{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:47:57Z","timestamp":1740138477863,"version":"3.37.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"crossref","award":["248576 PROGRAMA DE APOYO A LA MEJORA DE LAS CONDICIONES DE PRODUCCION DE LOS MIEMBROS DEL SNI (PROSNI) Y SNCA 2019"],"award-info":[{"award-number":["248576 PROGRAMA DE APOYO A LA MEJORA DE LAS CONDICIONES DE PRODUCCION DE LOS MIEMBROS DEL SNI (PROSNI) Y SNCA 2019"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s12033-021-00408-6","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T20:29:55Z","timestamp":1634934595000},"page":"413-423","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delivery of Anti-IFNAR1 shRNA to Hepatic Cells Decreases IFNAR1 Gene Expression and Improves Adenoviral Transduction and Transgene Expression"],"prefix":"10.1007","volume":"64","author":[{"given":"J.","family":"Guerrero-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"C\u00e1rdenas-Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gutierrez-Silerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sobrevilla-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bastidas-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hern\u00e1ndez-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gurrola-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gasca-Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Armend\u00e1riz-Borunda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-8955","authenticated-orcid":false,"given":"A.","family":"Salazar-Montes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"408_CR1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-7107-4","volume-title":"Molecular pathology of liver diseases","author":"Satdarshan Monga","year":"2011","unstructured":"Monga, S., & Monga, S. (2011). Molecular pathology of liver diseases. Springer."},{"key":"408_CR2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jconrel.2012.04.008","volume":"161","author":"Mauro Giacca","year":"2012","unstructured":"Giacca, M., & Zacchigna, S. (2012). Virus-mediated gene delivery for human gene therapy. Journal of Controlled Release, 161, 377\u2013388.","journal-title":"Journal of Controlled Release"},{"key":"408_CR3","doi-asserted-by":"crossref","first-page":"107502","DOI":"10.1016\/j.biotechadv.2019.107502","volume":"40","author":"Cui Cui Ma","year":"2020","unstructured":"Ma, C. C., Wang, Z. L., Xu, T., He, Z. Y., & Wei, Y. Q. (2020). The approved gene therapy drugs worldwide: from 1998 to 2019. Biotechnology Advances, 40, 107502.","journal-title":"Biotechnology Advances"},{"key":"408_CR4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/156652306776359478","volume":"6","author":"Dinesh Bangari","year":"2006","unstructured":"Bangari, D., & Mittal, S. (2006). Current strategies and future directions for eluding adenoviral vector immunity. Current Gene Therapy, 6, 215\u2013226.","journal-title":"Current Gene Therapy"},{"key":"408_CR5","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.3390\/ijms21103643","volume":"21","author":"Ana Ricobaraza","year":"2020","unstructured":"Ricobaraza, A., Gonzalez-aparicio, M., Mora-jimenez, L., Lumbreras, S., & Hernandez-alcoceba, R. (2020). High-capacity adenoviral vectors\u202f: Expanding the scope of gene therapy. International Journal of Molecular Sciences, 21, 3643.","journal-title":"International Journal of Molecular Sciences"},{"key":"408_CR6","first-page":"195","volume":"343","author":"Jason G. Smith","year":"2010","unstructured":"Smith, J. G., Wiethoff, C. M., Stewart, P. L., & Nemerow, G. R. (2010). Adenovirus. Current Topics in Microbiology and Immunology, 343, 195\u2013224.","journal-title":"Current Topics in Microbiology and Immunology"},{"key":"408_CR7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/biomedicines7030061","volume":"7","author":"Brennetha J. Crenshaw","year":"2019","unstructured":"Crenshaw, B. J., Jones, L. B., Bell, C. R., Kumar, S., & Matthews, Q. L. (2019). Perspective on adenoviruses: Epidemiology, pathogenicity, and gene therapy. Biomedicines, 