{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:55:56Z","timestamp":1788908156079,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s12033-024-01076-y","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T18:02:12Z","timestamp":1706810532000},"page":"649-660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular Analysis of Pseudomonas aeruginosa Isolates with Mutant gyrA Gene and Development of a New Ciprofloxacin Derivative for Antimicrobial Therapy"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-3849","authenticated-orcid":false,"given":"Yasir Adil Jabbar","family":"Alabdali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhay Ali","family":"Azeez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad G.","family":"Munahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab I.","family":"Kuwait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"1076_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/2049-632X.12033","volume":"67","author":"SL Gellatly","year":"2013","unstructured":"Gellatly, S. L., & Hancock, R. E. (2013). Pseudomonas aeruginosa: New insights into pathogenesis and host defenses. Pathogens and Disease, 67, 159\u2013173. https:\/\/doi.org\/10.1111\/2049-632X.12033","journal-title":"Pathogens and Disease"},{"key":"1076_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1742-481X.2006.00159.x","volume":"3","author":"K Gjodsbol","year":"2006","unstructured":"Gjodsbol, K., Christensen, J. J., Karlsmark, T., J\u00f8rgensen, B., Klein, B. M., & Krogfelt, K. A. (2006). Multiple bacterial species reside in chronic wounds: A longitudinal study. International Wound Journal, 3, 225\u201331. https:\/\/doi.org\/10.1111\/j.1742-481X.2006.00159.x","journal-title":"International Wound Journal"},{"key":"1076_CR3","unstructured":"CDC. Antibiotic Resistance Threats in the United States. [Accessed on 1 November 2022]. Available online: https:\/\/www.cdc.gov\/drugresistance\/biggest-threats.html"},{"key":"1076_CR4","doi-asserted-by":"publisher","first-page":"120440","DOI":"10.1016\/j.envpol.2022.120440","volume":"315","author":"S Bhatt","year":"2022","unstructured":"Bhatt, S., & Chatterjee, S. (2022). Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation\u2013A comprehensive review. Environmental Pollution, 315, 120440. https:\/\/doi.org\/10.1016\/j.envpol.2022.120440","journal-title":"Environmental Pollution"},{"key":"1076_CR5","doi-asserted-by":"crossref","unstructured":"Tamma, P., Aitken, S., Bonomo, R. (2022) IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0. IDSA; Arlington, VA, USA","DOI":"10.1093\/cid\/ciad428"},{"issue":"1","key":"1076_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/cells12010199.PMID:36611992;PMCID:PMC9818774","volume":"12","author":"SJ Wood","year":"2023","unstructured":"Wood, S. J., Kuzel, T. M., & Shafikhani, S. H. (2023). Pseudomonas aeruginosa: Infections, animal modeling, and therapeutics. Cells, 12(1), 199. https:\/\/doi.org\/10.3390\/cells12010199.PMID:36611992;PMCID:PMC9818774","journal-title":"Cells"},{"issue":"20","key":"1076_CR7","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1016\/j.bmcl.2017.05.032","volume":"27","author":"GF Zha","year":"2017","unstructured":"Zha, G. F., Leng, J., Darshini, N., Shubhavathi, T., Vivek, H. K., Asiri, A. M., & Qin, H. L. (2017). Synthesis, SAR and molecular docking studies of benzo[d]thiazole-hydrazones as potential antibacterial and antifungal agents. Bioorganic & Medicinal Chemistry Letters, 27(20), 3148\u201355.","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"1076_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1155\/2020\/4850492","volume":"2020","author":"JK Adu","year":"2020","unstructured":"Adu, J. K., Amengor, C. D. K., Ibrahim, N. M., Amaning-Danquah, C., OwusuAnsah, C., Gbadago, D. D., & Sarpong-Agyapong, J. (2020). Synthesis and in vitro antimicrobial and anthelminthic evaluation of naphtholic and phenolic azo dyes. Journal of Tropical Medicine, 2020, 8.","journal-title":"Journal of Tropical Medicine"},{"issue":"5","key":"1076_CR9","doi-asserted-by":"publisher","first-page":"e0215666","DOI":"10.1371\/journal.pone.0215666","volume":"14","author":"L Peters","year":"2019","unstructured":"Peters, L., Olson, L., Khu, D. T. K., Linnros, S., Le, N. K., Hanberger, H., Hoang, N. T. B., Tran, D. M., & Larsson, M. (2019). Multiple antibiotic resistance as a risk factor for mortality and prolonged hospital stay: A cohort study among neonatal intensive care patients with hospital-acquired infections caused by gram-negative bacteria in Vietnam. PLoS ONE., 14(5), e0215666. https:\/\/doi.org\/10.1371\/journal.pone.0215666","journal-title":"PLoS ONE."