{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:43:06Z","timestamp":1793371386528,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Yunnan Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["202102AA310068"],"award-info":[{"award-number":["202102AA310068"]}]},{"name":"Yunnan Clinical Medical Center for Traumatology and Orthopedics","award":["ZX20191001"],"award-info":[{"award-number":["ZX20191001"]}]},{"name":"Scientific Research Fund Project Department of Education of Yunnan Province","award":["2024Y251"],"award-info":[{"award-number":["2024Y251"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12033-025-01416-6","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:13:29Z","timestamp":1743747209000},"page":"926-942","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive Multi-omics and Mendelian Randomization Reveal the Key Role of Monocytes in Aging and Osteoarthritis"],"prefix":"10.1007","volume":"68","author":[{"given":"Xiangwen","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linmeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-4489","authenticated-orcid":false,"given":"Yongqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"issue":"9991","key":"1416_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones, S., Palmer, A. J., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., & Carr, A. J. (2015). Osteoarthritis. The Lancet, 386(9991), 376\u2013387.","journal-title":"The Lancet"},{"issue":"10264","key":"1416_CR2","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","volume":"396","author":"DJ Hunter","year":"2020","unstructured":"Hunter, D. J., March, L., & Chew, M. (2020). Osteoarthritis in 2020 and beyond: A Lancet Commission. The Lancet, 396(10264), 1711\u20131712.","journal-title":"The Lancet"},{"issue":"2","key":"1416_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12016-022-08941-1","volume":"64","author":"F Motta","year":"2023","unstructured":"Motta, F., Barone, E., Sica, A., & Selmi, C. (2023). Inflammaging and osteoarthritis. Clinical Reviews in Allergy and Immunology, 64(2), 222\u2013238.","journal-title":"Clinical Reviews in Allergy and Immunology"},{"issue":"9","key":"1416_CR4","doi-asserted-by":"publisher","first-page":"e496","DOI":"10.1016\/S2665-9913(23)00207-2","volume":"5","author":"AY Wong","year":"2023","unstructured":"Wong, A. Y., Samartzis, D., & Maher, C. (2023). The global burden of osteoarthritis: Past and future perspectives. The Lancet Rheumatology, 5(9), e496\u2013e497.","journal-title":"The Lancet Rheumatology"},{"issue":"11","key":"1416_CR5","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s40273-016-0424-x","volume":"34","author":"F Xie","year":"2016","unstructured":"Xie, F., Kovic, B., Jin, X., He, X., Wang, M., & Silvestre, C. (2016). Economic and humanistic burden of osteoarthritis: A systematic review of large sample studies. PharmacoEconomics, 34(11), 1087\u20131100.","journal-title":"PharmacoEconomics"},{"issue":"5","key":"1416_CR6","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/00002281-200209000-00017","volume":"14","author":"PM Brooks","year":"2002","unstructured":"Brooks, P. M. (2002). Impact of osteoarthritis on individuals and society: How much disability? Social consequences and health economic implications. Current Opinion in Rheumatology, 14(5), 573\u2013577.","journal-title":"Current Opinion in Rheumatology"},{"issue":"5","key":"1416_CR7","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/art.1780340502","volume":"34","author":"R Altman","year":"1991","unstructured":"Altman, R., Alarc\u00f3n, G., Appelrouth, D., Bloch, D., Borenstein, D., Brandt, K., Brown, C., Cooke, T. D., Daniel, W., Feldman, D., Greenwald, R., Hochberg, M., Howell, D., Ike, R., Kapila, P., Kaplan, D., Koopman, W., Marino, C., McDonald, E., \u2026 Wolfe, F. (1991). The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis and Rheumatism, 34(5), 505\u2013514.","journal-title":"Arthritis and Rheumatism"},{"key":"1416_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bmb\/lds038","volume":"105","author":"A Litwic","year":"2013","unstructured":"Litwic, A., Edwards, M. H., Dennison, E. M., & Cooper, C. (2013). Epidemiology and burden of osteoarthritis. British Medical Bulletin, 105, 185\u2013199.","journal-title":"British Medical Bulletin"},{"issue":"7","key":"1416_CR9","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1002\/art.38611","volume":"66","author":"L Sharma","year":"2014","unstructured":"Sharma, L., Chmiel, J. S., Almagor, O., Dunlop, D., Guermazi, A., Bathon, J. M., Eaton, C. B., Hochberg, M. C., Jackson, R. D., Kwoh, C. K., Mysiw, W. J., Crema, M. D., Roemer, F. W., & Nevitt, M. C. (2014). Significance of preradiographic magnetic resonance imaging lesions in persons at increased risk of knee osteoarthritis. Arthritis & Rhematology, 66(7), 1811\u20131819.","journal-title":"Arthritis & Rhematology"},{"issue":"6","key":"1416_CR10","first-page":"1513","volume":"27","author":"MT Hannan","year":"2000","unstructured":"Hannan, M. T., Felson, D. T., & Pincus, T. (2000). Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. Journal of Rheumatology, 27(6), 1513\u20131517.","journal-title":"Journal of Rheumatology"},{"issue":"2","key":"1416_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2023.101835","volume":"37","author":"AE Postler","year":"2023","unstructured":"Postler, A. E., L\u00fctzner, C., Goronzy, J., Lange, T., Deckert, S., G\u00fcnther, K. P., & L\u00fctzner, J. (2023). When are patients with osteoarthritis referred for surgery? Best Practice & Research Clinical Rheumatology, 37(2), 101835.","journal-title":"Best Practice & Research Clinical Rheumatology"},{"issue":"10134","key":"1416_CR12","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/S0140-6736(18)31064-X","volume":"391","author":"R Barnett","year":"2018","unstructured":"Barnett, R. (2018). Osteoarthritis. Lancet., 391(10134), 1985.","journal-title":"Lancet."},{"issue":"1","key":"1416_CR13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/BOR.0000000000000352","volume":"29","author":"SC Warner","year":"2017","unstructured":"Warner, S. C., & Valdes, A. M. (2017). Genetic association studies in osteoarthritis: Is it fairytale? Current Opinion in Rheumatology, 29(1), 103\u2013109.","journal-title":"Current Opinion in Rheumatology"},{"issue":"2","key":"1416_CR14","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/BOR.0b013e32835cfb8e","volume":"25","author":"MC Hochberg","year":"2013","unstructured":"Hochberg, M. C., Yerges-Armstrong, L., Yau, M., & Mitchell, B. D. (2013). Genetic epidemiology of osteoarthritis: Recent developments and future directions. Current Opinion in Rheumatology, 25(2), 192\u2013197.","journal-title":"Current Opinion in Rheumatology"},{"issue":"10","key":"1416_CR15","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1016\/j.joca.2013.07.004","volume":"21","author":"R Agricola","year":"2013","unstructured":"Agricola, R., Heijboer, M. P., Roze, R. H., Reijman, M., Bierma-Zeinstra, S. M., Verhaar, J. A., Weinans, H., & Waarsing, J. H. (2013). Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: Acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK). Osteoarthritis Cartilage, 21(10), 1514\u20131521.","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"1416_CR16","first-page":"398","volume":"14","author":"J Yu","year":"2023","unstructured":"Yu, J., Li, T., & Zhu, J. (2023). Gene therapy strategies targeting aging-related diseases. Aging & Disease, 14(2), 398\u2013417.","journal-title":"Aging & Disease"},{"issue":"8","key":"1416_CR17","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/ncb1909","volume":"11","author":"F Rodier","year":"2009","unstructured":"Rodier, F., Copp\u00e9, J. P., Patil, C. K., Hoeijmakers, W. A., Mu\u00f1oz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009). Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nature Cell Biology, 11(8), 973\u2013979.","journal-title":"Nature Cell Biology"},{"issue":"7","key":"1416_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nrm3823","volume":"15","author":"D Mu\u00f1oz-Esp\u00edn","year":"2014","unstructured":"Mu\u00f1oz-Esp\u00edn, D., & Serrano, M. (2014). Cellular senescence: From physiology to pathology. Nature Reviews Molecular Cell Biology, 15(7), 482\u2013496.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"11","key":"1416_CR19","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1016\/j.joca.2015.01.008","volume":"23","author":"MA Greene","year":"2015","unstructured":"Greene, M. A., & Loeser, R. F. (2015). Aging-related inflammation in osteoarthritis. Osteoarthritis Cartilage, 23(11), 1966\u20131971.","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"1416_CR20","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","volume":"169","author":"S He","year":"2017","unstructured":"He, S., & Sharpless, N. E. (2017). Senescence in health and disease. Cell, 169(6), 1000\u20131011.","journal-title":"Cell"},{"issue":"4","key":"1416_CR21","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI95147","volume":"128","author":"OH