{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:50:29Z","timestamp":1793040629901,"version":"4.5.0"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Open Foundation of Hubei Province Key Laboratory of Tumor Microencironment and Immunotherapy","award":["2023KZL018"],"award-info":[{"award-number":["2023KZL018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                <jats:title>Abstract<\/jats:title>\n                <jats:p>Aptamers, as a kind of small-molecule nucleic acid, have attracted much attention since their discovery. Compared with biological reagents such as antibodies, aptamers have the advantages of small molecular weight, low immunogenicity, low cost, and easy modification. At present, aptamers are mainly used in disease biomarker discovery, disease diagnosis, treatment, and targeted drug delivery vectors. In the process of screening and optimizing aptamers, it is found that there are still many problems need to be solved such as the design of the library, optimization of screening conditions, the truncation of screened aptamer, and the stability and toxicity of the aptamer. In recent years, the incidence of liver-related diseases is increasing year by year and the treatment measures are relatively lacking, which has attracted the people\u2019s attention in the application of aptamers in liver diseases. This article mainly summarizes the research status of aptamers in disease diagnosis and treatment, especially focusing on the application of aptamers in liver diseases, showing the crucial significance of aptamers in the diagnosis and treatment of liver diseases, and the use of Discovery Studio software to find the binding target and sequence of aptamers, and explore their possible interaction sites.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s12033-023-01030-4","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T13:02:48Z","timestamp":1706878968000},"page":"1000-1018","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Application of Aptamer\u00a0and Research Progress in Liver Disease"],"prefix":"10.1007","volume":"66","author":[{"given":"Cheng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-1436","authenticated-orcid":false,"given":"Lan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"issue":"6287","key":"1030_CR1","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/346818a0","volume":"346","author":"AD Ellington","year":"1990","unstructured":"Ellington, A. D., & Szostak, J. W. (1990). In vitro selection of RNA molecules that bind specific ligands. Nature, 346(6287), 818\u2013822.","journal-title":"Nature"},{"issue":"4968","key":"1030_CR2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1126\/science.2200121","volume":"249","author":"C Tuerk","year":"1990","unstructured":"Tuerk, C., & Gold, L. (1990). Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (New York, N.Y.), 249(4968), 505\u2013510.","journal-title":"Science (New York, N.Y.)"},{"issue":"32","key":"1030_CR3","doi-asserted-by":"publisher","first-page":"1606632","DOI":"10.1002\/adfm.201606632","volume":"27","author":"S Pal","year":"2017","unstructured":"Pal, S., Harmsen, S., Oseledchyk, A., Hsu, H. T., & Kircher, M. F. (2017). MUC1 aptamer targeted SERS nanoprobes. Advanced Functional Materials, 27(32), 1606632.","journal-title":"Advanced Functional Materials"},{"issue":"12","key":"1030_CR4","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1158\/1535-7163.MCT-06-0172","volume":"5","author":"CR Ireson","year":"2006","unstructured":"Ireson, C. R., & Kelland, L. R. (2006). Discovery and development of anticancer aptamers. Molecular Cancer Therapeutics, 5(12), 2957\u20132962.","journal-title":"Molecular Cancer Therapeutics"},{"issue":"6","key":"1030_CR5","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/nar\/24.6.1029","volume":"24","author":"A Geiger","year":"1996","unstructured":"Geiger, A., Burgstaller, P., von der Eltz, H., Roeder, A., & Famulok, M. (1996). RNA aptamers that bind l-arginine with sub-micromolar dissociation constants and high enantioselectivity. Nucleic Acids Research, 24(6), 1029\u20131036.","journal-title":"Nucleic Acids Research"},{"issue":"4","key":"1030_CR6","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1017\/S1355838200991763","volume":"6","author":"C Mannironi","year":"2000","unstructured":"Mannironi, C., Scerch, C., Fruscoloni, P., & Tocchini-Valentini, G. P. (2000). Molecular recognition of amino acids by RNA aptamers: the evolution into an l-tyrosine binder of a dopamine-binding RNA motif. RNA (New York, N.Y.), 6(4), 520\u2013527.","journal-title":"RNA (New York, N.Y.)"},{"issue":"23","key":"1030_CR7","doi-asserted-by":"publisher","first-page":"5798","DOI":"10.1002\/j.1460-2075.1995.tb00268.x","volume":"14","author":"K Harada","year":"1995","unstructured":"Harada, K., & Frankel, A. D. (1995). Identification of two novel arginine binding DNAs. The EMBO Journal, 14(23), 5798\u20135811.","journal-title":"The EMBO Journal"},{"issue":"21","key":"1030_CR8","doi-asserted-by":"publisher","first-page":"11285","DOI":"10.1073\/pnas.94.21.11285","volume":"94","author":"KP Williams","year":"1997","unstructured":"Williams, K. P., Liu, X. H., Schumacher, T. N., Lin, H. Y., Ausiello, D. A., Kim, P. S., & Barte, D. P. (1997). Bioactive and nuclease-resistantl-DNA ligand of vasopressin. Proceedings of the National Academy of Sciences of the United States of America, 94(21), 11285\u201390.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America."},{"issue":"21","key":"1030_CR9","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.1021\/bi9600106","volume":"35","author":"H Chen","year":"1996","unstructured":"Chen, H., McBroom, D. G., Zhu, Y. Q., Gold, L., & North, T. W. (1996). Inhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus. Biochemistry, 35(21), 6923\u20136930.","journal-title":"Biochemistry"},{"issue":"2","key":"1030_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1006\/jmbi.1996.0640","volume":"264","author":"C Dang","year":"1996","unstructured":"Dang, C., & Jayasena, S. D. (1996). Oligonucleotide inhibitors of Taq DNA polymerase facilitate detection of low copy number targets by PCR. Journal of Molecular Biology, 264(2), 268\u2013278.","journal-title":"Journal of Molecular Biology"},{"issue":"36","key":"1030_CR11","doi-asserted-by":"publisher","first-page":"11363","DOI":"10.1021\/bi00036a009","volume":"34","author":"D Jellinek","year":"1995","unstructured":"Jellinek, D., Green, L. S., Bell, C., Lynott, C. K., Gill, N., Vargeese, C., Kirschenheuter, G., McGee, D. P., Abesinghe, P., & Pieken, W. A. (1995). Potent 2\u2032-amino-2\u2032-deoxypyrimidine RNA inhibitors of basic fibroblast growth factor. Biochemistry, 34(36), 11363\u201311372.","journal-title":"Biochemistry"},{"issue":"17","key":"1030_CR12","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1093\/nar\/26.17.3915","volume":"26","author":"KA Davis","year":"1998","unstructured":"Davis, K. A., Lin, Y., Abrams, B., & Jayasena, S. D. (1998). Staining of cell surface human CD4 with 2\u2032-F-pyrimidine-containing RNA aptamers for flow cytometry. Nucleic Acids Research, 26(17), 3915\u20133924.","journal-title":"Nucleic Acids Research"},{"key":"1030_CR13","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1039\/b604778e","volume":"30","author":"P Mallikaratchy","year":"2006","unstructured":"Mallikaratchy, P., Stahelin, R. V., Cao, Z., Cho, W., & Tan, W. (2006). Selection of DNA ligands for protein kinase C-delta. Chemical Communications (Cambridge, England), 30, 3229\u20133231.","journal-title":"Chemical Communications (Cambridge, England)"},{"issue":"18","key":"1030_CR14","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.1021\/ac049857v","volume":"76","author":"SD Mendonsa","year":"2004","unstructured":"Mendonsa, S. D., & Bowser, M. T. (2004). In vitro selection of high-affinity DNA ligands for human IgE using capillary electrophoresis. Analytical Chemistry, 76(18), 5387\u20135392.","journal-title":"Analytical Chemistry"},{"issue":"1","key":"1030_CR15","first-page":"112","volume":"4","author":"ST Wallace","year":"1998","unstructured":"Wallace, S. T., & Schroeder, R. (1998). In vitro selection and characterization of streptomycin-binding RNAs: recognition discrimination between antibiotics. RNA (New York, N.Y.), 4(1), 112\u2013123.","journal-title":"RNA (New York, N.Y.)"