{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:03:23Z","timestamp":1761735803675,"version":"build-2065373602"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s12033-024-01308-1","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T19:10:24Z","timestamp":1731957024000},"page":"4203-4211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Relationship Between BigET-1 and Cardiac Remodeling in Patients with Hypertrophic Obstructive Cardiomyopathy"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1768-1265","authenticated-orcid":false,"given":"Hua","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"1308_CR1","doi-asserted-by":"publisher","DOI":"10.21542\/gcsp.2018.19","author":"C D\u00edez-L\u00f3pez","year":"2018","unstructured":"D\u00edez-L\u00f3pez, C., & Salazar-Mendiguch\u00eda, J. (2018). Clinical presentations of hypertrophic cardiomyopathy and implications for therapy. Global Cardiology Science Practice. https:\/\/doi.org\/10.21542\/gcsp.2018.19","journal-title":"Global Cardiology Science Practice"},{"issue":"7","key":"1308_CR2","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1161\/CIRCRESAHA.117.311059","volume":"121","author":"AJ Marian","year":"2017","unstructured":"Marian, A. J., & Braunwald, E. (2017). Hypertrophic cardiomyopathy: Genetics, pathogenesis, clinical manifestations, diagnosis, and therapy. Circulation Research, 121(7), 749\u2013770. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311059","journal-title":"Circulation Research"},{"issue":"12","key":"1308_CR3","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3390\/biom9120878","volume":"9","author":"P Teekakirikul","year":"2019","unstructured":"Teekakirikul, P., Zhu, W., Huang, H. C., & Fung, E. (2019). Hypertrophic Cardiomyopathy: An overview of genetics and management. Biomolecules, 9(12), 878. https:\/\/doi.org\/10.3390\/biom9120878","journal-title":"Biomolecules"},{"issue":"1","key":"1308_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.7861\/clinmedicine.19-1-61","volume":"19","author":"J Firth","year":"2019","unstructured":"Firth, J. (2019). Cardiology: Hypertrophic cardiomyopathy. Clinical Medicine (London, England), 19(1), 61\u201363. https:\/\/doi.org\/10.7861\/clinmedicine.19-1-61","journal-title":"Clinical Medicine (London, England)"},{"issue":"4","key":"1308_CR5","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.jacc.2021.11.021","volume":"79","author":"BJ Maron","year":"2022","unstructured":"Maron, B. J., Desai, M. Y., Nishimura, R. A., Spirito, P., Rakowski, H., Towbin, J. A., Dearani, J. A., Rowin, E. J., Maron, M. S., & Sherrid, M. V. (2022). Management of hypertrophic cardiomyopathy: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 79(4), 390\u2013414. https:\/\/doi.org\/10.1016\/j.jacc.2021.11.021","journal-title":"Journal of the American College of Cardiology"},{"issue":"14","key":"1308_CR6","doi-asserted-by":"publisher","first-page":"7722","DOI":"10.3390\/ijms22147722","volume":"22","author":"T Ciarambino","year":"2021","unstructured":"Ciarambino, T., Menna, G., Sansone, G., & Giordano, M. (2021). Cardiomyopathies: An overview. International Journal of Molecular Sciences, 22(14), 7722. https:\/\/doi.org\/10.3390\/ijms22147722","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"1308_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.hfc.2021.07.004","volume":"18","author":"M Lioncino","year":"2022","unstructured":"Lioncino, M., Monda, E., Verrillo, F., Moscarella, E., Calcagni, G., Drago, F., Marino, B., Digilio, M. C., Putotto, C., Calabr\u00f2, P., Russo, M. G., Roberts, A. E., Gelb, B. D., Tartaglia, M., & Limongelli, G. (2022). Hypertrophic cardiomyopathy in RASopathies: Diagnosis, clinical characteristics, prognostic implications, and management. Heart Failure Clinics, 18(1), 19\u201329. https:\/\/doi.org\/10.1016\/j.hfc.2021.07.004","journal-title":"Heart Failure