Jeon","year":"2018","unstructured":"Jeon, O. H., David, N., Campisi, J., & Elisseeff, J. H. (2018). Senescent cells and osteoarthritis: A painful connection. The Journal of Clinical Investigation, 128(4), 1229\u20131237.","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"1416_CR22","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194\u20131217.","journal-title":"Cell"},{"key":"1416_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459","volume":"2014","author":"P Wojdasiewicz","year":"2014","unstructured":"Wojdasiewicz, P., Poniatowski, \u0141A., & Szukiewicz, D. (2014). The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators of Inflammation, 2014, 561459.","journal-title":"Mediators of Inflammation"},{"issue":"6","key":"1416_CR24","doi-asserted-by":"publisher","first-page":"R187","DOI":"10.1186\/ar2099","volume":"8","author":"J Bondeson","year":"2006","unstructured":"Bondeson, J., Wainwright, S. D., Lauder, S., Amos, N., & Hughes, C. E. (2006). The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Research & Therapy, 8(6), R187.","journal-title":"Arthritis Research & Therapy"},{"issue":"7","key":"1416_CR25","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1136\/ard-2023-224420","volume":"83","author":"Y Fan","year":"2024","unstructured":"Fan, Y., Bian, X., Meng, X., Li, L., Fu, L., Zhang, Y., Wang, L., Zhang, Y., Gao, D., Guo, X., Lammi, M. J., Peng, G., & Sun, S. (2024). Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Annals of the Rheumatic Diseases, 83(7), 926\u2013944.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"1","key":"1416_CR26","doi-asserted-by":"publisher","first-page":"10868","DOI":"10.1038\/s41598-020-67730-y","volume":"10","author":"CH Chou","year":"2020","unstructured":"Chou, C. H., Jain, V., Gibson, J., Attarian, D. E., Haraden, C. A., Yohn, C. B., Laberge, R. M., Gregory, S., & Kraus, V. B. (2020). Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis. Science and Reports, 10(1), 10868.","journal-title":"Science and Reports"},{"issue":"8","key":"1416_CR27","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1177\/09622802231181220","volume":"32","author":"Y Deng","year":"2023","unstructured":"Deng, Y., Tu, D., O\u2019Callaghan, C. J., Liu, G., & Xu, W. (2023). Two-stage multivariate Mendelian randomization on multiple outcomes with mixed distributions. Statistical Methods in Medical Research, 32(8), 1543\u20131558.","journal-title":"Statistical Methods in Medical Research"},{"issue":"2","key":"1416_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2023.101852","volume":"37","author":"A Mobasheri","year":"2023","unstructured":"Mobasheri, A., Thudium, C. S., Bay-Jensen, A. C., Maleitzke, T., Geissler, S., Duda, G. N., & Winkler, T. (2023). Biomarkers for osteoarthritis: Current status and future prospects. Best Practice & Research Clinical Rheumatology, 37(2), 101852.","journal-title":"Best Practice & Research Clinical Rheumatology"},{"issue":"4","key":"1416_CR29","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/bib\/bby011","volume":"20","author":"SH Yip","year":"2019","unstructured":"Yip, S. H., Sham, P. C., & Wang, J. (2019). Evaluation of tools for highly variable gene discovery from single-cell RNA-seq data. Briefings in Bioinformatics, 20(4), 1583\u20131589.","journal-title":"Briefings in Bioinformatics"},{"issue":"12","key":"1416_CR30","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P. R., & Raychaudhuri, S. (2019). Fast, sensitive and accurate integration of single-cell data with harmony. Nature Methods, 16(12), 1289\u20131296.","journal-title":"Nature Methods"},{"issue":"2","key":"1416_CR31","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran, D., Looney, A. P., Liu, L., Wu, E., Fong, V., Hsu, A., Chak, S., Naikawadi, R. P., Wolters, P. J., Abate, A. R., Butte, A. J., & Bhattacharya, M. (2019). Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nature Immunology, 20(2), 163\u2013172.","journal-title":"Nature Immunology"},{"issue":"1","key":"1416_CR32","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S., Guerrero-Juarez, C. F., Zhang, L., Chang, I., Ramos, R., Kuan, C. H., Myung, P., Plikus, M. V., & Nie, Q. (2021). Inference and analysis of cell\u2013cell communication using Cell Chat. Nature Communications, 12(1), 1088.","journal-title":"Nature Communications"},{"key":"1416_CR33","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., Tan, V. Y., Yarmolinsky, J., Shihab, H. A., Timpson, N. J., Evans, D. M., Relton, C., Martin, R. M., Davey Smith, G., Gaunt, T. R., & Haycock, P. C. (2018). The MR-Base platform supports systematic causal inference across the human phenome. eLife, 7, e34408.","journal-title":"eLife"},{"issue":"2","key":"1416_CR34","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1161\/CIRCULATIONAHA.118.035905","volume":"139","author":"MK Georgakis","year":"2019","unstructured":"Georgakis, M. K., Gill, D., Rannikm\u00e4e, K., Traylor, M., Anderson, C. D., Lee, J. M., Kamatani, Y., Hopewell, J. C., Worrall, B. B., Bernhagen, J., Sudlow, C. L. M., Malik, R., & Dichgans, M. (2019). Genetically determined levels of circulating cytokines and risk of stroke. Circulation, 139(2), 256\u2013268.","journal-title":"Circulation"},{"issue":"21","key":"1416_CR35","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1002\/sim.6522","volume":"34","author":"MF Greco","year":"2015","unstructured":"Greco, M. F., Minelli, C., Sheehan, N. A., & Thompson, J. R. (2015). Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Statistics in Medicine, 34(21), 2926\u20132940.","journal-title":"Statistics in Medicine"},{"issue":"12","key":"1416_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.627","volume":"2","author":"D Rasooly","year":"2022","unstructured":"Rasooly, D., Peloso, G. M., & Giambartolomei, C. (2022). Bayesian genetic colocalization test of two traits using coloc. Current Protocols, 2(12), e627.","journal-title":"Current Protocols"},{"issue":"8","key":"1416_CR37","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1093\/brain\/awad070","volume":"146","author":"J Lin","year":"2023","unstructured":"Lin, J., Zhou, J., & Xu, Y. (2023). Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis. Brain, 146(8), 3364\u20133372.","journal-title":"Brain"},{"issue":"5","key":"1416_CR38","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/s41588-019-0404-0","volume":"51","author":"B Liu","year":"2019","unstructured":"Liu, B., Gloudemans, M. J., Rao, A. S., Ingelsson, E., & Montgomery, S. B. (2019). Abundant associations with gene expression complicate GWAS follow-up. Nature Genetics, 51(5), 768\u2013769.","journal-title":"Nature Genetics"},{"issue":"10","key":"1416_CR39","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1093\/bioinformatics\/btaa099","volume":"36","author":"EY Cao","year":"2020","unstructured":"Cao, E. Y., Ouyang, J. F., & Rackham, O. J. L. (2020). GeneSwitches: Ordering gene expression and functional events in single-cell experiments. Bioinformatics, 36(10), 3273\u20133275.","journal-title":"Bioinformatics"},{"issue":"8","key":"1416_CR40","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1093\/bioinformatics\/btn085","volume":"24","author":"JA Morris","year":"2008","unstructured":"Morris, J. A., Gayther, S. A., Jacobs, I. J., & Jones, C. (2008). A suite of Perl modules for handling microarray data. Bioinformatics, 24(8), 1102\u20131103.","journal-title":"Bioinformatics"},{"issue":"6","key":"1416_CR41","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E., & Storey, J. D. (2012). The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics, 28(6), 882\u2013883.","journal-title":"Bioinformatics"},{"issue":"3","key":"1416_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nargab\/lqaa078","volume":"2","author":"Y Zhang","year":"2020","unstructured":"Zhang, Y., Parmigiani, G., & Johnson, W. E. (2020). ComBat-seq: Batch effect adjustment for RNA-seq count data. NAR Genomics and Bioinformatics, 2(3), 1\u20132.","journal-title":"NAR Genomics and Bioinformatics"},{"issue":"2","key":"1416_CR43","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bone.2011.11.019","volume":"51","author":"HJ Braun","year":"2012","unstructured":"Braun, H. J., & Gold, G. E. (2012). Diagnosis of osteoarthritis: Imaging. Bone, 51(2), 278\u2013288.","journal-title":"Bone"},{"issue":"1","key":"1416_CR44","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1136\/annrheumdis-2017-212863","volume":"78","author":"Q Ji","year":"2019","unstructured":"Ji, Q., Zheng, Y., Zhang, G., Hu, Y., Fan, X., Hou, Y., Wen, L., Li, L., Xu, Y., Wang, Y., & Tang, F. (2019). Single-cell RNA-seq analysis reveals the progression of human osteoarthritis. Annals of the Rheumatic Diseases, 78(1), 100\u2013110.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1416_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.938075","volume":"13","author":"A Sebastian","year":"2022","unstructured":"Sebastian, A., Hum, N. R., McCool, J. L., Wilson, S. P., Murugesh, D. K., Martin, K. A., Rios-Arce, N. D., Amiri, B., Christiansen, B. A., & Loots, G. G. (2022). Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis. Frontiers in Immunology, 13, 938075.","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"1416_CR46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13075-018-1798-2","volume":"21","author":"A G\u00f3mez-Aristiz\u00e1bal","year":"2019","unstructured":"G\u00f3mez-Aristiz\u00e1bal, A., Gandhi, R., Mahomed, N. N., Marshall, K. W., & Viswanathan, S. (2019). Synovial fluid monocyte\/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: A cohort study. Arthritis Research & Therapy, 21(1), 26.","journal-title":"Arthritis Research & Therapy"},{"issue":"3","key":"1416_CR47","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1172\/JCI121561","volume":"129","author":"S Zhu","year":"2019","unstructured":"Zhu, S., Zhu, J., Zhen, G., Hu, Y., An, S., Li, Y., Zheng, Q., Chen, Z., Yang, Y., Wan, M., Skolasky, R. L., Cao, Y., Wu, T., Gao, B., Yang, M., Gao, M., Kuliwaba, J., Ni, S., Wang, L., \u2026 Cao, X. (2019). Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. The Journal of Clinical Investigation, 129(3), 1076\u20131093.","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"1416_CR48","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/ijms20030614","volume":"20","author":"E Rezu\u0219","year":"2019","unstructured":"Rezu\u0219, E., Cardoneanu, A., Burlui, A., Luca, A., Codreanu, C., Tamba, B. I., Stanciu, G. D., Dima, N., B\u0103descu, C., & Rezu\u0219, C. (2019). The link between inflammaging and degenerative joint diseases. International Journal of Molecular Sciences, 20(3), 614.","journal-title":"International Journal of Molecular Sciences"},{"key":"1416_CR49","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/bs.ai.2019.08.006","volume":"143","author":"S Culemann","year":"2019","unstructured":"Culemann, S., Gr\u00fcneboom, A., & Kr\u00f6nke, G. (2019). Origin and function of synovial macrophage subsets during inflammatory joint disease. Advances in Immunology, 143, 75\u201398.","journal-title":"Advances in Immunology"},{"issue":"5","key":"1416_CR50","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","volume":"76","author":"H Raghu","year":"2017","unstructured":"Raghu, H., Lepus, C. M., Wang, Q., Wong, H. H., Lingampalli, N., Oliviero, F., Punzi, L., Giori, N. J., Goodman, S. B., Chu, C. R., Sokolove, J. B., & Robinson, W. H. (2017). CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. Annals of the Rheumatic Diseases, 76(5), 914\u2013922.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"1","key":"1416_CR51","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.joca.2018.09.007","volume":"27","author":"AE Kozijn","year":"2019","unstructured":"Kozijn, A. E., Tartjiono, M. T., Ravipati, S., van der Ham, F., Barrett, D. A., Mastbergen, S. C., Korthagen, N. M., Lafeber, F. P. J. G., Zuurmond, A. M., Bobeldijk, I., Weinans, H., & Stoop, R. (2019). Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet. Osteoarthritis Cartilage, 27(1), 118\u2013128.","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"1416_CR52","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1073\/pnas.012511599","volume":"99","author":"RA Mitchell","year":"2002","unstructured":"Mitchell, R. A., Liao, H., Chesney, J., Fingerle-Rowson, G., Baugh, J., David, J., & Bucala, R. (2002). Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response. Proceedings of the National Academy of Sciences of the United States of America, 99(1), 345\u2013350.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"1416_CR53","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13075-021-02663-z","volume":"23","author":"L Zhang","year":"2021","unstructured":"Zhang, L., Kirkwood, C. L., Sohn, J., Lau, A., Bayers-Thering, M., Bali, S. K., Rachala, S., Marzo, J. M., Anders, M. J., Beier, F., & Kirkwood, K. L. (2021). Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling. Arthritis Research & Therapy, 23(1), 287.","journal-title":"Arthritis Research & Therapy"},{"issue":"2","key":"1416_CR54","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/art.39844","volume":"69","author":"MA Rowe","year":"2017","unstructured":"Rowe, M. A., Harper, L. R., McNulty, M. A., Lau, A. G., Carlson, C. S., Leng, L., Bucala, R. J., Miller, R. A., & Loeser, R. F. (2017). Reduced osteoarthritis severity in aged mice with deletion of macrophage migration inhibitory factor. Arthritis & Rhematology, 69(2), 352\u2013361.","journal-title":"Arthritis & Rhematology"},{"key":"1416_CR55","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2147\/JIR.S388934","volume":"16","author":"Q Zhao","year":"2023","unstructured":"Zhao, Q., Tang, Y., Zhang, L., Sun, N., Liu, Q., & Zhang, R. (2023). Biological functions of selenoprotein glutathione peroxidases (GPXs) and their expression in osteoarthritis. Journal of Inflammation Research, 16, 183\u2013196.","journal-title":"Journal of Inflammation Research"},{"issue":"4","key":"1416_CR56","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.bbadis.2016.01.003","volume":"1862","author":"P Lepetsos","year":"2016","unstructured":"Lepetsos, P., & Papavassiliou, A. G. (2016). ROS\/oxidative stress signaling in osteoarthritis. Biochimica et Biophysica Acta, 1862(4), 576\u2013591.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"1416_CR57","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","volume":"1830","author":"R Brigelius-Floh\u00e9","year":"2013","unstructured":"Brigelius-Floh\u00e9, R., & Maiorino, M. (2013). Glutathione peroxidases. Biochimica et Biophysica Acta, 1830(5), 3289\u20133303.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"12","key":"1416_CR58","doi-asserted-by":"publisher","first-page":"5930","DOI":"10.1002\/ptr.8351","volume":"38","author":"Y Xie","year":"2024","unstructured":"Xie, Y., Gan, C., Liu, H., Hou, Y., Su, X., Xue, T., Wang, D., Li, P., Yue, L., Qiu, Q., Xie, Y., He, J., & Ye, T. (2024). Polyphyllin VI ameliorates pulmonary fibrosis by suppressing the MAPK\/ERK and PI3K\/AKT signaling pathways via upregulating DUSP6. Phytotherapy Research, 38(12), 5930\u20135948.","journal-title":"Phytotherapy Research"},{"issue":"1","key":"1416_CR59","doi-asserted-by":"publisher","first-page":"17010","DOI":"10.1038\/s41598-018-34718-8","volume":"8","author":"B Rieder","year":"2018","unstructured":"Rieder, B., Weihs, A. M., Weidinger, A., Szwarc, D., N\u00fcrnberger, S., Redl, H., R\u00fcnzler, D., Huber-Gries, C., & Teuschl, A. H. (2018). Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures. Science and Reports, 8(1), 17010.","journal-title":"Science and Reports"},{"issue":"5","key":"1416_CR60","first-page":"58","volume":"10","author":"A Martinez-Sanchez","year":"2020","unstructured":"Martinez-Sanchez, A., Lazzarano, S., Sharma, E., Lockstone, H., & Murphy, C. L. (2020). High-throughput identification of MiR-145 targets in human articular chondrocytes. Life (Basel)., 10(5), 58.","journal-title":"Life (Basel)."},{"key":"1416_CR61","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.bbrc.2022.08.033","volume":"627","author":"R Wei","year":"2022","unstructured":"Wei, R., Zhang, L., Hu, W., Wu, J., & Zhang, W. (2022). CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12\/TREM2 pathway. Biochemical and Biophysical Research Communications., 627, 12\u201320.","journal-title":"Biochemical and Biophysical Research Communications."},{"issue":"1","key":"1416_CR62","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2741\/e361","volume":"4","author":"Q Bian","year":"2012","unstructured":"Bian, Q., Wang, Y. J., Liu, S. F., & Li, Y. P. (2012). Osteoarthritis: Genetic factors, animal models, mechanisms, and therapies. Frontiers in Bioscience (Elite Edition), 4(1), 74\u2013100.","journal-title":"Frontiers in Bioscience (Elite Edition)"},{"issue":"10","key":"1416_CR63","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/s43587-022-00285-x","volume":"2","author":"W Liang","year":"2022","unstructured":"Liang, W., Chen, Q., Cheng, S., Wei, R., Li, Y., Yao, C., Ouyang, Z., Kang, D., Chen, A., Liu, Z., Li, K., Bai, X., Li, Q., & Huang, B. (2022). Skin chronological aging drives age-related bone loss via secretion of cystatin-A. Nat Aging., 2(10), 906\u2013922.","journal-title":"Nat Aging."}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01416-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-025-01416-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01416-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:02:38Z","timestamp":1772863358000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-025-01416-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1416"],"URL":"https:\/\/doi.org\/10.1007\/s12033-025-01416-6","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"31 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"920th Hospital of Joint Logistics Support Force Institutional Animal Care and Use Commission approved this study and consented to participate [No. 202405301].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}