},{"issue":"32","key":"1030_CR16","doi-asserted-by":"publisher","first-page":"11838","DOI":"10.1073\/pnas.0602615103","volume":"103","author":"D Shangguan","year":"2006","unstructured":"Shangguan, D., Li, Y., Tang, Z., Cao, Z. C., Chen, H. W., Mallikaratchy, P., Sefah, K., Yang, C. J., & Tan, W. (2006). Aptamers evolved from live cells as effective molecular probes for cancer study. Proceedings of the National Academy of Sciences of the United States of America, 103(32), 11838\u201311843.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"13","key":"1030_CR17","doi-asserted-by":"publisher","first-page":"4900","DOI":"10.1021\/ac070189y","volume":"79","author":"Z Tang","year":"2007","unstructured":"Tang, Z., Shangguan, D., Wang, K., Shi, H., Sefah, K., Mallikratchy, P., Chen, H. W., Li, Y., & Tan, W. (2007). Selection of aptamers for molecular recognition and characterization of cancer cells. Analytical Chemistry, 79(13), 4900\u20134907.","journal-title":"Analytical Chemistry"},{"issue":"6","key":"1030_CR18","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/cmdc.200800030","volume":"3","author":"HW Chen","year":"2008","unstructured":"Chen, H. W., Medley, C. D., Sefah, K., Shangguan, D., Tang, Z., Meng, L., Smith, J. E., & Tan, W. (2008). Molecular recognition of small-cell lung cancer cells using aptamers. ChemMedChem, 3(6), 991\u20131001.","journal-title":"ChemMedChem"},{"issue":"2","key":"1030_CR19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/leu.2008.335","volume":"23","author":"K Sefah","year":"2009","unstructured":"Sefah, K., Tang, Z. W., Shangguan, D. H., Chen, H., Lopez-Colon, D., Li, Y., Parekh, P., Martin, J., Meng, L., Phillips, J. A., Kim, Y. M., & Tan, W. H. (2009). Molecular recognition of acute myeloid leukemia using aptamers. Leukemia, 23(2), 235\u2013244.","journal-title":"Leukemia"},{"issue":"25","key":"1030_CR20","doi-asserted-by":"publisher","first-page":"11509","DOI":"10.1073\/pnas.92.25.11509","volume":"92","author":"W Pan","year":"1995","unstructured":"Pan, W., Craven, R. C., Qiu, Q., Wilson, C. B., Wills, J. W., Golovine, S., & Wang, J. F. (1995). Isolation of virus-neutralizing RNAs from a large pool of random sequences. Proceedings of the National Academy of Sciences of the United States of America, 92(25), 11509\u201311513.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"1030_CR21","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1006\/viro.1997.8773","volume":"237","author":"PK Kumar","year":"1997","unstructured":"Kumar, P. K., Machida, K., Urvil, P. T., Kakiuchi, N., Vishnuvardhan, D., Shimotohno, K., Taira, K., & Nishikawa, S. (1997). Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA. Virology, 237(2), 270\u2013282.","journal-title":"Virology"},{"issue":"Pt 3","key":"1030_CR22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1099\/vir.0.81508-0","volume":"87","author":"SCB Gopinath","year":"2006","unstructured":"Gopinath, S. C. B., Misono, T. S., Kawasaki, K., Mizuno, T., Imai, M., Odagiri, T., & Kumar, P. K. R. (2006). An RNA aptamer that distinguishes between closely related human influenza viruses and inhibits haemagglutinin-mediated membrane fusion. The Journal of General Virology, 87(Pt 3), 479\u2013487.","journal-title":"The Journal of General Virology"},{"issue":"4","key":"1030_CR23","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1373\/clinchem.2008.113514","volume":"55","author":"Z Tang","year":"2009","unstructured":"Tang, Z., Parekh, P., Turner, P., Moyer, R. W., & Tan, W. (2009). Generating aptamers for recognition of virus-infected cells. Clinical Chemistry, 55(4), 813\u2013822.","journal-title":"Clinical Chemistry"},{"issue":"5","key":"1030_CR24","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0956-5663(99)00028-7","volume":"14","author":"JG Bruno","year":"1999","unstructured":"Bruno, J. G., & Kiel, J. L. (1999). In vitro selection of DNA aptamers to anthrax spores with electrochemiluminescence detection. Biosensors & Bioelectronics, 14(5), 457\u2013464.","journal-title":"Biosensors & Bioelectronics"},{"issue":"20","key":"1030_CR25","doi-asserted-by":"publisher","first-page":"7812","DOI":"10.1021\/ac801272s","volume":"80","author":"CL Hamula","year":"2008","unstructured":"Hamula, C. L., Zhang, H., Guan, L. L., Li, X. F., & Le, X. C. (2008). Selection of aptamers against live bacterial cells. Analytical Chemistry, 80(20), 7812\u20137819.","journal-title":"Analytical Chemistry"},{"issue":"4","key":"1030_CR26","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00216-007-1735-8","volume":"390","author":"M Rajendran","year":"2008","unstructured":"Rajendran, M., & Ellington, A. D. (2008). Selection of fluorescent aptamer beacons that light up in the presence of zinc. Analytical and Bioanalytical Chemistry, 390(4), 1067\u20131075.","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"7","key":"1030_CR27","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/jhbp.245","volume":"22","author":"E Seki","year":"2015","unstructured":"Seki, E., & Brenner, D. A. (2015). Recent advancement of molecular mechanisms of liver fibrosis. Journal of Hepato-Biliary-Pancreatic Sciences, 22(7), 512\u2013518.","journal-title":"Journal of Hepato-Biliary-Pancreatic Sciences"},{"issue":"3","key":"1030_CR28","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3350\/cmh.2020.0081","volume":"26","author":"TS Lim","year":"2020","unstructured":"Lim, T. S., & Kim, J. K. (2020). Is liver biopsy still useful in the era of non-invasive tests? Clinical and Molecular Hepatology, 26(3), 302\u2013304.","journal-title":"Clinical and Molecular Hepatology"},{"key":"1030_CR29","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.canlet.2020.12.022","volume":"501","author":"G Zhou","year":"2021","unstructured":"Zhou, G., Da, W., Bae, S., Nguyen, R., Huo, X., Han, S., Zhang, Z., Hebbard, L., Duan, W., Eslam, M., Liddle, C., Yuen, L., Lam, V., Qiao, L., & George, J. (2021). An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells. Cancer Letters, 501, 124\u2013132.","journal-title":"Cancer Letters"},{"issue":"6","key":"1030_CR30","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.7150\/thno.30972","volume":"9","author":"WY Lai","year":"2019","unstructured":"Lai, W. Y., Wang, J. W., Huang, B. T., Lin, E. P., & Yang, P. C. (2019). A novel TNF-\u03b1-targeting aptamer for TNF-\u03b1-mediated acute lung injury and acute liver failure. Theranostics, 9(6), 1741\u20131751.","journal-title":"Theranostics"},{"issue":"9","key":"1030_CR31","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1136\/bjo.2007.118562","volume":"91","author":"AL Takeda","year":"2007","unstructured":"Takeda, A. L., Colquitt, J., Clegg, A. J., & Jones, J. (2007). Pegaptanib and ranibizumab for neovascular age-related macular degeneration: A systematic review. British Journal of Ophthalmology, 91(9), 1177\u20131182.","journal-title":"British Journal of Ophthalmology"},{"issue":"3","key":"1030_CR32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.yexmp.2009.01.004","volume":"86","author":"PJ Bates","year":"2009","unstructured":"Bates, P. J., Laber, D. A., Miller, D. M., Thomas, S. D., & Trent, J. O. (2009). Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Experimental and molecular pathology, 86(3), 151\u2013164.","journal-title":"Experimental and molecular pathology"},{"issue":"10016","key":"1030_CR33","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0140-6736(15)00515-2","volume":"387","author":"AM Lincoff","year":"2016","unstructured":"Lincoff, A. M., Mehran, R., Povsic, T. J., Zelenkofske, S. L., Huang, Z., Armstrong, P. W., Steg, P. G., Bode, C., Cohen, M. G., Buller, C., Laanmets, P., Valgimigli, M., Marandi, T., Fridrich, V., Cantor, W. J., Merkely, B., Lopez-Sendon, J., Cornel, J. H., Kasprzak, J. D., \u2026 Investigators, R.E.G.U.L.A.T.E.