Clinics"},{"issue":"6","key":"1308_CR8","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1007\/s10741-022-10231-z","volume":"27","author":"F Luo","year":"2022","unstructured":"Luo, F., Liu, W., & Bu, H. (2022). MicroRNAs in hypertrophic cardiomyopathy: Pathogenesis, diagnosis, treatment potential and roles as clinical biomarkers. Heart Failure Reviews, 27(6), 2211\u20132221. https:\/\/doi.org\/10.1007\/s10741-022-10231-z","journal-title":"Heart Failure Reviews"},{"issue":"27","key":"1308_CR9","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","volume":"43","author":"S Frantz","year":"2022","unstructured":"Frantz, S., Hundertmark, M. J., Schulz-Menger, J., Bengel, F. M., & Bauersachs, J. (2022). Left ventricular remodelling post-myocardial infarction: Pathophysiology, imaging, and novel therapies. European Heart Journal, 43(27), 2549\u20132561. https:\/\/doi.org\/10.1093\/eurheartj\/ehac223","journal-title":"European Heart Journal"},{"key":"1308_CR10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2147\/VHRM.S365001","volume":"19","author":"MJ Litt","year":"2023","unstructured":"Litt, M. J., Ali, A., & Reza, N. (2023). Familial hypertrophic cardiomyopathy: Diagnosis and management. Vasc Health Risk Manag., 19, 211\u2013221. https:\/\/doi.org\/10.2147\/VHRM.S365001","journal-title":"Vasc Health Risk Manag."},{"key":"1308_CR11","doi-asserted-by":"publisher","first-page":"671","DOI":"10.33963\/KP.a2023.0140","volume":"81","author":"M Correale","year":"2023","unstructured":"Correale, M., Santoro, F., & Magr\u00ec, D. (2023). Fibrosis-specific biomarkers and interstitial fibrosis in hypertrophic cardiomyopathy. Kardiologia Polska, 81, 671\u2013672. https:\/\/doi.org\/10.33963\/KP.a2023.0140","journal-title":"Kardiologia Polska"},{"issue":"1","key":"1308_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tcm.2019.01.007","volume":"30","author":"M Jankowich","year":"2020","unstructured":"Jankowich, M., & Choudhary, G. (2020). Endothelin-1 levels and cardiovascular events. Trends in Cardiovascular Medicine, 30(1), 1\u20138. https:\/\/doi.org\/10.1016\/j.tcm.2019.01.007","journal-title":"Trends in Cardiovascular Medicine"},{"issue":"9","key":"1308_CR13","doi-asserted-by":"publisher","first-page":"v","DOI":"10.1139\/cjpp-2020-0376","volume":"98","author":"B Widyantoro","year":"2020","unstructured":"Widyantoro, B., & Emoto, N. (2020). Endothelin XVI. Canadian Journal of Physiology and Pharmacology, 98(9), v\u2013vii. https:\/\/doi.org\/10.1139\/cjpp-2020-0376","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"1","key":"1308_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1042\/CS20171366","volume":"132","author":"KM Mirabito Colafella","year":"2018","unstructured":"Mirabito Colafella, K. M. (2018). Endothelin type B (ET(B)) receptors: Friend or foe in the pathogenesis of pre-eclampsia and future cardiovascular disease (CVD) risk. Clinical Science (London, England), 132(1), 33\u201336. https:\/\/doi.org\/10.1042\/CS20171366","journal-title":"Clinical Science (London, England)"},{"key":"1308_CR15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf5074","author":"A Czopek","year":"2022","unstructured":"Czopek, A., Moorhouse, R., Gallacher, P. J., Pugh, D., Ivy, J. R., Farrah, T. E., Godden, E., Hunter, R. W., Webb, D. J., Tharaux, P. L., Kluth, D. C., Dear, J. W., Bailey, M. A., & Dhaun, N. (2022). Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice. Science Translational Medicine. https:\/\/doi.org\/10.1126\/scitranslmed.abf5074","journal-title":"Science Translational Medicine."