, Qin R, Sun H, Huang Q, Liu L, et al. Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing. Cancer Biol Med. 2022;19:1334\u201351. https:\/\/doi.org\/10.20892\/j.issn.2095-3941.2022.0050.","journal-title":"Cancer Biol Med"},{"key":"3413_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.stem.2024.06.009","volume":"31","author":"JL Thangaraj","year":"2024","unstructured":"Thangaraj JL, Coffey M, Lopez E, Kaufman DS. Disruption of TGF-\u03b2 signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells. Cell Stem Cell. 2024;31:1327-1343.e1325. https:\/\/doi.org\/10.1016\/j.stem.2024.06.009.","journal-title":"Cell Stem Cell"},{"key":"3413_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116270","volume":"225","author":"M Pociupany","year":"2024","unstructured":"Pociupany M, Snoeck R, Dierickx D, Andrei G. Treatment of Epstein-Barr virus infection in immunocompromised patients. Biochem Pharmacol. 2024;225:116270. https:\/\/doi.org\/10.1016\/j.bcp.2024.116270.","journal-title":"Biochem Pharmacol"},{"key":"3413_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.824208","volume":"12","author":"X Zheng","year":"2022","unstructured":"Zheng X, Liu X, Lei Y, Wang G, Liu M. Glypican-3: a novel and promising target for the treatment of hepatocellular carcinoma. Front Oncol. 2022;12:824208. https:\/\/doi.org\/10.3389\/fonc.2022.824208.","journal-title":"Front Oncol"},{"key":"3413_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111405","volume":"124","author":"X Wang","year":"2024","unstructured":"Wang X, Yang T, Shi X. NK cell-based immunotherapy in hepatocellular carcinoma: an attractive therapeutic option for the next decade. Cell Signal. 2024;124:111405. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111405.","journal-title":"Cell Signal"},{"key":"3413_CR11","doi-asserted-by":"publisher","first-page":"206","DOI":"10.2174\/0109298665351592250106062250","volume":"32","author":"G Lyu","year":"2025","unstructured":"Lyu G, Li D. ZNF165: a pan-cancer biomarker with prognostic and therapeutic potential. Protein Pept Lett. 2025;32:206\u201323. https:\/\/doi.org\/10.2174\/0109298665351592250106062250.","journal-title":"Protein Pept Lett"},{"key":"3413_CR12","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.jhep.2023.06.021","volume":"79","author":"L Wang","year":"2023","unstructured":"Wang L, Zhu L, Liang C, Huang X, Liu Z, Huo J, et al. Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis. J Hepatol. 2023;79:1185\u2013200. https:\/\/doi.org\/10.1016\/j.jhep.2023.06.021.","journal-title":"J Hepatol"},{"key":"3413_CR13","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000001446","author":"PC Lee","year":"2025","unstructured":"Lee PC, Wu CJ, Hung YW, Lee CJ, Mon HC, Chi CT, et al. Distinct gut microbiota but common metabolomic signatures between viral and MASLD HCC contribute to outcomes of combination immunotherapy. Hepatology. 2025. https:\/\/doi.org\/10.1097\/hep.0000000000001446.","journal-title":"Hepatology"},{"key":"3413_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.jhep.2020.10.016","volume":"74","author":"GN Ioannou","year":"2021","unstructured":"Ioannou GN. HCC surveillance after SVR in patients with F3\/F4 fibrosis. J Hepatol. 2021;74:458\u201365. https:\/\/doi.org\/10.1016\/j.jhep.2020.10.016.","journal-title":"J Hepatol"},{"key":"3413_CR15","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2174\/0929866530666230217160717","volume":"30","author":"T Li","year":"2023","unstructured":"Li T, Li T, Wang Z, Jin Y. Cyclopeptide-based anti-liver cancer agents: a mini-review. Protein Pept Lett. 2023;30:201\u201313. https:\/\/doi.org\/10.2174\/0929866530666230217160717.","journal-title":"Protein Pept Lett"},{"key":"3413_CR16","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1002\/hep.31855","volume":"74","author":"X Xu","year":"2021","unstructured":"Xu X, Ye L, Zhang Q, Shen H, Li S, Zhang X, et al. Group-2 innate lymphoid cells promote HCC progression through CXCL2-neutrophil-induced immunosuppression. Hepatology. 2021;74:2526\u201343. https:\/\/doi.org\/10.1002\/hep.31855.","journal-title":"Hepatology"},{"key":"3413_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41423-020-00572-w","volume":"18","author":"B Ruf","year":"2021","unstructured":"Ruf B, Heinrich B, Greten TF. Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells. Cell Mol Immunol. 2021;18:112\u201327. https:\/\/doi.org\/10.1038\/s41423-020-00572-w.","journal-title":"Cell Mol Immunol"},{"key":"3413_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1333864","volume":"14","author":"T Liu","year":"2023","unstructured":"Liu T, Guo Y, Liao Y, Liu J. Mechanism-guided fine-tuned microbiome potentiates anti-tumor immunity in HCC. Front Immunol. 2023;14:1333864. https:\/\/doi.org\/10.3389\/fimmu.2023.1333864.","journal-title":"Front Immunol"},{"key":"3413_CR19","doi-asserted-by":"publisher","DOI":"10.25259\/Cytojournal_273_2024","volume":"22","author":"T Yu","year":"2025","unstructured":"Yu T, Zhao X, Dong C, Lu H, Wang Y, Luo X, et al. AZ-628 sensitizes donafenib in hepatocellular carcinoma by targeting tyrosine kinase pathway and ferroptosis. Cytojournal. 2025;22:88. https:\/\/doi.org\/10.25259\/Cytojournal_273_2024.","journal-title":"Cytojournal"},{"key":"3413_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417686","volume":"12","author":"W Mu","year":"2025","unstructured":"Mu W, Xu G, Li L, Wen J, Xiu Y, Zhao J, et al. Carnosic Acid directly targets STING C-terminal tail to improve STING-mediated inflammatory diseases. Adv Sci. 2025;12:e2417686. https:\/\/doi.org\/10.1002\/advs.202417686.","journal-title":"Adv Sci"},{"key":"3413_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155404","volume":"128","author":"W Shi","year":"2024","unstructured":"Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, et al. Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction. Phytomedicine. 2024;128:155404. https:\/\/doi.org\/10.1016\/j.phymed.2024.155404.","journal-title":"Phytomedicine"},{"key":"3413_CR22","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13771","author":"Y Wang","year":"2024","unstructured":"Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, et al. Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome. Immunology. 2024. https:\/\/doi.org\/10.1111\/imm.13771.","journal-title":"Immunology"},{"key":"3413_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1160445","volume":"14","author":"W Luo","year":"2023","unstructured":"Luo W, Xu G, Song Z, Mu W, Wen J, Hui S, et al. Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis. Front Pharmacol. 2023;14:1160445. https:\/\/doi.org\/10.3389\/fphar.2023.1160445.","journal-title":"Front Pharmacol"},{"key":"3413_CR24","doi-asserted-by":"publisher","first-page":"742","DOI":"10.2174\/0109298665411024251015093155","volume":"32","author":"A Hajinourmohammadi","year":"2025","unstructured":"Hajinourmohammadi A, Zargan J, Jafary H, Ebrahimi F. Evaluation of the anti-liver cancer activity of protein fractions isolated from Adenium obesum leaf extract. Protein Pept Lett. 2025;32:742\u201355. https:\/\/doi.org\/10.2174\/0109298665411024251015093155.","journal-title":"Protein Pept Lett"},{"key":"3413_CR25","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/plb.13578","volume":"25","author":"Y Liang","year":"2023","unstructured":"Liang Y, Wei F, Qin S, Li M, Hu Y, Lin Y, et al. Sophora tonkinensis: response and adaptation of physiological characteristics, functional traits, and secondary metabolites to drought stress. Plant Biol (Stuttg). 2023;25:1109\u201320. https:\/\/doi.org\/10.1111\/plb.13578.","journal-title":"Plant Biol (Stuttg)"},{"key":"3413_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175562","author":"JJ Liang","year":"2022","unstructured":"Liang JJ, Zhang PP, Zhang W, Song D, Wei X, Yin X, et al. Biological activities and secondary metabolites from sophora tonkinensis and its endophytic fungi. Molecules. 2022. https:\/\/doi.org\/10.3390\/molecules27175562.","journal-title":"Molecules"},{"key":"3413_CR27","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1161\/strokeaha.121.037541","volume":"53","author":"S Yaghi","year":"2022","unstructured":"Yaghi S, Shu L, Bakradze E, Salehi Omran S, Giles JA, Amar JY, et al. Direct oral anticoagulants versus warfarin in the treatment of cerebral venous thrombosis (ACTION-CVT): a multicenter international study. Stroke. 