7, 61.","journal-title":"Biomedicines"},{"key":"408_CR8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1556\/EuJMI.4.2014.1.2","volume":"4","author":"B. Ghebremedhin","year":"2014","unstructured":"Ghebremedhin, B. (2014). Human adenovirus: Viral pathogen with increasing importance. European Journal of Microbiology and Immunology, 4, 26\u201333.","journal-title":"European Journal of Microbiology and Immunology"},{"key":"408_CR9","first-page":"1","volume":"7","author":"Ashrafali M. Ismail","year":"2018","unstructured":"Ismail, A. M., Cui, T., Dommaraju, K., Singh, G., Dehghan, S., Seto, J., Shrivastava, S., Fedorova, N. B., Gupta, N., Stockwell, T. B., & Madupu, R. (2018). Genomic analysis of a large set of currently\u2014And historically\u2014Important human adenovirus pathogens article. Emerging Microbes & Infections, 7, 1\u201322.","journal-title":"Emerging Microbes & Infections"},{"key":"408_CR10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/156652309787909544","volume":"9","author":"Delphyne Descamps","year":"2009","unstructured":"Descamps, D., & Benihoud, K. (2009). Two key challenges for effective adenovirus-mediated liver gene therapy: Innate immune responses and hepatocyte-specific transduction. Current Gene Therapy, 9, 115\u2013127.","journal-title":"Current Gene Therapy"},{"key":"408_CR11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/sj.gt.3301647","volume":"9","author":"J Garcia-Ba\u00f1uelos","year":"2002","unstructured":"Garcia-Banuelos, J., Siller-Lopez, F., Miranda, A., Aguilar, L. K., Aguilar-Cordova, E., & Armendariz-Borunda, J. (2002). Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion. Gene Therapy, 9, 127\u2013134.","journal-title":"Gene Therapy"},{"key":"408_CR12","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/JVI.02192-06","volume":"81","author":"Jiangao Zhu","year":"2007","unstructured":"Zhu, J., Huang, X., & Yang, Y. (2007). Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. Journal of Virology, 81, 3170\u20133180.","journal-title":"Journal of Virology"},{"key":"408_CR13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1172\/JCI78280","volume":"125","author":"Kylie M. Quinn","year":"2015","unstructured":"Quinn, K. M, Zak, D. E., Costa, A., Yamamoto, A., Kastenmuller, K., Hill, B. J., Lynn, G. M., Darrah, P. A., Lindsay, R. W. B., Wang, L., Cheng, C., Nicosia, A., Folgori, A., Colloca, S., Cortese, R., Gostick, E., Price, D. A., Gall, J. G. D., Roederer, M., \u2026 Seder, R. A. (2015). Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. The Journal of Clinical Investigation, 125, 1129\u20131146.","journal-title":"The Journal of Clinical Investigation"},{"key":"408_CR14","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ni.2667","volume":"14","author":"Nicole A De Weerd","year":"2013","unstructured":"de Weerd, N. A., Vivian, J. P., Nguyen, T. K., Mangan, N. E., Gould, J. A., Braniff, S. J., Zaker-Tabrizi, L., Fung, K. Y., Forster, S. C., Beddoe, T., Reid H. H., Rossjohn,  J., & Hertzog, P. J. (2013). Structural basis of a unique interferon-\u03b2 signaling axis mediated via the receptor IFNAR1. Nature Immunology, 14, 901\u2013907.","journal-title":"Nature Immunology"},{"key":"408_CR15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.coi.2015.03.002","volume":"34","author":"Laura M Snell","year":"2015","unstructured":"Snell, L. M., & Brooks, D. G. (2015). New insights into type I interferon and the immunopathogenesis of persistent viral infections. Current Opinion in Immunology, 34, 91\u201398.","journal-title":"Current Opinion in Immunology"},{"key":"408_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.00001","volume":"9","author":"Aamanda J Lee","year":"2018","unstructured":"Lee, A. J., & Ashkar, A. A. (2018). The dual nature of type I and type II interferons. Frontiers in Immunology, 9, 1\u201310.","journal-title":"Frontiers in Immunology"},{"key":"408_CR17","doi-asserted-by":"publisher","unstructured":"Atasheva, S., & Shayakhmetov, D. M. (2016). Innate immune response to adenovirus vector administration in