},{"issue":"8","key":"1308_CR16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/s41569-019-0176-3","volume":"16","author":"N Dhaun","year":"2019","unstructured":"Dhaun, N., & Webb, D. J. (2019). Endothelins in cardiovascular biology and therapeutics. Nature Reviews Cardiology, 16(8), 491\u2013502. https:\/\/doi.org\/10.1038\/s41569-019-0176-3","journal-title":"Nature Reviews Cardiology"},{"key":"1308_CR17","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85821","author":"FK Sano","year":"2023","unstructured":"Sano, F. K., Akasaka, H., Shihoya, W., & Nureki, O. (2023). Cryo-EM structure of the endothelin-1-ETB-Gi complex. eLife. https:\/\/doi.org\/10.7554\/eLife.85821","journal-title":"eLife"},{"issue":"6","key":"1308_CR18","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1097\/MCA.0000000000000752","volume":"30","author":"F Wang","year":"2019","unstructured":"Wang, F., Li, T., Cong, X., Hou, Z., Lu, B., Zhou, Z., & Chen, X. (2019). Association between circulating big endothelin-1 and noncalcified or mixed coronary atherosclerotic plaques. Coronary Artery Disease, 30(6), 461\u2013466. https:\/\/doi.org\/10.1097\/MCA.0000000000000752","journal-title":"Coronary Artery Disease"},{"issue":"37","key":"1308_CR19","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","volume":"44","author":"E Arbelo","year":"2023","unstructured":"Arbelo, E., Protonotarios, A., Gimeno, J. R., Arbustini, E., Barriales-Villa, R., Basso, C., Bezzina, C. R., Biagini, E., Blom, N. A., de Boer, R. A., De Winter, T., Elliott, P. M., Flather, M., Garcia-Pavia, P., Haugaa, K. H., Ingles, J., Jurcut, R. O., Klaassen, S., Limongelli, G., \u2026 ESC Scientific Document Group. (2023). 2023 ESC guidelines for the management of cardiomyopathies. European Heart Journal, 44(37), 3503\u20133626. https:\/\/doi.org\/10.1093\/eurheartj\/ehad194","journal-title":"European Heart Journal"},{"key":"1308_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2020.113950","volume":"611","author":"YY Chen","year":"2020","unstructured":"Chen, Y. Y., Li, S. L., Lin, H. L., Li, W. D., Zhu, X. Z., & Zhang, H. L. (2020). A chemiluminescence immunoassay for the detection of NT-proBNP. Analytical Biochemistry, 611, 113950. https:\/\/doi.org\/10.1016\/j.ab.2020.113950","journal-title":"Analytical Biochemistry"},{"issue":"3","key":"1308_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.24875\/ACM.21000301","volume":"92","author":"GA Llamas-Esper\u00f3n","year":"2022","unstructured":"Llamas-Esper\u00f3n, G. A., & Llamas-Delgado, G. (2022). Hypertrophic cardiomyopathy. Proposal for a new classification. Archivos de Cardiolog\u00eda de M\u00e9xico, 92(3), 377\u2013389. https:\/\/doi.org\/10.24875\/ACM.21000301","journal-title":"Archivos de Cardiolog\u00eda de M\u00e9xico"},{"issue":"3","key":"1308_CR22","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.athoracsur.2020.05.156","volume":"111","author":"X Bi","year":"2021","unstructured":"Bi, X., Yang, C., Song, Y., Yuan, J., Cui, J., Hu, F., & Qiao, S. (2021). Matrix metalloproteinases increase because of hypoperfusion in obstructive hypertrophic cardiomyopathy. Annals of Thoracic Surgery, 111(3), 915\u2013922. https:\/\/doi.org\/10.1016\/j.athoracsur.2020.05.156","journal-title":"Annals of Thoracic Surgery"},{"issue":"18","key":"1308_CR23","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.3390\/ijms20184411","volume":"20","author":"A Kr\u00fcger-Genge","year":"2019","unstructured":"Kr\u00fcger-Genge, A., Blocki, A., Franke, R. P., & Jung, F. (2019). Vascular Endothelial Cell Biology: An Update. International Journal of Molecular Sciences, 20(18), 4411. https:\/\/doi.org\/10.3390\/ijms20184411","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"1308_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41569-022-00770-1","volume":"20","author":"E Trimm","year":"2023","unstructured":"Trimm, E., & Red-Horse, K. (2023). Vascular endothelial cell development and diversity. Nature Reviews Cardiology, 20(3), 197\u2013210. https:\/\/doi.org\/10.1038\/s41569-022-00770-1","journal-title":"Nature Reviews Cardiology"},{"issue":"2","key":"1308_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10456-021-09785-7","volume":"24","author":"C