-P.C.I. (2016). Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): A randomised clinical trial. Lancet (London, England), 387(10016), 349\u2013356.","journal-title":"Lancet (London, England)"},{"key":"1030_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bios.2018.03.037","volume":"110","author":"S Dehghani","year":"2018","unstructured":"Dehghani, S., Nosrati, R., Yousefi, M., Nezami, A., Soltani, F., Taghdisi, S. M., Abnous, K., Alibolandi, M., & Ramezani, M. (2018). Aptamer-based biosensors and nanosensors for the detection of vascular endothelial growth factor (VEGF): A review. Biosensors & Bioelectronics, 110, 23\u201337.","journal-title":"Biosensors & Bioelectronics"},{"issue":"5","key":"1030_CR35","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3390\/molecules24050941","volume":"24","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y., Lai, B. S., & Juhas, M. (2019). Recent advances in aptamer discovery and applications. Molecules (Basel, Switzerland), 24(5), 941.","journal-title":"Molecules (Basel, Switzerland)"},{"key":"1030_CR36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1196\/annals.1348.062","volume":"1082","author":"EWM Ng","year":"2006","unstructured":"Ng, E. W. M., & Adamis, A. P. (2006). Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases. Annals of the New York Academy of Sciences, 1082, 151\u2013171.","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"6","key":"1030_CR37","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/nprot.2010.66","volume":"5","author":"K Sefah","year":"2010","unstructured":"Sefah, K., Shangguan, D., Xiong, X., O\u2019Donoghue, M. B., & Tan, W. (2010). Development of DNA aptamers using cell-SELEX. Nature protocols, 5(6), 1169\u20131185.","journal-title":"Nature protocols"},{"key":"1030_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ymeth.2016.03.008","volume":"106","author":"KN Meek","year":"2016","unstructured":"Meek, K. N., Rangel, A. E., & Heemstra, J. M. (2016). Enhancing aptamer function and stability via in vitro selection using modified nucleic acids. Methods (San Diego, California), 106, 29\u201336.","journal-title":"Methods (San Diego, California)"},{"issue":"12","key":"1030_CR39","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1007\/s11095-004-7676-4","volume":"21","author":"JM Healy","year":"2004","unstructured":"Healy, J. M., Lewis, S. D., Kurz, M., Boomer, R. M., Thompson, K. M., Wilson, C., & McCauley, T. G. (2004). Pharmacokinetics and biodistribution of novel aptamer compositions. Pharmaceutical Research, 21(12), 2234\u20132246.","journal-title":"Pharmaceutical Research"},{"issue":"10","key":"1030_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.30","volume":"4","author":"CH Lee","year":"2015","unstructured":"Lee, C. H., Lee, S. H., Kim, J. H., Noh, Y. H., Noh, G. J., & Lee, S. W. (2015). Pharmacokinetics of a cholesterol-conjugated aptamer against the hepatitis C Virus (HCV) NS5B protein. Molecular Therapy. Nucleic acids, 4(10), e254.","journal-title":"Molecular Therapy. Nucleic acids"},{"issue":"229","key":"1030_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2016.03.006","volume":"10","author":"K Heo","year":"2016","unstructured":"Heo, K., Min, S. W., Sung, H. J., Kim, H. G., Kim, H. J., Kim, Y. H., Choi, B. K., Han, S., Chung, S., Lee, E. S., Chung, J., & Kim, I. H. (2016). An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies. Journal of Controlled Release, 10(229), 1\u20139.","journal-title":"Journal of Controlled Release"},{"issue":"32","key":"1030_CR42","doi-asserted-by":"publisher","first-page":"10002","DOI":"10.1073\/pnas.1502159112","volume":"112","author":"L Chen","year":"2015","unstructured":"Chen, L., Rashid, F., Shah, A., Awan, H. M., Wu, M., Liu, A., Wang, J., Zhu, T., Luo, Z., & Shan, G. (2015). The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation. Proceedings of the National Academy of Sciences of the United States of America, 112(32), 10002\u201310007.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"1030_CR43","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/nar\/gkn1088","volume":"37","author":"M Takahashi","year":"2009","unstructured":"Takahashi, M., Minakawa, N., & Matsuda, A. (2009). Synthesis and characterization of 2\u2032-modified-4\u2032-thioRNA: A comprehensive comparison of nuclease stability. Nucleic Acids Research, 37(4), 1353\u20131362.","journal-title":"Nucleic Acids Research"},{"key":"1030_CR44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev-pharmtox-010716-104558","volume":"57","author":"SM Nimjee","year":"2017","unstructured":"Nimjee, S. M., White, R. R., Becker, R. C., & Sullenger, B. A. (2017). Aptamers as therapeutics. Annual Review of Pharmacology and Toxicology, 57, 61\u201379.","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"5","key":"1030_CR45","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1038\/mtna.2012.14","volume":"1","author":"SE Wilner","year":"2012","unstructured":"Wilner, S. E., Wengerter, B., Maier, K., de Lourdes Borba Magalh\u00e3es, M., Del-Amo, D. S., Pai, S., Opazo, F., Rizzoli, S. O., Yan, A., & Levy, M. (2012). An RNA alternative to human transferrin: a new tool for targeting human cells. Molecular Therapy Nucleic Acids, 1(5), e21.","journal-title":"Molecular Therapy Nucleic Acids"},{"issue":"5","key":"1030_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.44","volume":"48","author":"H Jo","year":"2016","unstructured":"Jo, H., & Ban, C. (2016). Aptamer\u2013nanoparticle complexes as powerful diagnostic and therapeutic tools. Experimental & Molecular Medicine, 48(5), e230.","journal-title":"Experimental & Molecular Medicine"},{"issue":"1","key":"1030_CR47","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ophtha.2015.09.004","volume":"123","author":"GJ Jaffe","year":"2016","unstructured":"Jaffe, G. J., Eliott, D., Wells, J. A., Prenner, J. L., Papp, A., & Patel, S. (2016). A phase 1 study of intravitreous E10030 in combination with ranibizumab in neovascular age-related macular degeneration. Ophthalmology, 123(1), 78\u201385.","journal-title":"Ophthalmology"},{"issue":"2","key":"1030_CR48","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ophtha.2016.10.010","volume":"124","author":"GJ Jaffe","year":"2017","unstructured":"Jaffe, G. J., Ciulla, T. A., Ciardella, A. P., Devin, F., Dugel, P. U., Eandi, C. M., Masonson, H., Mon\u00e9s, J., Pearlman, J. A., Quaranta-El Maftouhi, M., Ricci, F., Westby, K., & Patel, S. C. (2017). Dual antagonism of PDGF and VEGF in neovascular age-related macular degeneration: a phase IIb, multicenter, randomized controlled trial. Ophthalmology, 124(2), 224\u2013234.","journal-title":"Ophthalmology"},{"issue":"40","key":"1030_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902776","volume":"15","author":"A Shoval","year":"2019","unstructured":"Shoval, A., Markus, A., Zhou, Z., Liu, X., Cazelles, R., Willner, I., & Mandel, Y. (2019). Anti-VEGF-aptamer modified c-dots-a hybrid nanocomposite for topical treatment of ocular vascular disorders. Small (Weinheim an der Bergstrasse, Germany), 15(40), e1902776.","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"issue":"5","key":"1030_CR50","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1586\/17512433.2013.829645","volume":"6","author":"E Leung","year":"2013","unstructured":"Leung, E., & Landa, G. (2013). Update on current and future novel therapies for dry age-related macular degeneration. Expert Review of Clinical Pharmacology, 6(5), 565\u2013579.","journal-title":"Expert Review of Clinical Pharmacology"},{"issue":"1","key":"1030_CR51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.drudis.2014.09.004","volume":"20","author":"A Vater","year":"2015","unstructured":"Vater, A., & Klussmann, S. (2015). Turning