vivo. In Adenoviral vectors for gene therapy: Second Edition. Elsevier Inc. https:\/\/doi.org\/10.1016\/B978-0-12-800276-6.00014-0.","DOI":"10.1016\/B978-0-12-800276-6.00014-0"},{"key":"408_CR18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nprot.2006.83","volume":"1","author":"Piotr Chomczynski","year":"2006","unstructured":"Chomczynski, P., & Sacchi, N. (2006). The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nature Protocols, 1, 581\u2013585.","journal-title":"Nature Protocols"},{"key":"408_CR19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Marion Bradford","year":"1976","unstructured":"Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248\u2013254.","journal-title":"Analytical Biochemistry"},{"key":"408_CR20","unstructured":"GTCT (FMS19). https:\/\/a873679.fmphost.com\/fmi\/webd\/GTCT."},{"key":"408_CR21","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.4161\/hv.29594","volume":"10","author":"Hugues Fausther-Bovendo","year":"2015","unstructured":"Fausther-Bovendo, H., & Kobinger, G. P. (2015). Pre-existing immunity against Ad vectors. Human Vaccines & Immunotherapeutics, 10, 2875\u20132884.","journal-title":"Human Vaccines & Immunotherapeutics"},{"key":"408_CR22","first-page":"1","volume":"14","author":"Christopher M Gentile","year":"2019","unstructured":"Gentile, C. M., Borovjagin, A. V., Richter, J. R., Jani, A. H., Wu, H., Zinn, K. R., & Warram, J. M. (2019). Genetic strategy to decrease complement activation with adenoviral therapies. PLoS ONE, 14, 1\u201315.","journal-title":"PLoS ONE"},{"key":"408_CR23","doi-asserted-by":"crossref","first-page":"e1005084","DOI":"10.1371\/journal.ppat.1005084","volume":"11","author":"Karoly Toth","year":"2015","unstructured":"Toth, K., Lee, S. R., Ying, B., Spencer, J. F., Tollefson, A. E., Sagartz, J. E., Kong, I. K., Wang, Z., & Wold, W. S. (2015). STAT2 knockout syrian hamsters support enhanced replication and pathogenicity of human adenovirus, revealing an important role of type I interferon response in viral control. PLOS Pathogens, 11, e1005084.","journal-title":"PLOS Pathogens"},{"key":"408_CR24","doi-asserted-by":"crossref","first-page":"5915","DOI":"10.1128\/JVI.00500-16","volume":"90","author":"Daniela Anghelina","year":"2016","unstructured":"Anghelina, D., Lam, E., & Falck-Pedersen, E. (2016). Diminished antiviral innate response to Adenovirus vectors in cGAS\/STING deficient mice minimally impacts adaptive immunity. Journal of Virology, 90, 5915\u20135927.","journal-title":"Journal of Virology"},{"key":"408_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.005","author":"Eliana M. Coccia","year":"2015","unstructured":"Coccia, E. M., & Battistini, A. (2015). Early IFN type I response: Learning from microbial evasion strategies. Seminars in Immunology. https:\/\/doi.org\/10.1016\/j.smim.2015.03.005","journal-title":"Seminars in Immunology"},{"key":"408_CR26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","volume":"14","author":"Lionel B. Ivashkiv","year":"2014","unstructured":"Ivashkiv, L. B., & Donlin, L. T. (2014). Regulation of type I interferon responses. Nature Reviews Immunology, 14, 36\u201349.","journal-title":"Nature Reviews Immunology"},{"key":"408_CR27","first-page":"1","volume":"23","author":"Sravanthi Vupputuri","year":"2020","unstructured":"Vupputuri, S., Tayebi, L., Hikkaduwa Koralege, R. S., Nigatu, A., Mozafari, M., Mishra, A., Liu, L., & Ramsey, J. D. (2020). Polyethylene glycol\u2013modified DOTAP:Cholesterol\/adenovirus hybrid vectors have improved transduction efficiency and reduced immunogenicity. Journal of Nanoparticle Research, 23, 1\u201314.","journal-title":"Journal of Nanoparticle Research"},{"key":"408_CR28","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s11262-017-1498-z","volume":"53","author":"Franziska J\u00f6nsson","year":"2017","unstructured":"J\u00f6nsson, F., & Kreppel, F. (2017). Barriers to systemic application of virus-based vectors in gene therapy: Lessons from adenovirus type 5. Virus Genes, 53, 692\u2013699.","journal-title":"Virus Genes"},{"key":"408_CR29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature04721","volume":"441","author":"Diane M. Roberts","year":"2006","unstructured":"Roberts, D. M., Nanda, A., Havenga, M. J., Abbink, P., Lynch, D. M., Ewald, B. A., Liu, J., Thorner, A. R., Swanson, P. E., Gorgone, D. A., Lifton, M. A., Lemckert, A. A., Holterman, L., Chen, B., Dilraj, A., Carville, A., Mansfield, K. G., Goudsmit, J., & Barouch, D. H. (2006). Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity. Nature, 441, 239\u2013243.","journal-title":"Nature"},{"key":"408_CR30","doi-asserted-by":"crossref","first-page":"13207","DOI":"10.1128\/JVI.78.23.13207-13215.2004","volume":"78","author":"Lennart Holterman","year":"2004","unstructured":"Holterman, L., Vogels, R., van der Vlugt, R., Sieuwerts, M., Grimbergen, J., Kaspers, J., Geelen, E., van der Helm, E., Lemckert, A., Gillissen, G., Verhaagh, S., Custers, J.,   Zuijdgeest, D., Berkhout, B., Bakker, M., Quax, P., Goudsmit, J.,  & Havenga, M. (2004). Novel replication-incompetent vector derived from adenovirus type 11 (Ad11) for vaccination and gene therapy: Low seroprevalence and non-cross-reactivity with Ad5. Journal of Virology, 78, 13207\u201313215.","journal-title":"Journal of Virology"},{"key":"408_CR31","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.gt.3301299","volume":"7","author":"X Ye","year":"2000","unstructured":"Ye, X., Robinson, M. B., Pabin, C., Batshaw, M. L., & Wilson, J. M. (2000). Transient depletion of CD4 lymphocyte improves efficacy of repeated administration of recombinant adenovirus in the ornithine transcarbamylase deficient sparse fur mouse. Gene Therapy, 7, 1761.","journal-title":"Gene Therapy"},{"key":"408_CR32","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1128\/JVI.74.7.3345-3352.2000","volume":"74","author":"Narendra Chirmule","year":"2000","unstructured":"Chirmule, N., Raper, S. E., Burkly, L., Thomas, D., Tazelaar, J., Hughes, J. V., & Wilson, J. M. (2000). Readministration of adenovirus vector in nonhuman primate lungs by blockade of CD40-CD40 ligand interactions. Journal of Virology, 74, 3345\u20133352.","journal-title":"Journal of Virology"},{"key":"408_CR33","first-page":"496","volume":"3","author":"TA Smith","year":"1996","unstructured":"Smith, T. A., White, B. D., Gardner, J. M., Kaleko, M., & McClelland, A. (1996). Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector. Gene Therapy, 3, 496\u2013502.","journal-title":"Gene Therapy"},{"key":"408_CR34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s12033-018-0066-7","volume":"60","author":"Ana Alondra Sobrevilla-Navarro","year":"2018","unstructured":"Sobrevilla-Navarro, A. A., Sandoval-Rodr\u00edguez, A., Garc\u00eda-Ba\u00f1uelos, J. J., Armendariz-Borunda, J., & Salazar-Montes, A. M. (2018). Interferon-\u03b1 silencing by small interference RNA increases adenovirus transduction and transgene expression in Huh7 cells. Molecular Biotechnology, 60, 251\u2013258.","journal-title":"Molecular Biotechnology"},{"key":"408_CR35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2015.09.058","volume":"576","author":"Consuelo M. L\u00f3pez de Padilla","year":"2016","unstructured":"L\u00f3pez de Padilla, C. M., & Niewold, T. B. (2016). The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases. Gene, 576, 14\u201321.","journal-title":"Gene"},{"key":"408_CR36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.it.2015.01.004","volume":"36","author":"Hans-Heinrich Hoffmann","year":"2015","unstructured":"Hoffmann, H.