{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:42:43Z","timestamp":1788748963196,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s12033-023-01029-x","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T08:02:19Z","timestamp":1706169739000},"page":"991-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression Significance of Estrogen Receptor ER-\u03b136 in Breast Cancer Treated by Chemotherapy: A Meta-Analysis"],"prefix":"10.1007","volume":"66","author":[{"given":"Enping","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuliang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2560-2369","authenticated-orcid":false,"given":"Ping","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"issue":"173","key":"1029_CR1","first-page":"189","volume":"34","author":"CW Gao","year":"2022","unstructured":"Gao, C. W., Wang, J. G., He, P. S., & Xiong, X. (2022). Metastatic pattern of breast cancer by histologic grade: A seer population-based study. Discovery Medicine, 34(173), 189\u2013197.","journal-title":"Discovery Medicine"},{"issue":"2","key":"1029_CR2","first-page":"435","volume":"39","author":"L Li","year":"2023","unstructured":"Li, L., Zhu, X. H., & Wu, P. (2023). Correlation between the expression levels of c-erbb-2, pr and er and the characteristics of calcification foci in breast cancer. Acta Medica Mediterranea, 39(2), 435\u2013439.","journal-title":"Acta Medica Mediterranea"},{"issue":"6","key":"1029_CR3","first-page":"1399","volume":"32","author":"GD Yao","year":"2018","unstructured":"Yao, G. D., Niu, Y. Y., Chen, K. X., Meng, H. X., Song, H. T., Tian, Z. N., Geng, J. S., & Feng, M. Y. (2018). SOX2 gene expression and its role in triple negative breast cancer tissues. Journal of Biological Regulators and Homeostatic Agents, 32(6), 1399\u20131406.","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"issue":"5","key":"1029_CR4","first-page":"353","volume":"29","author":"V Gotzos","year":"1983","unstructured":"Gotzos, V., Cappelli-Gotzos, B., & Conti, G. (1983). Study on the multiplication of cancer cells in a pleural effusion from a woman having a breast adenocarcinoma. Cellular and Molecular Biology, 29(5), 353\u2013355.","journal-title":"Cellular and Molecular Biology"},{"issue":"1","key":"1029_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12940-020-00670-2","volume":"19","author":"M Koual","year":"2020","unstructured":"Koual, M., Tomkiewicz, C., Cano-Sancho, G., Antignac, J. P., Bats, A. S., & Coumoul, X. (2020). Environmental chemicals, breast cancer progression and drug resistance. Environmental Health, 19(1), 117.","journal-title":"Environmental Health"},{"issue":"10","key":"1029_CR6","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.7150\/ijbs.60292","volume":"17","author":"HL Yan","year":"2021","unstructured":"Yan, H. L., Luo, B., Wu, X. Y., Guan, F., Yu, X. X., Zhao, L. N., Ke, X. K., Wu, J., & Yuan, J. P. (2021). Cisplatin induces pyroptosis via activation of meg3\/nlrp3\/caspase-1\/gsdmd pathway in triple-negative breast cancer. International Journal of Biological Sciences, 17(10), 2606\u20132621.","journal-title":"International Journal of Biological Sciences"},{"issue":"3","key":"1029_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.21037\/cco.2020.01.06","volume":"9","author":"T Iwamoto","year":"2020","unstructured":"Iwamoto, T., Kajiwara, Y., Zhu, Y. D., & Iha, S. (2020). Biomarkers of neoadjuvant\/adjuvant chemotherapy for breast cancer. Chinese Clinical Oncology, 9(3), 27.","journal-title":"Chinese Clinical Oncology"},{"key":"1029_CR8","volume-title":"Subtypes of breast cancer","year":"2022","unstructured":"Orrantia-Borunda, E., Anchondo-Nu\u00f1ez, P., Acu\u00f1a-Aguilar, L. E., G\u00f3mez-Valles, F. O., Ram\u00edrez-Valdespino, C. A., & Mayrovitz, H. N. (Eds.). (2022). Subtypes of breast cancer. Exon Publications."