{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:16:22Z","timestamp":1781489782591,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82074265"],"award-info":[{"award-number":["82074265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81873158"],"award-info":[{"award-number":["81873158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Science Foundation of Guangdong Province, China","award":["2020A1515010324"],"award-info":[{"award-number":["2020A1515010324"]}]},{"name":"the National Science Foundation of Guangdong Province, China","award":["2021A1515011505"],"award-info":[{"award-number":["2021A1515011505"]}]},{"name":"the National Science Foundation of Guangdong Province, China","award":["2022A1515011719"],"award-info":[{"award-number":["2022A1515011719"]}]},{"name":"Construction Fund of Key Disciplines of Traditional Chinese Medicine in Guangdong, China","award":["G622299957"],"award-info":[{"award-number":["G622299957"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s12033-023-00851-7","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T03:21:57Z","timestamp":1692760917000},"page":"2230-2240","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In Vivo Evaluation of Self-assembled nano-Saikosaponin-a for Epilepsy Treatment"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0652-6373","authenticated-orcid":false,"given":"Xueqi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"851_CR1","doi-asserted-by":"publisher","first-page":"106949","DOI":"10.1016\/j.yebeh.2020.106949","volume":"105","author":"G Singh","year":"2020","unstructured":"Singh, G., & Sander, J. W. (2020). The global burden of epilepsy report: Implications for low- and middle-income countries. Epilepsy & Behavior, 105, 106949.","journal-title":"Epilepsy & Behavior"},{"issue":"3","key":"851_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","volume":"88","author":"KM Fiest","year":"2017","unstructured":"Fiest, K. M., Sauro, K. M., Wiebe, S., et al. (2017). Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology, 88(3), 296.","journal-title":"Neurology"},{"key":"851_CR3","doi-asserted-by":"crossref","unstructured":"Golub, V. M., & Reddy, D. S. (2022). Post-Traumatic Epilepsy and Comorbidities: Advanced Models, molecular mechanisms, biomarkers, and Novel Therapeutic Interventions. Pharmacological reviews, (2), 74.","DOI":"10.1124\/pharmrev.121.000375"},{"issue":"6","key":"851_CR4","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1055\/s-0040-1718719","volume":"40","author":"J Falco-Walter","year":"2020","unstructured":"Falco-Walter, J. (2020). Epilepsy-Definition, classification, pathophysiology, and Epidemiology. Seminars in neurology, 40(6), 617\u2013623.","journal-title":"Seminars in neurology"},{"key":"851_CR5","doi-asserted-by":"crossref","unstructured":"He, C., Peiwu, Yalinchen, Hongsong, Yijunyin, & Jianzhong (2021). Gamma-aminobutyric acid (GABA) changes in the hippocampus and anterior cingulate cortex in patients with temporal lobe epilepsy. Epilepsy & behavior, 115 (1).","DOI":"10.1016\/j.yebeh.2020.107683"},{"issue":"3","key":"851_CR6","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1007\/s12035-022-02725-6","volume":"59","author":"A Soltani Khaboushan","year":"2022","unstructured":"Soltani Khaboushan, A., Yazdanpanah, N., & Rezaei, N. (2022). Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis. Molecular neurobiology, 59(3), 1724\u20131743.","journal-title":"Molecular neurobiology"},{"issue":"4","key":"851_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1080\/14728222.2019.1586885","volume":"23","author":"R Celli","year":"2019","unstructured":"Celli, R., Santolini, I., Luijtelaar, G. V., et al. (2019). Targeting metabotropic glutamate receptors in the treatment of epilepsy: Rationale and current status. Expert opinion on therapeutic targets, 23(4), 341\u2013351.","journal-title":"Expert opinion on therapeutic targets"},{"issue":"13","key":"851_CR8","doi-asserted-by":"publisher","first-page":"e1363","DOI":"10.1212\/WNL.0000000000206758","volume":"100","author":"G Poke","year":"2023","unstructured":"Poke, G., Stanley, J., Scheffer, I., et al. (2023). Epidemiology of Developmental and Epileptic Encephalopathy and of intellectual disability and Epilepsy in Children. Neurology, 100(13), e1363\u2013e1375.","journal-title":"Neurology"},{"issue":"2","key":"851_CR9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1055\/s-0040-1702941","volume":"40","author":"E Gonzalez-Giraldo","year":"2020","unstructured":"Gonzalez-Giraldo, E., & Sullivan, J. (2020). Advances in the treatment of drug-resistant Pediatric Epilepsy. Seminars