Marziano","year":"2021","unstructured":"Marziano, C., Genet, G., & Hirschi, K. K. (2021). Vascular endothelial cell specification in health and disease. Angiogenesis, 24(2), 213\u2013236. https:\/\/doi.org\/10.1007\/s10456-021-09785-7","journal-title":"Angiogenesis"},{"issue":"4","key":"1308_CR26","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.cmet.2020.03.009","volume":"31","author":"K Rohlenova","year":"2020","unstructured":"Rohlenova, K., Goveia, J., Garc\u00eda-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, L., Zheng, Y., Lin, L., Sokol, L., Teuwen, L. A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L. C., Khan, S., Stegen, S., Panovska, D., \u2026 Carmeliet, P. (2020). Single-cell RNA sequencing maps endothelial metabolic plasticity in pathological angiogenesis. Cell Metabolism, 31(4), 862-877.e14. https:\/\/doi.org\/10.1016\/j.cmet.2020.03.009","journal-title":"Cell Metabolism"},{"issue":"9","key":"1308_CR27","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1161\/ATVBAHA.121.313788","volume":"41","author":"Z Alvandi","year":"2021","unstructured":"Alvandi, Z., & Bischoff, J. (2021). Endothelial-mesenchymal transition in cardiovascular disease. Arteriosclerosis Thrombosis and Vascular Biology, 41(9), 2357\u20132369. https:\/\/doi.org\/10.1161\/ATVBAHA.121.313788","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"issue":"36","key":"1308_CR28","doi-asserted-by":"publisher","first-page":"7400","DOI":"10.2174\/0929867328666210405122703","volume":"28","author":"A Angelopoulos","year":"2021","unstructured":"Angelopoulos, A., Oikonomou, E., Vogiatzi, G., Antonopoulos, A., Tsalamandris, S., Georgakopoulos, C., Papanikolaou, P., Lazaros, G., Charalambous, G., Siasos, G., Vlachopoulos, C., & Tousoulis, D. (2021). MicroRNAs as biomarkers in hypertrophic cardiomyopathy: current state of the art. Current Medicinal Chemistry, 28(36), 7400\u20137412. https:\/\/doi.org\/10.2174\/0929867328666210405122703","journal-title":"Current Medicinal Chemistry"},{"issue":"3","key":"1308_CR29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.pcad.2019.04.001","volume":"62","author":"ZD Goff","year":"2019","unstructured":"Goff, Z. D., & Calkins, H. (2019). Sudden death related cardiomyopathies\u2014Hypertrophic cardiomyopathy. Progress in Cardiovascular Diseases, 62(3), 212\u2013216. https:\/\/doi.org\/10.1016\/j.pcad.2019.04.001","journal-title":"Progress in Cardiovascular Diseases"},{"issue":"4","key":"1308_CR30","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.hlc.2020.08.009","volume":"30","author":"M Zuchowski","year":"2021","unstructured":"Zuchowski, M., & Chilcot, J. (2021). Illness perceptions in hypertrophic cardiomyopathy (HCM) patients and their association with heart-focussed anxiety. Heart, Lung & Circulation, 30(4), 496\u2013506. https:\/\/doi.org\/10.1016\/j.hlc.2020.08.009","journal-title":"Heart, Lung & Circulation"},{"issue":"1","key":"1308_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/21548331.2022.2162297","volume":"51","author":"SJ Rao","year":"2023","unstructured":"Rao, S. J., Iqbal, S. B., Kanwal, A. S., Aronow, W. S., & Naidu, S. S. (2023). Multi-modality management of hypertrophic cardiomyopathy. Hospital Practice, 51(1), 2\u201311. https:\/\/doi.org\/10.1080\/21548331.2022.2162297","journal-title":"Hospital Practice"},{"issue":"2","key":"1308_CR32","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1536\/ihj.18-438","volume":"60","author":"L Liu","year":"2019","unstructured":"Liu, L., Wu, L., Zheng, L., Ding, L., Chen, G., Fan, X., & Yao, Y. (2019). Associations between multiple circulating biomarkers and the presence of atrial fibrillation in hypertrophic cardiomyopathy with or without left ventricular outflow tract obstruction. International Heart Journal, 60(2), 327\u2013335.","journal-title":"International Heart Journal"},{"issue":"5","key":"1308_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/intimm\/dxaa008","volume":"32","author":"H Naito","year":"2020","unstructured":"Naito, H., Iba, T., & Takakura, N. (2020). Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells. International Immunology, 32(5), 295\u2013305. https:\/\/doi.org\/10.1093\/intimm\/dxaa008","journal-title":"International Immunology"},{"issue":"8","key":"1308_CR34","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.3390\/ijms20081820","volume":"20","author":"Z Cao","year":"2019","unstructured":"Cao, Z., Jia, Y., & Zhu, B. (2019). BNP and NT-proBNP as diagnostic biomarkers for cardiac dysfunction in both clinical and forensic medicine. International Journal of Molecular Sciences, 20(8), 1820. https:\/\/doi.org\/10.3390\/ijms20081820","journal-title":"International Journal of Molecular Sciences"},{"key":"1308_CR35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.clinbiochem.2018.01.012","volume":"53","author":"J Brynildsen","year":"2018","unstructured":"Brynildsen, J., Pet\u00e4j\u00e4, L., Pettil\u00e4, V., Nyg\u00e5rd, S., Vaara, S. T., Linko, R., Okkonen, M., Hagve, T. A., Soininen, L., Suojaranta-Ylinen, R., Lyngbakken, M. N., Omland, T., & R\u00f8sj\u00f8, H. (2018). The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients. Clinical Biochemistry, 53, 65\u201371. https:\/\/doi.org\/10.1016\/j.clinbiochem.2018.01.012","journal-title":"Clinical Biochemistry"},{"key":"1308_CR36","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.peptides.2018.04.003","volume":"111","author":"I Gergei","year":"2019","unstructured":"Gergei, I., Kr\u00e4mer, B. K., Scharnagl, H., Stojakovic, T., & M\u00e4rz, W. (2019). Renal function, N-terminal Pro-B-Type natriuretic peptide, propeptide big-endothelin and patients with heart failure and preserved ejection fraction. Peptides, 111, 112\u2013117. https:\/\/doi.org\/10.1016\/j.peptides.2018.04.003","journal-title":"Peptides"},{"issue":"6","key":"1308_CR37","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.hrtlng.2021.07.007","volume":"50","author":"S Shen","year":"2021","unstructured":"Shen, S., Ye, J., Wu, X., & Li, X. (2021). Association of N-terminal pro-brain natriuretic peptide level with adverse outcomes in patients with acute myocardial infarction: A meta-analysis. Heart and Lung, 50(6), 863\u2013869. https:\/\/doi.org\/10.1016\/j.hrtlng.2021.07.007","journal-title":"Heart and Lung"},{"issue":"3","key":"1308_CR38","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3390\/genes13030530","volume":"13","author":"T Yu","year":"2022","unstructured":"Yu, T., Huang, Z., & Pu, Z. (2022). Identification of potential diagnostic biomarkers and biological pathways in hypertrophic cardiomyopathy based on bioinformatics analysis. Genes (Basel), 13(3), 530. https:\/\/doi.org\/10.3390\/genes13030530","journal-title":"Genes (Basel)"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-024-01308-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-024-01308-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-024-01308-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:18:30Z","timestamp":1761711510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-024-01308-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1308"],"URL":"https:\/\/doi.org\/10.1007\/s12033-024-01308-1","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"type":"print","value":"1073-6085"},{"type":"electronic","value":"1559-0305"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"29 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no conflicting interests listed by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local ethics committee of the First Hospital of Jilin University. All experiments were performed in accordance with relevant guidelines and regulations such as the Declaration of Helsinki and the patients signed the informed consent form and agreed to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}