},{"issue":"22","key":"1029_CR9","doi-asserted-by":"publisher","first-page":"10327","DOI":"10.1111\/jcmm.16946","volume":"25","author":"Y Li","year":"2021","unstructured":"Li, Y., Kong, X. Y., Xuan, L. X., Wang, Z. Z., & Huang, Y. H. (2021). Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment. Journal of Cellular and Molecular Medicine, 25(22), 10327\u201310348.","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"2","key":"1029_CR10","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1042\/BST20191055","volume":"48","author":"S Lev","year":"2020","unstructured":"Lev, S. (2020). Targeted therapy and drug resistance in triple-negative breast cancer: The EGFR axis. Biochemical Society Transactions, 48(2), 657\u2013665.","journal-title":"Biochemical Society Transactions"},{"key":"1029_CR11","doi-asserted-by":"publisher","first-page":"100851","DOI":"10.1016\/j.drup.2022.100851","volume":"63","author":"D Singh","year":"2022","unstructured":"Singh, D., Assaraf, Y. G., & Gacche, R. N. (2022). Long non-coding RNA mediated drug resistance in breast cancer. Drug Resist Updat, 63, 100851.","journal-title":"Drug Resist Updat"},{"key":"1029_CR12","doi-asserted-by":"publisher","first-page":"104806","DOI":"10.1016\/j.phrs.2020.104806","volume":"156","author":"JP Kaboli","year":"2020","unstructured":"Kaboli, J. P., Salimian, F., Aghapour, S., Xiang, S. X., Zhao, Q. J., Li, M. X., Wu, X., Du, F. K., Zhao, Y. S., Shen, J., Cho, C. H., & Xiao, Z. G. (2020). Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer\u2014A comprehensive review from chemotherapy to immunotherapy. Pharmacological Research, 156, 104806.","journal-title":"Pharmacological Research"},{"issue":"1","key":"1029_CR13","doi-asserted-by":"publisher","first-page":"e126919","DOI":"10.5812\/ijpr-126919","volume":"21","author":"XH Pan","year":"2022","unstructured":"Pan, X. H., Song, Z., Cui, Y., Qi, M., Wu, G. J., & Wang, M. (2022). Enhancement of sensitivity to tamoxifen by berberine in breast cancer cells by inhibiting er-\u03b136 expression. Iranian Journal of Pharmaceutical Research, 21(1), e126919.","journal-title":"Iranian Journal of Pharmaceutical Research"},{"issue":"S1","key":"1029_CR14","doi-asserted-by":"publisher","first-page":"S123","DOI":"10.3233\/BD-219019","volume":"40","author":"A Juliansyah","year":"2021","unstructured":"Juliansyah, A., Rahman, S., Indra, I., Nelwan, B., & Prihantono, P. (2021). Association of ER\u03b1-36 expression with the de novo resistance of tamoxifen in ER-positive breast cancer. Breast Disease, 40(S1), S123\u2013S127.","journal-title":"Breast Disease"},{"issue":"2","key":"1029_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/path.5657","volume":"254","author":"YX Wang","year":"2021","unstructured":"Wang, Y. X., Pan, X. H., Li, Y. J., Wang, R., Yang, Y. Y., Jiang, B. C., Sun, G. P., Shao, C. S. H., Wang, M., & Gong, Y. Q. (2021). CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p\/ER-\u03b136 axis. The Journal of Pathology, 254(2), 185\u2013198.","journal-title":"The Journal of Pathology"},{"key":"1029_CR16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.steroids.2014.03.003","volume":"84","author":"LF Yu","year":"2014","unstructured":"Yu, L. F., Ke, W., Wang, Y. L., Ding, W., Wang, B., Huang, S., Chen, J., Wang, X. T., Wang, Z. Y., & Shen, P. (2014). Predictive and prognostic value of ER-\u03b136 expression in breast cancer patients treated with chemotherapy. Steroids, 84, 11\u201316.","journal-title":"Steroids"},{"issue":"2","key":"1029_CR17","first-page":"522","volume":"24","author":"SG Zhu","year":"2019","unstructured":"Zhu, S. G., Li, Y., Wang, Y. D., Cao, J. Q., Li, X. H., Wang, J., & Wang, X. M. (2019). Efficacy of neoadjuvant chemotherapy and Annexin A3 expression in breast cancer. Journal of B.U.ON., 24(2), 522\u2013528.","journal-title":"Journal of B.U.ON."