in neurology, 40(2), 257\u2013262.","journal-title":"Seminars in neurology"},{"issue":"2","key":"851_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/WCO.0000000000001144","volume":"36","author":"A Pong","year":"2023","unstructured":"Pong, A., Xu, K., & Klein, P. (2023). Recent advances in pharmacotherapy for epilepsy. Current opinion in neurology, 36(2), 77\u201385.","journal-title":"Current opinion in neurology"},{"issue":"3","key":"851_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/17425255.2020.1724956","volume":"16","author":"C Johannessen Landmark","year":"2020","unstructured":"Johannessen Landmark, C., Johannessen, S., & Patsalos, P. (2020). Therapeutic drug monitoring of antiepileptic drugs: Current status and future prospects. Expert opinion on drug metabolism & toxicology, 16(3), 227\u2013238.","journal-title":"Expert opinion on drug metabolism & toxicology"},{"issue":"11","key":"851_CR12","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.2174\/1570159X19666210826125341","volume":"19","author":"E Aky\u00fcz","year":"2021","unstructured":"Aky\u00fcz, E., K\u00f6kl\u00fc, B., Ozenen, C., et al. (2021). Elucidating the potential side Effects of current anti-seizure drugs for Epilepsy. Current neuropharmacology, 19(11), 1865\u20131883.","journal-title":"Current neuropharmacology"},{"key":"851_CR13","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.2147\/DDDT.S166408","volume":"12","author":"Y Hong","year":"2018","unstructured":"Hong, Y., Deng, N., Jin, H., et al. (2018). Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy. Drug design development and therapy, 12, 2945\u20132958.","journal-title":"Drug design development and therapy"},{"issue":"3","key":"851_CR14","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.bbrc.2017.09.139","volume":"493","author":"W Gao","year":"2017","unstructured":"Gao, W., Bi, Y., Ding, L., et al. (2017). SSa ameliorates the glu uptaking capacity of astrocytes in epilepsy via AP-1\/miR-155\/GLAST. Biochemical and biophysical research communications, 493(3), 1329\u20131335.","journal-title":"Biochemical and biophysical research communications"},{"key":"851_CR15","doi-asserted-by":"publisher","first-page":"713200","DOI":"10.3389\/fphar.2021.713200","volume":"12","author":"P Zhang","year":"2021","unstructured":"Zhang, P., Lai, X., Zhu, M. H., et al. (2021). Saikosaponin A, a Triterpene Saponin, suppresses angiogenesis and Tumor Growth by blocking VEGFR2-Mediated signaling pathway. Frontiers in pharmacology, 12, 713200.","journal-title":"Frontiers in pharmacology"},{"issue":"5","key":"851_CR16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2174\/1567201817999200820161438","volume":"18","author":"B Kheilnezhad","year":"2021","unstructured":"Kheilnezhad, B., & Hadjizadeh, A. (2021). Factors affecting the penetration of Niosome into the skin, their laboratory measurements and dependency to the Niosome composition: A review. Current drug delivery, 18(5), 555\u2013569.","journal-title":"Current drug delivery"},{"issue":"5","key":"851_CR17","doi-asserted-by":"publisher","first-page":"606","DOI":"10.2174\/0929867324666171009120154","volume":"25","author":"A Carita","year":"2018","unstructured":"Carita, A., Eloy, J., Chorilli, M., et al. (2018). Recent advances and perspectives in liposomes for cutaneous drug delivery. Current medicinal chemistry, 25(5), 606\u2013635.","journal-title":"Current medicinal chemistry"},{"issue":"100","key":"851_CR18","first-page":"1","volume":"25","author":"M Alami-Milani","year":"2020","unstructured":"Alami-Milani, M., Zakeri-Milani, P., Valizadeh, H., et al. (2020). PLA-PCL-PEG-PCL-PLA based micelles for improving the ocular permeability of dexamethasone: Development, characterization, and in vitro evaluation. Pharmaceutical Development and Technology, 25(100), 1\u201348.","journal-title":"Pharmaceutical Development and Technology"},{"key":"851_CR19","doi-asserted-by":"publisher","first-page":"102417","DOI":"10.1016\/j.nano.2021.102417","volume":"37","author":"N Di Trani","year":"2021","unstructured":"Di Trani, N., Liu, H., Qi, R., et al. (2021). Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension. Nanomedicine: nanotechnology biology and medicine, 37, 102417.","journal-title":"Nanomedicine: nanotechnology biology and medicine"},{"issue":"5","key":"851_CR20","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1080\/21691401.2017.1347880","volume":"46","author":"HK Manjili","year":"2018","unstructured":"Manjili, H. K., Malvandi, H., Mousavi, M. S., et al. (2018). In vitro and in vivo delivery of artemisinin loaded PCL-PEG-PCL micelles and its pharmacokinetic study. Artificial cells nanomedicine and biotechnology, 46(5), 926\u2013936.","journal-title":"Artificial cells nanomedicine and biotechnology"},{"key":"851_CR21","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.2147\/IJN.S374895","volume":"17","author":"G Li","year":"2022","unstructured":"Li, G., Shang, C., Li, Q., et al. (2022). Combined shikonin-loaded MPEG-PCL Micelles inhibits effective transition of endothelial-to-mesenchymal cells. International journal of nanomedicine, 17, 4497\u20134508.","journal-title":"International journal of nanomedicine"},{"issue":"5","key":"851_CR22","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1021\/acschemneuro.9b00691","volume":"11","author":"H Mohamadpour","year":"2020","unstructured":"Mohamadpour, H., Azadi, A., Rostamizadeh, K., et al. (2020). coPreparation, optimization, and evaluation of Methoxy Poly(ethylene glycol)--Poly(\u03b5-caprolactone) nanoparticles loaded by Rivastigmine for Brain Delivery. ACS chemical neuroscience, 11(5), 783\u2013795.","journal-title":"ACS chemical neuroscience"},{"issue":"27","key":"851_CR23","doi-asserted-by":"publisher","first-page":"30546","DOI":"10.1021\/acsami.2c06205","volume":"14","author":"L Wang","year":"2022","unstructured":"Wang, L., Geng, Z., Ho, Y., et al. (2022). Block Co-PolyMOC Micelles and Structural Synergy as Composite Nanocarriers. ACS applied materials & interfaces, 14(27), 30546\u201330556.","journal-title":"ACS applied materials & interfaces"},{"key":"851_CR24","doi-asserted-by":"crossref","unstructured":"Li, X., Wang, Y., Xu, F. (2020). Artemisinin loaded mPEG-PCL nanoparticle based photosensitive gelatin methacrylate hydrogels for the treatment of Gentamicin Induced hearing loss. International Journal of Nanomedicine.","DOI":"10.2147\/IJN.S245188"},{"issue":"NOV.1","key":"851_CR25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.matlet.2018.07.084","volume":"230","author":"M Zhou","year":"2018","unstructured":"Zhou, M., Xie, W., Hong, Y., et al. (2018). Saikosaponin-a loaded methoxy poly(ethylene glycol)- poly(\u03b5-caprolactone) nanoparticles for improved solubility and reduced hemolysis of Saikosaponin-a. Materials Letters, 230(NOV.1), 139\u2013142.","journal-title":"Materials Letters"},{"issue":"2","key":"851_CR26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000503831","volume":"54","author":"E Beghi","year":"2020","unstructured":"Beghi, E. (2020). The epidemiology of Epilepsy. Neuroepidemiology, 54(2), 185\u2013191.","journal-title":"Neuroepidemiology"},{"key":"851_CR27","doi-asserted-by":"crossref","unstructured":"Cutia, C., Leverton L. and, & Christian-Hinman, C. (2023). Sex and Estrous Cycle Stage Shape Left-Right Asymmetry in Chronic Hippocampal Seizures in Mice. eNeuro, 10 (6).","DOI":"10.1523\/ENEURO.0041-23.2023"},{"key":"851_CR28","doi-asserted-by":"publisher","first-page":"113492","DOI":"10.1016\/j.expneurol.2020.113492","volume":"334","author":"J Li","year":"2020","unstructured":"Li, J., Leverton, L., Naganatanahalli, L., et al. (2020). Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy. Experimental neurology, 334, 113492.","journal-title":"Experimental neurology"},{"key":"851_CR29","doi-asserted-by":"publisher","first-page":"8921","DOI":"10.2147\/IJN.S259172","volume":"15","author":"A Farrah","year":"2020","unstructured":"Farrah, A., Al-Mahallawi, A., Basalious, E., et al. (2020). Investigating the potential of phosphatidylcholine-based Nano-Sized carriers in boosting the Oto-Topical Delivery of Caroverine: In vitro characterization, Stability Assessment and ex vivo transport studies. International journal of nanomedicine, 15, 8921\u20138931.","journal-title":"International journal of nanomedicine"},{"issue":"19","key":"851_CR30","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1016\/j.neuron.2022.07.020","volume":"110","author":"A Whitebirch","year":"2022","unstructured":"Whitebirch, A., Lafrancois, J., Jain, S., et al. (2022). Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy. Neuron, 110(19), 3121\u20133138e8.","journal-title":"Neuron"},{"key":"851_CR31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.seizure.2022.07.007","volume":"101","author":"Y Feng","year":"2022","unstructured":"Feng, Y., Wei, Z., Liu, C., et al. (2022). Genetic variations in GABA metabolism and epilepsy. Seizure, 101, 22\u201329.","journal-title":"Seizure"},{"issue":"3","key":"851_CR32","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41563-023-01481-9","volume":"22","author":"D Tylawsky","year":"2023","unstructured":"Tylawsky, D., Kiguchi, H., Vaynshteyn, J., et al. (2023). P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis. Nature materials, 22(3), 391\u2013399.","journal-title":"Nature materials"},{"issue":"3","key":"851_CR33","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.7150\/thno.38147","volume":"10","author":"M Zhao","year":"2020","unstructured":"Zhao, M., Van Straten, D., Broekman, M., et al. (2020). Nanocarrier-based drug combination therapy for glioblastoma. Theranostics, 10(3), 1355\u20131372.","journal-title":"Theranostics"},{"issue":"1","key":"851_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13045-021-01096-0","volume":"14","author":"Z Cheng","year":"2021","unstructured":"Cheng, Z., Li, M., Dey, R., et al. (2021). Nanomaterials for cancer therapy: Current progress and perspectives. Journal of hematology & oncology, 14(1), 85.","journal-title":"Journal of hematology & oncology"},{"key":"851_CR35","doi-asserted-by":"crossref","unstructured":"Salameh, J., Zhou, L., Ward, S. (2020). Polymer-mediated gene therapy: Recent advances and merging of delivery techniques. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology, 12 (2), e1598.","DOI":"10.1002\/wnan.1598"},{"key":"851_CR36","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, A., Carreir\u00f3, F., Oliveira, A. (2020). Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology. Molecules (Basel, Switzerland), 25 (16).","DOI":"10.3390\/molecules25163731"},{"key":"851_CR37","doi-asserted-by":"publisher","first-page":"119551","DOI":"10.1016\/j.ijpharm.2020.119551","volume":"586","author":"W Fan","year":"2020","unstructured":"Fan, W., Yu, Z., Peng, H., et al. (2020). Effect of particle size on the pharmacokinetics and biodistribution of parenteral nanoemulsions. International journal of pharmaceutics, 586, 119551.","journal-title":"International journal of pharmaceutics"},{"key":"851_CR38","doi-asserted-by":"crossref","unstructured":"Hong, N., Deng (2018). Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy. Drug design, development and therapy.","DOI":"10.2147\/DDDT.S166408"},{"key":"851_CR39","doi-asserted-by":"publisher","first-page":"113138","DOI":"10.1016\/j.bbr.2021.113138","volume":"403","author":"A Wang","year":"2021","unstructured":"Wang, A., Mi, L., Zhang, Z., et al. (2021). Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB\/BDNF pathway. Behavioural brain research, 403, 113138.","journal-title":"Behavioural brain research"},{"issue":"1","key":"851_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.neulet.2012.08.075","volume":"529","author":"S Yoon","year":"2012","unstructured":"Yoon, S., Kim, H., Cho, H., et al. (2012). Effect of saikosaponin A on maintenance of intravenous morphine self-administration. Neuroscience letters, 529(1), 97\u2013101.","journal-title":"Neuroscience letters"},{"key":"851_CR41","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neulet.2016.04.022","volume":"621","author":"P Maccioni","year":"2016","unstructured":"Maccioni, P., Lorrai, I., Carai, M., et al. (2016). Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor. Neuroscience letters, 621, 62\u201367.","journal-title":"Neuroscience letters"},{"key":"851_CR42","doi-asserted-by":"crossref","unstructured":"Lim, S., Lee, H., Han, H. (2021). Saikosaponin A and D Inhibit Adipogenesis via the AMPK and MAPK Signaling Pathways in 3T3-L1 Adipocytes. International journal of molecular sciences, 22 (21).","DOI":"10.3390\/ijms222111409"},{"key":"851_CR43","doi-asserted-by":"publisher","first-page":"105534","DOI":"10.1016\/j.tiv.2022.105534","volume":"88","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Ma, R., Zou, B., et al. (2023). Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a-induced liver cell damage. Toxicology in vitro, 88, 105534.","journal-title":"Toxicology in vitro"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-023-00851-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-023-00851-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-023-00851-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T21:41:45Z","timestamp":1727300505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-023-00851-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["851"],"URL":"https:\/\/doi.org\/10.1007\/s12033-023-00851-7","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"10 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest related to the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"All the animal care and treatment regulations were implemented in line with the guidelines for the care and use of experimental animals of Southern Medical University, Guangzhou, China.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}