{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:28:22Z","timestamp":1773314902549,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR19625\/MED\/30\/1703\/2016"],"award-info":[{"award-number":["BT\/PR19625\/MED\/30\/1703\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12033-025-01418-4","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T18:58:57Z","timestamp":1743274737000},"page":"958-968","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of NF-\u03baB Inhibition in Glioblastoma: Gene Therapy Approach with rAAV-5 Mediated I\u03baB\u03b1M Overexpression"],"prefix":"10.1007","volume":"68","author":[{"given":"Ceera","family":"Manikandan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-3580","authenticated-orcid":false,"given":"Amit Kumar","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"1418_CR1","first-page":"85","volume":"1","author":"JL Shah","year":"2022","unstructured":"Shah, J. L., Li, G. H., & Soltys, S. G. (2022). Glioblastoma multiforme. CyberKnife Stereotactic Radiosurgery: Brain, 1, 85\u201398.","journal-title":"CyberKnife Stereotactic Radiosurgery: Brain"},{"issue":"1","key":"1418_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-022-02349-7","volume":"41","author":"L Rong","year":"2022","unstructured":"Rong, L., Li, N., & Zhang, Z. (2022). Emerging therapies for glioblastoma: Current state and future directions. Journal of Experimental & Clinical Cancer Research, 41(1), 1\u201318.","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"1418_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS15072116","author":"SSK Yalamarty","year":"2023","unstructured":"Yalamarty, S. S. K., Filipczak, N., Li, X., Subhan, M. A., Parveen, F., Ataide, J. A., Rajmalani, B. A., & Torchilin, V. P. (2023). Mechanisms of resistance and current treatment options for glioblastoma multiforme (GBM). Cancers (Basel). https:\/\/doi.org\/10.3390\/CANCERS15072116","journal-title":"Cancers (Basel)"},{"key":"1418_CR4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3002","author":"H Ohgaki","year":"2013","unstructured":"Ohgaki, H., & Kleihues, P. (2013). The definition of primary and secondary glioblastoma. Clinical Cancer Research. https:\/\/doi.org\/10.1158\/1078-0432.CCR-12-3002","journal-title":"Clinical Cancer Research"},{"key":"1418_CR5","first-page":"3","volume":"18","author":"F Hanif","year":"2017","unstructured":"Hanif, F., Muzaffar, K., Perveen, K., Malhi, S. M., & Simjee, S. U. (2017). Glioblastoma multiforme: A review of its epidemiology and pathogenesis through clinical presentation and treatment. Asian Pacific Journal of Cancer Prevention, 18, 3.","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"1418_CR6","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/cac2.12361","volume":"42","author":"E Verdugo","year":"2022","unstructured":"Verdugo, E., Puerto, I., & Medina, M. \u00c1. (2022). An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment. Cancer Communications, 42, 1083.","journal-title":"Cancer Communications"},{"key":"1418_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/FMOLB.2020.562798","author":"P Zhang","year":"2020","unstructured":"Zhang, P., Xia, Q., Liu, L., Li, S., & Dong, L. (2020). Current opinion on molecular characterization for GBM classification in guiding clinical diagnosis, prognosis, and therapy. Frontiers in Molecular Biosciences. https:\/\/doi.org\/10.3389\/FMOLB.2020.562798","journal-title":"Frontiers in Molecular Biosciences"},{"key":"1418_CR8","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.2147\/OTT.S161109","volume":"11","author":"L Xia","year":"2018","unstructured":"Xia, L., Tan, S., Zhou, Y., Lin, J., Wang, H., Oyang, L., Tian, Y., Liu, L.,\nSu, M., Wang, H. & Cao, D. (2018). Role of the NF\u03baB-signaling pathway in cancer. Oncotargets and Therapy, 11, 2063.","journal-title":"Oncotargets and Therapy"},{"key":"1418_CR9","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A000034","author":"A Oeckinghaus","year":"2009","unstructured":"Oeckinghaus, A., & Ghosh, S. (2009). The NF-kappaB family of transcription factors and its regulation. Cold Spring Harbor Perspectives in Biology. https:\/\/doi.org\/10.1101\/CSHPERSPECT.A000034","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"1418_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS7090125","author":"B Yamini","year":"2018","unstructured":"Yamini, B. (2018). NF-\u03baB, mesenchymal differentiation and glioblastoma. Cells. https:\/\/doi.org\/10.3390\/CELLS7090125","journal-title":"Cells"},{"issue":"1","key":"1418_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu, T., Zhang, L., Joo, D., & Sun, S. C. (2017). NF-\u03baB signaling in inflammation. Signal Transduction and Targeted Therapy, 2(1), 1\u20139.