},{"issue":"18","key":"1029_CR18","first-page":"3272","volume":"127","author":"QH Qin","year":"2014","unstructured":"Qin, Q. H., Gao, F. F., Jiang, W., Tan, Q. X., Mo, Q. G., & Wei, C. Y. (2014). Effect of neoadjuvant chemotherapy on expressions of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67 in breast cancer. Chinese Medical Journal (England), 127(18), 3272\u20133277.","journal-title":"Chinese Medical Journal (England)"},{"issue":"1","key":"1029_CR19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/jcp.2010.082776","volume":"64","author":"S Vranic","year":"2011","unstructured":"Vranic, S., Gatalica, Z., Deng, H., Frkovic-Grazio, S., Lee, L. M., Gurjeva, O., & Wang, Z. Y. (2011). ER-\u03b136, a novel isoform of ER-\u03b166, is commonly over-expressed in apocrine and adenoid cystic carcinomas of the breast. Journal of Clinical Pathology, 64(1), 54\u201357.","journal-title":"Journal of Clinical Pathology"},{"issue":"1","key":"1029_CR20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13058-020-01278-7","volume":"22","author":"HP Konan","year":"2020","unstructured":"Konan, H. P., Kassem, L., Omarjee, S., Surmieliova-Garn\u00e8s, A., Jacquemetton, J., Cascales, E., Rezza, A., Tr\u00e9dan, O., Treilleux, I., Poulard, C., & Le Romancer, M. (2020). ER\u03b1-36 regulates progesterone receptor activity in breast cancer. Breast Cancer Research, 22(1), 50.","journal-title":"Breast Cancer Research"},{"key":"1029_CR21","doi-asserted-by":"publisher","first-page":"102375","DOI":"10.1016\/j.ctrv.2022.102375","volume":"105","author":"AJ Kerr","year":"2022","unstructured":"Kerr, A. J., Dodwell, D., McGale, P., Holt, F., Duane, F., Mannu, G., Darby, S. C., & Taylor, C. W. (2022). Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality. Cancer Treatment Reviews, 105, 102375.","journal-title":"Cancer Treatment Reviews"},{"issue":"6","key":"1029_CR22","first-page":"3950","volume":"19","author":"L Yin","year":"2020","unstructured":"Yin, L., Qi, X. W., Liu, X. Z., Yang, Z. Y., Cai, R. L., Cui, H. J., Chen, L., & Yu, S. C. (2020). Icaritin enhances the efficacy of cetuximab against triple-negative breast cancer cells. Oncology Letters, 19(6), 3950\u20133958.","journal-title":"Oncology Letters"},{"key":"1029_CR23","doi-asserted-by":"publisher","first-page":"105307","DOI":"10.1016\/j.phrs.2020.105307","volume":"163","author":"F Mahboobifard","year":"2021","unstructured":"Mahboobifard, F., Dargahi, L., Jorjani, M., Ramezani Tehrani, F., & Pourgholami, M. H. (2021). The role of ER\u03b136 in cell type-specific functions of estrogen and cancer development. Pharmacological Research, 163, 105307.","journal-title":"Pharmacological Research"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-023-01029-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-023-01029-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-023-01029-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:26:45Z","timestamp":1715336805000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-023-01029-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["1029"],"URL":"https:\/\/doi.org\/10.1007\/s12033-023-01029-x","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"27 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}