},{"key":"1076_CR10","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.2147\/IDR.S234610","volume":"12","author":"P Dadgostar","year":"2019","unstructured":"Dadgostar, P. (2019). Antimicrobial resistance: Implications and costs. Infection and Drug Resistance, 12, 3903\u20133910. https:\/\/doi.org\/10.2147\/IDR.S234610","journal-title":"Infection and Drug Resistance"},{"issue":"3","key":"1076_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.drup.2006.06.002","volume":"9","author":"WTM Jansen","year":"2006","unstructured":"Jansen, W. T. M., Bruggen, J. T., Verhoef, J., & Fluit, A. C. (2006). Bacterial resistance: A sensitive issue: Complexity of the challenge and containment strategy in Europe. Drug Resistance Updates, 9(3), 123\u2013133. https:\/\/doi.org\/10.1016\/j.drup.2006.06.002","journal-title":"Drug Resistance Updates"},{"issue":"5","key":"1076_CR12","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1093\/jac\/dkg222","volume":"51","author":"J Ruiz","year":"2003","unstructured":"Ruiz, J. (2003). Mechanisms of resistance to quinolones: Target alterations, decreased accumulation and DNA gyrase protection. Journal of Antimicrobial Chemotherapy, 51(5), 1109\u20131117. https:\/\/doi.org\/10.1093\/jac\/dkg222","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"2","key":"1076_CR13","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1016\/j.survophthal.2004.01.005","volume":"49","author":"JM Blondeau","year":"2004","unstructured":"Blondeau, J. M. (2004). Fluoroquinolones: Mechanism of action, classification, and development of resistance. Survey of Ophthalmology, 49(2), S73\u2013S78. https:\/\/doi.org\/10.1016\/j.survophthal.2004.01.005","journal-title":"Survey of Ophthalmology"},{"key":"1076_CR14","doi-asserted-by":"publisher","first-page":"S120","DOI":"10.1086\/428052","volume":"41","author":"GA Jacoby","year":"2005","unstructured":"Jacoby, G. A. (2005). Mechanisms of resistance to quinolones. Clinical Infectious Diseases, 41, S120\u2013S126. https:\/\/doi.org\/10.1086\/428052","journal-title":"Clinical Infectious Diseases"},{"issue":"1","key":"1076_CR15","doi-asserted-by":"publisher","first-page":"P5","DOI":"10.1111\/j.1469-0691.2006.01492.x","volume":"13","author":"N Woodford","year":"2007","unstructured":"Woodford, N., & Ellington, M. J. (2007). The emergence of antibiotic resistance by mutation. Clinical Microbiology & Infection, 13(1), P5-18. https:\/\/doi.org\/10.1111\/j.1469-0691.2006.01492.x","journal-title":"Clinical Microbiology & Infection"},{"key":"1076_CR16","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1136\/sti.78.6.440","volume":"78","author":"U Chaudhry","year":"2002","unstructured":"Chaudhry, U., Ray, K., Bala, M., & Saluja, D. (2002). Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sexually Transmitted Infections, 78, 440\u201344.","journal-title":"Sexually Transmitted Infections"},{"key":"1076_CR17","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1007\/s00706-019-02478-4","volume":"150","author":"HHH Mohammed","year":"2019","unstructured":"Mohammed, H. H. H., Abbas, S. H., Abdelhafez, E. S. M. N., Berger, J. M., Mitarai, S., Arai, M., & Abuo-Rahma, G. E. D. A. (2019). Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole\/oxadiazole ciprofloxacin derivatives. Monatshefte f\u00fcr Chemie\u2014Chemical Monthly, 150, 1809\u201324. https:\/\/doi.org\/10.1007\/s00706-019-02478-4","journal-title":"Monatshefte f\u00fcr Chemie\u2014Chemical Monthly"},{"key":"1076_CR18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2147\/IDR.S182272","volume":"12","author":"X Feng","year":"2019","unstructured":"Feng, X., Zhang, Z., Li, X., Song, Y., Kang, J., Yin, D., & Duan, J. (2019). Mutations in gyrB play an important role in ciprofloxacin-resistant Pseudomonas aeruginosa. Infection and Drug Resistance, 12, 261\u201372. https:\/\/doi.org\/10.2147\/IDR.S182272","journal-title":"Infection and Drug Resistance"},{"key":"1076_CR19","doi-asserted-by":"publisher","first-page":"104658","DOI":"10.1016\/j.bioorg.2021.104658","volume":"108","author":"A Alsughayer","year":"2021","unstructured":"Alsughayer, A., Elassar, A. Z. A., Hasan, A. A., & Sagheer, A. F. (2021). Antibiotic