-H., Schneider, W. M., & Rice, C. M. (2015). Interferons and viruses: An evolutionary arms race of molecular interactions. Trends in Immunology, 36, 124\u2013138.","journal-title":"Trends in Immunology"},{"key":"408_CR37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/sj.gt.3302727","volume":"13","author":"D Grimm","year":"2006","unstructured":"Grimm, D., & Kay, M. (2006). Therapeutic short hairpin RNA expression in the liver: Viral targets and vectors. Gene Therapy, 13, 563\u2013575.","journal-title":"Gene Therapy"},{"key":"408_CR38","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.7314\/APJCP.2014.15.20.8829","volume":"15","author":"B Tu","year":"2014","unstructured":"Tu, B., Ma, T. T., Peng, X. Q., Wang, Q., Yang, H., & Huang, X. L. (2014). Targeting of COX-2 expression by recombinant adenovirus shRNA attenuates the malignant biological behavior of breast cancer cells. Asian Pacific Journal of Cancer Prevention, 15, 8829\u20138836.","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"408_CR39","doi-asserted-by":"crossref","first-page":"17089","DOI":"10.1073\/pnas.0508517102","volume":"102","author":"Akihiro Kimura","year":"2005","unstructured":"Kimura, A., Naka, T., Muta, T., Takeuchi, O., Akira, S., Kawase, I., & Kishimoto, T. (2005). Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. Proceedings of the National Academy of Sciences A, 102, 17089\u201317094.","journal-title":"Proceedings of the National Academy of Sciences A"},{"key":"408_CR40","doi-asserted-by":"publisher","first-page":"4931","DOI":"10.4049\/jimmunol.180.7.4931","volume":"180","author":"Haruna Sakurai","year":"2008","unstructured":"Sakurai, H., Tashiro, K., Kawabata, K., Yamaguchi, T., Sakurai, F., Nakagawa, S., & Mizuguchi, H. (2008). Adenoviral expression of suppressor of cytokine signaling-1. The Journal of Immunology, 180, 4931. https:\/\/doi.org\/10.4049\/jimmunol.180.7.4931","journal-title":"The Journal of Immunology"},{"key":"408_CR41","doi-asserted-by":"crossref","first-page":"e0183594","DOI":"10.1371\/journal.pone.0183594","volume":"12","author":"Justin Lee","year":"2017","unstructured":"Lee, J., Tam, H., Adler, L., Ilstad-Minnihan, A., Macaubas, C., & Mellins, E. D. (2017). The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines. PLoS ONE, 12, e0183594.","journal-title":"PLoS ONE"},{"key":"408_CR42","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.166.5.2961","volume":"166","author":"Tomoki Ito","year":"2001","unstructured":"Ito, T., Amakawa, R., Inaba, M., Ikehara, S., Inaba, K., & Fukuhara, S. (2001). Differential regulation of human blood dendritic cell subsets by IFNs. The Journal of Immunology, 166, 2961\u20132969.","journal-title":"The Journal of Immunology"},{"key":"408_CR43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.immuni.2005.01.005","volume":"22","author":"Bumsuk Hahm","year":"2005","unstructured":"Hahm, B., Trifilo, M. J., Zuniga, E. I., & Oldstone, M. B. A. (2005). Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity, 22, 247\u2013257.","journal-title":"Immunity"},{"key":"408_CR44","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.3390\/ijms22052417","volume":"22","author":"Florian Kreppel","year":"2021","unstructured":"Kreppel, F., & Hagedorn, C. (2021). Capsid and genome modification strategies to reduce the immunogenicity of adenoviral vectors. International Journal of Molecular Sciences, 22, 2417.","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"408_CR45","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1053\/j.gastro.2003.12.045","volume":"126","author":"Fernanda Siller-L\u00f3pez","year":"2004","unstructured":"Siller-L\u00f3pez, F., Sandoval, A., Salgado, S., Salazar, A., Bueno, M., Garcia, J., Vera, J., G\u00e1lvez, J., Hern\u00e1ndez, I., Ramos, M., & Aguilar-Cordova, E. (2004). Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology, 126(4), 1122\u20131133.","journal-title":"Gastroenterology"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-021-00408-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-021-00408-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-021-00408-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T08:09:43Z","timestamp":1645949383000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-021-00408-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["408"],"URL":"https:\/\/doi.org\/10.1007\/s12033-021-00408-6","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"type":"print","value":"1073-6085"},{"type":"electronic","value":"1559-0305"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"25 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}