{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:07:30Z","timestamp":1776866850939,"version":"3.51.2"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s12033-024-01327-y","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T11:58:09Z","timestamp":1733140689000},"page":"4342-4360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Scopoletin: A Validated Protector against Cerulein-induced Acute Pancreatitis &amp; Associated Lung Injury by Regulating PPAR- \u03b3 \u201cA Multidimensional Approach\u201d"],"prefix":"10.1007","volume":"67","author":[{"given":"Subhashini","family":"Brahadeeswaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran Kumar","family":"Chitluri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leema","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatraman","family":"Manickam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac Arnold","family":"Emerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-6308","authenticated-orcid":false,"given":"Ramasamy","family":"Tamizhselvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"issue":"13","key":"1327_CR1","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.3748\/wjg.v12.i13.1985","volume":"12","author":"GJD van Acker","year":"2006","unstructured":"van Acker, G. J. D., Perides, G., & Steer, M. L. (2006). Co-localization hypothesis: A mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis. World Journal of Gastroenterology, 12(13), 1985\u20131990. https:\/\/doi.org\/10.3748\/wjg.v12.i13.1985","journal-title":"World Journal of Gastroenterology"},{"key":"1327_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340200049","author":"R Makhija","year":"2002","unstructured":"Makhija, R., & Kingsnorth, A. N. (2002). Cytokine storm in acute pancreatitis. Journal of Hepato-Biliary-Pancreatic Surgery. https:\/\/doi.org\/10.1007\/s005340200049","journal-title":"Journal of Hepato-Biliary-Pancreatic Surgery"},{"key":"1327_CR3","unstructured":"Bhatia, M., Brady, M., Zagorski, J., Christmas, S. E., Campbell, F., Neoptolemos, J. P., & Slavin, J. (n.d.). Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury. Retrieved from www.gutjnl.com"},{"issue":"1","key":"1327_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1089\/sur.2006.011","volume":"8","author":"T De Campos","year":"2007","unstructured":"De Campos, T., Deree, J., & Coimbra, R. (2007). From Acute Pancreatitis to End-Organ Injury: Mechanisms of Acute Lung Injury. Surgical Infections, 8(1), 107\u2013120. https:\/\/doi.org\/10.1089\/sur.2006.011","journal-title":"Surgical Infections"},{"key":"1327_CR5","doi-asserted-by":"publisher","unstructured":"Rakonczay, Z., Hegyi, P., Tak\u00e1cs, T., McCarroll, J., & Saluja, A. K. (2008, February). The role of NF-\u03baB activation in the pathogenesis of acute pancreatitis. Gut. https:\/\/doi.org\/10.1136\/gut.2007.124115","DOI":"10.1136\/gut.2007.124115"},{"key":"1327_CR6","doi-asserted-by":"publisher","unstructured":"Altavilla, D., Famulari, C., Passaniti, M., Galeano, M., Macr\u00ec, A., Seminara, P., \u2026 Squadrito, F. (2003). Attenuated Cerulein-Induced Pancreatitis in Nuclear Factor-\u03ba B-Deficient Mice. Laboratory Investigation, 83(12), 1723\u20131732. https:\/\/doi.org\/10.1097\/01.LAB.0000101734.82054.BE","DOI":"10.1097\/01.LAB.0000101734.82054.BE"},{"key":"1327_CR7","unstructured":"Straus, D. S., Pascual, G., Li, M., Welch, J. S., Ricote, M., Hsiang, C.-H., \u2026 Glass, C. K. (2000). 5-Deoxy-12,14-prostaglandin J 2 inhibits multiple steps in the NF-B signaling pathway. Retrieved from www.pnas.org"},{"key":"1327_CR8","doi-asserted-by":"publisher","unstructured":"Martin, H. (2010). Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. Mutation research, 690(1\u20132), 57\u201363. https:\/\/doi.org\/10.1016\/j.mrfmmm.2009.09.009","DOI":"10.1016\/j.mrfmmm.2009.09.009"},{"issue":"6","key":"1327_CR9","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1124\/mol.105.017160","volume":"68","author":"RK So","year":"2005","unstructured":"So, R. K., Kyung, S. L., Hee, S. P., Seoung, J. P., Kyung, H. M., Sun, M. J., & Yong, C. L. (2005). Involvement of IL-10 in peroxisome proliferator-activated receptor \u03b3-mediated anti-inflammatory response in asthma. Molecular Pharmacology, 68(6), 1568\u20131575. https:\/\/doi.org\/10.1124\/mol.105.017160","journal-title":"Molecular Pharmacology"},{"issue":"2","key":"1327_CR10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.arcmed.2008.11.004","volume":"40","author":"C Chen","year":"2009","unstructured":"Chen, C., Xu, S., Wang, W. X., Ding, Y. M., Yu, K. H., Wang, B., & Chen, X. Y. (2009). Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated Lung Injury. Archives of Medical Research, 40(2), 79\u201388. https:\/\/doi.org\/10.1016\/j.arcmed.2008.11.004","journal-title":"Archives of Medical Research"},{"key":"1327_CR11","unstructured":"Celi\u0144ski, K., M\u0105dro, A., Prozorow-Kr\u00f3l, B., Korolczuk, A., Cicho\u017c-Lach, H., S\u0142omka, M., & Korobowicz, E. (n.d.). Rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPARg)-specific agonist, as a modulator in experimental acute pancreatitis. Retrieved from http:\/\/www.medscimonit.com\/abstract\/index\/idArt\/869527"},{"key":"1327_CR12","doi-asserted-by":"publisher","unstructured":"Rollins, M. D., Sudarshan, S., Firpo, M. A., Etherington, B. H., Hart, B. J., Jackson, H. H., \u2026 Glasgow, R. E. (2006). Anti-inflammatory Effects of PPAR-\u03b3 Agonists Directly Correlate With PPAR-\u03b3 Expression During Acute Pancreatitis. Journal of Gastrointestinal Surgery, 10(8), 1120\u20131130. https:\/\/doi.org\/10.1016\/j.gassur.2006.04.027","DOI":"10.1016\/j.gassur.2006.04.027"},{"key":"1327_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.354","author":"H Gu","year":"2013","unstructured":"Gu, H., Werner, J., Bergmann, F., Whitcomb, D. C., B\u00fcchler, M. W., & Fortunato, F. (2013). Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. Cell Death and Disease. https:\/\/doi.org\/10.1038\/cddis.2013.354","journal-title":"Cell Death and Disease"},{"issue":"5","key":"1327_CR14","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.2353\/ajpath.2007.061149","volume":"170","author":"Y Cao","year":"2007","unstructured":"Cao, Y., Adhikari, S., Cl\u00e9ment, M. V., Wallig, M., & Bhatia, M. (2007). Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology, 170(5), 1521\u20131534. https:\/\/doi.org\/10.2353\/ajpath.2007.061149","journal-title":"American Journal of Pathology"},{"key":"1327_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.vascn.2019.01.002","volume":"96","author":"S Bansod","year":"2019","unstructured":"Bansod, S., Khurana, A., & Godugu, C. (2019). Cerulein-induced chronic pancreatitis in Swiss albino mice: An improved short-term model for pharmacological screening. Journal of Pharmacological and Toxicological Methods, 96, 46\u201355. https:\/\/doi.org\/10.1016\/j.vascn.2019.01.002","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"issue":"5","key":"1327_CR16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1080\/08923973.2016.1203929","volume":"38","author":"P dos Santos","year":"2016","unstructured":"dos Santos, P., Nascimento, M. V., Arruda-Silva, F., Gobbo Luz, A. B., Baratto, B., Venzke, D., Mendes, B. G., & Dalmarco, E. M. (2016). Inhibition of the NF-\u03baB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy. Immunopharmacology and Immunotoxicology, 38(5), 344\u2013352. https:\/\/doi.org\/10.1080\/08923973.2016.1203929","journal-title":"Immunopharmacology and Immunotoxicology"},{"issue":"2","key":"1327_CR17","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.3390\/molecules20022786","volume":"20","author":"WC Chang","year":"2015","unstructured":"Chang, W. C., Wu, S. C., Xu, K. D., Liao, B. C., Wu, J. F., & Cheng, A. S. (2015). Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. Molecules, 20(2), 2786\u20132801. https:\/\/doi.org\/10.3390\/molecules20022786","journal-title":"Molecules"},{"issue":"15","key":"1327_CR18","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1016\/j.bmcl.2012.06.014","volume":"22","author":"W Liu","year":"2012","unstructured":"Liu, W., Hua, J., Zhou, J., Zhang, H., Zhu, H., Cheng, Y., & Gust, R. (2012). Synthesis and in vitro antitumor activity of novel scopoletin derivatives. Bioorganic and Medicinal Chemistry Letters, 22(15), 5008\u20135012. https:\/\/doi.org\/10.1016\/j.bmcl.2012.06.014","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"key":"1327_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2024.1268464","volume":"15","author":"XY Gao","year":"2024","unstructured":"Gao, X. Y., Li, X. Y., Zhang, C. Y., & Bai, C. Y. (2024). Scopoletin: A review of its pharmacology, pharmacokinetics, and toxicity. Frontiers in Pharmacology, 15, 1\u201324. https:\/\/doi.org\/10.3389\/fphar.2024.1268464","journal-title":"Frontiers in Pharmacology"},{"key":"1327_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00893","author":"M Heming","year":"2018","unstructured":"Heming, M., Gran, S., Jauch, S. L., Fischer-Riepe, L., Russo, A., Klotz, L., & Barczyk-Kahlert, K. (2018). Peroxisome proliferator-activated receptor-\u03b3 modulates the response of macrophages to lipopolysaccharide and glucocorticoids. Frontiers in Immunology. https:\/\/doi.org\/10.3389\/fimmu.2018.00893","journal-title":"Frontiers in Immunology"},{"key":"1327_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/318613","author":"D Ortu\u00f1oSahag\u00fan","year":"2012","unstructured":"Ortu\u00f1oSahag\u00fan, D., M\u00e1rquez-Aguirre, A. L., Quintero-Fabi\u00e1n, S., L\u00f3pez-Roa, R. I., & Rojas-Mayorqu\u00edn, A. E. (2012). Modulation of PPAR-\u03b3 by nutraceutics as complementary treatment for obesity-related disorders and inflammatory diseases. PPAR Research. https:\/\/doi.org\/10.1155\/2012\/318613","journal-title":"PPAR Research"},{"issue":"5","key":"1327_CR22","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1097\/MPA.0000000000001034","volume":"47","author":"G Leema","year":"2018","unstructured":"Leema, G., & Tamizhselvi, R. (2018). Protective effect of scopoletin against cerulein-induced acute pancreatitis and associated lung injury in mice. Pancreas, 47(5), 577\u2013585. https:\/\/doi.org\/10.1097\/MPA.0000000000001034","journal-title":"Pancreas"},{"key":"1327_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/595603","author":"TN Chang","year":"2012","unstructured":"Chang, T. N., Deng, J. S., Chang, Y. C., Lee, C. Y., Jung-Chun, L., Lee, M. M., & Huang, G. J. (2012). Ameliorative effects of scopoletin from Crossostephium chinensis against inflammation pain and its mechanisms in mice. Evidence-based Complementary and Alternative Medicine. https:\/\/doi.org\/10.1155\/2012\/595603","journal-title":"Evidence-based Complementary and Alternative Medicine"},{"issue":"12","key":"1327_CR24","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1080\/13880200802367155","volume":"46","author":"Z Ding","year":"2008","unstructured":"Ding, Z., Dai, Y., Hao, H., Pan, R., Yao, X., & Wang, Z. (2008). Anti-inflammatory effects of scopoletin and underlying mechanisms. Pharmaceutical Biology, 46(12), 854\u2013860. https:\/\/doi.org\/10.1080\/13880200802367155","journal-title":"Pharmaceutical Biology"},{"key":"1327_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432156","author":"M Lampel","year":"1977","unstructured":"Lampel, M., & Kern, H. F. (1977). Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Archiv A Pathological Anatomy and Histology. https:\/\/doi.org\/10.1007\/BF00432156","journal-title":"Virchows Archiv A Pathological Anatomy and Histology"},{"key":"1327_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01527-7","author":"MK Marimuthu","year":"2022","unstructured":"Marimuthu, M. K., Moorthy, A., & Ramasamy, T. (2022). Diallyl Disulfide Attenuates STAT3 and NF-\u03baB Pathway Through PPAR-\u03b3 Activation in Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice. Inflammation. https:\/\/doi.org\/10.1007\/s10753-021-01527-7","journal-title":"Inflammation"},{"issue":"2","key":"1327_CR27","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1582-4934.2007.00024.x","volume":"11","author":"R Tamizhselvi","year":"2007","unstructured":"Tamizhselvi, R., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide acts as a mediator of inflammation inacute pancreatitis: In vitro studies using isolated mouse pancreatic acinar cells. Journal of Cellular and Molecular Medicine, 11(2), 315\u2013326. https:\/\/doi.org\/10.1111\/j.1582-4934.2007.00024.x","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"9","key":"1327_CR28","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/jphp.12946","volume":"70","author":"RK Velusamy","year":"2018","unstructured":"Velusamy, R. K., & Tamizhselvi, R. (2018). Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice. Journal of Pharmacy and Pharmacology, 70(9), 1188\u20131199. https:\/\/doi.org\/10.1111\/jphp.12946","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"1327_CR29","doi-asserted-by":"publisher","unstructured":"George, L., Ramasamy, T., Sirajudeen, K. N. S., & Manickam, V. (2019). LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages. Immunological Investigations, 48(5), 451\u2013465. https:\/\/doi.org\/10.1080\/08820139.2019.1566355","DOI":"10.1080\/08820139.2019.1566355"},{"issue":"8","key":"1327_CR30","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1107\/S0907444904011679","volume":"60","author":"AW Sch\u00fcttelkopf","year":"2004","unstructured":"Sch\u00fcttelkopf, A. W., & Van Aalten, D. M. F. (2004). PRODRG: A tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallographica Section D: Biological Crystallography, 60(8), 1355\u20131363. https:\/\/doi.org\/10.1107\/S0907444904011679","journal-title":"Acta Crystallographica Section D: Biological Crystallography"},{"key":"1327_CR31","doi-asserted-by":"publisher","DOI":"10.4172\/jcsb.1000085","author":"V Sanghani","year":"2012","unstructured":"Sanghani, V., & H., H Ganatra, S., & Pande, R. (2012). Molecular \u2013 Docking Studies of Potent Anticancer Agent. Journal of Computer Science & Systems Biology. https:\/\/doi.org\/10.4172\/jcsb.1000085","journal-title":"Journal of Computer Science & Systems Biology"},{"key":"1327_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ph14040357","author":"MEA Zaki","year":"2021","unstructured":"Zaki, M. E. A., Al-Hussain, S. A., Masand, V. H., Akasapu, S., Bajaj, S. O., El-Sayed, N. N. E., & Lewaa, I. (2021). Identification of anti-sars-cov-2 compounds from food using qsar-based virtual screening, molecular docking, and molecular dynamics simulation analysis. Pharmaceuticals. https:\/\/doi.org\/10.3390\/ph14040357","journal-title":"Pharmaceuticals"},{"issue":"4","key":"1327_CR33","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1021\/acs.jctc.7b00028","volume":"13","author":"K Sargsyan","year":"2017","unstructured":"Sargsyan, K., Grauffel, C., & Lim, C. (2017). How molecular size impacts RMSD applications in molecular dynamics simulations. Journal of Chemical Theory and Computation, 13(4), 1518\u20131524. https:\/\/doi.org\/10.1021\/acs.jctc.7b00028","journal-title":"Journal of Chemical Theory and Computation"},{"key":"1327_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104762","author":"AA Khan","year":"2021","unstructured":"Khan, A. A., Baildya, N., Dutta, T., & Ghosh, N. N. (2021). Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study. Microbial Pathogenesis. https:\/\/doi.org\/10.1016\/j.micpath.2021.104762","journal-title":"Microbial Pathogenesis"},{"key":"1327_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12060770","author":"N Khare","year":"2022","unstructured":"Khare, N., Maheshwari, S. K., Rizvi, S. M. D., Albadrani, H. M., Alsagaby, S. A., Alturaiki, W., & Jha, A. K. (2022). Homology modelling, molecular docking and molecular dynamics simulation studies of CALMH1 against secondary metabolites of Bauhinia variegata to treat Alzheimer\u2019s Disease. Brain Sciences. https:\/\/doi.org\/10.3390\/brainsci12060770","journal-title":"Brain Sciences"},{"issue":"9","key":"1327_CR36","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1080\/07391102.2020.1761883","volume":"39","author":"R Islam","year":"2021","unstructured":"Islam, R., Parves, M. R., Paul, A. S., Uddin, N., Rahman, M. S., Mamun, A. A., & Halim, M. A. (2021). A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics, 39(9), 3213\u20133224. https:\/\/doi.org\/10.1080\/07391102.2020.1761883","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"key":"1327_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27155042","author":"S Tabrez","year":"2022","unstructured":"Tabrez, S., Zughaibi, T. A., Hoque, M., Suhail, M., Khan, M. I., & Khan, A. U. (2022). Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression. Molecules. https:\/\/doi.org\/10.3390\/molecules27155042","journal-title":"Molecules"},{"issue":"8","key":"1327_CR38","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1080\/07391102.2020.1753577","volume":"39","author":"RJ Khan","year":"2021","unstructured":"Khan, R. J., Jha, R. K., Amera, G. M., Jain, M., Singh, E., Pathak, A., & Singh, A. K. (2021). Targeting SARS-CoV-2: A systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2\u2032-O-ribose methyltransferase. Journal of Biomolecular Structure and Dynamics, 39(8), 2679\u20132692. https:\/\/doi.org\/10.1080\/07391102.2020.1753577","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"issue":"13","key":"1327_CR39","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.3748\/wjg.v13.i13.1983","volume":"13","author":"P Xu","year":"2007","unstructured":"Xu, P., Zhou, X.-J., Chen, L.-Q., Chen, J., Xie, Y., Lv, L.-H., & Hou, X.-H. (2007). Pioglitazone attenuates the severity of sodium taurocholate-induced severe acute pancreatitis RAPID COMMUNICATION. World Journal of Gastroenterology, 13(13), 1983\u20131988.","journal-title":"World Journal of Gastroenterology"},{"key":"1327_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-007-0141-2","volume-title":"May)","author":"R Di Paola","year":"2007","unstructured":"Di Paola, R., & Cuzzocrea, S. (2007). May). Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury: Naunyn-Schmiedeberg\u2019s Archives of Pharmacology. https:\/\/doi.org\/10.1007\/s00210-007-0141-2"},{"key":"1327_CR41","unstructured":"Yu, W.-G., Xu, G., Ren, G.-J., Xu, X., Yuan, H.-Q., Qi, X.-L., & Tian, K.-L. (n.d.). Preventive action of curcumin in experimental acute pancreatitis in mouse."},{"key":"1327_CR42","doi-asserted-by":"crossref","unstructured":"Xu, P., Lou, X.-L., & Chen, C. (2015). Apoptotic Mechanisms of Peroxisome Proliferator-Activated Receptor-\u03b3 Activation in Acinar Cells During Acute Pancreatitis. Retrieved from www.pancreasjournal.com","DOI":"10.1097\/MPA.0000000000000495"},{"issue":"7","key":"1327_CR43","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/J.LFS.2005.02.003","volume":"77","author":"EK Kim","year":"2005","unstructured":"Kim, E. K., Kwon, K. B., Shin, B. C., Seo, E. A., Lee, Y. R., Kim, J. S., & Ryu, D. G. (2005). Scopoletin induces apoptosis in human promyeloleukemic cells, accompanied by activations of nuclear factor \u03baB and caspase-3. Life Sciences, 77(7), 824\u2013836. https:\/\/doi.org\/10.1016\/J.LFS.2005.02.003","journal-title":"Life Sciences"},{"issue":"7","key":"1327_CR44","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1053\/j.gastro.2005.03.025","volume":"128","author":"K Shimizu","year":"2005","unstructured":"Shimizu, K., Kobayashi, M., Tahara, J., & Shiratori, K. (2005). Cytokines and peroxisome proliferator-activated receptor \u03b3 ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology, 128(7), 2105\u20132118. https:\/\/doi.org\/10.1053\/j.gastro.2005.03.025","journal-title":"Gastroenterology"},{"key":"1327_CR45","unstructured":"the role of pparg in macrophage differentiation and cholesterol uptake. (n.d.)