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"1418_CR12","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1056\/NEJMcibr1309402","volume":"369","author":"S Das","year":"2013","unstructured":"Das, S., & Marsden, P. A. (2013). Angiogenesis in glioblastoma. New England Journal of Medicine, 369, 1561.","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"1418_CR13","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s12035-020-01892-8","volume":"57","author":"BK Ahir","year":"2020","unstructured":"Ahir, B. K., Engelhard, H. H., & Lakka, S. S. (2020). Tumor development and angiogenesis in adult brain tumor: Glioblastoma. Molecular Neurobiology, 57(5), 2461\u20132478.","journal-title":"Molecular Neurobiology"},{"key":"1418_CR14","first-page":"555","volume":"24","author":"F Daneshimehr","year":"2022","unstructured":"Daneshimehr, F., Barabadi, Z., Abdolahi, S., Soleimani, M., Verdi, J., Ebrahimi-Barough, S., & Ai, J. (2022). Angiogenesis and its targeting in glioblastoma with focus on clinical approaches. Cell Journal (Yakhteh), 24, 555.","journal-title":"Cell Journal (Yakhteh)"},{"issue":"8","key":"1418_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/labinvest.3700123","volume":"84","author":"H Wang","year":"2004","unstructured":"Wang, H., Wang, H., Zhang, W., Huang, H. J., Liao, W. S. L., & Fuller, G. N. (2004). Analysis of the activation status of Akt, NF\u03baB, and Stat3 in human diffuse gliomas. Laboratory Investigation, 84(8), 941\u2013951.","journal-title":"Laboratory Investigation"},{"key":"1418_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00018-024-05293-1","volume":"81","author":"V Ramar","year":"2024","unstructured":"Ramar, V., Guo, S., Hudson, B., Khedri, A., Guo, A. A., Li, J., & Liu, M. (2024). Interaction of NF-\u03baB and FOSL1 drives glioma stemness. Cellular and Molecular Life Sciences, 81, 1\u201321.","journal-title":"Cellular and Molecular Life Sciences"},{"key":"1418_CR17","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.1501292\/SUPPL_FILE\/1501292_SM.PDF","author":"D Friedmann-Morvinski","year":"2016","unstructured":"Friedmann-Morvinski, D., Narasimamurthy, R., Xia, Y., Myskiw, C., Soda, Y., & Verma, I. M. (2016). Targeting NF-kB in glioblastoma: A therapeutic approach. Science Advances. https:\/\/doi.org\/10.1126\/SCIADV.1501292\/SUPPL_FILE\/1501292_SM.PDF","journal-title":"Science Advances"},{"key":"1418_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES5020029","author":"V Soubannier","year":"2017","unstructured":"Soubannier, V., & Stifani, S. (2017). NF-\u03baB signalling in glioblastoma. Biomedicines. https:\/\/doi.org\/10.3390\/BIOMEDICINES5020029","journal-title":"Biomedicines"},{"key":"1418_CR19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/neuonc\/nov265","volume":"18","author":"KE Cahill","year":"2015","unstructured":"Cahill, K. E., Morshed, R. A., & Yamini, B. (2015). Nuclear factor-\u03baB in glioblastoma: Insights into regulators and targeted therapy. Neuro-Oncology, 18, 329\u2013339.","journal-title":"Neuro-Oncology"},{"key":"1418_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1021\/acs.biochem.1c00732","volume":"61","author":"A Singh","year":"2022","unstructured":"Singh, A., Martinez-Yamout, M. A., Wright, P. E., & Dyson, H. J. (2022). Interaction of a long noncoding RNA with domains of NF-\u03baB and I\u03baB\u03b1: Implications for the inhibition of non-signal-related phosphorylation. Biochemistry, 61, 367.","journal-title":"Biochemistry"},{"key":"1418_CR21","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2147\/JIR.S140188","volume":"11","author":"S Giridharan","year":"2018","unstructured":"Giridharan, S., & Srinivasan, M. (2018). Mechanisms of NF-\u03baB p65 and strategies for therapeutic manipulation. Journal of Inflammation Research, 11, 407.","journal-title":"Journal of Inflammation Research"},{"key":"1418_CR22","doi-asserted-by":"publisher","first-page":"10337","DOI":"10.3390\/ijms241210337","volume":"24","author":"P Shi","year":"2023","unstructured":"Shi, P., Xu, J., & Cui, H. (2023). The recent research progress of NF-\u03baB signaling on the proliferation, migration, invasion, immune escape and drug resistance of glioblastoma. International Journal of Molecular Sciences, 24, 10337.","journal-title":"International Journal of Molecular