resistance and drug modification: Synthesis, characterization and bioactivity of newly modified potent ciprofloxacin derivatives. Bioorganic Chemistry, 108, 104658. https:\/\/doi.org\/10.1016\/j.bioorg.2021.104658","journal-title":"Bioorganic Chemistry"},{"key":"1076_CR20","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s00706-018-2215-x","volume":"149","author":"J Fedorowicz","year":"2019","unstructured":"Fedorowicz, J., & Saczewski, J. (2019). Modifications of quinolones and fluoroquinolones: Hybrid compounds and dual-action molecules. Monatshefte fuer Chemie, 149, 1199\u20131245. https:\/\/doi.org\/10.1007\/s00706-018-2215-x","journal-title":"Monatshefte fuer Chemie"},{"issue":"4","key":"1076_CR21","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3109\/14756360903373350","volume":"25","author":"PC Sharma","year":"2010","unstructured":"Sharma, P. C., Jain, A., & Jain, S. (2010). Ciprofloxacin: Review on developments in synthetic, analytical, and medicinal aspects. Journal of Enzyme Inhibition and Medicinal Chemistry, 25(4), 577\u2013589. https:\/\/doi.org\/10.3109\/14756360903373350","journal-title":"Journal of Enzyme Inhibition and Medicinal Chemistry"},{"key":"1076_CR22","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3390\/molecules22060875","volume":"22","author":"S Concilio","year":"2017","unstructured":"Concilio, S., Sessa, L., & Petrone, A. M. (2017). Structure modification of an active azo-compound as a route to new antimicrobial compounds. Molecules, 22, 875. https:\/\/doi.org\/10.3390\/molecules22060875","journal-title":"Molecules"},{"key":"1076_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00706-017-2073-y","volume":"149","author":"Z Ghasemi","year":"2018","unstructured":"Ghasemi, Z., Azizi, S., & Salehi, R. (2018). Synthesis of azo dyes possessing N-heterocycles and evaluation of their anticancer and antibacterial properties. Monatshefte fuer Chemie, 149, 149\u2013157. https:\/\/doi.org\/10.1007\/s00706-017-2073-y","journal-title":"Monatshefte fuer Chemie"},{"issue":"42","key":"1076_CR24","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1016\/j.tetlet.2018.08.053","volume":"59","author":"GFP de Souza","year":"2018","unstructured":"de Souza, G. F. P., von Zuben, T. W., & Salles, A. G. J. (2018). A metal-catalyst-free oxidative coupling of anilines to aromatic azo compounds in water using bleach. Tetrahedron Letters, 59(42), 3753\u20133755. https:\/\/doi.org\/10.1016\/j.tetlet.2018.08.053","journal-title":"Tetrahedron Letters"},{"issue":"11","key":"1076_CR25","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1016\/j.tetlet.2008.01.053","volume":"49","author":"Y Moglie","year":"2008","unstructured":"Moglie, Y., Vitale, C., & Radivoy, G. (2008). Synthesis of azo compounds by nanosized iron-promoted reductive coupling of aromatic nitro compounds. Tetrahedron Letters, 49(11), 1828\u20131831. https:\/\/doi.org\/10.1016\/j.tetlet.2008.01.053","journal-title":"Tetrahedron Letters"},{"issue":"6","key":"1076_CR26","doi-asserted-by":"publisher","first-page":"106449","DOI":"10.1016\/j.ijantimicag.2021.106449","volume":"58","author":"Z Ude","year":"2021","unstructured":"Ude, Z., Flothk\u00f6tter, N., Sheehan, G., Brennan, M., Kavanagh, K., & Marmion, C. J. (2021). Multi-targeted metallo-ciprofloxacin derivatives rationally designed and developed to overcome antimicrobial resistance. International Journal of Antimicrobial Agents, 58(6), 106449. https:\/\/doi.org\/10.1016\/j.ijantimicag.2021.106449","journal-title":"International Journal of Antimicrobial Agents"},{"key":"1076_CR27","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41570-021-00313-1","volume":"5","author":"M Miethke","year":"2021","unstructured":"Miethke, M., Pieroni, M., & Weber, T. (2021). Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry, 5, 726\u2013749. https:\/\/doi.org\/10.1038\/s41570-021-00313-1","journal-title":"Nature Reviews Chemistry"},{"key":"1076_CR28","doi-asserted-by":"publisher","first-page":"e00406","DOI":"10.1016\/j.sciaf.2020.e00406","volume":"8","author":"KS Kyei","year":"2020","unstructured":"Kyei, K. S., Akaranta, O., & Darko, G. (2020). Synthesis, characterization and antimicrobial activity of peanut skin extract-azo-compounds. Scientific African, 8, e00406. https:\/\/doi.org\/10.1016\/j.sciaf.2020.e00406","journal-title":"Scientific African"},{"key":"1076_CR29","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.dyepig.2004.06.017","volume":"65","author":"JJ Lee","year":"2005","unstructured":"Lee, J. J., Lee, W. J., & Choi, J. H. (2005). Synthesis and application of temporarily solubilised azo disperse dyes containing b sulphatoethylsulphonyl group. Dyes and Pigments, 65, 75\u201381.","journal-title":"Dyes and Pigments"},{"key":"1076_CR30","unstructured":"Cockerill, F.R. (2017) Performance Standards for Antimicrobial Susceptibility Testing: Twenty-First Informational Supplement. Wayne, PA: Clinical and Laboratory Standards Institute. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/"},{"issue":"1","key":"1076_CR31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.21608\/ejmm.2018.285598","volume":"94","author":"HM El Maghraby","year":"2019","unstructured":"El Maghraby, H. M., & Rabie, R. A. (2019). Ciprofloxacin resistance due to gyrA mutation in Pseudomonas aeruginosa isolates at Zagazig University Hospitals. Egyptian Journal of Medical Microbiology, 94(1), 5. https:\/\/doi.org\/10.21608\/ejmm.2018.285598","journal-title":"Egyptian Journal of Medical Microbiology"},{"issue":"2","key":"1076_CR32","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1574-6968.2005.00008.x","volume":"254","author":"JL Dumas","year":"2006","unstructured":"Dumas, J. L., Van, D. C. A., & Perron, K. (2006). Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR. FEMS Microbiology Letters, 254(2), 217\u2013225. https:\/\/doi.org\/10.1111\/j.1574-6968.2005.00008.x","journal-title":"FEMS Microbiology Letters"},{"issue":"13","key":"1076_CR33","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"T Schwede","year":"2003","unstructured":"Schwede, T., Kopp, J., Guex, N., & Peitsch, M. C. (2003). SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Research, 31(13), 3381\u20133385. https:\/\/doi.org\/10.1093\/nar\/gkg520","journal-title":"Nucleic Acids Research"},{"key":"1076_CR34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/prot.22570","volume":"77","author":"E Krieger","year":"2009","unstructured":"Krieger, E., Joo, K., & Lee, J. (2009). Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8. Proteins, 77, 114\u2013122. https:\/\/doi.org\/10.1002\/prot.22570","journal-title":"Proteins"},{"issue":"8","key":"1076_CR35","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.3390\/microorganisms10081660","volume":"10","author":"M Sada","year":"2022","unstructured":"Sada, M., Kimura, H., Nagasawa, N., Akagawa, M., Okayama, K., Shirai, T., Sunagawa, S., Kimura, R., Saraya, T., Ishii, H., Kurai, D., Tsugawa, T., Nishina, A., Tomita, H., Okodo, M., Hirai, S., Ryo, A., Ishioka, T., & Murakami, K. (2022). Molecular evolution of the Pseudomonas aeruginosa DNA Gyrase gyrA Gene. Microorganisms, 10(8), 1660. https:\/\/doi.org\/10.3390\/microorganisms10081660","journal-title":"Microorganisms"},{"issue":"1","key":"1076_CR36","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3390\/ijms19010222","volume":"19","author":"C Nastas\u0103","year":"2018","unstructured":"Nastas\u0103, C., Vodnar, D. C., & Ionu\u0163, I. (2018). Antibacterial Evaluation and virtual screening of new thiazolyl-triazole schiff bases as potential DNA-gyrase inhibitors. International Journal of Molecular Sciences, 19(1), 222. https:\/\/doi.org\/10.3390\/ijms19010222","journal-title":"International Journal of Molecular Sciences"},{"key":"1076_CR37","doi-asserted-by":"crossref","unstructured":"Hashemi, N.S., Mojiri, M., Yazdani, K.P., Eskandari, S., Mohammadian, M., & Alavi, I., (2017) Prevalence of antibiotic resistance and blaIMP-1 gene among Pseudomonas aeruginosa strains isolated from burn and urinary tract infections in Isfahan, central Iran. Microbiology Research. 8(2), 59\u201363. https:\/\/www.mdpi.com\/2036-7481\/8\/2\/7295#","DOI":"10.4081\/mr.2017.7295"},{"issue":"4","key":"1076_CR38","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.bjm.2016.07.016","volume":"47","author":"R Nouri","year":"2016","unstructured":"Nouri, R., Ahangarzadeh, R. M., & Hasani, A. (2016). The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran. Brazilian Journal of Microbiology, 47(4), 925\u2013930. https:\/\/doi.org\/10.1016\/j.bjm.2016.07.016","journal-title":"Brazilian Journal of Microbiology"},{"issue":"2","key":"1076_CR39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jmii.2022.08.017","volume":"56","author":"H Huang","year":"2023","unstructured":"Huang, H., Liu, H., & Chuang, H. (2023). Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study. Journal of Microbiology, Immunology, and Infection, 56(2), 337\u2013343. https:\/\/doi.org\/10.1016\/j.jmii.2022.08.017","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"issue":"1","key":"1076_CR40","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10156-012-0455-y","volume":"19","author":"R Salma","year":"2013","unstructured":"Salma, R., Dabboussi, F., Kassaa, I., Hamze, M., & Khudary, R. (2013). gyrA and parC mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa from Nini Hospital in north Lebanon. Journal of Infection and Chemotherapy, 19(1), 77\u201381. https:\/\/doi.org\/10.1007\/s10156-012-0455-y","journal-title":"Journal of Infection and Chemotherapy"},{"issue":"6","key":"1076_CR41","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s40265-021-01635-6","volume":"81","author":"D Reynolds","year":"2021","unstructured":"Reynolds, D., & Kollef, M. (2021). The epidemiology and pathogenesis and treatment of Pseudomonas aeruginosa Infections: an update. Drugs, 81(6), 747\u2013760. https:\/\/doi.org\/10.1007\/s40265-021-01635-6","journal-title":"Drugs"},{"issue":"12","key":"1076_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2147\/2FIDR.S182272","volume":"8","author":"X Feng","year":"2019","unstructured":"Feng, X., Zhang, Z., Li, X., Song, Y., Kang, J., Yin, D., & Duan, J. (2019). Mutations in gyrB play an important role in ciprofloxacin-resistant Pseudomonas aeruginosa. Infection and Drug Resistance, 8(12), 261\u201372. https:\/\/doi.org\/10.2147\/2FIDR.S182272","journal-title":"Infection and Drug Resistance"},{"issue":"8","key":"1076_CR43","doi-asserted-by":"publisher","first-page":"6271","DOI":"10.3390\/molecules16086271","volume":"16","author":"HZ Shams","year":"2011","unstructured":"Shams, H. Z., Mohareb, R. M., Helal, M. H., & Mahmoud, A. E. S. (2011). Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and\/or textile finishing based on 2-N-acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene systems. Molecules, 16(8), 6271\u2013305. https:\/\/doi.org\/10.3390\/molecules16086271","journal-title":"Molecules"},{"issue":"10","key":"1076_CR44","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3390\/91000815","volume":"9","author":"AA Jarrahpour","year":"2004","unstructured":"Jarrahpour, A. A., Motamedifar, M., & Pakshir, K. (2004). Synthesis of novel azo Schiff bases and their antibacterial and antifungal activities. Molecules, 9(10), 815\u2013824. https:\/\/doi.org\/10.3390\/91000815","journal-title":"Molecules"},{"issue":"17","key":"1076_CR45","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.3390\/molecules27175643","volume":"27","author":"MM Di","year":"2022","unstructured":"Di, M. M., Sessa, L., & Di, M. M. (2022). Azobenzene as antimicrobial molecules. Molecules, 27(17), 5643. https:\/\/doi.org\/10.3390\/molecules27175643","journal-title":"Molecules"},{"key":"1076_CR46","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1255","author":"EF Al-Jumaily","year":"2017","unstructured":"Al-Jumaily, E. F., & Abd, N. Q. (2017). Effect of quinoline-2-one derivatives on the gene expression of mexB of Pseudomonas aeruginosa. Biomedical and Pharmacology Journal. https:\/\/doi.org\/10.13005\/bpj\/1255","journal-title":"Biomedical and Pharmacology Journal"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-024-01076-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-024-01076-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-024-01076-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T12:10:01Z","timestamp":1736338201000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-024-01076-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1076"],"URL":"https:\/\/doi.org\/10.1007\/s12033-024-01076-y","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"26 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors claim no relevant conflicts of interest that affect the research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were conducted in strict adherence to the ethical standards of Al Muthanna University for the treatment of research subjects in Samawah, Iraq, following ethics- approval letter number 4513 in 4\/11\/2021.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Written informed consent has been received from all person\u2019s individuals concerned in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}