mirror-image oligonucleotides into drugs: The evolution of Spiegelmer(\u00ae) therapeutics. Drug Discovery Today, 20(1), 147\u2013155.","journal-title":"Drug Discovery Today"},{"key":"1030_CR52","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.1038\/ncomms7923","volume":"6","author":"D Oberth\u00fcr","year":"2015","unstructured":"Oberth\u00fcr, D., Achenbach, J., Gabdulkhakov, A., Buchner, K., Maasch, C., Falke, S., Rehders, D., Klussmann, S., & Betzel, C. (2015). Crystal structure of a mirror-image l-RNA aptamer (Spiegelmer) in complex with the natural l-protein target CCL2. Nature Communications, 6, 6923.","journal-title":"Nature Communications"},{"issue":"2","key":"1030_CR53","first-page":"307","volume":"32","author":"J Menne","year":"2017","unstructured":"Menne, J., Eulberg, D., Beyer, D., Baumann, M., Saudek, F., Valkusz, Z., Wi\u0119cek, A., Haller, H., Emapticap Study Group. (2017). C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria. Nephrology Dialysis Transplantation, 32(2), 307\u2013315.","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"7","key":"1030_CR54","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1182\/blood-2013-03-493924","volume":"123","author":"J Hoellenriegel","year":"2014","unstructured":"Hoellenriegel, J., Zboralski, D., Maasch, C., Rosin, N. Y., Wierda, W. G., Keating, M. J., Kruschinski, A., & Burger, J. A. (2014). The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. Blood, 123(7), 1032\u20131039.","journal-title":"Blood"},{"issue":"20","key":"1030_CR55","doi-asserted-by":"publisher","first-page":"5514","DOI":"10.1182\/blood-2010-10-311936","volume":"117","author":"EK Waters","year":"2011","unstructured":"Waters, E. K., Genga, R. M., Schwartz, M. C., Nelson, J. A., Schaub, R. G., Olson, K. A., Kurz, J. C., & McGinness, K. E. (2011). Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood, 117(20), 5514\u20135522.","journal-title":"Blood"},{"issue":"12","key":"1030_CR56","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1093\/nar\/gkx274","volume":"45","author":"NQ Do","year":"2017","unstructured":"Do, N. Q., Chung, W. J., Truong, T. H. A., Heddi, B., & Phan, A. T. (2017). G-quadruplex structure of an anti-proliferative DNA sequence. Nucleic Acids Research, 45(12), 7487\u20137493.","journal-title":"Nucleic Acids Research"},{"key":"1030_CR57","doi-asserted-by":"crossref","unstructured":"Lincoff, A.M., Mehran, R., Povsic, T.J., Zelenkofske, S.L., Huang, Z., Armstrong, P.W., Steg, P.G., Bode, C., Cohen, M.G., Buller, C., Laanmets, P., Valgimigli, M., Marandi, T., Fridrich, V., Cantor, W.J., Merkely, B., Lopez-Sendon, J., Cornel, J.H., Kasprzak, J.D., Aschermann, M., Guetta, V., Morais, J., Sinnaeve, P.R., Huber, K., Stables, R., Sellers, M.A., Borgman, M., Glenn, L., Levinson, A.I., Lopes, R.D., Hasselblad, V., Becker, R.C., Alexander, J. H., \u2026 REGULATE-PCI Investigators. (2016). Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): A randomised clinical trial. Lancet (London, England), 387(10016), 349\u2013356.","DOI":"10.1016\/S0140-6736(15)00515-2"},{"issue":"10","key":"1030_CR58","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1161\/ATVBAHA.119.312439","volume":"39","author":"WC Chen","year":"2019","unstructured":"Chen, W. C., Voos, K. M., Josephson, C. D., & Li, R. (2019). Short-acting anti-VWF (von Willebrand Factor) aptamer improves the recovery, survival, and hemostatic functions of refrigerated platelets. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(10), 2028\u20132037.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"35","key":"1030_CR59","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1039\/C7CC00310B","volume":"53","author":"Y Guo","year":"2017","unstructured":"Guo, Y., Wang, Y., Li, S., Niu, L., Wei, D., & Zhang, S. (2017). DNA-spheres decorated with magnetic nanocomposites based on terminal transfer reactions for versatile target detection and cellular targeted drug delivery. Chemical Communications (Cambridge, England), 53(35), 4826\u20134829.","journal-title":"Chemical Communications (Cambridge, England)"},{"key":"1030_CR60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.addr.2018.08.005","volume":"134","author":"G Zhu","year":"2018","unstructured":"Zhu, G., & Chen, X. (2018). Aptamer-based targeted therapy. Advanced Drug Delivery Reviews, 134, 65\u201378.","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"2","key":"1030_CR61","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrd1955","volume":"5","author":"EW Ng","year":"2006","unstructured":"Ng, E. W., Shima, D. T., Calias, P., Cunningham, E. T., Jr., Guyer, D. R., & Adamis, A. P. (2006). Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nature Reviews. Drug Discovery, 5(2), 123\u2013132.","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"1","key":"1030_CR62","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.clinthera.2006.01.009","volume":"28","author":"H Kourlas","year":"2006","unstructured":"Kourlas, H., & Schiller, D. S. (2006). Pegaptanib sodium for the treatment of neovascular age-related macular degeneration: A review. Clinical Therapeutics, 28(1), 36\u201344.","journal-title":"Clinical Therapeutics"},{"issue":"Suppl 1","key":"1030_CR63","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000337154","volume":"227","author":"D Veritti","year":"2012","unstructured":"Veritti, D., Sarao, V., & Lanzetta, P. (2012). Neovascular age-related macular degeneration. Ophthalmologica, 227(Suppl 1), 11\u201320.","journal-title":"Ophthalmologica"},{"issue":"2","key":"1030_CR64","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00006982-200204000-00002","volume":"22","author":"Eyetech Study Group","year":"2002","unstructured":"Eyetech Study Group. (2002). Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina, 22(2), 143\u2013152.","journal-title":"Retina"},{"issue":"3","key":"1030_CR65","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrd.2016.199","volume":"16","author":"J Zhou","year":"2017","unstructured":"Zhou, J., & Rossi, J. (2017). Aptamers as targeted therapeutics: Current potential and challenges. Nature Reviews. Drug Discovery, 16(3), 181\u2013202.","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"6","key":"1030_CR66","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1159\/000228926","volume":"223","author":"Z Ni","year":"2009","unstructured":"Ni, Z., & Hui, P. (2009). Emerging pharmacologic therapies for wet age-related macular degeneration. Ophthalmologica, 223(6), 401\u2013410.","journal-title":"Ophthalmologica"},{"issue":"12","key":"1030_CR67","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1182\/blood-2012-09-456756","volume":"121","author":"F Schwoebel","year":"2013","unstructured":"Schwoebel, F., van Eijk, L. T., Zboralski, D., Sell, S., Buchner, K., Maasch, C., Purschke, W. G., Humphrey, M., Z\u00f6llner, S., Eulberg, D., Morich, F., Pickkers, P., & Klussmann, S. (2013). The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood, 121(12), 2311\u20132315.","journal-title":"Blood"},{"issue":"10","key":"1030_CR68","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.3324\/haematol.2018.205930","volume":"104","author":"M Steurer","year":"2019","unstructured":"Steurer, M., Montillo, M., Scarf\u00f2, L., Mauro, F. R., Andel, J., Wildner, S., Trentin, L., Janssens, A., Burgstaller, S., Fr\u00f6mming, A., D\u00fcmmler, T., Riecke, K., Baumann, M., Beyer, D., Vaul\u00e9on, S., Ghia, P., Fo\u00e0, R., Caligaris-Cappio, F., & Gobbi, M. (2019). Olaptesed pegol (NOX-A12) with bendamustine and rituximab: A phase IIa study in patients with relapsed\/refractory chronic lymphocytic leukemia. Haematologica, 104(10), 2053\u20132060.","journal-title":"Haematologica"},{"issue":"3","key":"1030_CR69","doi-asserted-by":"publisher","first-page":"e151","DOI":"10.1016\/j.thromres.2012.05.010","volume":"130","author":"JY Chang","year":"2012","unstructured":"Chang, J. Y., Chantrathammachart, P., Monroe, D. M., & Key, N. S. (2012). Studies on the mechanism of action of the aptamer BAX499, an inhibitor of tissue factor pathway inhibitor. Thrombosis Research, 130(3), e151\u2013e157.","journal-title":"Thrombosis Research"},{"issue":"5 Pt B","key":"1030_CR70","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1016\/j.bbagen.2016.12.015","volume":"1861","author":"PJ Bates","year":"2017","unstructured":"Bates, P. J., Reyes-Reyes, E. M., Malik, M. T., Murphy, E. M., O\u2019Toole, M. G., & Trent, J. O. (2017). G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms. Biochimica et Biophysica Acta. General Subjects, 1861(5 Pt B), 1414\u20131428.","journal-title":"Biochimica et Biophysica Acta. General Subjects"},{"issue":"3","key":"1030_CR71","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1160\/TH10-08-0520","volume":"105","author":"P Jilma-Stohlawetz","year":"2011","unstructured":"Jilma-Stohlawetz, P., Gorczyca, M. E., Jilma, B., Siller-Matula, J., Gilbert, J. C., & Kn\u00f6bl, P. (2011). Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura. Thrombosis and Haemostasis, 105(3), 545\u2013552.","journal-title":"Thrombosis and Haemostasis"},{"key":"1030_CR72","doi-asserted-by":"crossref","unstructured":"Colquitt, J. L., Jones, J., Tan, S. C., Takeda, A., Clegg, A. J., & Price, A. (2008). Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: A systematic review and economic evaluation. Health Technology Assessment, 12(16) iii\u2013iv, ix\u2013201.","DOI":"10.3310\/hta12160"},{"issue":"10","key":"1030_CR73","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2165\/00019053-200725100-00005","volume":"25","author":"SE Wolowacz","year":"2007","unstructured":"Wolowacz, S. E., Roskell, N., Kelly, S., Maciver, F. M., & Brand, C. S. (2007). Cost effectiveness of pegaptanib for the treatment of age-related macular degeneration in the UK. PharmacoEconomics, 25(10), 863\u2013879.","journal-title":"PharmacoEconomics"},{"issue":"6","key":"1030_CR74","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.ophtha.2006.09.019","volume":"114","author":"GC Brown","year":"2007","unstructured":"Brown, G. C., Brown, M. M., Brown, H. C., Kindermann, S., & Sharma, S. (2007). A value-based medicine comparison of interventions for subfoveal neovascular macular degeneration. Ophthalmology, 114(6), 1170\u20131178.","journal-title":"Ophthalmology"},{"issue":"4","key":"1030_CR75","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/j.1524-4733.2007.00283.x","volume":"11","author":"JC Javitt","year":"2008","unstructured":"Javitt, J. C., Zlateva, G. P., Earnshaw, S. R., Pleil, A. M., Graham, C. N., Brogan, A. J., Shah, S. N., & Adamis, A. P. (2008). Cost-effectiveness model for neovascular age-related macular degeneration: Comparing early and late treatment with pegaptanib sodium based on visual acuity. Value Health, 11(4), 563\u2013574.","journal-title":"Value Health."},{"issue":"6","key":"1030_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2014.21","volume":"3","author":"J Zhou","year":"2014","unstructured":"Zhou, J., & Rossi, J. J. (2014). Cell-type-specific, aptamer-functionalized agents for targeted disease therapy. Molecular Therapy. Nucleic Acids, 3(6), e169.","journal-title":"Molecular Therapy. Nucleic Acids"},{"issue":"7228","key":"1030_CR77","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature07758","volume":"457","author":"D Castanotto","year":"2009","unstructured":"Castanotto, D., & Rossi, J. J. (2009). The promises and pitfalls of RNA-interference-based therapeutics. Nature, 457(7228), 426\u2013433.","journal-title":"Nature"},{"issue":"4","key":"1030_CR78","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1089\/cbr.2019.3402","volume":"35","author":"E Sicco","year":"2020","unstructured":"Sicco, E., Baez, J., Ibarra, M., Fern\u00e1ndez, M., Cabral, P., Moreno, M., Cerecetto, H., & Calzada, V. (2020). Sgc8-c aptamer as a potential theranostic agent for hemato-oncological malignancies. Cancer Biotherapy & Radiopharmaceuticals, 35(4), 262\u2013270.","journal-title":"Cancer Biotherapy & Radiopharmaceuticals"},{"issue":"3","key":"1030_CR79","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1089\/nat.2018.0732","volume":"28","author":"AC Yan","year":"2018","unstructured":"Yan, A. C., & Levy, M. (2018). Aptamer-mediated delivery and cell-targeting aptamers: room for improvement. Nucleic Acid Therapeutics, 28(3), 194\u2013199.","journal-title":"Nucleic Acid Therapeutics"},{"issue":"4","key":"1030_CR80","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","volume":"147","author":"T Luedde","year":"2014","unstructured":"Luedde, T., Kaplowitz, N., & Schwabe, R. F. (2014). Cell death and cell death responses in liver disease: Mechanisms and clinical relevance. Gastroenterology, 147(4), 765\u2013783.","journal-title":"Gastroenterology"},{"issue":"9204","key":"1030_CR81","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0140-6736(99)00219-6","volume":"355","author":"MC Kew","year":"2000","unstructured":"Kew, M. C. (2000). Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet (London, England), 355(9204), 591\u2013592.","journal-title":"Lancet (London, England)"},{"issue":"79","key":"1030_CR82","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.bios.2015.12.060","volume":"15","author":"X Chen","year":"2016","unstructured":"Chen, X., Pan, Y., Liu, H., Bai, X., Wang, N., & Zhang, B. (2016). Label-free detection of liver cancer cells by aptamer-based microcantilever biosensor. Biosensors & Bioelectronics, 15(79), 353\u2013358.","journal-title":"Biosensors & Bioelectronics"},{"issue":"2","key":"1030_CR83","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/anie.201909691","volume":"59","author":"L Zhang","year":"2020","unstructured":"Zhang, L., Wang, S., Yang, Z., Hoshika, S., Xie, S., Li, J., Chen, X., Wan, S., Li, L., Benner, S. A., & Tan, W. (2020). An aptamer-nanotrain assembled from six-letter DNA delivers doxorubicin selectively to liver cancer cells. Angewandte Chemie International Edition, 59(2), 663\u2013668.","journal-title":"Angewandte Chemie International Edition"},{"key":"1030_CR84","doi-asserted-by":"publisher","first-page":"950141","DOI":"10.3389\/fphys.2022.950141","volume":"13","author":"X Guo","year":"2022","unstructured":"Guo, X., Huang, Z., Chen, J., He, K., Lin, J., Zhang, H., & Zeng, Y. (2022). Synergistic delivery of resveratrol and ultrasmall copper-based nanoparticles by aptamer-functionalized ultrasound nanobubbles for the treatment of nonalcoholic fatty liver disease. Frontiers in Physiology, 13, 950141.","journal-title":"Frontiers in Physiology"},{"issue":"5","key":"1030_CR85","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.3892\/or.2017.5527","volume":"37","author":"Z Lai","year":"2017","unstructured":"Lai, Z., Tan, J., Wan, R., Tan, J., Zhang, Z., Hu, Z., Li, J., Yang, W., Wang, Y., Jiang, Y., He, J., Yang, N., Lu, X., & Zhao, Y. (2017). An \u2018activatable\u2019 aptamer-based fluorescence probe for the detection of HepG2 cells. Oncology Reports, 37(5), 2688\u20132694.","journal-title":"Oncology Reports"},{"issue":"1","key":"1030_CR86","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s11671-017-1890-6","volume":"12","author":"Z Hu","year":"2017","unstructured":"Hu, Z., Tan, J., Lai, Z., Zheng, R., Zhong, J., Wang, Y., Li, X., Yang, N., Li, J., Yang, W., Huang, Y., Zhao, Y., & Lu, X. (2017). Aptamer combined with fluorescent silica nanoparticles for detection of hepatoma cells. Nanoscale Research Letters, 12(1), 96.","journal-title":"Nanoscale Research Letters"},{"issue":"9","key":"1030_CR87","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1166\/jbn.2018.2619","volume":"14","author":"Z Hu","year":"2018","unstructured":"Hu, Z., He, J., Gong, W., Zhou, N., Zhou, S., Lai, Z., Zheng, R., Wang, Y., Yang, X., Yang, W., Zhong, L., Lu, X., & Zhao, Y. (2018). TLS11a aptamer\/CD3 antibody anti-tumor system for liver cancer. Journal of Biomedical Nanotechnology, 14(9), 