2022;53:728\u201338. https:\/\/doi.org\/10.1161\/strokeaha.121.037541.","journal-title":"Stroke"},{"key":"3413_CR28","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/s41590-024-01858-1","volume":"25","author":"RA Elsner","year":"2024","unstructured":"Elsner RA, Smita S, Shlomchik MJ. IL-12 induces a B cell-intrinsic IL-12\/IFN\u03b3 feed-forward loop promoting extrafollicular B cell responses. Nat Immunol. 2024;25:1283\u201395. https:\/\/doi.org\/10.1038\/s41590-024-01858-1.","journal-title":"Nat Immunol"},{"key":"3413_CR29","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.cell.2021.01.018","volume":"184","author":"CR Glassman","year":"2021","unstructured":"Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, et al. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell. 2021;184:983-999.e924. https:\/\/doi.org\/10.1016\/j.cell.2021.01.018.","journal-title":"Cell"},{"key":"3413_CR30","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/eji.202149733","volume":"52","author":"K Abdi","year":"2022","unstructured":"Abdi K, Laky K, Abshari M, Hill EM, Lantz L, Singh NJ, et al. Dendritic cells trigger IFN-\u03b3 secretion by NK cells independent of IL-12 and IL-18. Eur J Immunol. 2022;52:1431\u201340. https:\/\/doi.org\/10.1002\/eji.202149733.","journal-title":"Eur J Immunol"},{"key":"3413_CR31","doi-asserted-by":"publisher","first-page":"4868417","DOI":"10.1155\/2018\/4868417","volume":"2018","author":"M Grudzien","year":"2018","unstructured":"Grudzien M, Rapak A. Effect of natural compounds on NK cell activation. J Immunol Res. 2018;2018:4868417. https:\/\/doi.org\/10.1155\/2018\/4868417.","journal-title":"J Immunol Res"},{"key":"3413_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118681","volume":"335","author":"J Jang","year":"2024","unstructured":"Jang J, He Z, Huang L, Hwang JY, Kim MY, Cho JY. Upregulation of NK cell activity, cytokine expression, and NF-\u03baB pathway by ginsenoside concentrates from Panax ginseng berries in healthy mice and macrophage cell lines. J Ethnopharmacol. 2024;335:118681. https:\/\/doi.org\/10.1016\/j.jep.2024.118681.","journal-title":"J Ethnopharmacol"},{"key":"3413_CR33","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1038\/s41590-019-0511-1","volume":"20","author":"X Zheng","year":"2019","unstructured":"Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, et al. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol. 2019;20:1656\u201367. https:\/\/doi.org\/10.1038\/s41590-019-0511-1.","journal-title":"Nat Immunol"},{"key":"3413_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417545","author":"L Wei","year":"2023","unstructured":"Wei L, Xiang Z, Zou Y. The role of NKG2D and Its ligands in autoimmune diseases: new targets for immunotherapy. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms242417545.","journal-title":"Int J Mol Sci"},{"key":"3413_CR35","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.molimm.2025.03.012","volume":"181","author":"X Wen","year":"2025","unstructured":"Wen X, Wang X, Yao Q, Chen S, Li C, Zheng C, et al. Hypericin impedes M2 macrophage polarization and protects against hepatocellular carcinoma. Mol Immunol. 2025;181:160\u20138. https:\/\/doi.org\/10.1016\/j.molimm.2025.03.012.","journal-title":"Mol Immunol"},{"key":"3413_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1369563","volume":"15","author":"H Yang","year":"2024","unstructured":"Yang H, Zhan X, Zhao J, Shi W, Liu T, Wei Z, et al. Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity. Front Pharmacol. 2024;15:1369563. https:\/\/doi.org\/10.3389\/fphar.2024.1369563.","journal-title":"Front Pharmacol"},{"key":"3413_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.680611","volume":"12","author":"B Yao","year":"2021","unstructured":"Yao B, Yang Q, Yang Y, Li Y, Peng H, Wu S, et al. Screening for active compounds targeting human natural killer cell activation identifying daphnetin as an enhancer for IFN-\u03b3 production and direct cytotoxicity. Front Immunol. 2021;12:680611. https:\/\/doi.org\/10.3389\/fimmu.2021.680611.","journal-title":"Front Immunol"},{"key":"3413_CR38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/cdd.2014.134","volume":"22","author":"S Tugues","year":"2015","unstructured":"Tugues S, Burkhard SH, Ohs I, Vrohlings M, Nussbaum K, Vom Berg J, et al. New insights into IL-12-mediated tumor suppression. Cell Death Differ. 