."},{"issue":"5","key":"1327_CR46","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/eji.200636398","volume":"37","author":"G Majai","year":"2007","unstructured":"Majai, G., Sarang, Z., Csom\u00f3s, K., Zahuczky, G., & F\u00e9s\u00fcs, L. (2007). PPAR\u03b3-dependent regulation of human macrophages in phagocytosis of apoptotic cells. European Journal of Immunology, 37(5), 1343\u20131354. https:\/\/doi.org\/10.1002\/eji.200636398","journal-title":"European Journal of Immunology"},{"issue":"8","key":"1327_CR47","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1158\/0008-5472.CAN-06-4257","volume":"67","author":"AB Kunnumakkara","year":"2007","unstructured":"Kunnumakkara, A. B., Guha, S., Krishnan, S., Diagaradjane, P., Gelovani, J., & Aggarwal, B. B. (2007). Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer research, 67(8), 3853\u20133861. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-4257","journal-title":"Cancer research"},{"issue":"4","key":"1327_CR48","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jjcc.2015.05.004","volume":"66","author":"EA Ivanova","year":"2015","unstructured":"Ivanova, E. A., Parolari, A., Myasoedova, V., Melnichenko, A. A., Bobryshev, Y. V., & Orekhov, A. N. (2015). Peroxisome proliferator-activated receptor (PPAR) gamma in cardiovascular disorders and cardiovascular surgery. Journal of Cardiology, 66(4), 271\u2013278. https:\/\/doi.org\/10.1016\/j.jjcc.2015.05.004","journal-title":"Journal of Cardiology"},{"key":"1327_CR49","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ejmech.2015.01.040","volume":"93","author":"L Li","year":"2015","unstructured":"Li, L., Zhao, P., Hu, J., Liu, J., Liu, Y., Wang, Z., & Chen, L. (2015). Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids. European Journal of Medicinal Chemistry, 93, 300\u2013307. https:\/\/doi.org\/10.1016\/j.ejmech.2015.01.040","journal-title":"European Journal of Medicinal Chemistry"},{"key":"1327_CR50","doi-asserted-by":"publisher","unstructured":"Antika, L. D., Tasfiyati, A. N., Hikmat, H., & Septama, A. W. (2022, July 1). Scopoletin: A review of its source, biosynthesis, methods of extraction, and pharmacological activities. Zeitschrift fur Naturforschung - Section C Journal of Biosciences. De Gruyter Open Ltd. https:\/\/doi.org\/10.1515\/znc-2021-0193","DOI":"10.1515\/znc-2021-0193"},{"issue":"3","key":"1327_CR51","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.taap.2011.04.010","volume":"253","author":"SS Bhattacharyya","year":"2011","unstructured":"Bhattacharyya, S. S., Paul, S., De, A., Das, D., Samadder, A., Boujedaini, N., & Khuda-Bukhsh, A. R. (2011). Poly (lactide-co-glycolide) acid nanoencapsulation of a synthetic coumarin: Cytotoxicity and bio-distribution in mice, in cancer cell line and interaction with calf thymus DNA as target. Toxicology and applied pharmacology, 253(3), 270\u2013281. https:\/\/doi.org\/10.1016\/j.taap.2011.04.010","journal-title":"Toxicology and applied pharmacology"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-024-01327-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-024-01327-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-024-01327-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:18:15Z","timestamp":1761711495000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-024-01327-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1327"],"URL":"https:\/\/doi.org\/10.1007\/s12033-024-01327-y","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"assertion":[{"value":"1 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report there are no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}