1645\u20131653.","journal-title":"Journal of Biomedical Nanotechnology"},{"issue":"11","key":"1030_CR88","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.7150\/thno.15284","volume":"6","author":"S Wang","year":"2016","unstructured":"Wang, S., Zhang, C., Wang, G., Cheng, B., Wang, Y., Chen, F., Chen, Y., Feng, M., & Xiong, B. (2016). Aptamer-mediated transparent-biocompatible nanostructured surfaces for hepotocellular circulating tumor cells enrichment. Theranostics, 6(11), 1877\u20131886.","journal-title":"Theranostics"},{"key":"1030_CR89","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.colsurfb.2017.03.010","volume":"154","author":"M Joo","year":"2017","unstructured":"Joo, M., Baek, S. H., Cheon, S. A., Chun, H. S., Choi, S. W., & Park, T. J. (2017). Development of aflatoxin B(1) aptasensor based on wide-range fluorescence detection using graphene oxide quencher. Colloids and Surfaces B, Biointerfaces, 154, 27\u201332.","journal-title":"Colloids and Surfaces B, Biointerfaces"},{"issue":"7","key":"1030_CR90","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.1166\/jnn.2019.16735","volume":"19","author":"H Kaur","year":"2019","unstructured":"Kaur, H. (2019). Aptamer conjugated quantum dots for imaging cellular uptake in cancer cells. Journal of Nanoscience and Nanotechnology, 19(7), 3798\u20133803.","journal-title":"Journal of Nanoscience and Nanotechnology"},{"key":"1030_CR91","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.talanta.2018.10.014","volume":"194","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y., Li, W., Tseng, Y., Zhang, J., & Liu, J. (2019). Developing slow-off dickkopf-1 aptamers for early-diagnosis of hepatocellular carcinoma. Talanta, 194, 422\u2013429.","journal-title":"Talanta"},{"issue":"20","key":"1030_CR92","doi-asserted-by":"publisher","first-page":"17047","DOI":"10.1021\/acsami.8b02648","volume":"10","author":"H Yan","year":"2018","unstructured":"Yan, H., Gao, X., Zhang, Y., Chang, W., Li, J., Li, X., Du, Q., & Li, C. (2018). Imaging tiny hepatic tumor xenografts via endoglin-targeted paramagnetic\/optical nanoprobe. ACS Applied Materials & Interfaces, 10(20), 17047\u201317057.","journal-title":"ACS Applied Materials & Interfaces"},{"issue":"2","key":"1030_CR93","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1166\/jbn.2019.2688","volume":"15","author":"L Zhong","year":"2019","unstructured":"Zhong, L., Zou, H., Huang, Y., Gong, W., He, J., Tan, J., Lai, Z., Li, Y., Zhou, C., Zhang, G., Li, G., Yang, N., & Zhao, Y. (2019). Magnetic endoglin aptamer nanoprobe for targeted diagnosis of solid tumor. Journal of Biomedical Nanotechnology, 15(2), 352\u2013362.","journal-title":"Journal of Biomedical Nanotechnology"},{"issue":"2","key":"1030_CR94","doi-asserted-by":"publisher","first-page":"151","DOI":"10.21037\/qims.2018.01.09","volume":"8","author":"M Zhao","year":"2018","unstructured":"Zhao, M., Dong, L., Liu, Z., Yang, S., Wu, W., & Lin, J. (2018). In vivo fluorescence imaging of hepatocellular carcinoma using a novel GPC3-specific aptamer probe. Quantitative Imaging in Medicine and Surgery, 8(2), 151\u2013160.","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"issue":"12","key":"1030_CR95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189558","volume":"12","author":"W Alshaer","year":"2017","unstructured":"Alshaer, W., Ababneh, N., Hatmal, M., Izmirli, H., Choukeife, M., Shraim, A., Sharar, N., Abu-Shiekah, A., Odeh, F., Al Bawab, A., Awidi, A., & Ismail, S. (2017). Selection and targeting of EpCAM protein by ssDNA aptamer. PLoS ONE, 12(12), e189558.","journal-title":"PLoS ONE"},{"issue":"6","key":"1030_CR96","doi-asserted-by":"publisher","first-page":"6830","DOI":"10.18632\/oncotarget.23564","volume":"9","author":"Z Liu","year":"2018","unstructured":"Liu, Z., Sun, X., Xiao, S., Lin, Y., Li, C., Hao, N., Zhou, M., Deng, R., Ke, S., & Zhong, Z. (2018). Characterization of aptamer-mediated gene delivery system for liver cancer therapy. Oncotarget, 9(6), 6830\u20136840.","journal-title":"Oncotarget"},{"key":"1030_CR97","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.2147\/IJN.S108128","volume":"11","author":"Y Liu","year":"2016","unstructured":"Liu, Y., Wu, X., Gao, Y., Zhang, J., Zhang, D., Gu, S., Zhu, G., Liu, G., & Li, X. (2016). Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. International Journal of Nanomedicine, 11, 3891\u20133905.","journal-title":"International Journal of Nanomedicine"},{"issue":"10","key":"1030_CR98","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.1021\/am5006783","volume":"6","author":"L Qu","year":"2014","unstructured":"Qu, L., Xu, J., Tan, X., Liu, Z., Xu, L., & Peng, R. (2014). Dual-aptamer modification generates a unique interface for highly sensitive and specific electrochemical detection of tumor cells. ACS Applied Materials & Interfaces, 6(10), 7309\u20137315.","journal-title":"ACS Applied Materials & Interfaces"},{"key":"1030_CR99","doi-asserted-by":"publisher","first-page":"15552","DOI":"10.1038\/srep15552","volume":"5","author":"L Dong","year":"2015","unstructured":"Dong, L., Tan, Q., Ye, W., Liu, D., Chen, H., Hu, H., Wen, D., Liu, Y., Cao, Y., Kang, J., Fan, J., Guo, W., & Wu, W. (2015). Screening and identifying a novel ssDNA aptamer against alpha-fetoprotein using CE-SELEX. Scientific Reports, 5, 15552.","journal-title":"Scientific Reports"},{"issue":"8","key":"1030_CR100","doi-asserted-by":"publisher","first-page":"5162","DOI":"10.1021\/acs.analchem.7b05277","volume":"90","author":"J Duo","year":"2018","unstructured":"Duo, J., Chiriac, C., Huang, R. Y., Mehl, J., Chen, G., Tymiak, A., Sabbatini, P., Pillutla, R., & Zhang, Y. (2018). Slow off-rate modified aptamer (SOMAmer) as a novel reagent in immunoassay development for accurate soluble glypican-3 quantification in clinical samples. Analytical Chemistry, 90(8), 5162\u20135170.","journal-title":"Analytical Chemistry"},{"issue":"8","key":"1030_CR101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160822","volume":"11","author":"Y Cho","year":"2016","unstructured":"Cho, Y., Lee, Y. B., Lee, J. H., Lee, D. H., Cho, E. J., Yu, S. J., Kim, Y. J., Kim, J. I., Im, J. H., Lee, J. H., Oh, E. J., & Yoon, J. H. (2016). Modified AS1411 Aptamer suppresses hepatocellular carcinoma by up-regulating galectin-14. PLoS ONE, 11(8), e160822.","journal-title":"PLoS ONE"},{"issue":"11","key":"1030_CR102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136673","volume":"10","author":"TL Trinh","year":"2015","unstructured":"Trinh, T. L., Zhu, G., Xiao, X., Puszyk, W., Sefah, K., Wu, Q., Tan, W., & Liu, C. (2015). A synthetic aptamer-drug adduct for targeted liver cancer therapy. PLoS ONE, 10(11), e136673.","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"1030_CR103","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijpharm.2016.04.031","volume":"506","author":"B Scaggiante","year":"2016","unstructured":"Scaggiante, B., Farra, R., Dapas, B., Baj, G., Pozzato, G., Grassi, M., Zanconati, F., & Grassi, G. (2016). Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects. International Journal of Pharmaceutics, 506(1\u20132), 268\u2013279.","journal-title":"International Journal of Pharmaceutics"},{"key":"1030_CR104","doi-asserted-by":"publisher","first-page":"10897","DOI":"10.1038\/srep10897","volume":"5","author":"KA Lee","year":"2015","unstructured":"Lee, K. A., Ahn, J. Y., Lee, S. H., Singh Sekhon, S., Kim, D. G., Min, J., & Kim, Y. H. (2015). Aptamer-based sandwich assay and its clinical outlooks for detecting lipocalin-2 in hepatocellular carcinoma (HCC). Scientific Reports, 5, 10897.","journal-title":"Scientific Reports"},{"issue":"2","key":"1030_CR105","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/SLA.0b013e31823e3a1c","volume":"255","author":"SD Bhattacharya","year":"2012","unstructured":"Bhattacharya, S. D., Mi, Z., Kim, V. M., Guo, H., Talbot, L. J., & Kuo, P. C. (2012). Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model. Annals of Surgery, 255(2), 319\u2013325.","journal-title":"Annals of Surgery"},{"key":"1030_CR106","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.omtn.2019.11.004","volume":"19","author":"T Wang","year":"2020","unstructured":"Wang, T., Rahimizadeh, K., & Veedu, R. N. (2020). Development of a novel DNA oligonucleotide targeting low-density lipoprotein receptor. Molecular Therapy. Nucleic Acids, 19, 190\u2013198.","journal-title":"Molecular Therapy. Nucleic Acids"},{"issue":"19","key":"1030_CR107","doi-asserted-by":"publisher","first-page":"4700","DOI":"10.3390\/ijms20194700","volume":"20","author":"T Wang","year":"2019","unstructured":"Wang, T., Philippovich, S., Mao, J., & Veedu, R. N. (2019). Efficient epidermal growth factor receptor targeting oligonucleotide as a potential molecule for targeted cancer therapy. International Journal of Molecular Sciences, 20(19), 4700.","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"1030_CR108","doi-asserted-by":"publisher","first-page":"8282","DOI":"10.18632\/oncotarget.6988","volume":"7","author":"Y Rong","year":"2016","unstructured":"Rong, Y., Chen, H., Zhou, X. F., Yin, C. Q., Wang, B. C., Peng, C. W., Liu, S. P., & Wang, F. B. (2016). Identification of an aptamer through whole cell-SELEX for targeting high metastatic liver cancers. Oncotarget, 7(7), 8282\u20138294.","journal-title":"Oncotarget"},{"key":"1030_CR109","doi-asserted-by":"publisher","first-page":"34778","DOI":"10.1038\/srep34778","volume":"6","author":"J Hwang","year":"2016","unstructured":"Hwang, J., Seo, Y., Jo, Y., Son, J., & Choi, J. (2016). Aptamer-conjugated live human immune cell based biosensors for the accurate detection of C-reactive protein. Scientific Reports, 6, 34778.","journal-title":"Scientific Reports"},{"issue":"6","key":"1030_CR110","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1016\/j.bmcl.2008.02.023","volume":"18","author":"J Kang","year":"2008","unstructured":"Kang, J., Lee, M. S., Copland, J. A., 3rd., Luxon, B. A., & Gorenstein, D. G. (2008). Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-beta1 protein. Bioorganic & Medicinal Chemistry Letters, 18(6), 1835\u20131839.","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"12","key":"1030_CR111","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.7150\/thno.19374","volume":"7","author":"Z Chen","year":"2017","unstructured":"Chen, Z., Liu, H., Jain, A., Zhang, L., Liu, C., & Cheng, K. (2017). Discovery of aptamer ligands for hepatic stellate cells using SELEX. Theranostics, 7(12), 2982\u20132995.","journal-title":"Theranostics"},{"issue":"1","key":"1030_CR112","doi-asserted-by":"publisher","first-page":"9444","DOI":"10.1038\/s41598-018-27792-5","volume":"8","author":"Z Xi","year":"2018","unstructured":"Xi, Z., Gong, Q., Wang, C., & Zheng, B. (2018). Highly sensitive chemiluminescent aptasensor for detecting HBV infection based on rapid magnetic separation and double-functionalized gold nanoparticles. Scientific Reports, 8(1), 9444.","journal-title":"Scientific Reports"},{"issue":"2","key":"1030_CR113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090333","volume":"9","author":"Y Gao","year":"2014","unstructured":"Gao, Y., Yu, X., Xue, B., Zhou, F., Wang, X., Yang, D., Liu, N., Xu, L., Fang, X., & Zhu, H. (2014). Inhibition of hepatitis C virus infection by DNA aptamer against NS2 protein. PLoS ONE, 9(2), e90333.","journal-title":"PLoS ONE"},{"issue":"12","key":"1030_CR114","doi-asserted-by":"publisher","first-page":"7064","DOI":"10.1128\/JVI.00405-13","volume":"87","author":"CH Lee","year":"2013","unstructured":"Lee, C. H., Lee, Y. J., Kim, J. H., Lim, J. H., Kim, J. H., Han, W., Lee, S. H., Noh, G. J., & Lee, S. W. (2013). Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. Journal of Virology, 87(12), 7064\u20137074.","journal-title":"Journal of Virology"},{"key":"1030_CR115","first-page":"295","volume":"23","author":"N Nakamura","year":"2017","unstructured":"Nakamura, N., Matsui, T., Ishibashi, Y., Sotokawauchi, A., Fukami, K., Higashimoto, Y., & Yamagishi, S. I. (2017). RAGE-aptamer attenuates the growth and liver metastasis of malignant melanoma in nude mice. Molecular Medicine (Cambridge, Massachusetts), 23, 295\u2013306.","journal-title":"Molecular Medicine (Cambridge, Massachusetts)"},{"issue":"26","key":"1030_CR116","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.3748\/wjg.v25.i26.3359","volume":"25","author":"GQ Zhang","year":"2019","unstructured":"Zhang, G. Q., Zhong, L. P., Yang, N., & Zhao, Y. X. (2019). Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer. World Journal of Gastroenterology, 25(26), 3359\u20133369.","journal-title":"World Journal of Gastroenterology"},{"issue":"9822","key":"1030_CR117","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","volume":"379","author":"A Forner","year":"2012","unstructured":"Forner, A., Llovet, J. M., & Bruix, J. (2012). Hepatocellular carcinoma. Lancet (London, England), 379(9822), 1245\u20131255.","journal-title":"Lancet (London, England)"},{"issue":"13","key":"1030_CR118","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.3748\/wjg.v22.i13.3547","volume":"22","author":"JH Sun","year":"2016","unstructured":"Sun, J. H., Luo, Q., Liu, L. L., & Song, G. B. (2016). Liver cancer stem cell markers: progression and therapeutic implications. World Journal of Gastroenterology, 22(13), 3547\u20133557.","journal-title":"World Journal of Gastroenterology"},{"issue":"1","key":"1030_CR119","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/1878-0261.12155","volume":"12","author":"S Sigismund","year":"2018","unstructured":"Sigismund, S., Avanzato, D., & Lanzetti, L. (2018). Emerging functions of the EGFR in cancer. Molecular Oncology, 12(1), 3\u201320.","journal-title":"Molecular Oncology"},{"issue":"1","key":"1030_CR120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0036-1597816","volume":"37","author":"L Campana","year":"2017","unstructured":"Campana, L., & Iredale, J. P. (2017). Regression of liver fibrosis. Seminars in Liver Disease, 37(1), 1\u201310.","journal-title":"Seminars in Liver Disease"},{"key":"1030_CR121","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","volume":"6","author":"V Hernandez-Gea","year":"2011","unstructured":"Hernandez-Gea, V., & Friedman, S. L. (2011). Pathogenesis of liver fibrosis. Annual Review of Pathology, 6, 425\u2013456.","journal-title":"Annual Review of Pathology"},{"issue":"Suppl 1","key":"1030_CR122","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/j.clinre.2015.06.015","volume":"39","author":"M Sun","year":"2015","unstructured":"Sun, M., & Kisseleva, T. (2015). Reversibility of liver fibrosis. Clinics and Research in Hepatology and Gastroenterology, 39(Suppl 1), S60\u2013S63.","journal-title":"Clinics and Research in Hepatology and Gastroenterology"},{"key":"1030_CR123","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_2016_6","volume":"172","author":"R Omar","year":"2016","unstructured":"Omar, R., Yang, J., Liu, H., Davies, N. M., & Gong, Y. (2016). Hepatic stellate cells in liver fibrosis and siRNA-based therapy. Reviews of Physiology, Biochemistry and Pharmacology, 172, 1\u201337.","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"issue":"3","key":"1030_CR124","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.rgmx.2014.05.003","volume":"79","author":"A Cequera","year":"2014","unstructured":"Cequera, A., de Le\u00f3n, G., & M\u00e9ndez, M. C. (2014). Biomarcadores para fibrosis hep\u00e1tica, avances, ventajas y desventajas [Biomarkers for liver fibrosis: Advances, advantages and disadvantages]. Revista de Gastroenterologia de Mexico, 79(3), 187\u2013199.","journal-title":"Revista de Gastroenterologia de Mexico"},{"issue":"4","key":"1030_CR125","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00063-017-0282-0","volume":"112","author":"A Koch","year":"2017","unstructured":"Koch, A., Trautwein, C., & Tacke, F. (2017). Acute liver failure. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 112(4), 371\u2013381.","journal-title":"Medizinische Klinik, Intensivmedizin und Notfallmedizin"},{"issue":"1","key":"1030_CR126","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1021\/cb3003557","volume":"8","author":"EW Orava","year":"2013","unstructured":"Orava, E. W., Jarvik, N., Shek, Y. L., Sidhu, S. S., & Gari\u00e9py, J. (2013). A short DNA aptamer that recognizes TNF\u03b1 and blocks its activity in vitro. ACS Chemical Biology, 8(1), 170\u2013178.","journal-title":"ACS Chemical Biology"},{"key":"1030_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.103736","volume":"137","author":"S Zhang","year":"2019","unstructured":"Zhang, S., Hu, B., Xu, J., Ren, Q., Wang, L., & Wang, S. (2019). Influenza A virus infection induces liver injury in mice. Microbial Pathogenesis, 137, 103736.","journal-title":"Microbial Pathogenesis"},{"issue":"7","key":"1030_CR128","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.cgh.2020.04.002","volume":"18","author":"Z Fan","year":"2020","unstructured":"Fan, Z., Chen, L., Li, J., Cheng, X., Yang, J., Tian, C., Zhang, Y., Huang, S., Liu, Z., & Cheng, J. (2020). Clinical Features of COVID-19-Related Liver Functional Abnormality. Clinical Gastroenterology and Hepatology\u202f: The Official Clinical Practice Journal of the American Gastroenterological Association, 18(7), 1561\u20131566.","journal-title":"Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association"},{"issue":"10161","key":"1030_CR129","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1016\/S0140-6736(18)31865-8","volume":"392","author":"WK Seto","year":"2018","unstructured":"Seto, W. K., Lo, Y. R., Pawlotsky, J. M., & Yuen, M. F. (2018). Chronic hepatitis B virus infection. Lancet (London, England), 392(10161), 2313\u20132324.","journal-title":"Lancet (London, England)"},{"issue":"15","key":"1030_CR130","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1177\/1535370216658144","volume":"241","author":"AM Clark","year":"2016","unstructured":"Clark, A. M., Ma, B., Taylor, D. L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. Experimental Biology and Medicine (Maywood, N.J.), 241(15), 1639\u20131652.","journal-title":"Experimental Biology and Medicine (Maywood, N.J.)"},{"issue":"6","key":"1030_CR131","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1002\/hep.22243","volume":"47","author":"T Takahara","year":"2008","unstructured":"Takahara, T., Xue, F., Mazzone, M., Yata, Y., Nonome, K., Kanayama, M., Kawai, K., Pisacane, A. M., Takahara, S., Li, X. K., Comoglio, P. M., Sugiyama, T., & Michieli, P. (2008). Metron factor-1 prevents liver injury without promoting tumor growth and metastasis. Hepatology, 47(6), 2010\u20132025.","journal-title":"Hepatology"},{"issue":"24","key":"1030_CR132","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1158\/1078-0432.CCR-16-0460","volume":"22","author":"P Brodt","year":"2016","unstructured":"Brodt, P. (2016). Role of the microenvironment in liver metastasis: from pre- to prometastatic niches. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 22(24), 5971\u20135982.","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"12","key":"1030_CR133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007000","volume":"12","author":"W Gong","year":"2018","unstructured":"Gong, W., Huang, F., Sun, L., Yu, A., Zhang, X., Xu, Y., Shen, Y., & Cao, J. (2018). Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis. PLoS Neglected Tropical Diseases, 12(12), e7000.","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"1030_CR134","doi-asserted-by":"publisher","first-page":"24986","DOI":"10.1038\/srep24986","volume":"6","author":"Y Long","year":"2016","unstructured":"Long, Y., Qin, Z., Duan, M., Li, S., Wu, X., Lin, W., Li, J., Zhao, Z., Liu, J., Xiong, D., Huang, Y., Hu, X., Yang, C., Ye, M., & Tan, W. (2016). Screening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX. Scientific Reports, 6, 24986.","journal-title":"Scientific Reports"},{"issue":"23","key":"1030_CR135","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.1016\/j.jmb.2018.06.038","volume":"430","author":"S Alberti","year":"2018","unstructured":"Alberti, S., Saha, S., Woodruff, J. B., Franzmann, T. M., Wang, J., & Hyman, A. A. (2018). A user\u2019s guide for phase separation assays with purified proteins. Journal of Molecular Biology, 430(23), 4806\u20134820.","journal-title":"Journal of Molecular Biology"},{"key":"1030_CR136","doi-asserted-by":"publisher","first-page":"5041683","DOI":"10.1155\/2017\/5041683","volume":"2017","author":"PC Hsieh","year":"2017","unstructured":"Hsieh, P. C., Lin, H. T., Chen, W. Y., Tsai, J. J. P., & Hu, W. P. (2017). The Combination of computational and biosensing technologies for selecting aptamer against prostate specific antigen. BioMed Research International, 2017, 5041683.","journal-title":"BioMed Research International"},{"key":"1030_CR137","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jbiotec.2016.05.021","volume":"230","author":"M Heiat","year":"2016","unstructured":"Heiat, M., Najafi, A., Ranjbar, R., Latifi, A. M., & Rasaee, M. J. (2016). Computational approach to analyze isolated ssDNA aptamers against angiotensin II. Journal of Biotechnology, 230, 34\u201339.","journal-title":"Journal of Biotechnology"},{"issue":"14","key":"1030_CR138","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks339","volume":"40","author":"M Popenda","year":"2012","unstructured":"Popenda, M., Szachniuk, M., Antczak, M., Purzycka, K. J., Lukasiak, P., Bartol, N., Blazewicz, J., & Adamiak, R. W. (2012). Automated 3D structure composition for large RNAs. Nucleic Acids Research, 40(14), e112.","journal-title":"Nucleic Acids Research"},{"key":"1030_CR139","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/658712","volume":"2015","author":"WP Hu","year":"2015","unstructured":"Hu, W. P., Kumar, J. V., Huang, C. J., & Chen, W. Y. (2015). Computational selection of RNA aptamer against angiopoietin-2 and experimental evaluation. BioMed Research International, 2015, 658712.","journal-title":"BioMed Research International"},{"issue":"3","key":"1030_CR140","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/17425247.2019.1575808","volume":"16","author":"LY Wan","year":"2019","unstructured":"Wan, L. Y., Yuan, W. F., Ai, W. B., Ai, Y. W., Wang, J. J., Chu, L. Y., Zhang, Y. Q., & Wu, J. F. (2019). An exploration of aptamer internalization mechanisms and their applications in drug delivery. Expert Opinion on Drug Delivery, 16(3), 207\u2013218.","journal-title":"Expert Opinion on Drug Delivery"},{"issue":"7","key":"1030_CR141","doi-asserted-by":"publisher","first-page":"11959","DOI":"10.3390\/molecules200711959","volume":"20","author":"H Sun","year":"2015","unstructured":"Sun, H., & Zu, Y. (2015). A highlight of recent advances in aptamer technology and its application. Molecules (Basel, Switzerland), 20(7), 11959\u201311980.","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"9","key":"1030_CR142","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1021\/acs.accounts.6b00283","volume":"49","author":"MR Gotrik","year":"2016","unstructured":"Gotrik, M. R., Feagin, T. A., Csordas, A. T., Nakamoto, M. A., & Soh, H. T. (2016). Advancements in aptamer discovery technologies. Accounts of Chemical Research, 49(9), 1903\u20131910.","journal-title":"Accounts of Chemical Research"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-023-01030-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-023-01030-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-023-01030-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:27:28Z","timestamp":1715336848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-023-01030-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":142,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["1030"],"URL":"https:\/\/doi.org\/10.1007\/s12033-023-01030-4","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"26 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}