Sciences"},{"key":"1418_CR23","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"A Oeckinghaus","year":"2009","unstructured":"Oeckinghaus, A., & Ghosh, S. (2009). The NF-\u03baB family of transcription factors and its regulation. Cold Spring Harbor Perspectives in Biology, 1, a000034.","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"1","key":"1418_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-01600-y","volume":"7","author":"J Sakai","year":"2017","unstructured":"Sakai, J., Cammarota, E., Wright, J. A., Cicuta, P., Gottschalk, R. A., Li, N., Fraser, I. D. C., & Bryant, C. E. (2017). Lipopolysaccharide-induced NF-\u03baB nuclear translocation is primarily dependent on MyD88, but TNF\u03b1 expression requires TRIF and MyD88. Scientific Reports, 7(1), 1\u20139.","journal-title":"Scientific Reports"},{"issue":"1","key":"1418_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024). NF-\u03baB in biology and targeted therapy: New insights and translational implications. Signal Transduction and Targeted Therapy, 9(1), 1\u201337.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"1418_CR26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cytogfr.2024.09.003","volume":"80","author":"D Liu","year":"2024","unstructured":"Liu, D., Li, T., Liu, L., Che, X., Li, X., Liu, C., & Wu, G. (2024). Adeno-associated virus therapies: Pioneering solutions for human genetic diseases. Cytokine & Growth Factor Reviews, 80, 109\u2013120.","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"1","key":"1418_CR27","first-page":"1","volume":"9","author":"JH Wang","year":"2024","unstructured":"Wang, J. H., Gessler, D. J., Zhan, W., Gallagher, T. L., & Gao, G. (2024). Adeno-associated virus as a delivery vector for gene therapy of human diseases. Signal Transduction and Targeted Therapy, 9(1), 1\u201333.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"1418_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1743-422X-4-99","volume":"4","author":"RDS Coura","year":"2007","unstructured":"Coura, R. D. S., & Nardi, N. B. (2007). The state of the art of adeno-associated virus-based vectors in gene therapy. Virology Journal, 4, 99.","journal-title":"Virology Journal"},{"key":"1418_CR29","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3390\/cells12050785","volume":"12","author":"SS Issa","year":"2023","unstructured":"Issa, S. S., Shaimardanova, A. A., Solovyeva, V. V., & Rizvanov, A. A. (2023). Various AAV serotypes and their applications in gene therapy: An overview. Cells, 12, 785.","journal-title":"Cells"},{"key":"1418_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.omtm.2019.11.012","volume":"17","author":"DL Haggerty","year":"2019","unstructured":"Haggerty, D. L., Grecco, G. G., Reeves, K. C., & Atwood, B. (2019). Adeno-associated viral vectors in neuroscience research. Molecular Therapy Methods & Clinical Development, 17, 69.","journal-title":"Molecular Therapy Methods & Clinical Development"},{"key":"1418_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0188830","author":"SL Hammond","year":"2017","unstructured":"Hammond, S. L., Leek, A. N., Richman, E. H., & Tjalkens, R. B. (2017). Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. PLoS ONE. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0188830","journal-title":"PLoS ONE"},{"key":"1418_CR32","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01702-24","author":"P Baindara","year":"2025","unstructured":"Baindara, P., Roy, D., Boosani, C. S., Mandal, S. M., & Green, J. A. (2025). AAV-based gene delivery of antimicrobial peptides to combat drug-resistant pathogens. Applied and Environment Microbiology. https:\/\/doi.org\/10.1128\/AEM.01702-24","journal-title":"Applied and Environment Microbiology"},{"key":"1418_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/BRAINSCI13111536","author":"RS Angom","year":"2023","unstructured":"Angom, R. S., Nakka, N. M. R., & Bhattacharya, S. (2023). Advances in glioblastoma therapy: An update on current approaches. Brain Sciences. https:\/\/doi.org\/10.3390\/BRAINSCI13111536","journal-title":"Brain Sciences"},{"issue":"7","key":"1418_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-024-06904-2","volume":"15","author":"J Bou-Gharios","year":"2024","unstructured":"Bou-Gharios, J., No\u00ebl, G., & Burckel, H. (2024). Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme. Cell Death & Disease, 15(7), 1\u201312.","journal-title":"Cell Death & Disease"},{"key":"1418_CR35","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuroscience.2022.03.030","volume":"491","author":"AF Aldoghachi","year":"2022","unstructured":"Aldoghachi, A. F., Aldoghachi, A. F., Breyne, K., Ling, K. H., & Cheah, P. S. (2022). Recent advances in the therapeutic strategies of glioblastoma multiforme. Neuroscience, 491, 240\u2013270.","journal-title":"Neuroscience"},{"key":"1418_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105780","volume":"171","author":"W Wu","year":"2021","unstructured":"Wu, W., Klockow, J. L., Zhang, M., Lafortune, F., Chang, E., Jin, L., Wu, Y., & Daldrup-Link, H. E. (2021). Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance. Pharmacological Research, 171, 105780.","journal-title":"Pharmacological Research"},{"issue":"7","key":"1418_CR37","first-page":"1","volume":"10","author":"NG Avci","year":"2020","unstructured":"Avci, N. G., Ebrahimzadeh-Pustchi, S., Akay, Y. M., Esquenazi, Y., Tandon, N., Zhu, J. J., & Akay, M. (2020). NF-\u03baB inhibitor with Temozolomide results in significant apoptosis in glioblastoma via the NF-\u03baB(p65) and actin cytoskeleton regulatory pathways. Scientific Reports, 10(7), 1\u201314.","journal-title":"Scientific Reports"},{"key":"1418_CR38","first-page":"227","volume":"8","author":"S Mitchell","year":"2016","unstructured":"Mitchell, S., Vargas, J., & Hoffmann, A. (2016). Signaling via the NF\u03baB system. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 8, 227\u2013241.","journal-title":"Wiley Interdisciplinary Reviews: Systems Biology and Medicine"},{"key":"1418_CR39","doi-asserted-by":"publisher","DOI":"10.4161\/23723548.2014.963478","author":"VT Puliyappadamba","year":"2014","unstructured":"Puliyappadamba, V. T., Hatanpaa, K. J., Chakraborty, S., & Habib, A. A. (2014). The role of NF-\u03baB in the pathogenesis of glioma. Molecular & Cellular Oncology. https:\/\/doi.org\/10.4161\/23723548.2014.963478","journal-title":"Molecular & Cellular Oncology"},{"key":"1418_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.574706","volume":"8","author":"X Wang","year":"2020","unstructured":"Wang, X., Peng, H., Huang, Y., Kong, W., Cui, Q., Du, J., & Jin, H. (2020). Post-translational modifications of I\u03baB\u03b1: The state of the art. Frontiers in Cell and Developmental Biology, 8, 574706.","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"1418_CR41","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0006-291X(02)02573-1","volume":"299","author":"L Xu","year":"2002","unstructured":"Xu, L., Zhan, Y., Wang, Y., Feuerstein, G. Z., & Wang, X. (2002). Recombinant adenoviral expression of dominant negative I\u03baB\u03b1 protects brain from cerebral ischemic injury. Biochemical and Biophysical Research Communications, 299, 14\u201317.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"1418_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12985-024-02286-1","volume":"21","author":"M Hadi","year":"2024","unstructured":"Hadi, M., Qutaiba, B., Allela, O., Jabari, M., Jasoor, A. M., Naderloo, O., Yasamineh, S., Gholizadeh, O., & Kalantari, L. (2024). Recent advances in various adeno-associated viruses (AAVs) as gene therapy agents in hepatocellular carcinoma. Virology Journal, 21(1), 1\u201322.","journal-title":"Virology Journal"},{"issue":"1","key":"1418_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-024-05661-2","volume":"22","author":"L Xu","year":"2024","unstructured":"Xu, L., Yao, S., Ding, Y. E., Xie, M., Feng, D., Sha, P., Tan, L., Bei, F., & Yao, Y. (2024). Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: From bench to bedside. Journal of Translational Medicine, 22(1), 1\u201317.","journal-title":"Journal of Translational Medicine"},{"key":"1418_CR44","doi-asserted-by":"publisher","first-page":"1187187","DOI":"10.3389\/fmolb.2023.1187187","volume":"10","author":"P Downton","year":"2023","unstructured":"Downton, P., Bagnall, J. S., England, H., Spiller, D. G., Humphreys, N. E., Jackson, D. A., Paszek, P., White, M. R. H., & Adamson, A. D. (2023). Overexpression of I\u03baB\u237a modulates NF-\u03baB activation of inflammatory target gene expression. Frontiers in Molecular Biosciences, 10, 1187187.","journal-title":"Frontiers in Molecular Biosciences"},{"issue":"50","key":"1418_CR45","doi-asserted-by":"publisher","first-page":"8137","DOI":"10.1038\/sj.onc.1206911","volume":"22","author":"M Zhou","year":"2003","unstructured":"Zhou, M., Gu, L., Zhu, N., Woods, W. G., & Findley, H. W. (2003). Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: Interaction of IkBm and p53. Oncogene, 22(50), 8137\u20138144.","journal-title":"Oncogene"},{"key":"1418_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1385\/MB:30:1:009","volume":"30","author":"H Haleem-Smith","year":"2005","unstructured":"Haleem-Smith, H., Derfoul, A., Okafor, C., Tuli, R., Olsen, D., Hall, D. J., & Tuan, R. S. (2005). Optimization of high-efficiency transfection of adult human mesenchymal stem cells in vitro. Molecular Biotechnology, 30, 9\u201319.","journal-title":"Molecular Biotechnology"},{"issue":"9","key":"1418_CR47","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","volume":"18","author":"CT Taylor","year":"2022","unstructured":"Taylor, C. T., & Scholz, C. C. (2022). The effect of HIF on metabolism and immunity. Nature Reviews Nephrology, 18(9), 573\u2013587.","journal-title":"Nature Reviews Nephrology"},{"key":"1418_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10409238.2013.838205","volume":"49","author":"VL Dengler","year":"2014","unstructured":"Dengler, V. L., Galbraith, M. D., & Espinosa, J. M. (2014). Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology, 49, 1.","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"1418_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2172-8-1","volume":"8","author":"O Sharif","year":"2007","unstructured":"Sharif, O., Bolshakov, V. N., Raines, S., Newham, P., & Perkins, N. D. (2007). Transcriptional profiling of the LPS induced NF-\u03baB response in macrophages. BMC Immunology, 8, 1\u201317.","journal-title":"BMC Immunology"},{"key":"1418_CR50","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1007\/s13346-023-01362-3","volume":"13","author":"DM Dogbey","year":"2023","unstructured":"Dogbey, D. M., Torres, V. E. S., Fajemisin, E., Mpondo, L., Ngwenya, T., Akinrinmade, O. A., Perriman, A. W., & Barth, S. (2023). Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy. Drug Delivery and Translational Research, 13, 2719.","journal-title":"Drug Delivery and Translational Research"},{"key":"1418_CR51","first-page":"GE01","volume":"9","author":"M Ramamoorth","year":"2015","unstructured":"Ramamoorth, M., & Narvekar, A. (2015). Non viral vectors in gene therapy\u2014An overview. Journal of Clinical and Diagnostic Research, 9, GE01.","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"1418_CR52","first-page":"627","volume":"72","author":"NA Helal","year":"2017","unstructured":"Helal, N. A., Osami, A., Helmy, A., McDonald, T., Shaaban, L. A., & Nounou, M. I. (2017). Non-viral gene delivery systems: Hurdles for bench-to-bedside transformation. Die Pharmazie, 72, 627\u2013651.","journal-title":"Die Pharmazie"},{"key":"1418_CR53","doi-asserted-by":"publisher","first-page":"2411062","DOI":"10.1002\/advs.202411062","volume":"12","author":"F Tan","year":"2025","unstructured":"Tan, F., Dong, Y., Qi, J., Yu, W., & Chai, R. (2025). Artificial intelligence-based approaches for AAV vector engineering. Advanced Science, 12, 2411062.","journal-title":"Advanced Science"},{"key":"1418_CR54","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41392-024-01780-w","volume":"9","author":"JH Wang","year":"2024","unstructured":"Wang, J. H., Gessler, D. J., Zhan, W., Gallagher, T. L., & Gao, G. (2024). Adeno-associated virus as a delivery vector for gene therapy of human diseases. Signal Transduction and Targeted Therapy, 9, 78.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"1418_CR55","doi-asserted-by":"publisher","first-page":"S120","DOI":"10.1016\/S1525-0016(16)33110-0","volume":"24","author":"J Sullivan","year":"2016","unstructured":"Sullivan, J., Stanek, L., Lukason, M., Barry, E., Russell, S., Morris, J.,\nMastis, B., Alves, A., Bu, J., Shihabuddin, L.S. & Cheng, S. (2016). 301. AAV capsid engineering to improve transduction in retina and brain. Molecular Therapy, 24, S120\u2013S121.","journal-title":"Molecular Therapy"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01418-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-025-01418-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01418-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:03:09Z","timestamp":1772863389000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-025-01418-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1418"],"URL":"https:\/\/doi.org\/10.1007\/s12033-025-01418-4","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"10 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Ethical approval is\u00a0not required as this study did not involve experiments on human subjects or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}