2015;22:237\u201346. https:\/\/doi.org\/10.1038\/cdd.2014.134.","journal-title":"Cell Death Differ"},{"key":"3413_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-02693-6","volume":"15","author":"K Liu","year":"2025","unstructured":"Liu K, Dong H, Zhang K, Yan W, Wu H, Fan J, et al. IL-15-activated CD38(+)HLA-DR(+)CD8(+) T cells induce liver injury in cirrhosis via JAK\/STAT5 and PI3K\/mTOR pathways. Sci Rep. 2025;15:17612. https:\/\/doi.org\/10.1038\/s41598-025-02693-6.","journal-title":"Sci Rep"},{"key":"3413_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1498706","volume":"16","author":"Y Chen","year":"2025","unstructured":"Chen Y, Jin C, Guo D, Hui X, Ji Y, Huang Y, et al. Co-expression of IL-15\/IL-15Ra complex enhances NKG2D-CAR T cell-mediated anti-pancreatic cancer immunity by activating the JAK\/STAT5 signaling pathway. Front Immunol. 2025;16:1498706. https:\/\/doi.org\/10.3389\/fimmu.2025.1498706.","journal-title":"Front Immunol"},{"key":"3413_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2026.158584","volume":"159","author":"Y Gao","year":"2026","unstructured":"Gao Y, Gong Y, Du Z, Zhang W, Lai L, Lan M, et al. Dihydroartemisinin promotes ABCG5\/G8-mediated cholesterol efflux to potentiate anti-PD-1 therapy through YAP1-TEAD1 complex disruption in hepatocellular carcinoma. Phytomedicine. 2026;159:158584. https:\/\/doi.org\/10.1016\/j.phymed.2026.158584.","journal-title":"Phytomedicine"},{"key":"3413_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1377722","volume":"15","author":"Y Gao","year":"2024","unstructured":"Gao Y, Gong Y, Lu J, Hao H, Shi X. Targeting YAP1 to improve the efficacy of immune checkpoint inhibitors in liver cancer: mechanism and strategy. Front Immunol. 2024;15:1377722. https:\/\/doi.org\/10.3389\/fimmu.2024.1377722.","journal-title":"Front Immunol"},{"key":"3413_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116294","volume":"225","author":"Y Gao","year":"2024","unstructured":"Gao Y, Gong Y, Lu J, Yang Y, Zhang Y, Xiong Y, et al. Dihydroartemisinin breaks the positive feedback loop of YAP1 and GLUT1-mediated aerobic glycolysis to boost the CD8(+) effector T cells in hepatocellular carcinoma. Biochem Pharmacol. 2024;225:116294. https:\/\/doi.org\/10.1016\/j.bcp.2024.116294.","journal-title":"Biochem Pharmacol"},{"key":"3413_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157307","volume":"148","author":"Y Gao","year":"2025","unstructured":"Gao Y, Gong Y, Song X, Xiong Y, Lu J, Yang Y, et al. Dihydroartemisinin inhibits histone lactylation through YAP1 to act as a \u2018hot\u2019 switch for \u2018cold\u2019 tumor in hepatocellular carcinoma. Phytomedicine. 2025;148:157307. https:\/\/doi.org\/10.1016\/j.phymed.2025.157307.","journal-title":"Phytomedicine"},{"key":"3413_CR45","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/sla.0000000000003404","volume":"271","author":"S Dueland","year":"2020","unstructured":"Dueland S, Syversveen T, Solheim JM, Solberg S, Grut H, Bj\u00f8rnbeth BA, et al. Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases. Ann Surg. 2020;271:212\u20138. https:\/\/doi.org\/10.1097\/sla.0000000000003404.","journal-title":"Ann Surg"},{"key":"3413_CR46","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/s1470-2045(24)00438-8","volume":"25","author":"LA Dawson","year":"2024","unstructured":"Dawson LA, Ringash J, Fairchild A, Stos P, Dennis K, Mahmud A, et al. Palliative radiotherapy versus best supportive care in patients with painful hepatic cancer (CCTG HE1): a multicentre, open-label, randomised, controlled, phase 3 study. Lancet Oncol. 2024;25:1337\u201346. https:\/\/doi.org\/10.1016\/s1470-2045(24)00438-8.","journal-title":"Lancet Oncol"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03413-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-026-03413-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-026-03413-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:52:34Z","timestamp":1791269554000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-026-03413-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["3413"],"URL":"https:\/\/doi.org\/10.1007\/s12032-026-03413-4","relation":{},"ISSN":["1559-131X"],"issn-type":[{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"10 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"306"}}